Ppil2 (peptidylprolyl isomerase like 2)

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Gene: Ppil2 (peptidylprolyl isomerase like 2) Ictidomys tridecemlineatus

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Symbol:

Ppil2

Name:

peptidylprolyl isomerase like 2

RGD ID:

12551750

Description:

ENCODES a protein that exhibits peptidyl-prolyl cis-trans isomerase activity (ortholog); INVOLVED IN protein polyubiquitination (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH autistic disorder (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); DiGeorge syndrome (ortholog); FOUND IN catalytic step 2 spliceosome (inferred); cytoplasm (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

peptidyl-prolyl cis-trans isomerase-like 2; RING-type E3 ubiquitin-protein ligase PPIL2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,727,557 - 140,770,279 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	1,981,214 - 2,027,074 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	1,983,602 - 2,026,494 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

DiGeorge syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein folding (IEA)

protein localization to plasma membrane (IEA)

protein polyubiquitination (IEA,ISO)

protein ubiquitination (IEA)

Cellular Component

catalytic step 2 spliceosome (IEA)

cytoplasm (IEA)

nucleoplasm (IEA)

nucleus (IEA)

plasma membrane (IEA)

Molecular Function

peptidyl-prolyl cis-trans isomerase activity (IEA,ISO)

protein binding (ISO)

ubiquitin protein ligase activity (IEA)

ubiquitin-protein transferase activity (IEA)

ubiquitin-ubiquitin ligase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ppil2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,727,557 - 140,770,279 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	1,981,214 - 2,027,074 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	1,983,602 - 2,026,494 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPIL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	21,666,012 - 21,700,015 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	21,666,000 - 21,700,015 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	22,020,301 - 22,054,304 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	20,350,273 - 20,382,202 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	20,344,863 - 20,376,713	NCBI
Celera	22	5,837,808 - 5,869,733 (+)	NCBI		Celera
Cytogenetic Map	22	q11.21-q11.22	NCBI
HuRef	22	4,978,170 - 5,009,851 (+)	NCBI		HuRef
CHM1_1	22	22,020,457 - 22,052,396 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	22,079,481 - 22,113,495 (+)	NCBI		T2T-CHM13v2.0

Ppil2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	16,904,419 - 16,929,126 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	16,904,419 - 16,929,121 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	17,086,555 - 17,111,263 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	17,086,555 - 17,111,257 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	17,086,648 - 17,111,306 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	17,000,118 - 17,024,776 (-)	NCBI		MGSCv36	mm8
Celera	16	17,659,344 - 17,684,006 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	10.59	NCBI

Ppil2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	97,401,944 - 97,424,581 (+)	NCBI		GRCr8
mRatBN7.2	11	83,897,719 - 83,920,970 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,897,764 - 83,922,144 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,621,317 - 92,643,906 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	85,282,459 - 85,305,048 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	84,336,040 - 84,358,629 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	88,147,342 - 88,169,968 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	88,147,377 - 88,169,968 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	91,200,042 - 91,222,633 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,903,199 - 85,925,790 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,943,795 - 85,966,387 (+)	NCBI
Celera	11	82,653,458 - 82,676,049 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Ppil2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	17,425,231 - 17,449,832 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	17,426,154 - 17,449,079 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPIL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	31,211,209 - 31,243,317 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	33,759,935 - 33,792,047 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	3,788,603 - 3,821,090 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	20,272,383 - 20,304,142 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	20,272,383 - 20,304,130 (+)	Ensembl	panpan1.1		panPan2

PPIL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	30,939,556 - 30,966,210 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	30,939,628 - 30,964,880 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	30,896,754 - 30,923,407 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	32,345,292 - 32,371,949 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	32,345,355 - 32,374,381 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	30,394,595 - 30,421,250 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	30,018,362 - 30,044,789 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	31,108,382 - 31,134,809 (+)	NCBI		UU_Cfam_GSD_1.0

PPIL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,208,374 - 50,232,830 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,206,807 - 50,232,845 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	53,657,300 - 53,683,355 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPIL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,412,575 - 4,448,759 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,414,953 - 4,445,891 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	2,555,074 - 2,587,050 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppil2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	1,221,631 - 1,248,391 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	1,221,703 - 1,248,398 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005334480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040289270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000000909 ⟹ ENSSTOP00000000815

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936619	1,981,214 - 2,027,074 (-)	Ensembl

RefSeq Acc Id:

XM_005334480 ⟹ XP_005334537

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	140,727,557 - 140,770,279 (+)	NCBI
SpeTri2.0	NW_004936619	1,983,602 - 2,026,494 (-)	NCBI

Sequence:

show sequence

GGCGGGTCTGCAAGACCCGGAAGTGGTGAGGAAACTCCGAGGAGGCTTGGGGATCTGAGTGGTA
GGCGGTCACTTTTTCGCTTTAGCTGTTTCTGCTGCTGCCACCGCTGCCATGGGGAAACGACAGC
ACCAGAAGGACAAGATGTACATTACCTGTGCTGAATACACTCACTTCTATGGTGGCAAGAAGCC
AGATATCCCACAAACAAATTTTCGTCGATTACCTTTTGACCACTGCAGTCTTTCTCTGCAGCCC
TTTGTCTACCCTGTCTGCACCCCAGAAGGTGTCGTCTTTGACTTGCTGAATATCGTTCCATGGC
TTAAGAAGTATGGGACTAACCCCAGCAATGGAGAGAAACTTGATGGTAGGTCCCTGATAAAGCT
GAACTTTTCCAAGAACAGTGAAGAGAAGTATCACTGCCCGGTGCTGTTCACTGTGTTCACCAAT
AACACCCACATTGTGGCCATCAGGACAACTGGCAATGTCTATGCCTACGAGGCAGTGGAGCAGC
TAAACATCAAGGCAAAGAACTTTCGGGACCTGTTGACTGATGAGCCCTTCTCTCGACAGGACAT
CATCACTCTCCAGGACCCCACCAATTTGGACAAGTTCAATGTCTCCAACTTCTTTCATGTTAAG
AATAACATGAAGATAACAGACCCAGATGAGGAAAAGGCCAAACAGGACCCATCTTATTATTTGA
AAAACACAAACACTGAGACCCGAGAAACACTGCAGGAGCTGTACAAGGAGTTCAAAGGGGATGA
AATCTTGGCAGCCACCATGAAGGCCCCAGAGAAGAAGAAAGTGGACCAGCTAAATGCTGCCCAC
TATTCCACGGGGAAGGTCAGTGCTTCCTTCACCTCCACTGCCATGATGCCGGAGACGACACATG
AAGCAGCTGCTATTGATGAAGATGTGCTACGCTACCAGTTTGTGAAGAAGAAGGGCTATGTGCG
GTTGCACACCAACAAAGGTGATCTTAATCTGGAACTGCACTGCGACTTGACACCAAAAACCTGC
GAAAACTTCATCAAGCTCTGCAAGAAGTGCTATTATGATGGCACCATCTTTCACAGGTCCATCA
GGAACTTTGTGATCCAAGGAGGAGACCCCACAGGCACAGGCACAGGAGGTGAGTCATACTGGGG
AAAGCCCTTCAGAGATGAGTTCCGGCCCAATCTCTCTCACACAGGACGAGGCATCCTCAGCATG
GCCAACTCGGGGCCGAACACCAACAAGTCTCAGTTCTTTATCACATTCCGTTCCTGTGCTTACC
TGGACAAGAAGCACACCATCTTTGGAAGGGTTGTTGGGGGCTTTGACACACTGACAGCCATGGA
GAATGTGGAAAGCGACCCCAAAACTGACCGCCCTAAGGAGGAGGTCCGCATTGATGCCACCACA
GTGTTTGTAGACCCCTATGAGGAGGCAGATGCCCAGATTGCACAGGAGCGGAAGAAGACACAGC
TTGAAGTGGCCCCAGAGGCCAAGGTGAAGTCCAGCCAGCCTCAGCCTGGGAGCCAGGGCCCCCA
GACATATCGCCAAGGGGTGGGCAAGTACATCAATCCAGCTGCCACGAAACGAGCAGCTGAAGAA
GAACCATCAACCAGTACAGCTGCCTCCATATCCAAGAAAAAGCCCAGCCGGGGTTTTGGGGACT
TCAGCTCCTGGTAGCAGCAGTCAAAAGCTCGGCGACCAGGCAGTGTGATACAGCAGTAGGACTC
CAGCAGCTCTGAGACCCCAAAACAGCCCTTTGCTCTGGTGAGCTCTGCAGGAAACCTGGGGCTC
ATCCCTCATTAAGGGCACAGCCTCCTCAACAATGAGCAACATGTAAAACAAGAAGTCTGACATC
AGAAGCTTTATTTATAAACCTCACACAAACATAGGACCAAAGGCCAGTGGCATGGCTTGGGGTA
GGGGAAACTGAAGGCGGTGTGTGCACTTGAGCTTGATCATCCTTGCTCCTTGAAGCGAAGCTTC
CTGCTGCCTCCAGGCTGCTGTCCATCTGTCCATCCAGCCTTATCCAGTGATCTGCACCTGCCCC
AAGGGGAGGGCCATATCCTCACCCAAACTTGCCCTCCAGGGCAGAAGACAGGCCTGACCAAGTC
CTTTGACAGAAGGTTTATATTTCTGTAGTTCATTTTAGAGCTTAAATTATGTCCTTCTAGATAT
TAAACCACTTGGATTTTGTAACTGCCTGATGAGATCATCAGGTAGAATAAAAGACTTTTGGAAA
AAAATCTCATCTCTGATCCTTTTGAATATCTGACAGATGCCATCAAGAATAAATTTTAAGATAT
AAAAATACTATGAGTGTACATATATAAAATGACAAAACTAAACCACATTTCTAAAGCAAATGTA
CTGTGCCAGAATGTACTACAAATGTATTTATAATCCTAGATACAACTCCAAATATTCTCAAG

hide sequence

RefSeq Acc Id:

XM_040289270 ⟹ XP_040145204

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	140,727,557 - 140,770,279 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005334537	(Get FASTA)	NCBI Sequence Viewer
	XP_040145204	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000000815.3
GenBank Protein	KAG3278748	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005334537 ⟸ XM_005334480
- Peptide Label:	isoform X1
- UniProtKB:	I3LXK3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGKRQHQKDKMYITCAEYTHFYGGKKPDIPQTNFRRLPFDHCSLSLQPFVYPVCTPEGVVFDLL NIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEEKYHCPVLFTVFTNNTHIVAIRTTGNVYAY EAVEQLNIKAKNFRDLLTDEPFSRQDIITLQDPTNLDKFNVSNFFHVKNNMKITDPDEEKAKQD PSYYLKNTNTETRETLQELYKEFKGDEILAATMKAPEKKKVDQLNAAHYSTGKVSASFTSTAMM PETTHEAAAIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKCYYDGTI FHRSIRNFVIQGGDPTGTGTGGESYWGKPFRDEFRPNLSHTGRGILSMANSGPNTNKSQFFITF RSCAYLDKKHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVRIDATTVFVDPYEEADAQIAQE RKKTQLEVAPEAKVKSSQPQPGSQGPQTYRQGVGKYINPAATKRAAEEEPSTSTAASISKKKPS RGFGDFSSW hide sequence

RefSeq Acc Id:	XP_040145204 ⟸ XM_040289270
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000000815 ⟸ ENSSTOT00000000909

Protein Domains

PPIase cyclophilin-type U-box

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000000909	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000000909.3	UniProtKB/TrEMBL
Gene3D-CATH	2.40.100.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Single helix bin	UniProtKB/TrEMBL
InterPro	Cyclophilin-like_dom_sf	UniProtKB/TrEMBL
	Cyclophilin-type_PPIase_CS	UniProtKB/TrEMBL
	Cyclophilin-type_PPIase_dom	UniProtKB/TrEMBL
	Cyclophilin_A-like	UniProtKB/TrEMBL
	PPIL2_U-box_dom	UniProtKB/TrEMBL
	Ubox_domain	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
NCBI Gene	Ppil2	ENTREZGENE
PANTHER	PTHR45625	UniProtKB/TrEMBL
	RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2	UniProtKB/TrEMBL
Pfam	Pro_isomerase	UniProtKB/TrEMBL
PRINTS	CSAPPISMRASE	UniProtKB/TrEMBL
PROSITE	CSA_PPIASE_1	UniProtKB/TrEMBL
	CSA_PPIASE_2	UniProtKB/TrEMBL
	U_BOX	UniProtKB/TrEMBL
SMART	Ubox	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF50891	UniProtKB/TrEMBL
UniProt	I3LXK3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations