Zdhhc19 (zinc finger DHHC-type palmitoyltransferase 19) - Rat Genome Database

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Gene: Zdhhc19 (zinc finger DHHC-type palmitoyltransferase 19) Rattus norvegicus
Analyze
Symbol: Zdhhc19
Name: zinc finger DHHC-type palmitoyltransferase 19
RGD ID: 1309014
Description: Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in Golgi membrane and perinucleolar compartment. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC19 (zinc finger DHHC-type palmitoyltransferase 19); INTERACTS WITH bisphenol A; dibutyl phthalate; furan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC288045; membrane-associated DHHC19 zinc finger protein; MGC156468; palmitoyltransferase ZDHHC19; probable palmitoyltransferase ZDHHC19; RGD1560310; zinc finger, DHHC domain containing 19; zinc finger, DHHC-type containing 19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,277,847 - 68,289,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,277,848 - 68,288,954 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,114,893 - 77,125,993 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01169,779,264 - 69,790,498 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01168,804,008 - 68,815,111 (-)NCBIRnor_WKY
Rnor_6.01171,490,346 - 71,522,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,511,715 - 71,523,267 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,596,365 - 74,607,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,093,702 - 70,105,297 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,151,290 - 70,152,622 (-)NCBI
Celera1167,710,629 - 67,721,664 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16647879   PMID:20074548  


Genomics

Comparative Map Data
Zdhhc19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,277,847 - 68,289,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,277,848 - 68,288,954 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,114,893 - 77,125,993 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01169,779,264 - 69,790,498 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01168,804,008 - 68,815,111 (-)NCBIRnor_WKY
Rnor_6.01171,490,346 - 71,522,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,511,715 - 71,523,267 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,596,365 - 74,607,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,093,702 - 70,105,297 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,151,290 - 70,152,622 (-)NCBI
Celera1167,710,629 - 67,721,664 (-)NCBICelera
Cytogenetic Map11q22NCBI
ZDHHC19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,197,452 - 196,211,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3196,197,452 - 196,211,437 (-)EnsemblGRCh38hg38GRCh38
GRCh373195,924,323 - 195,938,271 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,408,720 - 197,422,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 343197,412,634 - 197,426,610NCBI
Celera3194,504,929 - 194,518,767 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,224,055 - 193,238,141 (-)NCBIHuRef
CHM1_13195,895,258 - 195,909,130 (-)NCBICHM1_1
T2T-CHM13v2.03198,917,010 - 198,930,875 (-)NCBIT2T-CHM13v2.0
Zdhhc19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,315,059 - 32,326,032 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,315,083 - 32,380,784 (+)EnsemblGRCm39 Ensembl
GRCm381632,496,241 - 32,507,214 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,496,265 - 32,561,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,496,367 - 32,507,300 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,416,028 - 32,426,961 (+)NCBIMGSCv36mm8
Celera1632,978,956 - 32,990,189 (+)NCBICelera
Cytogenetic Map16B3NCBI
Zdhhc19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,432,279 - 12,442,249 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,432,342 - 12,442,411 (-)NCBIChiLan1.0ChiLan1.0
ZDHHC19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13203,485,139 - 203,499,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,486,005 - 203,498,915 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03193,537,735 - 193,551,564 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ZDHHC19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,332,947 - 29,335,942 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,332,959 - 29,336,531 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,349,643 - 29,360,097 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,559,340 - 29,569,886 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,559,287 - 29,569,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,321,996 - 29,356,421 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,399,761 - 29,410,316 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03329,998,746 - 30,033,332 (-)NCBIUU_Cfam_GSD_1.0
LOC101977244
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,041,020 - 125,060,330 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936784748,381 - 833,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZDHHC19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,875,309 - 133,885,763 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,873,072 - 133,886,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,313,255 - 143,331,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZDHHC19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,974,291 - 90,989,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,974,703 - 90,989,006 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604164,816,002 - 64,830,466 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zdhhc19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,362,941 - 61,370,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,357,276 - 61,405,048 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zdhhc19
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:103
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000033026
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
RH138375  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,277,868 - 68,278,535 (+)MAPPERmRatBN7.2
Rnor_6.01171,511,866 - 71,512,532NCBIRnor6.0
Rnor_5.01174,596,387 - 74,597,053UniSTSRnor5.0
RGSC_v3.41170,093,724 - 70,094,390UniSTSRGSC3.4
Celera1167,710,651 - 67,711,317UniSTS
RH 3.4 Map11403.9UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 4 13 12 5 12 1 5 5 4 3
Below cutoff 3 17 31 17 13 17 8 9 46 22 13 7 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033026   ⟹   ENSRNOP00000038846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,277,848 - 68,288,954 (-)Ensembl
Rnor_6.0 Ensembl1171,511,715 - 71,523,267 (-)Ensembl
RefSeq Acc Id: NM_001039259   ⟹   NP_001034348
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,277,847 - 68,288,953 (-)NCBI
Rnor_6.01171,511,844 - 71,522,945 (-)NCBI
Rnor_5.01174,596,365 - 74,607,670 (-)NCBI
RGSC_v3.41170,093,702 - 70,105,297 (-)RGD
Celera1167,710,629 - 67,721,664 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248447   ⟹   XP_006248509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,277,847 - 68,289,110 (-)NCBI
Rnor_6.01171,511,844 - 71,522,959 (-)NCBI
Rnor_5.01174,596,365 - 74,607,670 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088116   ⟹   XP_038944044
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,278,581 - 68,289,099 (-)NCBI
RefSeq Acc Id: XM_039088117   ⟹   XP_038944045
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,277,847 - 68,286,332 (-)NCBI
RefSeq Acc Id: XR_005491000
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,278,652 - 68,289,099 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001034348 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248509 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944044 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944045 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27442 (Get FASTA)   NCBI Sequence Viewer  
  AAX73397 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001034348   ⟸   NM_001039259
- UniProtKB: Q2TGJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248509   ⟸   XM_006248447
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000038846   ⟸   ENSRNOT00000033026
RefSeq Acc Id: XP_038944045   ⟸   XM_039088117
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038944044   ⟸   XM_039088116
- Peptide Label: isoform X2
Protein Domains
DHHC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2TGJ0-F1-model_v2 AlphaFold Q2TGJ0 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309014 AgrOrtholog
BioCyc Gene G2FUF-21098 BioCyc
Ensembl Genes ENSRNOG00000025055 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000038846 ENTREZGENE
  ENSRNOP00000038846.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033026 ENTREZGENE
  ENSRNOT00000033026.7 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111596 IMAGE-MGC_LOAD
InterPro Znf_DHHC UniProtKB/TrEMBL
KEGG Report rno:288045 UniProtKB/TrEMBL
MGC_CLONE MGC:156468 IMAGE-MGC_LOAD
NCBI Gene 288045 ENTREZGENE
Pfam zf-DHHC UniProtKB/TrEMBL
PhenoGen Zdhhc19 PhenoGen
UniProt Q2TGJ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Zdhhc19  zinc finger DHHC-type palmitoyltransferase 19  Zdhhc19  zinc finger, DHHC-type containing 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Zdhhc19  zinc finger, DHHC-type containing 19  Zdhhc19  zinc finger, DHHC domain containing 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 Zdhhc19  zinc finger, DHHC domain containing 19  Zdhhc19_predicted  zinc finger, DHHC domain containing 19 (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Zdhhc19_predicted  zinc finger, DHHC domain containing 19 (predicted)      Symbol and Name status set to approved 70820 APPROVED