Ppil2 (peptidylprolyl isomerase like 2)

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Gene: Ppil2 (peptidylprolyl isomerase like 2) Rattus norvegicus

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Symbol:

Ppil2

Name:

peptidylprolyl isomerase like 2

RGD ID:

1309484

Description:

Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein folding and protein localization to plasma membrane. Predicted to act upstream of or within protein polyubiquitination. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPIL2 (peptidylprolyl isomerase like 2); PARTICIPATES IN spliceosome pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC360746; peptidyl-prolyl cis-trans isomerase-like 2; peptidylprolyl isomerase (cyclophilin)-like 2; peptidylprolyl isomerase-like 2; RING-type E3 ubiquitin-protein ligase PPIL2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PPIL2 (peptidylprolyl isomerase like 2)	RGD	RGD
Mus musculus (house mouse):	Ppil2 (peptidylprolyl isomerase (cyclophilin)-like 2)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Ppil2 (peptidylprolyl isomerase like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PPIL2 (peptidylprolyl isomerase like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PPIL2 (peptidylprolyl isomerase like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ppil2 (peptidylprolyl isomerase like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PPIL2 (peptidylprolyl isomerase like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PPIL2 (peptidylprolyl isomerase like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ppil2 (peptidylprolyl isomerase like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PPIL2 (peptidylprolyl isomerase like 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ppil2 (peptidylprolyl isomerase (cyclophilin)-like 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ppil2 (peptidylprolyl isomerase (cyclophilin)-like 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyn-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7747	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ppil2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Ppil2-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	97,401,944 - 97,424,581 (+)	NCBI		GRCr8
mRatBN7.2	11	83,897,719 - 83,920,970 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,897,764 - 83,922,144 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,621,317 - 92,643,906 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	85,282,459 - 85,305,048 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	84,336,040 - 84,358,629 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	88,147,342 - 88,169,968 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	88,147,377 - 88,169,968 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	91,200,042 - 91,222,633 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,903,199 - 85,925,790 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,943,795 - 85,966,387 (+)	NCBI
Celera	11	82,653,458 - 82,676,049 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

DiGeorge syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

mercury dibromide (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

N-nitrosodiethylamine (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

potassium chromate (ISO)

SB 431542 (ISO)

selenium atom (ISO)

tamoxifen (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

protein folding (IBA)

protein localization to plasma membrane (ISO)

protein polyubiquitination (ISO)

Cellular Component

catalytic step 2 spliceosome (IBA)

cytoplasm (ISO)

nucleoplasm (ISO)

nucleus (ISO)

plasma membrane (ISO)

Molecular Function

peptidyl-prolyl cis-trans isomerase activity (ISO)

protein binding (ISO)

ubiquitin protein ligase activity (IBA,ISO)

ubiquitin-ubiquitin ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (ISO)

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Spliceosomal immunophilins.	Mesa A, etal., FEBS Lett. 2008 Jul 9;582(16):2345-51. doi: 10.1016/j.febslet.2008.06.006. Epub 2008 Jun 9.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:11435423	PMID:12477932	PMID:15946952	PMID:20676357

Genomics

Comparative Map Data

Ppil2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	97,401,944 - 97,424,581 (+)	NCBI		GRCr8
mRatBN7.2	11	83,897,719 - 83,920,970 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,897,764 - 83,922,144 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,621,317 - 92,643,906 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	85,282,459 - 85,305,048 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	84,336,040 - 84,358,629 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	88,147,342 - 88,169,968 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	88,147,377 - 88,169,968 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	91,200,042 - 91,222,633 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,903,199 - 85,925,790 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,943,795 - 85,966,387 (+)	NCBI
Celera	11	82,653,458 - 82,676,049 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

PPIL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	21,666,012 - 21,700,015 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	21,666,000 - 21,700,015 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	22,020,301 - 22,054,304 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	20,350,273 - 20,382,202 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	20,344,863 - 20,376,713	NCBI
Celera	22	5,837,808 - 5,869,733 (+)	NCBI		Celera
Cytogenetic Map	22	q11.21-q11.22	NCBI
HuRef	22	4,978,170 - 5,009,851 (+)	NCBI		HuRef
CHM1_1	22	22,020,457 - 22,052,396 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	22,079,481 - 22,113,495 (+)	NCBI		T2T-CHM13v2.0

Ppil2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	16,904,419 - 16,929,126 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	16,904,419 - 16,929,121 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	17,086,555 - 17,111,263 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	17,086,555 - 17,111,257 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	17,086,648 - 17,111,306 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	17,000,118 - 17,024,776 (-)	NCBI		MGSCv36	mm8
Celera	16	17,659,344 - 17,684,006 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	10.59	NCBI

Ppil2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	17,425,231 - 17,449,832 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	17,426,154 - 17,449,079 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPIL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	31,211,209 - 31,243,317 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	33,759,935 - 33,792,047 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	3,788,603 - 3,821,090 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	20,272,383 - 20,304,142 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	20,272,383 - 20,304,130 (+)	Ensembl	panpan1.1		panPan2

PPIL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	30,939,556 - 30,966,210 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	30,939,628 - 30,964,880 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	30,896,754 - 30,923,407 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	32,345,292 - 32,371,949 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	32,345,355 - 32,374,381 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	30,394,595 - 30,421,250 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	30,018,362 - 30,044,789 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	31,108,382 - 31,134,809 (+)	NCBI		UU_Cfam_GSD_1.0

Ppil2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,727,557 - 140,770,279 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	1,981,214 - 2,027,074 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	1,983,602 - 2,026,494 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPIL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,208,374 - 50,232,830 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,206,807 - 50,232,845 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	53,657,300 - 53,683,355 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPIL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,412,575 - 4,448,759 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,414,953 - 4,445,891 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	2,555,074 - 2,587,050 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppil2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	1,221,631 - 1,248,391 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	1,221,703 - 1,248,398 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ppil2
71 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	145
Count of miRNA genes:	107
Interacting mature miRNAs:	117
Transcripts:	ENSRNOT00000034506
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat

Markers in Region

BE111642

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	83,905,434 - 83,905,607 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	88,155,038 - 88,155,210	NCBI	Rnor6.0
Rnor_5.0	11	91,207,703 - 91,207,875	UniSTS	Rnor5.0
RGSC_v3.4	11	85,910,860 - 85,911,032	UniSTS	RGSC3.4
Celera	11	82,661,119 - 82,661,291	UniSTS
RH 3.4 Map	11	653.41	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001017383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010055963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000034506 ⟹ ENSRNOP00000035467

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,897,764 - 83,920,364 (+)	Ensembl
Rnor_6.0 Ensembl	11	88,147,377 - 88,169,968 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104516 ⟹ ENSRNOP00000097314

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,903,135 - 83,922,144 (+)	Ensembl

RefSeq Acc Id:

NM_001017383 ⟹ NP_001017383

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,401,984 - 97,424,579 (+)	NCBI
mRatBN7.2	11	83,897,769 - 83,920,366 (+)	NCBI
Rnor_6.0	11	88,147,377 - 88,169,968 (+)	NCBI
Rnor_5.0	11	91,200,042 - 91,222,633 (+)	NCBI
RGSC_v3.4	11	85,903,199 - 85,925,790 (+)	RGD
Celera	11	82,653,458 - 82,676,049 (+)	RGD

Sequence:

show sequence

CGCTAGAGCCTGAGTGTCTGCTGTGATCTCGGTTCGTCGCCACCATGGGGAAGCGACAGCACCA
GAAGGACAAGATGTACATCACCTGTGCAGAGTACACTCATTTCTATGGTGGCAGGAAGCCAGAT
ATCACACAGACAAGTTTTCGCCGCTTACCTTTTGACCATTGCAGTCTCTCTCTCCAGCCTTTTG
TCTACCCAGTCTGCACCCCGGAAGGTGTCGTCTTCGACTTGCTGAACATTGTCCCATGGCTTAA
GAAGTATGGGACCGATCCGAGCACTGGAGAGAAACTTGATGGGAAGTCCCTGATTAAGCTGAAC
TTTGCAAAGAACAGTGAAGGGCAGTACCACTGTCCAGTGCTGTACTCCGTGTTCACTGACAACA
CCCACATCGTGGCCATCAGGACAACTGGCAATGTCTACACCTATGAGGCAGTGGAGCAGCTAAA
CATCAAGGCCAAGAACTTGAGGGACCTGTTAACTGATGAGCCCTTTTCCAGGCAAGACATCATC
ACCCTGCAGGACCCCACCAATCTGGACAAATTTAACGTCAGCAGCTTCTTCCATGTAAAGAATA
ACATGCGAATGATAGATCCAGATGAGGAAAAGGCCAAACAAGACCCATCTTATTATTTGAAAAA
TACAAATGCGGAGACCCGAGAGACGCTACAGGAGCTCTACAAAGAGTTCAAAGGAGATGAGATT
TTAGCAGCTACCATGAAGCCACCTGAGAAGAAGAAGGTGGACCAACTGAATGCCGCCCACTATT
CCACAGGGAAGGTCAGCGCGTCCTTCACCTCTACCGCCATGGTGCCTGAGACCACGCATGAAGC
AGCTGTCATTGATGAAGATGTCCTGCGCTACCAGTTTGTGAAGAAGAAGGGCTATGTGAGGCTA
CACACCAACAAGGGTGACCTCAACCTCGAGCTGCACTGTGACCTGACACCAAAAACCTGTGAAA
ACTTCATCAAGCTCTGCAAGAAACAGTATTATGATGGTACCATCTTTCACAGATCCATCAGGAA
CTTTGTGATCCAGGGTGGTGACCCTACTGGTACAGGCACAGGAGGAGAGTCATACTGGGGCAAG
CCTTTCAAAGACGAGTTCCGTCCCAATCTTTCACACACAGGCCGTGGGGTGCTCAGCATGGCCA
ATTCAGGGCCCAACACCAACAAGTCTCAGTTCTTCATCACCTTCCGGTCCTGTGCTTACCTGGA
CAAGAAGCACACCATCTTTGGACGGGTTGTCGGGGGCTTTGACACGCTGACAGCTATGGAGAAT
GTGGAGAGTGACCCCAAAACTGACCGCCCTAAGGAAGAAGTGCGCATCTGTACCACCACAGTGT
TTGTGGATCCCTATGAGGAGGCCGACGCCCAGATTGCCCAGGAACGGAAGAAGACACAGCACCA
AGTGGATCCAGAGGCCAAGGCCAAGACGAACCAGCCCCAGCCTGGAAACCAGGGCCCCCAGACA
TACCGCCAGGGGGTGGGCAAGTACATCAACCCTGCAGCCACGAAACGAGCAGCAGAGGAAGAAC
CATCCACCAGCACAGCTATCCCCACAGCCAAGAAAAGGCCCAGTCGGGGCTTTGGGGACTTCAG
CTCCTGGTAGCAGCAGGCTGGCCTCAGGGATCCTGGTAGGGGTGCAGGGCTGTGGGCCTCCAGG
TCTGTCCCTGAGCCCTTTACCCTTGCCATCAGTTTGGGCTGTGAACCAATAAATCTGTTGCCTA
GGACCTGGGTCCAGTTTGGGCCCCTGGGACTCCTGGGATCCCCTTCCTAAAAAAAAAAAAAAAA
AAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063270662 ⟹ XP_063126732

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,401,950 - 97,424,581 (+)	NCBI

RefSeq Acc Id:

XM_063270663 ⟹ XP_063126733

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,414,708 - 97,424,581 (+)	NCBI

RefSeq Acc Id:

XR_010055963

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,401,944 - 97,423,882 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001017383	(Get FASTA)	NCBI Sequence Viewer
	XP_063126732	(Get FASTA)	NCBI Sequence Viewer
	XP_063126733	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85890	(Get FASTA)	NCBI Sequence Viewer
	EDL77871	(Get FASTA)	NCBI Sequence Viewer
	EDL77872	(Get FASTA)	NCBI Sequence Viewer
	EDL77873	(Get FASTA)	NCBI Sequence Viewer
	EDL77874	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035467.5
	ENSRNOP00000097314.1

RefSeq Acc Id:

NP_001017383 ⟸ NM_001017383

- UniProtKB:

Q5RKH8 (UniProtKB/TrEMBL), A6JSN3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGKRQHQKDKMYITCAEYTHFYGGRKPDITQTSFRRLPFDHCSLSLQPFVYPVCTPEGVVFDLL
NIVPWLKKYGTDPSTGEKLDGKSLIKLNFAKNSEGQYHCPVLYSVFTDNTHIVAIRTTGNVYTY
EAVEQLNIKAKNLRDLLTDEPFSRQDIITLQDPTNLDKFNVSSFFHVKNNMRMIDPDEEKAKQD
PSYYLKNTNAETRETLQELYKEFKGDEILAATMKPPEKKKVDQLNAAHYSTGKVSASFTSTAMV
PETTHEAAVIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKQYYDGTI
FHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGVLSMANSGPNTNKSQFFITF
RSCAYLDKKHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVRICTTTVFVDPYEEADAQIAQE
RKKTQHQVDPEAKAKTNQPQPGNQGPQTYRQGVGKYINPAATKRAAEEEPSTSTAIPTAKKRPS
RGFGDFSSW

hide sequence

Ensembl Acc Id:

ENSRNOP00000035467 ⟸ ENSRNOT00000034506

Ensembl Acc Id:

ENSRNOP00000097314 ⟸ ENSRNOT00000104516

RefSeq Acc Id:	XP_063126732 ⟸ XM_063270662
- Peptide Label:	isoform X1
- UniProtKB:	F7FHL6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063126733 ⟸ XM_063270663
- Peptide Label:	isoform X2

Protein Domains

PPIase cyclophilin-type U-box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5RKH8-F1-model_v2	AlphaFold	Q5RKH8	1-521	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698338

Promoter ID:

EPDNEW_R8863

Type:

initiation region

Name:

Ppil2_1

Description:

peptidylprolyl isomerase like 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	88,147,364 - 88,147,424	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309484	AgrOrtholog
BioCyc Gene	G2FUF-20567	BioCyc
Ensembl Genes	ENSRNOG00000026900	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000034506.5	UniProtKB/TrEMBL
	ENSRNOT00000104516.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.100.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Single helix bin	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7192457	IMAGE-MGC_LOAD
InterPro	Cyclophilin-like_dom	UniProtKB/TrEMBL
	Cyclophilin_A-like	UniProtKB/TrEMBL
	NOSIP	UniProtKB/TrEMBL
	Pep-Pro_Isoase_cyclophilin_CS	UniProtKB/TrEMBL
	PPIase_cyclophilin	UniProtKB/TrEMBL
	PPIL2_U-box_dom	UniProtKB/TrEMBL
	Ubox_domain	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:360746	UniProtKB/TrEMBL
MGC_CLONE	MGC:94681	IMAGE-MGC_LOAD
NCBI Gene	360746	ENTREZGENE
PANTHER	ENOS INTERACTING PROTEIN	UniProtKB/TrEMBL
	NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN	UniProtKB/TrEMBL
	PTHR45625	UniProtKB/TrEMBL
	RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2	UniProtKB/TrEMBL
Pfam	Pro_isomerase	UniProtKB/TrEMBL
	Rtf2	UniProtKB/TrEMBL
PhenoGen	Ppil2	PhenoGen
PRINTS	CSAPPISMRASE	UniProtKB/TrEMBL
PROSITE	CSA_PPIASE_1	UniProtKB/TrEMBL
	CSA_PPIASE_2	UniProtKB/TrEMBL
	U_BOX	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000026900	RatGTEx
SMART	Ubox	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF50891	UniProtKB/TrEMBL
UniProt	A0A8I6ARD8_RAT	UniProtKB/TrEMBL
	A6JSN3	ENTREZGENE, UniProtKB/TrEMBL
	A6JSN4_RAT	UniProtKB/TrEMBL
	A6JSN5_RAT	UniProtKB/TrEMBL
	A6JSN6_RAT	UniProtKB/TrEMBL
	F7FHL6	ENTREZGENE, UniProtKB/TrEMBL
	Q5RKH8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Ppil2	peptidylprolyl isomerase like 2	Ppil2	peptidylprolyl isomerase (cyclophilin)-like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Ppil2	peptidylprolyl isomerase (cyclophilin)-like 2	Ppil2_predicted	peptidylprolyl isomerase (cyclophilin)-like 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ppil2_predicted	peptidylprolyl isomerase (cyclophilin)-like 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)