Lrrc15 (leucine rich repeat containing 15)

Gene: Lrrc15 (leucine rich repeat containing 15) Rattus norvegicus

Analyze

Symbol:

Lrrc15

Name:

leucine rich repeat containing 15

RGD ID:

70551

Description:

Predicted to enable several functions, including fibronectin binding activity; laminin binding activity; and protein sequestering activity. Predicted to be involved in several processes, including negative regulation of protein localization to plasma membrane; negative regulation of viral entry into host cell; and receptor-mediated virion attachment to host cell. Located in cell surface. Orthologous to human LRRC15 (leucine rich repeat containing 15); INTERACTS WITH 17beta-estradiol 3-benzoate; acrylamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

leucine-rich repeat protein induced by amyloid-beta; leucine-rich repeat protein induced by beta amyloid; leucine-rich repeat protein induced by beta-amyloid; leucine-rich repeat-containing protein 15; Lib; rLib

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LRRC15 (leucine rich repeat containing 15)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Lrrc15 (leucine rich repeat containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lrrc15 (leucine rich repeat containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LRRC15 (leucine rich repeat containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LRRC15 (leucine rich repeat containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lrrc15 (leucine rich repeat containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LRRC15 (leucine rich repeat containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LRRC15 (leucine rich repeat containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lrrc15 (leucine rich repeat containing 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LRRC15 (leucine rich repeat containing 15)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lrrc15 (leucine rich repeat containing 15)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lrrc15 (leucine rich repeat containing 15)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7509	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector)
Caenorhabditis elegans (roundworm):	lron-1	Alliance	DIOPT (OMA\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lrrc15	Alliance	DIOPT (OMA\|OrthoFinder\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	83,974,708 - 83,989,157 (+)	NCBI		GRCr8
mRatBN7.2	11	70,469,817 - 70,484,268 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	70,469,804 - 70,484,267 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	79,322,922 - 79,324,658 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	71,957,413 - 71,959,149 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	71,012,023 - 71,013,759 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	74,040,846 - 74,052,179 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	74,050,166 - 74,051,902 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	77,102,016 - 77,113,020 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	72,377,090 - 72,378,826 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	72,434,678 - 72,436,415 (+)	NCBI
Celera	11	69,452,040 - 69,453,776 (+)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

calcitriol (ISO)

cantharidin (ISO)

capecitabine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

Didecyldimethylammonium (ISO)

doxorubicin (ISO)

ethylparaben (ISO)

flavonoids (EXP)

folic acid (ISO)

genistein (ISO)

graphite (EXP)

L-methionine (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenethyl caffeate (EXP)

potassium dichromate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

tetrachloroethene (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IBA)

negative regulation of protein localization to plasma membrane (IEA,ISO)

negative regulation of viral entry into host cell (IEA,ISO)

positive regulation of cell migration (IEA,ISO)

receptor-mediated virion attachment to host cell (IEA,ISO)

Cellular Component

apical plasma membrane (IEA,ISO)

cell surface (IDA)

collagen-containing extracellular matrix (IEA,ISO)

extracellular space (IEA)

plasma membrane (ISO,ISS)

Molecular Function

collagen binding (IEA,ISO)

fibronectin binding (IEA,ISO)

laminin binding (IEA,ISO)

protein binding (ISO)

protein sequestering activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Effects of guanethidine on histamine release during reflex vasodilatation in the dog.	Condorelli M, etal., Br J Pharmacol 1977 Jul;60(3):379-84.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by beta-amyloid.	Satoh K, etal., Biochem Biophys Res Commun 2002 Jan 18;290(2):756-62.

Additional References at PubMed

PMID:16098915	PMID:18385238	PMID:19056867	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Lrrc15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	83,974,708 - 83,989,157 (+)	NCBI		GRCr8
mRatBN7.2	11	70,469,817 - 70,484,268 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	70,469,804 - 70,484,267 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	79,322,922 - 79,324,658 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	71,957,413 - 71,959,149 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	71,012,023 - 71,013,759 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	74,040,846 - 74,052,179 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	74,050,166 - 74,051,902 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	77,102,016 - 77,113,020 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	72,377,090 - 72,378,826 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	72,434,678 - 72,436,415 (+)	NCBI
Celera	11	69,452,040 - 69,453,776 (+)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

LRRC15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	194,355,249 - 194,369,743 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	194,355,249 - 194,369,743 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	194,075,978 - 194,090,472 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	195,557,273 - 195,571,761 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	195,557,280 - 195,571,769	NCBI
Celera	3	192,490,979 - 192,505,408 (-)	NCBI		Celera
Cytogenetic Map	3	q29	NCBI
HuRef	3	191,455,388 - 191,469,818 (-)	NCBI		HuRef
CHM1_1	3	194,038,840 - 194,053,338 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	197,053,410 - 197,067,898 (-)	NCBI		T2T-CHM13v2.0

Lrrc15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	30,088,120 - 30,102,072 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	30,088,120 - 30,102,074 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	30,269,302 - 30,283,254 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	30,269,302 - 30,283,256 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	30,269,388 - 30,283,340 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	30,189,051 - 30,202,972 (-)	NCBI		MGSCv36	mm8
Celera	16	30,776,217 - 30,790,244 (-)	NCBI		Celera
Cytogenetic Map	16	B2	NCBI
cM Map	16	21.23	NCBI

Lrrc15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	14,407,926 - 14,409,656 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	14,401,080 - 14,410,277 (+)	NCBI	ChiLan1.0	ChiLan1.0

LRRC15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	192,278,010 - 192,292,470 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	192,286,051 - 192,290,830 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	191,655,181 - 191,666,727 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	201,968,851 - 201,980,636 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	201,970,221 - 201,974,286 (-)	Ensembl	panpan1.1		panPan2

LRRC15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	31,332,502 - 31,345,895 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	31,332,496 - 31,342,583 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	31,364,113 - 31,377,495 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	31,592,490 - 31,605,874 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	33	31,389,449 - 31,402,834 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	31,418,407 - 31,431,789 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	32,105,985 - 32,118,522 (-)	NCBI		UU_Cfam_GSD_1.0

Lrrc15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	123,802,384 - 123,808,008 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936711	441,804 - 443,615 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936711	441,804 - 443,615 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRC15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	131,343,940 - 131,345,685 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	131,339,778 - 131,354,691 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	140,841,378 - 140,849,189 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRC15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	88,451,090 - 88,465,241 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	88,455,015 - 88,456,760 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	62,137,819 - 62,152,046 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrc15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	63,400,463 - 63,409,006 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lrrc15
129 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	60
Count of miRNA genes:	56
Interacting mature miRNAs:	60
Transcripts:	ENSRNOT00000002348
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	45459323	75190161	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	66113321	82169223	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
1354656	Bvd3	Brain ventricular dilatation QTL 3	3.64	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	69446070	82846715	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low	1				1		1	2	8	20	24	1	1
Below cutoff	1	12	22	21	8	21	4	5	52	2	12	7	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_145083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB071036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002348 ⟹ ENSRNOP00000064155

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	11	74,050,166 - 74,051,902 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095941 ⟹ ENSRNOP00000091199

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	70,469,804 - 70,484,267 (+)	Ensembl

RefSeq Acc Id:

NM_145083 ⟹ NP_659551

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	83,974,708 - 83,989,157 (+)	NCBI
mRatBN7.2	11	70,469,817 - 70,484,268 (+)	NCBI
Rnor_6.0	11	74,050,166 - 74,051,902 (+)	NCBI
Rnor_5.0	11	77,102,016 - 77,113,020 (+)	NCBI
RGSC_v3.4	11	72,377,090 - 72,378,826 (+)	RGD
Celera	11	69,452,040 - 69,453,776 (+)	RGD

Sequence:

show sequence

ATGCCGCTGAAACATTACCTCCTCTTGCTGGTGGGCTGCCAGGCCTGGGCTCTAGGTTTGGCCT
ACTATGGCTGCCCCAGTGAATGCACCTGTTCCCGGGCCTCCCAGGTGGAGTGCACAGGAGCGCG
GATTGTGGCGATGCCTACCCCCCTGCCCTGGAATGCTATGAGCCTGCAGGTCGTTAACACGCAC
ATTACTGAGCTCCCTGAGAACCTGTTCCTCAACATTTCAGCGCTCATTGCCCTAAAGATGGAGA
AGAATGAGCTGTCAACCATCATGCCGGGTGCCTTCCGCAATCTGGGCTCTCTGCGCTACCTCAG
CCTCGCCAACAACAAACTGAGGATGCTGCCCATCAGGGTCTTCCAGGACGTAAACAATCTGGAG
TCCCTTCTGCTCTCCAATAACCAGCTGGTGCAGATCCAGCCAGCCCAGTTCTCCCAGTTTAGTA
ATCTTAGGGAACTCCAGTTGCATGGCAACAATCTGGAATCCATTCCCGAAGAAGCCTTCGACCA
CCTAGTAGGACTCACCAAACTCAACCTGGGCAGGAACAGCTTCACCCACCTATCGCCTAGGCTC
TTTCAGCATCTGGGCAACCTCCAGGTGCTCCGGCTACACGAGAACAGGCTTTCAGACATCCCCA
TGGGCACGTTCGATGCACTCGGCAACCTCCAGGAGCTTGCCCTCCAAGAGAACCAGATTGGCAC
CCTCTCCCCTGGCTTGTTCCACAATAACCGTAACCTCCAGAGACTGTATCTGTCCAACAACCAC
ATCTCCCAGCTGCCCCCTGGCATCTTCATGCAGCTGCCCCAGCTTAACAAGCTCACACTCTTTG
GGAATTCCCTGAGGGAGCTTTCCCCGGGGGTCTTCGGGCCCATGCCCAACCTGAGGGAGCTTTG
GCTCTACAACAACCACATCACCTCCCTCGCCGACAACACCTTCAGCCACCTGAACCAGCTGCAG
GTCCTGATTCTCAGTCACAACCAGCTCACTTACATCTCCCCAGGAGCCTTCAATGGGCTGACGA
ACCTCCGAGAACTGTCCCTCCACACCAACGCTCTACAGGACCTGGACAGCAACGTCTTCCGATC
GCTGGCCAACCTGCAGAACATCTCGCTCCAGAGTAACCGCCTCCGACAGCTTCCGGGCAGCATC
TTTGCCAACGTCAACGGCCTCACAACCATCCAACTGCAGAACAACAATCTAGAAAACTTGCCTT
TGGGCATCTTTGATCACTTGGTGAACCTGTGTGAGCTTCGCCTCTACGACAACCCCTGGAGATG
TGACTCAGATATCCTCCCACTTCATAACTGGCTCCTTCTCAACAGAGCCAGGCTGGGGACAGAC
ACTCTTCCAGTGTGTTCCAGTCCCGCCAACGTCCGAGGCCAGTCCCTCGTCATCATCAATATCA
ATTTCCCTGGACCCAGTGTCCAGGGCCCAGAGACCCCTGAAGTACCTAGTTACCCAGATACGCC
CAGCTATCCCGACACCACATCTGTTTCCTCTACCACGGAGATCACCAGCGCCGTCGACGACTAC
ACCGATCTAACCACCATTGAAGCCACCGATGACCGAAATACGTGGGGCATGACTGAGGCCCAGA
GCGGGCTGGCCATTGCTGCCATCGTGATCGGCATCATAGCTTTGGCCTGTTCCCTAGCCGCCTG
CATCTGCTGCTGCTGCTGCAAAAAGAGGAGCCAAGCAGTCCTGATGCAGATGAAGGCTCCCAAT
GAGTGCTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_659551	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB84586	(Get FASTA)	NCBI Sequence Viewer
	EDL78155	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000091199
	ENSRNOP00000091199.1
	ENSRNOP00055021715
GenBank Protein	Q8R5M3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_659551 ⟸ NM_145083
- Peptide Label:	precursor
- UniProtKB:	M0R476 (UniProtKB/TrEMBL), A6JRV2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPLKHYLLLLVGCQAWALGLAYYGCPSECTCSRASQVECTGARIVAMPTPLPWNAMSLQVVNTH ITELPENLFLNISALIALKMEKNELSTIMPGAFRNLGSLRYLSLANNKLRMLPIRVFQDVNNLE SLLLSNNQLVQIQPAQFSQFSNLRELQLHGNNLESIPEEAFDHLVGLTKLNLGRNSFTHLSPRL FQHLGNLQVLRLHENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNH ISQLPPGIFMQLPQLNKLTLFGNSLRELSPGVFGPMPNLRELWLYNNHITSLADNTFSHLNQLQ VLILSHNQLTYISPGAFNGLTNLRELSLHTNALQDLDSNVFRSLANLQNISLQSNRLRQLPGSI FANVNGLTTIQLQNNNLENLPLGIFDHLVNLCELRLYDNPWRCDSDILPLHNWLLLNRARLGTD TLPVCSSPANVRGQSLVIININFPGPSVQGPETPEVPSYPDTPSYPDTTSVSSTTEITSAVDDY TDLTTIEATDDRNTWGMTEAQSGLAIAAIVIGIIALACSLAACICCCCCKKRSQAVLMQMKAPN EC hide sequence

RefSeq Acc Id:

ENSRNOP00000064155 ⟸ ENSRNOT00000002348

RefSeq Acc Id:

ENSRNOP00000091199 ⟸ ENSRNOT00000095941

Protein Domains

LRRCT LRRNT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R5M3-F1-model_v2	AlphaFold	Q8R5M3	1-578	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70551	AgrOrtholog
BioCyc Gene	G2FUF-21002	BioCyc
Ensembl Genes	ENSRNOG00000038539	Ensembl
	ENSRNOG00000068415	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055015763	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000095941	ENTREZGENE
	ENSRNOT00000095941.1	UniProtKB/TrEMBL
	ENSRNOT00055026836	UniProtKB/Swiss-Prot
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Cys-rich_flank_reg_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leu-rich_rpt_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:246296	UniProtKB/Swiss-Prot
NCBI Gene	246296	ENTREZGENE
PANTHER	C2H2-TYPE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
	LEUCINE RICH REPEAT FAMILY PROTEIN	UniProtKB/Swiss-Prot
	LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15	UniProtKB/TrEMBL
	SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN	UniProtKB/TrEMBL
Pfam	LRR_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Lrrc15	PhenoGen
PROSITE	LRR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000038539	RatGTEx
	ENSRNOG00000068415	RatGTEx
	ENSRNOG00055015763	RatGTEx
SMART	LRR_SD22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRRCT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6JRV2	ENTREZGENE, UniProtKB/TrEMBL
	LRC15_RAT	UniProtKB/Swiss-Prot
	M0R476	ENTREZGENE, UniProtKB/TrEMBL
	Q8R5M3	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Lrrc15	leucine rich repeat containing 15		leucine-rich repeat protein induced by beta-amyloid	Name updated	1299863	APPROVED
2004-09-10	Lrrc15	leucine-rich repeat protein induced by beta-amyloid	Lib		Symbol and Name updated	1299863	APPROVED
2002-06-10	Lib	leucine-rich repeat protein induced by beta-amyloid			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to cell surfaces	70253
gene_disease	associated with Alzheimers disease	70253
gene_domains	extracellular domain contains fifteen leucine-rich repeats	70253
gene_process	may function in extracellular protein recognition and encourage neuronal intercellular interactions	70253
gene_protein	578 amino acid protein	70253
gene_regulation	mRNA increased by pro-inflammatory cytokines	70253

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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