Klhl22 (kelch-like family member 22) - Rat Genome Database

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Gene: Klhl22 (kelch-like family member 22) Rattus norvegicus
Analyze
Symbol: Klhl22
Name: kelch-like family member 22
RGD ID: 1306288
Description: Predicted to have 14-3-3 protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; cellular response to leucine; and positive regulation of TORC1 signaling. Predicted to colocalize with lysosome and nucleus. Orthologous to human KLHL22 (kelch like family member 22); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: kelch-like 22; kelch-like 22 (Drosophila); kelch-like protein 22; LOC303792; RGD1306288; similar to hypothetical protein FLJ14360
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,190,891 - 83,231,746 (-)NCBI
Rnor_6.0 Ensembl1187,677,966 - 87,718,826 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01187,646,489 - 87,718,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01190,699,112 - 90,771,253 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,179,262 - 85,220,103 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,219,855 - 85,260,693 (-)NCBI
Celera1181,962,736 - 82,003,585 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IBA,IEA,ISO,ISS)
Cul3-RING ubiquitin ligase complex  (IEA,ISO,ISS)
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO,ISS)
intercellular bridge  (IEA,ISO)
intracellular membrane-bounded organelle  (ISO)
lysosome  (IEA,ISO,ISS)
microtubule cytoskeleton  (ISO)
mitotic spindle  (IBA,IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
polar microtubule  (IBA,IEA,ISO,ISS)

Molecular Function

References

Additional References at PubMed
PMID:19995937   PMID:23455478   PMID:29769719  


Genomics

Comparative Map Data
Klhl22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,190,891 - 83,231,746 (-)NCBI
Rnor_6.0 Ensembl1187,677,966 - 87,718,826 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01187,646,489 - 87,718,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01190,699,112 - 90,771,253 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,179,262 - 85,220,103 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,219,855 - 85,260,693 (-)NCBI
Celera1181,962,736 - 82,003,585 (-)NCBICelera
Cytogenetic Map11q23NCBI
KLHL22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2220,441,519 - 20,495,844 (-)EnsemblGRCh38hg38GRCh38
GRCh382220,441,519 - 20,497,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372220,795,806 - 20,850,082 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,125,806 - 19,180,122 (-)NCBINCBI36hg18NCBI36
Celera224,282,529 - 4,336,886 (-)NCBI
Cytogenetic Map22q11.21NCBI
HuRef224,059,895 - 4,107,538 (-)NCBIHuRef
CHM1_12220,796,082 - 20,850,455 (-)NCBICHM1_1
Klhl22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,577,485 - 17,611,246 (+)NCBIGRCm39mm39
GRCm39 Ensembl1617,577,482 - 17,611,246 (+)Ensembl
GRCm381617,759,621 - 17,793,382 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,759,618 - 17,793,382 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,759,714 - 17,793,475 (+)NCBIGRCm37mm9NCBIm37
MGSCv361617,673,234 - 17,706,943 (+)NCBImm8
Celera1618,332,703 - 18,366,464 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.01NCBI
Klhl22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,009,155 - 19,051,393 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,010,971 - 19,051,300 (-)NCBIChiLan1.0ChiLan1.0
KLHL22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12219,126,658 - 19,174,839 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,122,875 - 19,174,842 (-)Ensemblpanpan1.1panPan2
KLHL22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,248,253 - 30,281,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,248,240 - 30,281,843 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,207,137 - 30,246,532 (-)NCBI
ROS_Cfam_1.02631,656,570 - 31,696,204 (-)NCBI
UMICH_Zoey_3.12629,702,711 - 29,742,120 (-)NCBI
UNSW_CanFamBas_1.02629,327,051 - 29,366,309 (-)NCBI
UU_Cfam_GSD_1.02630,416,255 - 30,455,878 (-)NCBI
Klhl22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,854,676 - 139,899,247 (-)NCBI
SpeTri2.0NW_0049366192,854,915 - 2,899,386 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11450,773,917 - 50,809,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,334,392 - 54,451,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,211,732 - 5,264,953 (+)NCBI
ChlSab1.1 Ensembl195,218,653 - 5,265,063 (+)Ensembl
Vero_WHO_p1.0NW_0236660851,671,542 - 1,725,149 (-)NCBI
Klhl22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624945409,093 - 446,619 (-)NCBI

Position Markers
RH138822  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,191,424 - 83,191,545 (-)MAPPER
Rnor_6.01187,718,154 - 87,718,274NCBIRnor6.0
Rnor_5.01190,770,599 - 90,770,719UniSTSRnor5.0
RGSC_v3.41185,179,793 - 85,179,913UniSTSRGSC3.4
Celera1181,963,267 - 81,963,387UniSTS
RH 3.4 Map11710.1UniSTS
Cytogenetic Map11q23UniSTS
RH131807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,191,027 - 83,191,210 (-)MAPPER
Rnor_6.01187,718,489 - 87,718,671NCBIRnor6.0
Rnor_5.01190,770,934 - 90,771,116UniSTSRnor5.0
RGSC_v3.41185,179,396 - 85,179,578UniSTSRGSC3.4
Celera1181,962,870 - 81,963,052UniSTS
RH 3.4 Map11707.6UniSTS
Cytogenetic Map11q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:59
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000068711
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 35 44 28 19 28 8 11 74 35 36 11 8
Low 2 8 13 13 13 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000068711   ⟹   ENSRNOP00000063573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1187,677,966 - 87,718,805 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091675   ⟹   ENSRNOP00000075207
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1187,678,295 - 87,718,826 (+)Ensembl
RefSeq Acc Id: NM_001107079   ⟹   NP_001100549
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,190,894 - 83,231,738 (-)NCBI
Rnor_6.01187,677,966 - 87,718,805 (+)NCBI
Rnor_5.01190,699,112 - 90,771,253 (+)NCBI
RGSC_v3.41185,179,262 - 85,220,103 (-)RGD
Celera1181,962,736 - 82,003,585 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248699   ⟹   XP_006248761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,190,891 - 83,231,670 (-)NCBI
Rnor_6.01187,678,203 - 87,718,808 (+)NCBI
Rnor_5.01190,699,112 - 90,771,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248700   ⟹   XP_006248762
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,190,891 - 83,231,671 (-)NCBI
Rnor_6.01187,678,202 - 87,718,808 (+)NCBI
Rnor_5.01190,699,112 - 90,771,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248701   ⟹   XP_006248763
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,646,489 - 87,718,808 (+)NCBI
Rnor_5.01190,699,112 - 90,771,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088267   ⟹   XP_038944195
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,190,891 - 83,231,746 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100549 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248761 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248762 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944195 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZZC3 (Get FASTA)   NCBI Sequence Viewer  
  EDL77904 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100549   ⟸   NM_001107079
- UniProtKB: D3ZZC3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248763   ⟸   XM_006248701
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006248762   ⟸   XM_006248700
- Peptide Label: isoform X2
- UniProtKB: A0A0G2KA06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248761   ⟸   XM_006248699
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000063573   ⟸   ENSRNOT00000068711
RefSeq Acc Id: ENSRNOP00000075207   ⟸   ENSRNOT00000091675
RefSeq Acc Id: XP_038944195   ⟸   XM_039088267
- Peptide Label: isoform X3
Protein Domains
BTB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698324
Promoter ID:EPDNEW_R8849
Type:initiation region
Name:Klhl22_1
Description:kelch-like family member 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,677,946 - 87,678,006EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306288 AgrOrtholog
Ensembl Genes ENSRNOG00000001878 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000063573 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000075207 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068711 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000091675 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLHL22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:303792 UniProtKB/Swiss-Prot
NCBI Gene 303792 ENTREZGENE
PANTHER PTHR45632:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klhl22 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KA06 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZC3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D4A9W5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-06 Klhl22  kelch-like family member 22  Klhl22  kelch-like 22 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Klhl22  kelch-like 22 (Drosophila)   Klhl22_predicted  kelch-like 22 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Klhl22_predicted  kelch-like 22 (Drosophila) (predicted)  RGD1306288_predicted  similar to hypothetical protein FLJ14360 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1306288_predicted  similar to hypothetical protein FLJ14360 (predicted)  LOC303792_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303792_predicted  similar to hypothetical protein FLJ14360 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL