![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | ISO | RGD:1345509 | 6480464 | Estradiol results in decreased expression of SLC12A8 mRNA | CTD | PMID:19167446 | 17beta-estradiol | increases expression | ISO | RGD:1345509 | 6480464 | Estradiol results in increased expression of SLC12A8 mRNA | CTD | PMID:31614463 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:1553135 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:1553135 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1553135 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SLC12A8 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SLC12A8 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1553135 | 6480464 | [Tetrachlorodibenzodioxin affects the methylation of SLC12A8 intron] which results in decreased expression of SLC12A8 mRNA | CTD | PMID:33017471 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | RGD:1345509 | 6480464 | 2 more ... | CTD | PMID:26705709 | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of SLC12A8 mRNA | CTD | PMID:24780913 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of SLC12A8 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | RGD:1345509 | 6480464 | Aflatoxin B1 results in decreased methylation of SLC12A8 intron | CTD | PMID:30157460 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SLC12A8 mRNA | CTD | PMID:16483693 | aristolochic acid A | decreases expression | ISO | RGD:1345509 | 6480464 | aristolochic acid I results in decreased expression of SLC12A8 mRNA | CTD | PMID:33212167 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of SLC12A8 gene | CTD | PMID:28931070 | benzo[a]pyrene | affects methylation | ISO | RGD:1345509 | 6480464 | Benzo(a)pyrene affects the methylation of SLC12A8 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | RGD:1345509 | 6480464 | Benzo(a)pyrene results in decreased expression of SLC12A8 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | RGD:1553135 | 6480464 | Benzo(a)pyrene results in increased methylation of SLC12A8 exon, Benzo(a)pyrene results in increased methylation of SLC12A8 intron | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | RGD:1345509 | 6480464 | Benzo(a)pyrene results in decreased methylation of SLC12A8 5' UTR | CTD | PMID:27901495 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SLC12A8 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | RGD:1345509 | 6480464 | bisphenol A results in decreased methylation of SLC12A8 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | RGD:1345509 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SLC12A8 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SLC12A8 mRNA | CTD | PMID:30816183 | bisphenol A | increases expression | ISO | RGD:1345509 | 6480464 | bisphenol A results in increased expression of SLC12A8 mRNA | CTD | PMID:29275510 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of SLC12A8 mRNA | CTD | PMID:19167457 | cadmium atom | multiple interactions | ISO | RGD:1345509 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC12A8 mRNA | CTD | PMID:35301059 | cadmium dichloride | increases expression | ISO | RGD:1345509 | 6480464 | Cadmium Chloride results in increased expression of SLC12A8 mRNA | CTD | PMID:25596134 | cadmium dichloride | multiple interactions | ISO | RGD:1345509 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC12A8 mRNA | CTD | PMID:35301059 | CGP 52608 | multiple interactions | ISO | RGD:1345509 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SLC12A8 gene] | CTD | PMID:28238834 | chloroacetaldehyde | affects expression | ISO | RGD:1345509 | 6480464 | chloroacetaldehyde affects the expression of SLC12A8 mRNA | CTD | PMID:25596134 | chlorpromazine | increases expression | EXP | | 6480464 | Chlorpromazine results in increased expression of SLC12A8 mRNA | CTD | PMID:25596134 | choline | multiple interactions | ISO | RGD:1553135 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC12A8 mRNA | CTD | PMID:20938992 | chromium(6+) | affects expression | ISO | RGD:1345509 | 6480464 | chromium hexavalent ion affects the expression of SLC12A8 mRNA | CTD | PMID:30690063 | cidofovir anhydrous | affects expression | ISO | RGD:1345509 | 6480464 | Cidofovir affects the expression of SLC12A8 mRNA | CTD | PMID:25596134 | cisplatin | decreases expression | ISO | RGD:1345509 | 6480464 | Cisplatin results in decreased expression of SLC12A8 mRNA | CTD | PMID:25596134 | cisplatin | multiple interactions | ISO | RGD:1345509 | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of SLC12A8 mRNA | CTD | PMID:27392435 | clodronic acid | decreases expression | ISO | RGD:1345509 | 6480464 | Clodronic Acid results in decreased expression of SLC12A8 mRNA | CTD | PMID:25596134 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of SLC12A8 mRNA | CTD | PMID:20187946 | cocaine | decreases expression | EXP | | 6480464 | Cocaine results in decreased expression of SLC12A8 mRNA | CTD | PMID:27899881 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of SLC12A8 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of SLC12A8 mRNA | CTD | PMID:26033743 | coumestrol | multiple interactions | ISO | RGD:1345509 | 6480464 | [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SLC12A8 mRNA | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | RGD:1345509 | 6480464 | Coumestrol results in decreased expression of SLC12A8 mRNA | CTD | PMID:19167446 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of SLC12A8 mRNA | CTD | PMID:26577399, PMID:27523638 | cyclosporin A | increases expression | ISO | RGD:1345509 | 6480464 | Cyclosporine results in increased expression of SLC12A8 mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of SLC12A8 mRNA | CTD | PMID:25596134 | dioxygen | decreases expression | ISO | RGD:1345509 | 6480464 | Oxygen deficiency results in decreased expression of SLC12A8 mRNA | CTD | PMID:25596134 | doxorubicin | decreases expression | ISO | RGD:1345509 | 6480464 | Doxorubicin results in decreased expression of SLC12A8 mRNA | CTD | PMID:29803840 | Enterolactone | multiple interactions | ISO | RGD:1345509 | 6480464 | [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SLC12A8 mRNA | CTD | PMID:19167446 | entinostat | increases expression | ISO | RGD:1345509 | 6480464 | entinostat results in increased expression of SLC12A8 mRNA | CTD | PMID:27188386 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of SLC12A8 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | RGD:1553135 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC12A8 mRNA | CTD | PMID:20938992 | fulvestrant | multiple interactions | ISO | RGD:1345509 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SLC12A8 gene | CTD | PMID:31601247 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of SLC12A8 mRNA | CTD | PMID:25539665, PMID:27387713 | gallic acid | decreases expression | ISO | RGD:1345509 | 6480464 | Gallic Acid results in decreased expression of SLC12A8 mRNA | CTD | PMID:34408198 | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of SLC12A8 mRNA | CTD | PMID:24915197 | hydrogen peroxide | multiple interactions | ISO | RGD:1345509 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC12A8 protein | CTD | PMID:18951874 | hydrogen peroxide | decreases expression | ISO | RGD:1345509 | 6480464 | Hydrogen Peroxide results in decreased expression of SLC12A8 mRNA | CTD | PMID:18951874 | ifosfamide | decreases expression | ISO | RGD:1345509 | 6480464 | Ifosfamide results in decreased expression of SLC12A8 mRNA | CTD | PMID:25596134 | L-methionine | multiple interactions | ISO | RGD:1553135 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC12A8 mRNA | CTD | PMID:20938992 | lead diacetate | increases expression | ISO | RGD:1345509 | 6480464 | lead acetate results in increased expression of SLC12A8 mRNA | CTD | PMID:22839698 | metformin | increases expression | EXP | | 6480464 | Metformin results in increased expression of SLC12A8 mRNA | CTD | PMID:25596134 | mono(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1553135 | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of SLC12A8 mRNA | CTD | PMID:22401849 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of SLC12A8 gene | CTD | PMID:33148267 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC12A8 mRNA | CTD | PMID:20360939 | nickel atom | increases expression | ISO | RGD:1345509 | 6480464 | Nickel results in increased expression of SLC12A8 mRNA | CTD | PMID:25583101 | paracetamol | decreases expression | ISO | RGD:1345509 | 6480464 | Acetaminophen results in decreased expression of SLC12A8 mRNA | CTD | PMID:29067470 | PCB138 | multiple interactions | ISO | RGD:1553135 | 6480464 | [2 more ... | CTD | PMID:25510870 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of SLC12A8 gene | CTD | PMID:33148267 | phenethyl caffeate | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC12A8 mRNA | CTD | PMID:20360939 | potassium chromate | increases expression | ISO | RGD:1345509 | 6480464 | potassium chromate(VI) results in increased expression of SLC12A8 mRNA | CTD | PMID:22714537 | silver atom | increases expression | ISO | RGD:1553135 | 6480464 | Silver results in increased expression of SLC12A8 mRNA | CTD | PMID:27131904 | silver(0) | increases expression | ISO | RGD:1553135 | 6480464 | Silver results in increased expression of SLC12A8 mRNA | CTD | PMID:27131904 | sodium arsenite | increases expression | ISO | RGD:1345509 | 6480464 | sodium arsenite results in increased expression of SLC12A8 mRNA | CTD | PMID:22714537 | sulforaphane | increases expression | ISO | RGD:1345509 | 6480464 | sulforaphane results in increased expression of SLC12A8 mRNA | CTD | PMID:31838189 | sunitinib | increases expression | ISO | RGD:1345509 | 6480464 | Sunitinib results in increased expression of SLC12A8 mRNA | CTD | PMID:31533062 | temozolomide | decreases expression | ISO | RGD:1345509 | 6480464 | Temozolomide results in decreased expression of SLC12A8 mRNA | CTD | PMID:31758290 | theophylline | multiple interactions | ISO | RGD:1345509 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC12A8 protein | CTD | PMID:18951874 | titanium dioxide | decreases expression | ISO | RGD:1553135 | 6480464 | titanium dioxide results in decreased expression of SLC12A8 mRNA | CTD | PMID:23131501 | tributylstannane | increases expression | ISO | RGD:1553135 | 6480464 | tributyltin results in increased expression of SLC12A8 mRNA | CTD | PMID:31939706 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SLC12A8 mRNA | CTD | PMID:33387578 | triptonide | affects expression | ISO | RGD:1553135 | 6480464 | triptonide affects the expression of SLC12A8 mRNA | CTD | PMID:33045310 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of SLC12A8 mRNA | CTD | PMID:25596134 | valproic acid | decreases expression | ISO | RGD:1345509 | 6480464 | Valproic Acid results in decreased expression of SLC12A8 mRNA | CTD | PMID:29154799 | valproic acid | affects expression | ISO | RGD:1345509 | 6480464 | Valproic Acid affects the expression of SLC12A8 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | RGD:1345509 | 6480464 | Valproic Acid results in increased expression of SLC12A8 mRNA | CTD | PMID:23179753, PMID:27188386 | XL147 | multiple interactions | ISO | RGD:1553135 | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC12A8 mRNA | CTD | PMID:27935865 | |