 Gene Ontology Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Component
Molecular Function
 |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
Save List to My RGD
| Create Name: | |
| Description: |
|
| Save what matters to you |
| {{ loginError }} |
| Sign in with your RGD account |
| Create New Account | Recover Password |
{{ watchLinkText }}
Select categories you would like to watch. Updates to this gene will be send to {{ username }}
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Cellular Component
Molecular Function
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology AnnotationsBiological Process
|
|
Cellular Component
|
Molecular Function
|
|
References - curated| 1. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | MGD data from the GO Consortium |
| 3. | RGD automated data pipeline |
| 4. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 5. | RGD automated import pipeline for gene-chemical interactions |
Genomics
Comparative Map Data| Slc12a8 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SLC12A8 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Slc12a8 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Slc12a8 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SLC12A8 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SLC12A8 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Slc12a8 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SLC12A8 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SLC12A8 (Chlorocebus sabaeus - African green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Slc12a8 (Heterocephalus glaber - naked mole-rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Position Markers| RH128794 |
|
|||||||||||||||||||||||||||||||||||
| BM385725 |
|
|||||||||||||||||||||||||||||||||||
| AU049215 |
|
QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
||||||||
Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 3 | 16 | |||||||||||
| Low | 2 | 8 | 13 | 64 | 19 | 36 | 11 | ||||||
| Below cutoff | 41 | 40 | 32 | 6 | 32 | 8 | 11 | 10 | 5 | 8 |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_153625 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006248422 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006248423 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006248424 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006248426 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006248427 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006248429 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017597889 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017597890 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07034415 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07034416 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07034417 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07034418 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07072248 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069787 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069788 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069789 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069790 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069791 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069792 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069793 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069794 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AB024430 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AB024431 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC110981 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000002439 ⟹ ENSRNOP00000002439 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
|
| RefSeq Acc Id: | ENSRNOT00000040167 ⟹ ENSRNOP00000045345 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
|
| RefSeq Acc Id: | ENSRNOT00000086495 ⟹ ENSRNOP00000072100 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
|
| RefSeq Acc Id: | NM_153625 ⟹ NP_705889 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
|
||||||||||||||||||||
| Sequence: |
AGAGGGNCTCCCCATCTAGAGGATCAGAACCTCACTTGCTGAAGAATGGCCCAGAGGTCTCCAChide sequence |
| RefSeq Acc Id: | XM_006248422 ⟹ XP_006248484 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
|
||||||||||||
| Sequence: |
GCGGGCGTGGCCTCCGGAGCCCGGGGAGGTGCAGGTGAAGGTCCGGGTACTGCTCCGCGGAGGGhide sequence |
| RefSeq Acc Id: | XM_006248423 ⟹ XP_006248485 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
|
||||||||||||
| Sequence: |
GCGGGCGTGGCCTCCGGAGCCCGGGGAGGTGCAGGTGAAGGTCCGGGTACTGCTCCGCGGAGGGhide sequence |
| RefSeq Acc Id: | XM_006248424 ⟹ XP_006248486 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
|
||||||||||||
| Sequence: |
GAATCTTTTCTCCCCGGCAGGATGGGGTGCACGGTCGGTTGCCTCAGCCCTTCTCTCTCCCTCChide sequence |
| RefSeq Acc Id: | XM_006248426 ⟹ XP_006248488 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
|
||||||||||||
| Sequence: |
GCGGGCGTGGCCTCCGGAGCCCGGGGAGGTGCAGGTGAAGGTCCGGGTACTGCTCCGCGGAGGGhide sequence |
| RefSeq Acc Id: | XM_006248427 ⟹ XP_006248489 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
|
||||||||||||
| Sequence: |
GCGGGCGTGGCCTCCGGAGCCCGGGGAGGTGCAGGTGAAGGTCCGGGTACTGCTCCGCGGAGGGhide sequence |
| RefSeq Acc Id: | XM_006248429 ⟹ XP_006248491 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
|
||||||||||||
| Sequence: |
GCGGGCGTGGCCTCCGGAGCCCGGGGAGGTGCAGGTGAAGGTCCGGGTACTGCTCCGCGGAGGGhide sequence |
| RefSeq Acc Id: | XM_017597889 ⟹ XP_017453378 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
|
||||||||
| Sequence: |
GCGGGCGTGGCCTCCGGAGCCCGGGGAGGTGCAGGTGAAGGTCCGGGTACTGCTCCGCGGAGGGhide sequence |
| RefSeq Acc Id: | XM_017597890 ⟹ XP_017453379 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
|
||||||||
| Sequence: |
CACACCCCCATCCCCTTTTCCTCCCCAGTCCGTCCCTCCCTGGGAGGCACAGTCTTTATGAGCThide sequence |
Protein Sequences| Protein RefSeqs | NP_705889 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006248484 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006248485 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006248486 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006248488 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006248489 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006248491 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017453378 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017453379 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | BAC20264 | (Get FASTA) | NCBI Sequence Viewer |
| BAC20265 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11357 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11358 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11359 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11360 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11361 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11362 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11363 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11364 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11365 | (Get FASTA) | NCBI Sequence Viewer | |
| Q8CJI3 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_705889 ⟸ NM_153625 |
| - UniProtKB: | Q8CJI3 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MAQRSPQELFHEAAQQGVLARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLhide sequence |
| RefSeq Acc Id: | XP_006248485 ⟸ XM_006248423 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | F1M7M6 (UniProtKB/TrEMBL) |
| - Sequence: |
MAQRSPQELFHEAAQQGALARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLhide sequence |
| RefSeq Acc Id: | XP_006248488 ⟸ XM_006248426 |
| - Peptide Label: | isoform X2 |
| - Sequence: |
MAQRSPQELFHEAAQQGALARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLhide sequence |
| RefSeq Acc Id: | XP_006248489 ⟸ XM_006248427 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MAQRSPQELFHEAAQQGALARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLhide sequence |
| RefSeq Acc Id: | XP_006248491 ⟸ XM_006248429 |
| - Peptide Label: | isoform X5 |
| - Sequence: |
MAQRSPQELFHEAAQQGALARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLhide sequence |
| RefSeq Acc Id: | XP_006248484 ⟸ XM_006248422 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | F1M7M6 (UniProtKB/TrEMBL) |
| - Sequence: |
MAQRSPQELFHEAAQQGALARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLhide sequence |
| RefSeq Acc Id: | XP_006248486 ⟸ XM_006248424 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | F1M7M6 (UniProtKB/TrEMBL) |
| - Sequence: |
MAQRSPQELFHEAAQQGALARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLhide sequence |
| RefSeq Acc Id: | XP_017453379 ⟸ XM_017597890 |
| - Peptide Label: | isoform X6 |
| - Sequence: |
MGSGGVYSMISSVLGGQMGGTVGLLYVFGQCVAGAMYLTGFAESISDLLGLGNIWAVRGISVAVhide sequence |
| RefSeq Acc Id: | XP_017453378 ⟸ XM_017597889 |
| - Peptide Label: | isoform X4 |
| - Sequence: |
MAQRSPQELFHEAAQQGALARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLhide sequence |
| RefSeq Acc Id: | ENSRNOP00000002439 ⟸ ENSRNOT00000002439 |
| RefSeq Acc Id: | ENSRNOP00000072100 ⟸ ENSRNOT00000086495 |
| RefSeq Acc Id: | ENSRNOP00000045345 ⟸ ENSRNOT00000040167 |
Protein Domains
AA_permease
TranscriptomePromoters| RGD ID: | 13698205 | ||||||||
| Promoter ID: | EPDNEW_R8724 | ||||||||
| Type: | single initiation site | ||||||||
| Name: | Slc12a8_1 | ||||||||
| Description: | solute carrier family 12, member 8 | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
|
Strain Variation
Strain Sequence Variants (Rnor 6.0)
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
Damaging VariantsAssembly: Rnor_5.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 11 | 73469687 | 73469688 | A | G | snv | SR/JrHsd (MCW) |
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:628730 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000001792 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000002439 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000045345 | ENTREZGENE, UniProtKB/TrEMBL | |
| ENSRNOP00000072100 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000002439 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000040167 | ENTREZGENE, UniProtKB/TrEMBL | |
| ENSRNOT00000086495 | UniProtKB/TrEMBL | |
| InterPro | AA-permease/SLC12A_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| KEGG Report | rno:266733 | UniProtKB/Swiss-Prot |
| NCBI Gene | 266733 | ENTREZGENE |
| Pfam | AA_permease | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| PhenoGen | Slc12a8 | PhenoGen |
| UniGene | Rn.15381 | ENTREZGENE |
| UniProt | A0A0G2K244_RAT | UniProtKB/TrEMBL |
| D4AAY5_RAT | UniProtKB/TrEMBL | |
| F1M7M6 | ENTREZGENE, UniProtKB/TrEMBL | |
| Q8CJI3 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| UniProt Secondary | Q8CJI2 | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2013-08-02 | Slc12a8 | solute carrier family 12, member 8 | Slc12a8 | solute carrier family 12 (potassium/chloride transporters), member 8 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2006-03-30 | Slc12a8 | solute carrier family 12 (potassium/chloride transporters), member 8 | cation-chloride cotransporter 9 | Name updated | 1299863 | APPROVED | |
| 2004-09-10 | Slc12a8 | cation-chloride cotransporter 9 | Ccc9 | Symbol and Name updated | 1299863 | APPROVED | |
| 2003-02-27 | Ccc9 | cation-chloride cotransporter 9 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
 |
| More on Slc12a8 | |
|
Alliance Gene |
|
NCBI Gene |
|
Ensembl Gene |
|
|
JBrowse: rn5 rn6 |
|
NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 628730 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-08-20 |
| Status: | ACTIVE |
