Mylk (myosin light chain kinase) - Rat Genome Database

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Gene: Mylk (myosin light chain kinase) Rattus norvegicus
Analyze
Symbol: Mylk
Name: myosin light chain kinase
RGD ID: 1310915
Description: Predicted to enable enzyme binding activity; myosin light chain kinase activity; and scaffold protein binding activity. Involved in regulation of synaptic vesicle endocytosis. Is active in synapse. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; coronary artery disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC288057; myosin light chain kinase, smooth muscle; myosin, light polypeptide kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81179,288,243 - 79,535,450 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1179,288,243 - 79,535,659 (-)EnsemblGRCr8
mRatBN7.21165,783,008 - 66,030,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1165,783,008 - 66,030,261 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1174,604,614 - 74,815,083 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,267,069 - 67,477,427 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01166,297,014 - 66,507,509 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01169,013,060 - 69,260,039 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1169,013,050 - 69,223,158 (-)Ensemblrn6Rnor6.0
Rnor_5.01172,103,710 - 72,350,517 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41167,602,540 - 67,848,794 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1165,239,196 - 65,448,599 (-)NCBICelera
RGSC_v3.11167,661,997 - 67,920,369 (-)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1,4-dithiothreitol  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methoxyethanol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
captan  (ISO)
carbachol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (EXP)
glafenine  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
lipopolysaccharide  (EXP,ISO)
loperamide  (ISO)
losartan  (EXP)
luteolin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
ML-7  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mosapride citrate dihydrate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
Pervanadate  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vasopressin  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA,ISO)
cell-cell junction  (ISO)
cleavage furrow  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
lamellipodium  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)
stress fiber  (IBA,IEA,ISO)
synapse  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
prostaglandin I2 signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma. Christie JD, etal., Crit Care Med. 2008 Aug 28.
2. Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Gao L, etal., Am J Respir Cell Mol Biol. 2006 Apr;34(4):487-95. Epub 2006 Jan 6.
3. Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. Gao L, etal., J Allergy Clin Immunol. 2007 May;119(5):1111-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. Horne BD, etal., Ann Hum Genet. 2009 Nov;73(Pt 6):551-8. doi: 10.1111/j.1469-1809.2009.00540.x. Epub 2009 Aug 25.
7. Myosin light chain kinase facilitates endocytosis of synaptic vesicles at hippocampal boutons. Li L, etal., J Neurochem. 2016 Jul;138(1):60-73. doi: 10.1111/jnc.13635. Epub 2016 May 16.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons. Tokuoka H and Goda Y, J Neurosci. 2006 Nov 8;26(45):11606-14. doi: 10.1523/JNEUROSCI.3400-06.2006.
15. Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. Wang GY, etal., Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H913-20. Epub 2009 Dec 24.
Additional References at PubMed
PMID:11976941   PMID:15020676   PMID:15825080   PMID:16284075   PMID:18524939   PMID:18586037   PMID:19826488   PMID:20018858   PMID:20053363   PMID:20181817   PMID:21055718   PMID:21070574  
PMID:21074048   PMID:21551973   PMID:22302242   PMID:23376485   PMID:23793062   PMID:29262413   PMID:33035716  


Genomics

Comparative Map Data
Mylk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81179,288,243 - 79,535,450 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1179,288,243 - 79,535,659 (-)EnsemblGRCr8
mRatBN7.21165,783,008 - 66,030,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1165,783,008 - 66,030,261 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1174,604,614 - 74,815,083 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,267,069 - 67,477,427 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01166,297,014 - 66,507,509 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01169,013,060 - 69,260,039 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1169,013,050 - 69,223,158 (-)Ensemblrn6Rnor6.0
Rnor_5.01172,103,710 - 72,350,517 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41167,602,540 - 67,848,794 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1165,239,196 - 65,448,599 (-)NCBICelera
RGSC_v3.11167,661,997 - 67,920,369 (-)NCBI
Cytogenetic Map11q22NCBI
MYLK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383123,610,049 - 123,884,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3123,610,049 - 123,884,375 (-)Ensemblhg38GRCh38
GRCh373123,328,896 - 123,603,179 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363124,813,833 - 125,085,839 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343124,813,834 - 124,822,220NCBI
Celera3121,738,078 - 122,010,598 (-)NCBICelera
Cytogenetic Map3q21.1NCBI
HuRef3120,704,092 - 120,976,941 (-)NCBIHuRef
CHM1_13123,294,136 - 123,566,156 (-)NCBICHM1_1
T2T-CHM13v2.03126,330,173 - 126,610,461 (-)NCBIT2T-CHM13v2.0
Mylk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391634,565,569 - 34,822,806 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1634,565,580 - 34,822,790 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381634,745,199 - 35,002,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1634,745,210 - 35,002,420 (+)Ensemblmm10GRCm38
MGSCv371634,785,036 - 35,002,520 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361634,704,668 - 34,920,359 (+)NCBIMGSCv36mm8
Celera1635,252,169 - 35,470,294 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1624.49NCBI
Mylk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542722,762,221 - 22,970,508 (-)Ensembl
ChiLan1.0NW_00495542722,760,432 - 23,008,432 (-)NCBIChiLan1.0ChiLan1.0
MYLK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22121,568,257 - 121,839,962 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13121,573,032 - 121,844,737 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03120,711,705 - 120,983,432 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13127,612,369 - 127,831,009 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3127,614,173 - 127,793,261 (-)EnsemblpanPan2panpan1.1
MYLK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13326,663,991 - 26,867,370 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3326,664,800 - 26,843,181 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3326,685,793 - 26,889,011 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03326,897,335 - 27,100,530 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3326,897,335 - 27,166,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13326,692,727 - 26,872,402 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03326,737,402 - 26,940,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03327,349,403 - 27,553,330 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mylk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602127,510,307 - 127,686,249 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367251,424,130 - 1,592,840 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367251,418,930 - 1,594,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYLK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13136,509,755 - 136,809,668 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113136,509,878 - 136,809,674 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213146,205,306 - 146,232,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYLK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12257,032,264 - 57,259,253 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2257,065,331 - 57,257,464 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041109,093,851 - 109,369,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mylk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249121,953,838 - 2,172,561 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249121,952,053 - 2,213,196 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mylk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1419,595,180 - 19,775,758 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mylk
2190 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:153
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000067060
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
D11Rat63  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81179,345,022 - 79,345,225 (+)Marker Load Pipeline
mRatBN7.21165,839,799 - 65,840,002 (+)MAPPERmRatBN7.2
Rnor_6.01169,069,808 - 69,070,010NCBIRnor6.0
Rnor_5.01172,160,297 - 72,160,499UniSTSRnor5.0
RGSC_v3.41167,659,761 - 67,660,133RGDRGSC3.4
RGSC_v3.41167,659,790 - 67,659,992UniSTSRGSC3.4
RGSC_v3.11167,717,379 - 67,717,581RGD
RH 3.4 Map11434.1UniSTS
RH 3.4 Map11434.1RGD
RH 2.0 Map11163.4RGD
SHRSP x BN Map1129.8399RGD
Cytogenetic Map11q22UniSTS
D11Rat94  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81179,331,640 - 79,331,832 (+)Marker Load Pipeline
mRatBN7.21165,826,406 - 65,826,598 (+)MAPPERmRatBN7.2
Rnor_6.01169,056,431 - 69,056,622NCBIRnor6.0
Rnor_5.01172,146,956 - 72,147,147UniSTSRnor5.0
RGSC_v3.41167,646,210 - 67,646,401UniSTSRGSC3.4
RGSC_v3.41167,646,209 - 67,646,401RGDRGSC3.4
Celera1165,282,678 - 65,282,900UniSTS
RGSC_v3.11167,703,799 - 67,703,990RGD
RH 3.4 Map11432.4RGD
RH 3.4 Map11432.4UniSTS
RH 2.0 Map11165.7RGD
SHRSP x BN Map1129.8599RGD
Cytogenetic Map11q22UniSTS
BM389975  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,798,149 - 65,798,345 (+)MAPPERmRatBN7.2
Rnor_6.01169,028,186 - 69,028,381NCBIRnor6.0
Rnor_5.01172,118,875 - 72,119,070UniSTSRnor5.0
RGSC_v3.41167,617,671 - 67,617,866UniSTSRGSC3.4
Celera1165,254,401 - 65,254,596UniSTS
RH 3.4 Map11429.9UniSTS
Cytogenetic Map11q22UniSTS
RH127440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,783,159 - 65,783,370 (+)MAPPERmRatBN7.2
Rnor_6.01169,013,212 - 69,013,422NCBIRnor6.0
Rnor_5.01172,103,862 - 72,104,072UniSTSRnor5.0
RGSC_v3.41167,602,671 - 67,602,881UniSTSRGSC3.4
Celera1165,239,348 - 65,239,558UniSTS
RH 3.4 Map11435.9UniSTS
Cytogenetic Map11q22UniSTS
BI293815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,833,933 - 65,834,134 (+)MAPPERmRatBN7.2
Rnor_6.01169,063,963 - 69,064,163NCBIRnor6.0
Rnor_5.01172,154,488 - 72,154,688UniSTSRnor5.0
RGSC_v3.41167,653,742 - 67,653,942UniSTSRGSC3.4
Celera1165,290,340 - 65,290,540UniSTS
RH 3.4 Map11429.1UniSTS
Cytogenetic Map11q22UniSTS
AA851174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,783,168 - 65,783,364 (+)MAPPERmRatBN7.2
Rnor_6.01169,013,221 - 69,013,416NCBIRnor6.0
Rnor_5.01172,103,871 - 72,104,066UniSTSRnor5.0
RGSC_v3.41167,602,680 - 67,602,875UniSTSRGSC3.4
Celera1165,239,357 - 65,239,552UniSTS
RH 3.4 Map11434.0UniSTS
Cytogenetic Map11q22UniSTS
AU049255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,826,395 - 65,826,600 (+)MAPPERmRatBN7.2
Rnor_6.01169,056,420 - 69,056,624NCBIRnor6.0
Rnor_5.01172,146,945 - 72,147,149UniSTSRnor5.0
RGSC_v3.41167,646,199 - 67,646,403UniSTSRGSC3.4
Celera1165,282,667 - 65,282,902UniSTS
Cytogenetic Map11q22UniSTS
AU049487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,956,251 - 65,956,368 (+)MAPPERmRatBN7.2
mRatBN7.269,806,213 - 9,806,359 (-)MAPPERmRatBN7.2
Rnor_6.068,120,695 - 8,120,840NCBIRnor6.0
Rnor_6.01169,185,931 - 69,186,047NCBIRnor6.0
Rnor_5.01172,276,723 - 72,276,839UniSTSRnor5.0
Rnor_5.068,054,707 - 8,054,852UniSTSRnor5.0
RGSC_v3.41167,774,662 - 67,774,778UniSTSRGSC3.4
RGSC_v3.468,223,013 - 8,223,158UniSTSRGSC3.4
Celera69,528,098 - 9,528,235UniSTS
Celera1165,411,499 - 65,411,615UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067060   ⟹   ENSRNOP00000062274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1179,288,243 - 79,498,574 (-)Ensembl
mRatBN7.2 Ensembl1165,783,008 - 65,993,368 (-)Ensembl
Rnor_6.0 Ensembl1169,013,060 - 69,223,158 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085618   ⟹   ENSRNOP00000071545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1179,288,243 - 79,535,659 (-)Ensembl
mRatBN7.2 Ensembl1165,783,008 - 66,030,261 (-)Ensembl
Rnor_6.0 Ensembl1169,013,050 - 69,201,380 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110507   ⟹   ENSRNOP00000095967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1179,288,243 - 79,498,574 (-)Ensembl
mRatBN7.2 Ensembl1165,783,008 - 65,993,368 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118349   ⟹   ENSRNOP00000086286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1179,288,243 - 79,469,199 (-)Ensembl
mRatBN7.2 Ensembl1165,783,008 - 65,963,985 (-)Ensembl
RefSeq Acc Id: NM_001105874   ⟹   NP_001099344
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81179,288,243 - 79,498,574 (-)NCBI
mRatBN7.21165,783,008 - 65,993,368 (-)NCBI
Rnor_6.01169,013,060 - 69,223,158 (-)NCBI
Rnor_5.01172,103,710 - 72,350,517 (-)NCBI
RGSC_v3.41167,602,540 - 67,848,794 (-)RGD
Celera1165,239,196 - 65,448,599 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248433   ⟹   XP_006248495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81179,288,263 - 79,476,855 (-)NCBI
mRatBN7.21165,783,012 - 65,971,645 (-)NCBI
Rnor_6.01169,014,898 - 69,201,503 (-)NCBI
Rnor_5.01172,103,710 - 72,350,517 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248434   ⟹   XP_006248496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81179,288,263 - 79,535,450 (-)NCBI
mRatBN7.21165,783,012 - 66,030,239 (-)NCBI
Rnor_6.01169,014,898 - 69,260,039 (-)NCBI
Rnor_5.01172,103,710 - 72,350,517 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088119   ⟹   XP_038944047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81179,288,263 - 79,498,549 (-)NCBI
mRatBN7.21165,783,012 - 65,993,343 (-)NCBI
RefSeq Acc Id: XM_039088120   ⟹   XP_038944048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81179,288,263 - 79,396,147 (-)NCBI
mRatBN7.21165,783,012 - 65,890,960 (-)NCBI
RefSeq Acc Id: XM_063270377   ⟹   XP_063126447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81179,288,263 - 79,366,582 (-)NCBI
RefSeq Acc Id: NP_001099344   ⟸   NM_001105874
- UniProtKB: A0A8I6A5J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248496   ⟸   XM_006248434
- Peptide Label: isoform X2
- UniProtKB: D3ZFU9 (UniProtKB/TrEMBL),   A0A8I6AQ53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248495   ⟸   XM_006248433
- Peptide Label: isoform X2
- UniProtKB: D3ZFU9 (UniProtKB/TrEMBL),   A0A8I6AQ53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062274   ⟸   ENSRNOT00000067060
Ensembl Acc Id: ENSRNOP00000071545   ⟸   ENSRNOT00000085618
RefSeq Acc Id: XP_038944047   ⟸   XM_039088119
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944048   ⟸   XM_039088120
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000086286   ⟸   ENSRNOT00000118349
Ensembl Acc Id: ENSRNOP00000095967   ⟸   ENSRNOT00000110507
RefSeq Acc Id: XP_063126447   ⟸   XM_063270377
- Peptide Label: isoform X4
- UniProtKB: A6IRH8 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFU9-F1-model_v2 AlphaFold D3ZFU9 1-1961 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698197
Promoter ID:EPDNEW_R8718
Type:initiation region
Name:Mylk_1
Description:myosin light chain kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01169,201,323 - 69,201,383EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310915 AgrOrtholog
BioCyc Gene G2FUF-21159 BioCyc
Ensembl Genes ENSRNOG00000002215 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067060 ENTREZGENE
  ENSRNOT00000067060.4 UniProtKB/TrEMBL
  ENSRNOT00000085618 ENTREZGENE
  ENSRNOT00000085618.3 UniProtKB/TrEMBL
  ENSRNOT00000110507.2 UniProtKB/TrEMBL
  ENSRNOT00000118349.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Telokin/Myosin_light_ch_kin UniProtKB/TrEMBL
NCBI Gene 288057 ENTREZGENE
PANTHER IMMUNOGLOBULIN UniProtKB/TrEMBL
  MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE UniProtKB/TrEMBL
  STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE UniProtKB/TrEMBL
Pfam 23ISL UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PharmGKB MYLK RGD
PhenoGen Mylk PhenoGen
PRINTS FNTYPEIII UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002215 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K0Q7_RAT UniProtKB/TrEMBL
  A0A8I6A5J5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQ53 ENTREZGENE, UniProtKB/TrEMBL
  A6IRH8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFU9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Mylk  myosin light chain kinase  Mylk  myosin, light polypeptide kinase   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mylk  myosin, light polypeptide kinase   Mylk_predicted  myosin, light polypeptide kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mylk_predicted  myosin, light polypeptide kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED