RGD Reference Report - Spliceosomal immunophilins. - Rat Genome Database

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Spliceosomal immunophilins.

Authors: Mesa, Annia  Somarelli, Jason A  Herrera, Rene J 
Citation: Mesa A, etal., FEBS Lett. 2008 Jul 9;582(16):2345-51. doi: 10.1016/j.febslet.2008.06.006. Epub 2008 Jun 9.
RGD ID: 9686376
Pubmed: PMID:18544344   (View Abstract at PubMed)
PMCID: PMC2546689   (View Article at PubMed Central)
DOI: DOI:10.1016/j.febslet.2008.06.006   (Journal Full-text)

The spliceosome is a dynamic, macromolecular complex, which removes non-protein-coding introns from pre-mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine-rich small nuclear RNAs (snRNAs) as well as over 300 proteins. In humans, several of the known proteinaceous splicing factors are members of the immunophilin superfamily. Immunophilins are peptidyl-prolyl cis-trans isomerases that catalyze the conversion of proteins from cis to trans at Xaa-Pro bonds. Our review of the data indicates that some members of this protein family are activators of spliceosomal proteins by way of folding and transport.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Ppie  (peptidylprolyl isomerase E)
Ppig  (peptidylprolyl isomerase G)
Ppih  (peptidylprolyl isomerase H)
Ppil1  (peptidylprolyl isomerase like 1)
Ppil2  (peptidylprolyl isomerase like 2)
Ppil3  (peptidylprolyl isomerase like 3)

Genes (Mus musculus)
Ppie  (peptidylprolyl isomerase E (cyclophilin E))
Ppig  (peptidyl-prolyl isomerase G (cyclophilin G))
Ppih  (peptidyl prolyl isomerase H)
Ppil1  (peptidylprolyl isomerase (cyclophilin)-like 1)
Ppil2  (peptidylprolyl isomerase (cyclophilin)-like 2)
Ppil3  (peptidylprolyl isomerase (cyclophilin)-like 3)

Genes (Homo sapiens)
PPIE  (peptidylprolyl isomerase E)
PPIG  (peptidylprolyl isomerase G)
PPIH  (peptidylprolyl isomerase H)
PPIL1  (peptidylprolyl isomerase like 1)
PPIL2  (peptidylprolyl isomerase like 2)
PPIL3  (peptidylprolyl isomerase like 3)


Additional Information