Gpr156 (G protein-coupled receptor 156) - Rat Genome Database

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Gene: Gpr156 (G protein-coupled receptor 156) Rattus norvegicus
Analyze
Symbol: Gpr156
Name: G protein-coupled receptor 156
RGD ID: 708438
Description: Predicted to enable G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Orthologous to human GPR156 (G protein-coupled receptor 156); INTERACTS WITH ammonium chloride; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GABAB-related G-protein coupled receptor; Gababl; LOC103693583; probable G-protein coupled receptor 156
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21162,723,464 - 62,815,444 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,723,872 - 62,815,435 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,535,110 - 71,627,906 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01164,197,347 - 64,290,120 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01163,247,667 - 63,339,971 (-)NCBIRnor_WKY
Rnor_6.01165,285,468 - 65,350,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,285,468 - 65,350,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,732,875 - 66,797,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,506,980 - 64,571,771 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,564,568 - 64,629,360 (-)NCBI
Celera1162,224,426 - 62,287,310 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor. Calver AR, etal., Brain Res Mol Brain Res 2003 Feb 20;110(2):305-17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14707142  


Genomics

Comparative Map Data
Gpr156
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21162,723,464 - 62,815,444 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,723,872 - 62,815,435 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,535,110 - 71,627,906 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01164,197,347 - 64,290,120 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01163,247,667 - 63,339,971 (-)NCBIRnor_WKY
Rnor_6.01165,285,468 - 65,350,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,285,468 - 65,350,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,732,875 - 66,797,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,506,980 - 64,571,771 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,564,568 - 64,629,360 (-)NCBI
Celera1162,224,426 - 62,287,310 (-)NCBICelera
Cytogenetic Map11q21NCBI
GPR156
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383120,165,478 - 120,285,222 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3120,164,645 - 120,285,222 (-)EnsemblGRCh38hg38GRCh38
GRCh373119,884,325 - 120,004,069 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,368,569 - 121,445,635 (-)NCBINCBI36Build 36hg18NCBI36
Build 343121,368,568 - 121,445,635NCBI
Celera3118,294,084 - 118,372,514 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3117,260,277 - 117,338,955 (-)NCBIHuRef
CHM1_13119,847,785 - 119,926,714 (-)NCBICHM1_1
T2T-CHM13v2.03122,885,139 - 123,004,735 (-)NCBIT2T-CHM13v2.0
Gpr156
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,736,551 - 37,827,892 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,736,858 - 37,827,892 (+)EnsemblGRCm39 Ensembl
GRCm381637,916,185 - 38,007,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1637,916,496 - 38,007,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv371637,916,582 - 38,007,616 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361637,835,735 - 37,926,769 (+)NCBIMGSCv36mm8
Celera1638,323,911 - 38,415,263 (+)NCBICelera
Cytogenetic Map16B3NCBI
Gpr156
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,742,359 - 19,796,334 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,742,505 - 19,796,288 (-)NCBIChiLan1.0ChiLan1.0
GPR156
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13124,198,293 - 124,317,704 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3124,198,293 - 124,317,704 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03117,285,032 - 117,406,448 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GPR156
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,720,883 - 23,804,289 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,722,672 - 23,774,283 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,750,856 - 23,834,264 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,961,177 - 24,044,625 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,962,013 - 24,018,638 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,761,949 - 23,845,633 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,803,449 - 23,887,091 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,366,632 - 24,450,038 (-)NCBIUU_Cfam_GSD_1.0
Gpr156
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,474,898 - 130,568,539 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,953,486 - 7,047,108 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365366,954,896 - 7,047,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR156
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,007,711 - 140,074,166 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113139,974,430 - 140,074,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,300,471 - 149,367,418 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR156
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,520,726 - 60,654,971 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2260,565,094 - 60,653,271 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,659,529 - 105,747,729 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr156
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473127,956,383 - 28,091,285 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473127,956,317 - 28,090,259 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr156
522 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:56
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000003773
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

Markers in Region
D11Rat4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,790,342 - 62,790,509 (+)MAPPERmRatBN7.2
Rnor_6.01165,687,080 - 65,687,246NCBIRnor6.0
Rnor_6.01165,352,097 - 65,352,263NCBIRnor6.0
Rnor_5.01166,731,054 - 66,731,220UniSTSRnor5.0
RGSC_v3.41164,573,222 - 64,573,702RGDRGSC3.4
RGSC_v3.41164,573,426 - 64,573,592UniSTSRGSC3.4
RGSC_v3.11164,631,015 - 64,631,181RGD
Celera1162,288,965 - 62,289,117UniSTS
RH 3.4 Map11493.0UniSTS
RH 3.4 Map11493.0RGD
RH 2.0 Map11184.3RGD
SHRSP x BN Map1128.7798RGD
Cytogenetic Map11q21UniSTS
BE115109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,757,822 - 62,758,007 (+)MAPPERmRatBN7.2
Rnor_6.01165,654,154 - 65,654,338NCBIRnor6.0
Rnor_6.01165,318,576 - 65,318,760NCBIRnor6.0
Rnor_5.01166,764,506 - 66,764,690UniSTSRnor5.0
RGSC_v3.41164,540,088 - 64,540,272UniSTSRGSC3.4
Celera1162,257,392 - 62,257,576UniSTS
RH 3.4 Map11498.0UniSTS
Cytogenetic Map11q21UniSTS
BQ204693  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,730,458 - 62,730,655 (+)MAPPERmRatBN7.2
Rnor_6.01165,291,219 - 65,291,415NCBIRnor6.0
Rnor_5.01166,791,851 - 66,792,047UniSTSRnor5.0
RGSC_v3.41164,512,731 - 64,512,927UniSTSRGSC3.4
Celera1162,230,177 - 62,230,373UniSTS
RH 3.4 Map11500.9UniSTS
Cytogenetic Map11q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12
Low 50 22 28
Below cutoff 3 32 18 4 11 4 5 5 12 12 12 9 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003773   ⟹   ENSRNOP00000003773
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,723,872 - 62,815,435 (-)Ensembl
Rnor_6.0 Ensembl1165,285,468 - 65,350,442 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117329   ⟹   ENSRNOP00000080021
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,723,872 - 62,815,435 (-)Ensembl
RefSeq Acc Id: NM_153295   ⟹   NP_695207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21162,724,707 - 62,788,688 (-)NCBI
Rnor_6.01165,285,468 - 65,350,442 (-)NCBI
Rnor_5.01166,732,875 - 66,797,798 (+)NCBI
RGSC_v3.41164,506,980 - 64,571,771 (-)RGD
Celera1162,224,426 - 62,287,310 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088047   ⟹   XP_038943975
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21162,723,464 - 62,815,444 (-)NCBI
RefSeq Acc Id: XM_039088048   ⟹   XP_038943976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21162,723,464 - 62,759,011 (-)NCBI
Protein Sequences
Protein RefSeqs NP_695207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943975 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943976 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN03797 (Get FASTA)   NCBI Sequence Viewer  
  EDM11237 (Get FASTA)   NCBI Sequence Viewer  
  Q8K451 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_695207   ⟸   NM_153295
- UniProtKB: G3V6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003773   ⟸   ENSRNOT00000003773
RefSeq Acc Id: XP_038943975   ⟸   XM_039088047
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943976   ⟸   XM_039088048
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000080021   ⟸   ENSRNOT00000117329
Protein Domains
G_PROTEIN_RECEP_F3_4

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708438 AgrOrtholog
BioCyc Gene G2FUF-21263 BioCyc
Ensembl Genes ENSRNOG00000002797 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003773 ENTREZGENE
  ENSRNOP00000003773.1 UniProtKB/TrEMBL
  ENSRNOP00000080021.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003773 ENTREZGENE
  ENSRNOT00000003773.3 UniProtKB/TrEMBL
  ENSRNOT00000117329.1 UniProtKB/TrEMBL
InterPro GPCR3_GABA-B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR156_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:260430 UniProtKB/Swiss-Prot
NCBI Gene 260430 ENTREZGENE
PANTHER PTHR10519 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr156 PhenoGen
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPM0_RAT UniProtKB/TrEMBL
  G3V6C5 ENTREZGENE, UniProtKB/TrEMBL
  GP156_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gpr156  G protein-coupled receptor 156  LOC103693583  probable G-protein coupled receptor 156  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103693583  probable G-protein coupled receptor 156      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Gpr156  G protein-coupled receptor 156  Gababl  GABAB-related G-protein coupled receptor  Symbol and Name updated 1299863 APPROVED