Tssk2 (testis-specific serine kinase 2) - Rat Genome Database

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Gene: Tssk2 (testis-specific serine kinase 2) Rattus norvegicus
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Symbol: Tssk2
Name: testis-specific serine kinase 2
RGD ID: 1304951
Description: Predicted to enable magnesium ion binding activity and protein serine/threonine kinase activity. Predicted to be involved in spermatid development. Predicted to be located in acrosomal vesicle and centriole. Orthologous to human TSSK2 (testis specific serine kinase 2); INTERACTS WITH bisphenol A; cocaine; fluoxetine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC304181; serine/threonine kinase 22B (spermiogenesis associated); Stk22b; testis-specific serine/threonine-protein kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,590,864 - 96,592,219 (-)NCBIGRCr8
mRatBN7.21183,086,578 - 83,087,933 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1191,815,190 - 91,816,545 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,476,324 - 84,477,679 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,529,939 - 83,531,294 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,235,058 - 87,236,413 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,221,613 - 87,236,445 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,326,621 - 90,327,976 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,074,711 - 85,076,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,115,308 - 85,116,663 (-)NCBI
Celera1181,862,589 - 81,863,944 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11. Gong W, etal., Hum Mol Genet. 1996 Jun;5(6):789-800.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18367677   PMID:18495105   PMID:18533145   PMID:20729278   PMID:21630459   PMID:23599433   PMID:32046715  


Genomics

Comparative Map Data
Tssk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,590,864 - 96,592,219 (-)NCBIGRCr8
mRatBN7.21183,086,578 - 83,087,933 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1191,815,190 - 91,816,545 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,476,324 - 84,477,679 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,529,939 - 83,531,294 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,235,058 - 87,236,413 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,221,613 - 87,236,445 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,326,621 - 90,327,976 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,074,711 - 85,076,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,115,308 - 85,116,663 (-)NCBI
Celera1181,862,589 - 81,863,944 (-)NCBICelera
Cytogenetic Map11q23NCBI
TSSK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,131,308 - 19,132,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,131,308 - 19,132,622 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,118,821 - 19,120,135 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,498,790 - 17,500,136 (+)NCBINCBI36Build 36hg18NCBI36
Celera222,970,345 - 2,972,160 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef222,739,863 - 2,741,678 (+)NCBIHuRef
CHM1_12219,117,902 - 19,119,717 (+)NCBICHM1_1
T2T-CHM13v2.02219,505,922 - 19,507,236 (+)NCBIT2T-CHM13v2.0
Tssk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,716,501 - 17,717,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,716,501 - 17,717,888 (+)EnsemblGRCm39 Ensembl
GRCm381617,898,637 - 17,900,024 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,898,637 - 17,900,024 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,898,730 - 17,900,117 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,812,275 - 17,813,587 (+)NCBIMGSCv36mm8
Celera1618,471,702 - 18,473,089 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.09NCBI
Tssk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544218,846,491 - 18,847,485 (-)NCBIChiLan1.0ChiLan1.0
TSSK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22328,750,114 - 28,755,674 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,298,866 - 31,303,271 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0221,885,099 - 1,887,139 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12217,562,399 - 17,567,123 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2217,563,492 - 17,564,568 (+)Ensemblpanpan1.1panPan2
TSSK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2630,004,242 - 30,005,580 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,451,456 - 31,452,794 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,451,587 - 31,452,663 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,499,612 - 29,500,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,124,052 - 29,125,390 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,212,196 - 30,213,534 (-)NCBIUU_Cfam_GSD_1.0
Tssk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,623,195 - 139,625,939 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,129,580 - 3,130,656 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,126,625 - 3,130,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSSK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,943,017 - 50,944,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,943,017 - 50,944,093 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,449,144 - 54,450,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSSK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,617,030 - 6,618,932 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,617,256 - 6,618,344 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666085313,963 - 315,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tssk2
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000057806
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118256654583440803Rat

Markers in Region
Stk22b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,086,785 - 83,087,030 (+)MAPPERmRatBN7.2
Rnor_6.01187,235,266 - 87,235,510NCBIRnor6.0
Rnor_5.01190,326,829 - 90,327,073UniSTSRnor5.0
RGSC_v3.41185,074,919 - 85,075,163UniSTSRGSC3.4
Celera1181,862,797 - 81,863,041UniSTS
Cytogenetic Map11q23UniSTS
BE110023  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,086,707 - 83,086,890 (+)MAPPERmRatBN7.2
Rnor_6.01187,235,188 - 87,235,370NCBIRnor6.0
Rnor_5.01190,326,751 - 90,326,933UniSTSRnor5.0
RGSC_v3.41185,074,841 - 85,075,023UniSTSRGSC3.4
Celera1181,862,719 - 81,862,901UniSTS
RH 3.4 Map11715.2UniSTS
Cytogenetic Map11q23UniSTS
AW534143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,086,485 - 83,086,639 (+)MAPPERmRatBN7.2
Rnor_6.01187,234,966 - 87,235,119NCBIRnor6.0
Rnor_5.01190,326,529 - 90,326,682UniSTSRnor5.0
RGSC_v3.41185,074,619 - 85,074,772UniSTSRGSC3.4
Celera1181,862,497 - 81,862,650UniSTS
RH 3.4 Map11731.33UniSTS
Cytogenetic Map11q23UniSTS
UniSTS:260486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,086,557 - 83,086,659 (+)MAPPERmRatBN7.2
Rnor_6.01187,235,038 - 87,235,139NCBIRnor6.0
Rnor_5.01190,326,601 - 90,326,702UniSTSRnor5.0
RGSC_v3.41185,074,691 - 85,074,792UniSTSRGSC3.4
Celera1181,862,569 - 81,862,670UniSTS
Cytogenetic Map11q23UniSTS
UniSTS:260495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,086,833 - 83,086,976 (+)MAPPERmRatBN7.2
Rnor_6.01187,235,314 - 87,235,456NCBIRnor6.0
Rnor_5.01190,326,877 - 90,327,019UniSTSRnor5.0
RGSC_v3.41185,074,967 - 85,075,109UniSTSRGSC3.4
Celera1181,862,845 - 81,862,987UniSTS
Cytogenetic Map11q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 1 1 8 1 9 1 2 2 2 5 3 2
Below cutoff 11 16 7 10 7 6 9 20 13 4 7 6

Sequence


RefSeq Acc Id: ENSRNOT00000057806   ⟹   ENSRNOP00000054618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1187,221,613 - 87,236,445 (-)Ensembl
RefSeq Acc Id: NM_001012019   ⟹   NP_001012019
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,590,864 - 96,592,219 (-)NCBI
mRatBN7.21183,086,578 - 83,087,933 (-)NCBI
Rnor_6.01187,235,058 - 87,236,413 (-)NCBI
Rnor_5.01190,326,621 - 90,327,976 (-)NCBI
RGSC_v3.41185,074,711 - 85,076,066 (-)RGD
Celera1181,862,589 - 81,863,944 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012019 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79037 (Get FASTA)   NCBI Sequence Viewer  
  AAQ22770 (Get FASTA)   NCBI Sequence Viewer  
  EDL77910 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012019   ⟸   NM_001012019
- UniProtKB: Q6VAH7 (UniProtKB/TrEMBL),   Q6AYI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054618   ⟸   ENSRNOT00000057806
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FH45-F1-model_v2 AlphaFold F7FH45 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698326
Promoter ID:EPDNEW_R8840
Type:multiple initiation site
Name:Tssk2_1
Description:Testis-specific serine/threonine-protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,236,438 - 87,236,498EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304951 AgrOrtholog
BioCyc Gene G2FUF-20619 BioCyc
Ensembl Genes ENSRNOG00000037997 Ensembl
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114351 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:304181 UniProtKB/TrEMBL
MGC_CLONE MGC:93966 IMAGE-MGC_LOAD
NCBI Gene 304181 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Tssk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037997 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt Q6AYI0 ENTREZGENE, UniProtKB/TrEMBL
  Q6VAH7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Tssk2  testis-specific serine kinase 2  Stk22b  serine/threonine kinase 22B (spermiogenesis associated)  Symbol and Name updated 1299863 APPROVED
2005-12-06 Stk22b  serine/threonine kinase 22B (spermiogenesis associated)  Stk22b_predicted  serine/threonine kinase 22B (spermiogenesis associated) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Stk22b_predicted  serine/threonine kinase 22B (spermiogenesis associated) (predicted)      Symbol and Name status set to approved 70820 APPROVED