Slc12a8 (solute carrier family 12, member 8) - Rat Genome Database

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Gene: Slc12a8 (solute carrier family 12, member 8) Rattus norvegicus
Analyze
Symbol: Slc12a8
Name: solute carrier family 12, member 8
RGD ID: 628730
Description: Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Orthologous to human SLC12A8 (solute carrier family 12 member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cation-chloride cotransporter 9; Ccc9; solute carrier family 12 (potassium/chloride transporters), member 8; solute carrier family 12 member 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,622,000 - 80,771,674 (-)NCBIGRCr8
mRatBN7.21167,116,876 - 67,266,548 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,116,877 - 67,266,834 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1175,949,593 - 76,099,488 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,611,466 - 68,761,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,642,062 - 67,791,952 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,344,771 - 70,499,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,344,797 - 70,499,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,432,330 - 73,586,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,934,104 - 69,087,168 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,991,693 - 69,144,757 (-)NCBI
Celera1166,567,029 - 66,714,564 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallic acid  (ISO)
glycidol  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
metformin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
NMN zwitterion  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
potassium chromate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
XL147  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Slc12a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,622,000 - 80,771,674 (-)NCBIGRCr8
mRatBN7.21167,116,876 - 67,266,548 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,116,877 - 67,266,834 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1175,949,593 - 76,099,488 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,611,466 - 68,761,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,642,062 - 67,791,952 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,344,771 - 70,499,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,344,797 - 70,499,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,432,330 - 73,586,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,934,104 - 69,087,168 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,991,693 - 69,144,757 (-)NCBI
Celera1166,567,029 - 66,714,564 (-)NCBICelera
Cytogenetic Map11q22NCBI
SLC12A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383125,082,644 - 125,212,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3125,082,636 - 125,212,864 (-)EnsemblGRCh38hg38GRCh38
GRCh373124,801,488 - 124,931,592 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363126,284,170 - 126,414,299 (-)NCBINCBI36Build 36hg18NCBI36
Build 343126,284,171 - 126,414,273NCBI
Celera3123,208,830 - 123,340,801 (-)NCBICelera
Cytogenetic Map3q21.2NCBI
HuRef3122,175,576 - 122,307,515 (-)NCBIHuRef
CHM1_13124,764,695 - 124,894,611 (-)NCBICHM1_1
T2T-CHM13v2.03127,808,303 - 127,940,353 (-)NCBIT2T-CHM13v2.0
Slc12a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391633,337,440 - 33,484,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1633,337,698 - 33,484,505 (+)EnsemblGRCm39 Ensembl
GRCm381633,517,328 - 33,664,138 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1633,517,328 - 33,664,135 (+)EnsemblGRCm38mm10GRCm38
MGSCv371633,518,415 - 33,664,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361633,438,085 - 33,583,150 (+)NCBIMGSCv36mm8
Celera1634,001,716 - 34,147,712 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1624.12NCBI
Slc12a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,137,228 - 24,284,070 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,137,420 - 24,284,485 (-)NCBIChiLan1.0ChiLan1.0
SLC12A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22123,078,737 - 123,209,450 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13123,083,006 - 123,214,229 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03122,214,558 - 122,344,797 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13129,080,749 - 129,210,870 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3129,080,749 - 129,210,872 (-)Ensemblpanpan1.1panPan2
SLC12A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13328,085,345 - 28,200,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3328,085,350 - 28,214,022 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3328,108,177 - 28,241,143 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03328,318,223 - 28,450,846 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3328,318,226 - 28,451,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13328,117,173 - 28,249,376 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03328,161,405 - 28,293,994 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03328,781,397 - 28,913,009 (-)NCBIUU_Cfam_GSD_1.0
Slc12a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602126,211,080 - 126,329,094 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936725100,823 - 237,223 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936725100,780 - 237,525 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13135,105,896 - 135,249,120 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113135,105,723 - 135,249,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213144,631,230 - 144,751,929 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC12A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12255,623,961 - 55,754,969 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2255,646,406 - 55,754,209 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041110,556,797 - 110,658,171 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,113,489 - 1,259,344 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,114,079 - 1,259,832 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc12a8
875 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:281
Count of miRNA genes:146
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000002439, ENSRNOT00000040167
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat

Markers in Region
RH128794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21167,116,935 - 67,117,132 (+)MAPPERmRatBN7.2
Rnor_6.01170,344,831 - 70,345,027NCBIRnor6.0
Rnor_5.01173,432,390 - 73,432,586UniSTSRnor5.0
RGSC_v3.41168,934,164 - 68,934,360UniSTSRGSC3.4
Celera1166,567,089 - 66,567,285UniSTS
RH 3.4 Map11411.6UniSTS
Cytogenetic Map11q22UniSTS
BM385725  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21167,185,172 - 67,185,364 (+)MAPPERmRatBN7.2
Rnor_6.01170,413,081 - 70,413,272NCBIRnor6.0
Rnor_5.01173,500,198 - 73,500,389UniSTSRnor5.0
RGSC_v3.41169,003,012 - 69,003,203UniSTSRGSC3.4
Celera1166,634,906 - 66,635,097UniSTS
RH 3.4 Map11407.7UniSTS
Cytogenetic Map11q22UniSTS
AU049215  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1166,605,880 - 66,606,004UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 81 80 49 25 49 6 208 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_153625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB024430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB024431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000002439   ⟹   ENSRNOP00000002439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,116,877 - 67,265,804 (-)Ensembl
Rnor_6.0 Ensembl1170,344,797 - 70,499,200 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000040167   ⟹   ENSRNOP00000045345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,116,877 - 67,246,688 (-)Ensembl
Rnor_6.0 Ensembl1170,345,038 - 70,498,391 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086495   ⟹   ENSRNOP00000072100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,116,877 - 67,266,834 (-)Ensembl
Rnor_6.0 Ensembl1170,345,128 - 70,498,437 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108813   ⟹   ENSRNOP00000081818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,116,877 - 67,265,804 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119564   ⟹   ENSRNOP00000091705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,116,877 - 67,265,804 (-)Ensembl
RefSeq Acc Id: NM_153625   ⟹   NP_705889
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,622,000 - 80,770,915 (-)NCBI
mRatBN7.21167,116,876 - 67,265,804 (-)NCBI
Rnor_6.01170,344,771 - 70,498,437 (-)NCBI
Rnor_5.01173,432,330 - 73,586,317 (-)NCBI
RGSC_v3.41168,934,104 - 69,087,168 (-)RGD
Celera1166,567,029 - 66,714,564 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248423   ⟹   XP_006248485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,622,000 - 80,771,674 (-)NCBI
mRatBN7.21167,116,876 - 67,266,548 (-)NCBI
Rnor_6.01170,344,771 - 70,499,202 (-)NCBI
Rnor_5.01173,432,330 - 73,586,317 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088051   ⟹   XP_038943979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,622,000 - 80,770,955 (-)NCBI
mRatBN7.21167,117,179 - 67,265,796 (-)NCBI
RefSeq Acc Id: XM_039088052   ⟹   XP_038943980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,622,000 - 80,704,856 (-)NCBI
mRatBN7.21167,116,876 - 67,199,669 (-)NCBI
RefSeq Acc Id: XM_063270314   ⟹   XP_063126384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,622,000 - 80,771,674 (-)NCBI
RefSeq Acc Id: NP_705889   ⟸   NM_153625
- UniProtKB: Q8CJI3 (UniProtKB/Swiss-Prot),   Q8CJI2 (UniProtKB/Swiss-Prot),   F1M7M6 (UniProtKB/TrEMBL),   A6IRK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248485   ⟸   XM_006248423
- Peptide Label: isoform X1
- UniProtKB: Q8CJI3 (UniProtKB/Swiss-Prot),   Q8CJI2 (UniProtKB/Swiss-Prot),   F1M7M6 (UniProtKB/TrEMBL),   A6IRK4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002439   ⟸   ENSRNOT00000002439
Ensembl Acc Id: ENSRNOP00000072100   ⟸   ENSRNOT00000086495
Ensembl Acc Id: ENSRNOP00000045345   ⟸   ENSRNOT00000040167
RefSeq Acc Id: XP_038943980   ⟸   XM_039088052
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K244 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943979   ⟸   XM_039088051
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G6I7 (UniProtKB/TrEMBL),   A6IRK9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081818   ⟸   ENSRNOT00000108813
Ensembl Acc Id: ENSRNOP00000091705   ⟸   ENSRNOT00000119564
RefSeq Acc Id: XP_063126384   ⟸   XM_063270314
- Peptide Label: isoform X1
- UniProtKB: A6IRK4 (UniProtKB/TrEMBL),   F1M7M6 (UniProtKB/TrEMBL)
Protein Domains
Amino acid permease/ SLC12A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJI3-F1-model_v2 AlphaFold Q8CJI3 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698205
Promoter ID:EPDNEW_R8724
Type:single initiation site
Name:Slc12a8_1
Description:solute carrier family 12, member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01170,498,513 - 70,498,573EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628730 AgrOrtholog
BioCyc Gene G2FUF-21130 BioCyc
Ensembl Genes ENSRNOG00000001792 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002439.8 UniProtKB/TrEMBL
  ENSRNOT00000040167.6 UniProtKB/TrEMBL
  ENSRNOT00000086495.2 UniProtKB/TrEMBL
  ENSRNOT00000108813.1 UniProtKB/TrEMBL
  ENSRNOT00000119564.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266733 UniProtKB/Swiss-Prot
NCBI Gene 266733 ENTREZGENE
PANTHER PTHR11827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11827:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc12a8 PhenoGen
RatGTEx ENSRNOG00000001792 RatGTEx
UniProt A0A0G2K244 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AE65_RAT UniProtKB/TrEMBL
  A0A8I6G6I7 ENTREZGENE, UniProtKB/TrEMBL
  A6IRK4 ENTREZGENE, UniProtKB/TrEMBL
  A6IRK5_RAT UniProtKB/TrEMBL
  A6IRK6_RAT UniProtKB/TrEMBL
  A6IRK7_RAT UniProtKB/TrEMBL
  A6IRK8_RAT UniProtKB/TrEMBL
  A6IRK9 ENTREZGENE, UniProtKB/TrEMBL
  A6IRL0_RAT UniProtKB/TrEMBL
  A6IRL1_RAT UniProtKB/TrEMBL
  A6IRL2_RAT UniProtKB/TrEMBL
  D4AAY5_RAT UniProtKB/TrEMBL
  F1M7M6 ENTREZGENE, UniProtKB/TrEMBL
  Q8CJI2 ENTREZGENE
  Q8CJI3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8CJI2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-02 Slc12a8  solute carrier family 12, member 8  Slc12a8  solute carrier family 12 (potassium/chloride transporters), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc12a8  solute carrier family 12 (potassium/chloride transporters), member 8    cation-chloride cotransporter 9  Name updated 1299863 APPROVED
2004-09-10 Slc12a8  cation-chloride cotransporter 9  Ccc9    Symbol and Name updated 1299863 APPROVED
2003-02-27 Ccc9  cation-chloride cotransporter 9      Symbol and Name status set to provisional 70820 PROVISIONAL