Urb1 (URB1 ribosome biogenesis homolog) - Rat Genome Database

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Gene: Urb1 (URB1 ribosome biogenesis homolog) Rattus norvegicus
Analyze
Symbol: Urb1
Name: URB1 ribosome biogenesis homolog
RGD ID: 1304621
Description: Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in fibrillar center. Predicted to be active in nucleolus. Orthologous to human URB1 (URB1 ribosome biogenesis homolog); INTERACTS WITH (+)-schisandrin B; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC304104; nucleolar pre-ribosomal-associated protein 1; RGD1304621; similar to Hypothetical protein KIAA0539 ; URB1 ribosome biogenesis 1 homolog; URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,490,633 - 43,551,398 (-)NCBIGRCr8
mRatBN7.21130,004,539 - 30,065,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,004,539 - 30,065,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,690,104 - 38,750,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,361,515 - 31,422,227 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,536,196 - 30,596,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,916,740 - 30,977,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,916,730 - 30,977,483 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01134,528,215 - 34,588,898 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,732,790 - 30,793,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,738,941 - 30,818,441 (-)NCBI
Celera1129,672,337 - 29,733,034 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
fibrillar center  (IEA,ISO)
nucleolus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16963496   PMID:22658674   PMID:22681889  


Genomics

Comparative Map Data
Urb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,490,633 - 43,551,398 (-)NCBIGRCr8
mRatBN7.21130,004,539 - 30,065,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,004,539 - 30,065,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,690,104 - 38,750,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,361,515 - 31,422,227 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,536,196 - 30,596,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,916,740 - 30,977,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,916,730 - 30,977,483 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01134,528,215 - 34,588,898 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,732,790 - 30,793,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,738,941 - 30,818,441 (-)NCBI
Celera1129,672,337 - 29,733,034 (-)NCBICelera
Cytogenetic Map11q11NCBI
URB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382132,311,018 - 32,393,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2132,311,018 - 32,393,012 (-)EnsemblGRCh38hg38GRCh38
GRCh372133,683,329 - 33,765,321 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,683,330 - 33,765,312 (-)NCBINCBI36Build 36hg18NCBI36
Celera2118,866,931 - 18,948,939 (-)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2119,092,100 - 19,174,182 (-)NCBIHuRef
CHM1_12133,245,146 - 33,327,161 (-)NCBICHM1_1
T2T-CHM13v2.02130,680,775 - 30,762,860 (-)NCBIT2T-CHM13v2.0
Urb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,548,415 - 90,607,312 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1690,548,415 - 90,607,301 (-)EnsemblGRCm39 Ensembl
GRCm381690,751,527 - 90,810,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,751,527 - 90,810,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv371690,751,772 - 90,810,658 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361690,640,386 - 90,699,251 (-)NCBIMGSCv36mm8
Celera1691,832,957 - 91,891,665 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.92NCBI
Urb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540731,848,012 - 31,915,362 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540731,849,103 - 31,915,457 (-)NCBIChiLan1.0ChiLan1.0
URB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22228,388,428 - 28,513,989 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12123,248,051 - 23,375,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02118,637,996 - 18,761,045 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12132,028,801 - 32,141,275 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2132,061,966 - 32,141,275 (-)Ensemblpanpan1.1panPan2
URB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13127,087,196 - 27,158,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3127,087,570 - 27,158,164 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3127,080,534 - 27,151,483 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03127,207,657 - 27,278,618 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3127,207,735 - 27,278,625 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13127,152,622 - 27,223,569 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03127,164,342 - 27,235,271 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03127,672,375 - 27,742,811 (-)NCBIUU_Cfam_GSD_1.0
Urb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497127,679,168 - 27,748,856 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365009,718,925 - 9,788,666 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365009,718,981 - 9,790,094 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
URB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13195,974,790 - 196,047,863 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113195,974,790 - 196,047,882 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
URB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,733,260 - 59,811,990 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl259,733,902 - 59,814,018 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660712,275,305 - 2,354,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Urb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474520,648,230 - 20,715,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474520,647,661 - 20,716,262 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Urb1
281 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:408
Count of miRNA genes:228
Interacting mature miRNAs:268
Transcripts:ENSRNOT00000002851
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
RH129927  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21130,004,693 - 30,004,858 (+)MAPPERmRatBN7.2
Rnor_6.01130,916,895 - 30,917,059NCBIRnor6.0
Rnor_5.01134,528,370 - 34,528,534UniSTSRnor5.0
RGSC_v3.41130,732,945 - 30,733,109UniSTSRGSC3.4
Celera1129,672,492 - 29,672,656UniSTS
RH 3.4 Map11164.2UniSTS
Cytogenetic Map11q11UniSTS
BE114314  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21130,023,019 - 30,023,183 (+)MAPPERmRatBN7.2
Rnor_6.01130,935,219 - 30,935,382NCBIRnor6.0
Rnor_5.01134,546,694 - 34,546,857UniSTSRnor5.0
RGSC_v3.41130,751,269 - 30,751,432UniSTSRGSC3.4
Celera1129,690,816 - 29,690,979UniSTS
RH 3.4 Map11169.3UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002851   ⟹   ENSRNOP00000002851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,004,539 - 30,065,363 (-)Ensembl
Rnor_6.0 Ensembl1130,916,730 - 30,977,483 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111086   ⟹   ENSRNOP00000086072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,004,539 - 30,065,363 (-)Ensembl
RefSeq Acc Id: NM_001191661   ⟹   NP_001178590
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,490,633 - 43,551,316 (-)NCBI
mRatBN7.21130,004,539 - 30,065,227 (-)NCBI
Rnor_6.01130,916,740 - 30,977,423 (-)NCBI
Rnor_5.01134,528,215 - 34,588,898 (-)NCBI
Celera1129,672,337 - 29,733,034 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088427   ⟹   XP_038944355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,501,410 - 43,551,398 (-)NCBI
mRatBN7.21130,017,261 - 30,065,315 (-)NCBI
RefSeq Acc Id: XM_039088428   ⟹   XP_038944356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,508,462 - 43,551,397 (-)NCBI
mRatBN7.21130,022,376 - 30,065,315 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178590 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944355 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944356 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002851.6
  ENSRNOP00000086072.1
RefSeq Acc Id: NP_001178590   ⟸   NM_001191661
- UniProtKB: D4A7S4 (UniProtKB/TrEMBL),   A0A8I6GDM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002851   ⟸   ENSRNOT00000002851
RefSeq Acc Id: XP_038944355   ⟸   XM_039088427
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944356   ⟸   XM_039088428
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000086072   ⟸   ENSRNOT00000111086
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7S4-F1-model_v2 AlphaFold D4A7S4 1-2278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698047
Promoter ID:EPDNEW_R8572
Type:initiation region
Name:Urb1_1
Description:URB1 ribosome biogenesis 1 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01130,977,487 - 30,977,547EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304621 AgrOrtholog
BioCyc Gene G2FUF-21932 BioCyc
Ensembl Genes ENSRNOG00000002080 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002851.8 UniProtKB/TrEMBL
  ENSRNOT00000111086.1 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  NopRA1_C UniProtKB/TrEMBL
  Npa1 UniProtKB/TrEMBL
  URB1 UniProtKB/TrEMBL
KEGG Report rno:304104 UniProtKB/TrEMBL
NCBI Gene 304104 ENTREZGENE
PANTHER NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1 UniProtKB/TrEMBL
  PTHR13500 UniProtKB/TrEMBL
Pfam NopRA1 UniProtKB/TrEMBL
  Npa1 UniProtKB/TrEMBL
PhenoGen Urb1 PhenoGen
RatGTEx ENSRNOG00000002080 RatGTEx
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A8I6GDM7 ENTREZGENE, UniProtKB/TrEMBL
  D4A7S4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-21 Urb1  URB1 ribosome biogenesis homolog  Urb1  URB1 ribosome biogenesis 1 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-16 Urb1  URB1 ribosome biogenesis 1 homolog (S. cerevisiae)  RGD1304621  similar to Hypothetical protein KIAA0539   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1304621  similar to Hypothetical protein KIAA0539   RGD1304621_predicted  similar to Hypothetical protein KIAA0539 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1304621_predicted  similar to Hypothetical protein KIAA0539 (predicted)  LOC304104_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC304104_predicted  similar to Hypothetical protein KIAA0539 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL