Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of GRAMD1C mRNA | CTD | PMID:27840820 | 1,2-dimethylhydrazine | decreases expression | ISO | Gramd1c (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of GRAMD1C mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | GRAMD1C (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of GRAMD1C mRNA | CTD | PMID:30165855 | 17beta-estradiol | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Estradiol results in decreased expression of GRAMD1C mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Gramd1c (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GRAMD1C mRNA and [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of GRAMD1C mRNA | CTD | PMID:16214954 and PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Gramd1c (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRAMD1C mRNA | CTD | PMID:26377647 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of GRAMD1C mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of GRAMD1C mRNA | CTD | PMID:30851411 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Gramd1c (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of GRAMD1C mRNA | CTD | PMID:20188158 | 4-hydroxyphenyl retinamide | increases expression | ISO | Gramd1c (Mus musculus) | 6480464 | Fenretinide results in increased expression of GRAMD1C mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of GRAMD1C mRNA | CTD | PMID:24780913 and PMID:25825206 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of GRAMD1C mRNA | CTD | PMID:30047161 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of GRAMD1C mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases expression | ISO | Gramd1c (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of GRAMD1C mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of GRAMD1C mRNA | CTD | PMID:22100608 and PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Tretinoin results in increased expression of GRAMD1C mRNA | CTD | PMID:21934132 and PMID:23724009 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of GRAMD1C mRNA | CTD | PMID:30047161 | benzo[a]pyrene | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of GRAMD1C mRNA | CTD | PMID:32234424 | Benzo[k]fluoranthene | decreases expression | ISO | Gramd1c (Mus musculus) | 6480464 | benzo(k)fluoranthene results in decreased expression of GRAMD1C mRNA | CTD | PMID:26377693 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GRAMD1C mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Gramd1c (Mus musculus) | 6480464 | bisphenol A results in increased expression of GRAMD1C mRNA | CTD | PMID:34585602 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GRAMD1C mRNA | CTD | PMID:30816183 more ... | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of GRAMD1C gene | CTD | PMID:28505145 | butanal | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of GRAMD1C mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | Gramd1c (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GRAMD1C mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Gramd1c (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GRAMD1C mRNA | CTD | PMID:37325564 | carbon nanotube | decreases expression | ISO | Gramd1c (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | chloroethene | increases expression | ISO | Gramd1c (Mus musculus) | 6480464 | Vinyl Chloride results in increased expression of GRAMD1C mRNA | CTD | PMID:18579281 | cisplatin | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Cisplatin results in increased expression of GRAMD1C mRNA | CTD | PMID:27392435 | clothianidin | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | clothianidin results in decreased expression of GRAMD1C mRNA | CTD | PMID:31626844 | cyclosporin A | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of GRAMD1C mRNA | CTD | PMID:20106945 and PMID:27989131 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of GRAMD1C mRNA | CTD | PMID:25152437 | dorsomorphin | multiple interactions | ISO | GRAMD1C (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | entinostat results in increased expression of GRAMD1C mRNA | CTD | PMID:27188386 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of GRAMD1C mRNA | CTD | PMID:24793618 | glyphosate | increases methylation | EXP | | 6480464 | Glyphosate results in increased methylation of GRAMD1C gene | CTD | PMID:31011160 | ivermectin | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Ivermectin results in increased expression of GRAMD1C protein | CTD | PMID:32959892 | mercury dibromide | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | mercuric bromide results in decreased expression of GRAMD1C mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | GRAMD1C (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA | CTD | PMID:27188386 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of GRAMD1C mRNA | CTD | PMID:30047161 | methylmercury chloride | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of GRAMD1C mRNA | CTD | PMID:23179753 more ... | nickel atom | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Nickel results in decreased expression of GRAMD1C mRNA | CTD | PMID:24768652 and PMID:25583101 | nickel sulfate | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of GRAMD1C mRNA | CTD | PMID:22714537 | p-chloromercuribenzoic acid | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of GRAMD1C mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | GRAMD1C (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA | CTD | PMID:27188386 | paracetamol | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of GRAMD1C mRNA | CTD | PMID:21420995 and PMID:29067470 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of GRAMD1C mRNA | CTD | PMID:33387578 | pentanal | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | pentanal results in increased expression of GRAMD1C mRNA | CTD | PMID:26079696 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of GRAMD1C mRNA | CTD | PMID:27153767 | phenylmercury acetate | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of GRAMD1C mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | GRAMD1C (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRAMD1C mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | Gramd1c (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GRAMD1C mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | ISO | Gramd1c (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of GRAMD1C mRNA | CTD | PMID:23811191 | propanal | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of GRAMD1C mRNA | CTD | PMID:26079696 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of GRAMD1C mRNA | CTD | PMID:30047161 | rac-lactic acid | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of GRAMD1C mRNA | CTD | PMID:30851411 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of GRAMD1C mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | ISO | GRAMD1C (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | serpentine asbestos | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Asbestos and Serpentine results in increased expression of GRAMD1C mRNA | CTD | PMID:21148743 | sodium arsenite | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of GRAMD1C mRNA | CTD | PMID:22714537 | tetraphene | decreases expression | ISO | Gramd1c (Mus musculus) | 6480464 | benz(a)anthracene results in decreased expression of GRAMD1C mRNA | CTD | PMID:26377693 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of GRAMD1C mRNA | CTD | PMID:23411599 | triadimefon | decreases expression | EXP | | 6480464 | triadimefon results in decreased expression of GRAMD1C mRNA | CTD | PMID:30047161 | trichostatin A | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | trichostatin A results in increased expression of GRAMD1C mRNA | CTD | PMID:24935251 | trichostatin A | affects expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | trichostatin A affects the expression of GRAMD1C mRNA | CTD | PMID:28542535 | trichostatin A | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of GRAMD1C mRNA | CTD | PMID:24935251 | triptonide | increases expression | ISO | Gramd1c (Mus musculus) | 6480464 | triptonide results in increased expression of GRAMD1C mRNA | CTD | PMID:33045310 | valproic acid | decreases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of GRAMD1C mRNA | CTD | PMID:23179753 and PMID:24935251 | valproic acid | affects expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Valproic Acid affects the expression of GRAMD1C mRNA | CTD | PMID:25979313 | valproic acid | decreases methylation | ISO | GRAMD1C (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of GRAMD1C gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of GRAMD1C mRNA | CTD | PMID:23179753 more ... | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of GRAMD1C gene | CTD | PMID:31682807 | vorinostat | increases expression | ISO | GRAMD1C (Homo sapiens) | 6480464 | vorinostat results in increased expression of GRAMD1C mRNA | CTD | PMID:27188386 | |