Top3b (DNA topoisomerase III beta) - Rat Genome Database

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Gene: Top3b (DNA topoisomerase III beta) Rattus norvegicus
Analyze
Symbol: Top3b
Name: DNA topoisomerase III beta
RGD ID: 1309468
Description: Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity and RNA topoisomerase activity. Predicted to be involved in DNA recombination; DNA repair; and DNA topological change. Predicted to act upstream of or within chromosome segregation. Predicted to be located in condensed chromosome. Predicted to be part of DNA topoisomerase III-beta-TDRD3 complex. Predicted to be active in nucleus. Orthologous to human TOP3B (DNA topoisomerase III beta); PARTICIPATES IN homologous recombination pathway of double-strand break repair; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA topoisomerase 3-beta-1; LOC287930; topoisomerase (DNA) III beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,601,223 - 97,629,678 (-)NCBIGRCr8
mRatBN7.21184,097,018 - 84,125,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,097,026 - 84,125,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,821,137 - 92,849,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,482,270 - 85,510,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,535,862 - 84,564,108 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,346,305 - 88,374,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,346,313 - 88,374,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,401,389 - 91,429,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,116,936 - 86,145,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,157,538 - 86,185,850 (-)NCBI
Celera1182,851,647 - 82,880,025 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12591952   PMID:22658674   PMID:22681889   PMID:25931508  


Genomics

Comparative Map Data
Top3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,601,223 - 97,629,678 (-)NCBIGRCr8
mRatBN7.21184,097,018 - 84,125,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,097,026 - 84,125,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,821,137 - 92,849,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,482,270 - 85,510,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,535,862 - 84,564,108 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,346,305 - 88,374,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,346,313 - 88,374,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,401,389 - 91,429,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,116,936 - 86,145,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,157,538 - 86,185,850 (-)NCBI
Celera1182,851,647 - 82,880,025 (-)NCBICelera
Cytogenetic Map11q23NCBI
TOP3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,957,025 - 21,982,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,957,025 - 21,982,813 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,311,397 - 22,337,184 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,641,403 - 20,667,147 (-)NCBINCBI36Build 36hg18NCBI36
Build 342220,635,957 - 20,661,701NCBI
Celera226,128,944 - 6,154,663 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,268,479 - 5,294,196 (-)NCBIHuRef
CHM1_12222,311,501 - 22,337,220 (-)NCBICHM1_1
T2T-CHM13v2.02222,370,556 - 22,396,320 (-)NCBIT2T-CHM13v2.0
Top3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,688,587 - 16,710,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,688,600 - 16,710,854 (+)EnsemblGRCm39 Ensembl
GRCm381616,870,722 - 16,892,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,870,736 - 16,892,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,870,984 - 16,893,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,784,454 - 16,806,549 (+)NCBIMGSCv36mm8
Celera1617,442,801 - 17,464,977 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.46NCBI
Top3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,200,453 - 17,225,335 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,201,079 - 17,223,824 (+)NCBIChiLan1.0ChiLan1.0
TOP3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,498,751 - 31,524,557 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12234,047,630 - 34,073,423 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,076,295 - 4,102,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12220,557,248 - 20,583,307 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,557,248 - 20,583,464 (-)Ensemblpanpan1.1panPan2
TOP3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,198,371 - 31,223,133 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,198,382 - 31,215,134 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2631,154,388 - 31,178,817 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,604,302 - 32,628,806 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,604,310 - 32,628,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,652,585 - 30,677,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,276,606 - 30,301,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,367,160 - 31,391,836 (-)NCBIUU_Cfam_GSD_1.0
Top3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,971,807 - 140,997,296 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,756,791 - 1,785,953 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,756,829 - 1,782,063 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,020,509 - 50,037,856 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,020,412 - 50,037,854 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,462,935 - 53,480,381 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,137,823 - 4,163,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,137,862 - 4,166,436 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,836,805 - 2,865,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,446,412 - 1,473,600 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,450,236 - 1,473,467 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Top3b
132 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:98
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000002524
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001105861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000002524   ⟹   ENSRNOP00000002524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,097,026 - 84,125,392 (-)Ensembl
Rnor_6.0 Ensembl1188,346,313 - 88,374,679 (-)Ensembl
RefSeq Acc Id: NM_001105861   ⟹   NP_001099331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,597 (-)NCBI
mRatBN7.21184,097,018 - 84,125,392 (-)NCBI
Rnor_6.01188,346,305 - 88,374,679 (-)NCBI
Rnor_5.01191,401,389 - 91,429,964 (-)NCBI
RGSC_v3.41186,116,936 - 86,145,314 (-)RGD
Celera1182,851,647 - 82,880,025 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248671   ⟹   XP_006248733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,678 (-)NCBI
mRatBN7.21184,097,024 - 84,125,474 (-)NCBI
Rnor_6.01188,346,311 - 88,374,896 (-)NCBI
Rnor_5.01191,401,389 - 91,429,964 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248673   ⟹   XP_006248735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,441 (-)NCBI
mRatBN7.21184,097,024 - 84,125,233 (-)NCBI
Rnor_6.01188,346,311 - 88,374,530 (-)NCBI
Rnor_5.01191,401,389 - 91,429,964 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597893   ⟹   XP_017453382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,594 (-)NCBI
mRatBN7.21184,097,024 - 84,125,393 (-)NCBI
Rnor_6.01188,346,311 - 88,374,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597894   ⟹   XP_017453383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,583 (-)NCBI
mRatBN7.21184,097,024 - 84,125,379 (-)NCBI
Rnor_6.01188,346,311 - 88,374,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597895   ⟹   XP_017453384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,576 (-)NCBI
mRatBN7.21184,097,024 - 84,125,379 (-)NCBI
Rnor_6.01188,346,311 - 88,374,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597896   ⟹   XP_017453385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,479 (-)NCBI
mRatBN7.21184,097,024 - 84,125,073 (-)NCBI
Rnor_6.01188,346,311 - 88,374,366 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597897   ⟹   XP_017453386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,483 (-)NCBI
mRatBN7.21184,097,024 - 84,125,230 (-)NCBI
Rnor_6.01188,346,311 - 88,374,530 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597898   ⟹   XP_017453387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,477 (-)NCBI
mRatBN7.21184,097,024 - 84,125,239 (-)NCBI
Rnor_6.01188,346,311 - 88,374,530 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597899   ⟹   XP_017453388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,458 (-)NCBI
mRatBN7.21184,097,024 - 84,125,069 (-)NCBI
Rnor_6.01188,346,311 - 88,374,366 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597900   ⟹   XP_017453389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,598 (-)NCBI
mRatBN7.21184,097,024 - 84,125,400 (-)NCBI
Rnor_6.01188,346,311 - 88,374,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088060   ⟹   XP_038943988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,480 (-)NCBI
mRatBN7.21184,097,024 - 84,124,908 (-)NCBI
RefSeq Acc Id: XM_039088061   ⟹   XP_038943989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,629,480 (-)NCBI
mRatBN7.21184,097,024 - 84,125,068 (-)NCBI
RefSeq Acc Id: XM_039088063   ⟹   XP_038943991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,607,560 (-)NCBI
mRatBN7.21184,097,024 - 84,106,524 (-)NCBI
RefSeq Acc Id: XM_063270319   ⟹   XP_063126389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,601,223 - 97,626,614 (-)NCBI
RefSeq Acc Id: XR_005490986
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,603,980 - 97,629,594 (-)NCBI
mRatBN7.21184,099,787 - 84,125,392 (-)NCBI
RefSeq Acc Id: XR_005490987
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,603,999 - 97,629,594 (-)NCBI
mRatBN7.21184,099,797 - 84,125,392 (-)NCBI
RefSeq Acc Id: XR_005490988
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,604,778 - 97,629,594 (-)NCBI
mRatBN7.21184,100,573 - 84,125,392 (-)NCBI
RefSeq Acc Id: NP_001099331   ⟸   NM_001105861
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248733   ⟸   XM_006248671
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248735   ⟸   XM_006248673
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453382   ⟸   XM_017597893
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453389   ⟸   XM_017597900
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453383   ⟸   XM_017597894
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453384   ⟸   XM_017597895
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453387   ⟸   XM_017597898
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453386   ⟸   XM_017597897
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453385   ⟸   XM_017597896
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453388   ⟸   XM_017597899
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002524   ⟸   ENSRNOT00000002524
RefSeq Acc Id: XP_038943989   ⟸   XM_039088061
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943988   ⟸   XM_039088060
- Peptide Label: isoform X1
- UniProtKB: D4A9Z2 (UniProtKB/TrEMBL),   A6JSP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943991   ⟸   XM_039088063
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126389   ⟸   XM_063270319
- Peptide Label: isoform X1
- UniProtKB: A6JSP3 (UniProtKB/TrEMBL),   D4A9Z2 (UniProtKB/TrEMBL)
Protein Domains
Toprim

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9Z2-F1-model_v2 AlphaFold D4A9Z2 1-862 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698341
Promoter ID:EPDNEW_R8866
Type:multiple initiation site
Name:Top3b_1
Description:DNA topoisomerase III beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,374,669 - 88,374,729EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309468 AgrOrtholog
BioCyc Gene G2FUF-20563 BioCyc
Ensembl Genes ENSRNOG00000001845 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002524.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.290.10 UniProtKB/TrEMBL
  1.10.460.10 UniProtKB/TrEMBL
  2.70.20.10 UniProtKB/TrEMBL
  3.40.50.140 UniProtKB/TrEMBL
InterPro Topo_IA_2 UniProtKB/TrEMBL
  Topo_IA_AS UniProtKB/TrEMBL
  Topo_IA_cen UniProtKB/TrEMBL
  Topo_IA_cen_sub1 UniProtKB/TrEMBL
  Topo_IA_cen_sub2 UniProtKB/TrEMBL
  Topo_IA_cen_sub3 UniProtKB/TrEMBL
  Topo_IA_core UniProtKB/TrEMBL
  Topo_IA_core_domain UniProtKB/TrEMBL
  Topo_IA_DNA-bd UniProtKB/TrEMBL
  Toprim_domain UniProtKB/TrEMBL
  TOPRIM_TopoIII UniProtKB/TrEMBL
KEGG Report rno:287930 UniProtKB/TrEMBL
NCBI Gene 287930 ENTREZGENE
PANTHER DNA TOPOISOMERASE 3-BETA-1 UniProtKB/TrEMBL
  Topo_IA UniProtKB/TrEMBL
Pfam Topoisom_bac UniProtKB/TrEMBL
  Toprim UniProtKB/TrEMBL
PhenoGen Top3b PhenoGen
PRINTS PRTPISMRASEI UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_I_PROK UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001845 RatGTEx
SMART TOP1Ac UniProtKB/TrEMBL
  TOP1Bc UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
Superfamily-SCOP Topo_IA_core UniProtKB/TrEMBL
UniProt A6JSP3 ENTREZGENE, UniProtKB/TrEMBL
  D4A9Z2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Top3b  DNA topoisomerase III beta  Top3b  topoisomerase (DNA) III beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Top3b  topoisomerase (DNA) III beta   Top3b_predicted  topoisomerase (DNA) III beta (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Top3b_predicted  topoisomerase (DNA) III beta (predicted)      Symbol and Name status set to approved 70820 APPROVED