Mylk (myosin light chain kinase) - Rat Genome Database

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Gene: Mylk (myosin light chain kinase) Rattus norvegicus
Analyze
Symbol: Mylk
Name: myosin light chain kinase
RGD ID: 1310915
Description: Predicted to have enzyme binding activity and myosin light chain kinase activity. Predicted to be involved in several processes, including aorta smooth muscle tissue morphogenesis; bleb assembly; and cellular response to metal ion. Predicted to localize to several cellular components, including cleavage furrow; lamellipodium; and stress fiber. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC288057; myosin light chain kinase, smooth muscle; myosin, light polypeptide kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21165,783,008 - 66,030,239 (-)NCBI
Rnor_6.0 Ensembl1169,013,050 - 69,223,158 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01169,013,060 - 69,260,039 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01172,103,710 - 72,350,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,602,540 - 67,848,794 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11167,661,997 - 67,920,369 (-)NCBI
Celera1165,239,196 - 65,448,599 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
captan  (ISO)
carbachol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
genistein  (ISO)
ginsenoside Re  (EXP)
glafenine  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methoxyacetic acid  (EXP)
methylmercury chloride  (ISO)
ML-7  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vasopressin  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
prostaglandin I2 signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Additional References at PubMed
PMID:11976941   PMID:15020676   PMID:15825080   PMID:16284075   PMID:18524939   PMID:18586037   PMID:19826488   PMID:20018858   PMID:20053363   PMID:20181817   PMID:21055718   PMID:21070574  
PMID:21074048   PMID:21551973   PMID:22302242   PMID:23376485   PMID:23793062   PMID:29262413  


Genomics

Comparative Map Data
Mylk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21165,783,008 - 66,030,239 (-)NCBI
Rnor_6.0 Ensembl1169,013,050 - 69,223,158 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01169,013,060 - 69,260,039 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01172,103,710 - 72,350,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,602,540 - 67,848,794 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11167,661,997 - 67,920,369 (-)NCBI
Celera1165,239,196 - 65,448,599 (-)NCBICelera
Cytogenetic Map11q22NCBI
MYLK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3123,610,049 - 123,884,331 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3123,610,049 - 123,884,332 (-)EnsemblGRCh38hg38GRCh38
GRCh383123,610,049 - 123,884,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373123,328,896 - 123,603,179 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363124,813,833 - 125,085,839 (-)NCBINCBI36hg18NCBI36
Build 343124,813,834 - 124,822,220NCBI
Celera3121,738,078 - 122,010,598 (-)NCBI
Cytogenetic Map3q21.1NCBI
HuRef3120,704,092 - 120,976,941 (-)NCBIHuRef
CHM1_13123,294,136 - 123,566,156 (-)NCBICHM1_1
Mylk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391634,565,569 - 34,822,806 (+)NCBIGRCm39mm39
GRCm39 Ensembl1634,565,580 - 34,822,790 (+)Ensembl
GRCm381634,745,199 - 35,002,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1634,745,210 - 35,002,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv371634,785,036 - 35,002,520 (+)NCBIGRCm37mm9NCBIm37
MGSCv361634,704,668 - 34,920,359 (+)NCBImm8
Celera1635,252,169 - 35,470,294 (+)NCBICelera
Cytogenetic Map16B3NCBI
Mylk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542722,762,221 - 22,970,508 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542722,760,432 - 23,008,432 (-)NCBIChiLan1.0ChiLan1.0
MYLK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13127,612,369 - 127,831,009 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3127,614,173 - 127,793,261 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03120,711,705 - 120,983,432 (-)NCBIMhudiblu_PPA_v0panPan3
MYLK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13326,663,991 - 26,867,370 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3326,664,800 - 26,843,181 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3326,685,793 - 26,889,011 (-)NCBI
ROS_Cfam_1.03326,897,335 - 27,100,530 (-)NCBI
UMICH_Zoey_3.13326,692,727 - 26,872,402 (-)NCBI
UNSW_CanFamBas_1.03326,737,402 - 26,940,787 (-)NCBI
UU_Cfam_GSD_1.03327,349,403 - 27,553,330 (-)NCBI
Mylk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602127,510,307 - 127,686,249 (+)NCBI
SpeTri2.0NW_0049367251,418,930 - 1,594,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYLK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13136,508,808 - 136,809,674 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113136,509,878 - 136,809,674 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213146,205,306 - 146,232,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYLK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12257,032,264 - 57,259,253 (+)NCBI
ChlSab1.1 Ensembl2257,065,331 - 57,257,464 (+)Ensembl
Mylk
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249121,952,053 - 2,213,196 (-)NCBI

Position Markers
D11Rat63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,839,799 - 65,840,002 (+)MAPPER
Rnor_6.01169,069,808 - 69,070,010NCBIRnor6.0
Rnor_5.01172,160,297 - 72,160,499UniSTSRnor5.0
RGSC_v3.41167,659,761 - 67,660,133RGDRGSC3.4
RGSC_v3.41167,659,790 - 67,659,992UniSTSRGSC3.4
RGSC_v3.11167,717,379 - 67,717,581RGD
RH 3.4 Map11434.1UniSTS
RH 3.4 Map11434.1RGD
RH 2.0 Map11163.4RGD
SHRSP x BN Map1129.8399RGD
Cytogenetic Map11q22UniSTS
D11Rat94  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,826,406 - 65,826,598 (+)MAPPER
Rnor_6.01169,056,431 - 69,056,622NCBIRnor6.0
Rnor_5.01172,146,956 - 72,147,147UniSTSRnor5.0
RGSC_v3.41167,646,209 - 67,646,401RGDRGSC3.4
RGSC_v3.41167,646,210 - 67,646,401UniSTSRGSC3.4
RGSC_v3.11167,703,799 - 67,703,990RGD
Celera1165,282,678 - 65,282,900UniSTS
RH 3.4 Map11432.4RGD
RH 3.4 Map11432.4UniSTS
RH 2.0 Map11165.7RGD
SHRSP x BN Map1129.8599RGD
Cytogenetic Map11q22UniSTS
BM389975  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,798,149 - 65,798,345 (+)MAPPER
Rnor_6.01169,028,186 - 69,028,381NCBIRnor6.0
Rnor_5.01172,118,875 - 72,119,070UniSTSRnor5.0
RGSC_v3.41167,617,671 - 67,617,866UniSTSRGSC3.4
Celera1165,254,401 - 65,254,596UniSTS
RH 3.4 Map11429.9UniSTS
Cytogenetic Map11q22UniSTS
RH127440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,783,159 - 65,783,370 (+)MAPPER
Rnor_6.01169,013,212 - 69,013,422NCBIRnor6.0
Rnor_5.01172,103,862 - 72,104,072UniSTSRnor5.0
RGSC_v3.41167,602,671 - 67,602,881UniSTSRGSC3.4
Celera1165,239,348 - 65,239,558UniSTS
RH 3.4 Map11435.9UniSTS
Cytogenetic Map11q22UniSTS
BI293815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,833,933 - 65,834,134 (+)MAPPER
Rnor_6.01169,063,963 - 69,064,163NCBIRnor6.0
Rnor_5.01172,154,488 - 72,154,688UniSTSRnor5.0
RGSC_v3.41167,653,742 - 67,653,942UniSTSRGSC3.4
Celera1165,290,340 - 65,290,540UniSTS
RH 3.4 Map11429.1UniSTS
Cytogenetic Map11q22UniSTS
AA851174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,783,168 - 65,783,364 (+)MAPPER
Rnor_6.01169,013,221 - 69,013,416NCBIRnor6.0
Rnor_5.01172,103,871 - 72,104,066UniSTSRnor5.0
RGSC_v3.41167,602,680 - 67,602,875UniSTSRGSC3.4
Celera1165,239,357 - 65,239,552UniSTS
RH 3.4 Map11434.0UniSTS
Cytogenetic Map11q22UniSTS
AU049255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,826,395 - 65,826,600 (+)MAPPER
Rnor_6.01169,056,420 - 69,056,624NCBIRnor6.0
Rnor_5.01172,146,945 - 72,147,149UniSTSRnor5.0
RGSC_v3.41167,646,199 - 67,646,403UniSTSRGSC3.4
Celera1165,282,667 - 65,282,902UniSTS
Cytogenetic Map11q22UniSTS
AU049487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,956,251 - 65,956,368 (+)MAPPER
mRatBN7.269,806,213 - 9,806,359 (-)MAPPER
Rnor_6.068,120,695 - 8,120,840NCBIRnor6.0
Rnor_6.01169,185,931 - 69,186,047NCBIRnor6.0
Rnor_5.01172,276,723 - 72,276,839UniSTSRnor5.0
Rnor_5.068,054,707 - 8,054,852UniSTSRnor5.0
RGSC_v3.41167,774,662 - 67,774,778UniSTSRGSC3.4
RGSC_v3.468,223,013 - 8,223,158UniSTSRGSC3.4
Celera69,528,098 - 9,528,235UniSTS
Celera1165,411,499 - 65,411,615UniSTS
Cytogenetic Map11q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)1132503169342559Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112540112970401129Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112572003870720038Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112572003870720038Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113215552082443118Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113590063480900634Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)114444434769649708Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114790104978471527Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:153
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000067060
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 31 41 29 15 29 3 3 8 35 36 11 3
Low 12 16 12 4 12 5 8 66 5 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067060   ⟹   ENSRNOP00000062274
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1169,013,060 - 69,223,158 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085618   ⟹   ENSRNOP00000071545
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1169,013,050 - 69,201,380 (-)Ensembl
RefSeq Acc Id: NM_001105874   ⟹   NP_001099344
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,783,008 - 65,993,368 (-)NCBI
Rnor_6.01169,013,060 - 69,223,158 (-)NCBI
Rnor_5.01172,103,710 - 72,350,517 (-)NCBI
RGSC_v3.41167,602,540 - 67,848,794 (-)RGD
Celera1165,239,196 - 65,448,599 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248433   ⟹   XP_006248495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,783,012 - 65,971,645 (-)NCBI
Rnor_6.01169,014,898 - 69,201,503 (-)NCBI
Rnor_5.01172,103,710 - 72,350,517 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248434   ⟹   XP_006248496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,783,012 - 66,030,239 (-)NCBI
Rnor_6.01169,014,898 - 69,260,039 (-)NCBI
Rnor_5.01172,103,710 - 72,350,517 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768711   ⟹   XP_008766933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01169,013,064 - 69,201,504 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768712   ⟹   XP_008766934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01169,013,064 - 69,091,681 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597921   ⟹   XP_017453410
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01169,013,064 - 69,193,387 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088119   ⟹   XP_038944047
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,783,012 - 65,993,343 (-)NCBI
RefSeq Acc Id: XM_039088120   ⟹   XP_038944048
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,783,012 - 65,890,960 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001099344   ⟸   NM_001105874
- UniProtKB: D3ZFU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248496   ⟸   XM_006248434
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K0Q7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248495   ⟸   XM_006248433
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K0Q7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766933   ⟸   XM_008768711
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008766934   ⟸   XM_008768712
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017453410   ⟸   XM_017597921
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000062274   ⟸   ENSRNOT00000067060
RefSeq Acc Id: ENSRNOP00000071545   ⟸   ENSRNOT00000085618
RefSeq Acc Id: XP_038944047   ⟸   XM_039088119
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944048   ⟸   XM_039088120
- Peptide Label: isoform X3
Protein Domains
Fibronectin type-III   Ig-like   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698197
Promoter ID:EPDNEW_R8718
Type:initiation region
Name:Mylk_1
Description:myosin light chain kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01169,201,323 - 69,201,383EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 72136027 72136028 C T snv DOB/Oda (KyushuU)
11 72189238 72189239 C T snv ZFDM (KyushuU), SBH/Ygl (MCW), SBN/Ygl (MCW), DOB/Oda (KyushuU), F344/Jcl (KyushuU), F344/Stm (KyushuU), IS-Tlk/Kyo (KyushuU), F344/NSlc (KyushuU), F344/DuCrlCrlj (KyushuU), NIG-III/Hok (KyushuU), BUF/MNa (KyushuU), IS/Kyo (KyushuU), Crl:SD (UDEL), SDLEF7/Barth (UDEL), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), LL/MavRrrc (KNAW), LN/MavRrrc (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), BBDP/WorN (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), F344/NRrrc (Illumina) (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), BUF/N (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), GK/Ox (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), MNS/Gib (KNAW)
11 72189292 72189293 G A snv DOB/Oda (KyushuU), SBN/Ygl (MCW), IS-Tlk/Kyo (KyushuU), WKY/NHsd (KNAW), WKY/N (KNAW), SBN/Ygl (KNAW), IS/Kyo (KyushuU)
11 72189483 72189484 C T snv SBN/Ygl (KNAW), SBN/Ygl (MCW)
11 72197619 72197620 T G snv LE/Stm (KyushuU)
11 72197624 72197625 C A snv LE/Stm (KyushuU), HWY/Slc (KyushuU)


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 69098749 69098750 C T snv SR/JrHsd (RGD), SBN/Ygl (RGD), SBN/Ygl (MCW), WKY/NHsd (RGD), SBH/Ygl (MCW), SS/Jr (RGD), SS/JrHsdMcwi (RGD), WKY/NCrl (RGD), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), Buf/N (MCW), F344/NRrrc (MCW), M520/N (MCW), MR/N (MCW), WKY/N (MCW), BBDP/Wor (RGD), F344/NCrl (RGD), GK/Ox (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LH/MavRrrc (RGD), LN/MavRrrc (RGD), LL/MavRrrc (RGD), SBH/Ygl (RGD)
11 69098803 69098804 G A snv SBN/Ygl (RGD), WKY/N (MCW), SBN/Ygl (MCW), WKY/NHsd (RGD)
11 69098994 69098995 C T snv SBN/Ygl (RGD), SBN/Ygl (MCW)
11 69100156 69100157 G A snv SBN/Ygl (RGD), SBN/Ygl (MCW), WKY/NHsd (RGD)
11 69133173 69133174 C T snv SBN/Ygl (MCW), SBN/Ygl (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310915 AgrOrtholog
Ensembl Genes ENSRNOG00000002215 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062274 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071545 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067060 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085618 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Telokin/Myosin_light_ch_kin UniProtKB/TrEMBL
KEGG Report rno:288057 UniProtKB/TrEMBL
NCBI Gene 288057 ENTREZGENE
Pfam fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PharmGKB MYLK RGD
PhenoGen Mylk PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K0Q7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFU9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Mylk  myosin light chain kinase  Mylk  myosin, light polypeptide kinase   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mylk  myosin, light polypeptide kinase   Mylk_predicted  myosin, light polypeptide kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mylk_predicted  myosin, light polypeptide kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED