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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sema5b | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SEMA5B mRNA | CTD | PMID:22206623 | Sema5b | Rat | 17beta-estradiol | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of SEMA5B mRNA | CTD | PMID:30165855 | Sema5b | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Sema5b (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | Sema5b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Sema5b (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin affects the methylation of SEMA5B intron] which results in decreased expression of SEMA5B mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SEMA5B promoter] | CTD | PMID:19654925 and PMID:33017471 | Sema5b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEMA5B mRNA | CTD | PMID:32109520 | Sema5b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sema5b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEMA5B mRNA | CTD | PMID:26377647 and PMID:28922406 | Sema5b | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Sema5b | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Sema5b (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SEMA5B mRNA | CTD | PMID:20188158 | Sema5b | Rat | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SEMA5B mRNA | CTD | PMID:30071829 | Sema5b | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | Sema5b (Mus musculus) | 6480464 | bisphenol S results in increased methylation of SEMA5B exon | CTD | PMID:33297965 | Sema5b | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of SEMA5B mRNA | CTD | PMID:24780913 | Sema5b | Rat | acrylamide | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | Acrylamide results in decreased expression of SEMA5B mRNA | CTD | PMID:29261810 | Sema5b | Rat | acrylamide | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of SEMA5B mRNA | CTD | PMID:32763439 | Sema5b | Rat | aflatoxin B1 | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of SEMA5B mRNA | CTD | PMID:22100608 | Sema5b | Rat | aflatoxin B1 | decreases methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of SEMA5B gene | CTD | PMID:27153756 | Sema5b | Rat | Aflatoxin B2 alpha | increases methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of SEMA5B intron | CTD | PMID:30157460 | Sema5b | Rat | all-trans-retinoic acid | increases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SEMA5B mRNA | CTD | PMID:21934132 and PMID:23724009 | Sema5b | Rat | antirheumatic drug | increases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SEMA5B mRNA | CTD | PMID:24449571 | Sema5b | Rat | aristolochic acid A | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SEMA5B mRNA | CTD | PMID:33212167 | Sema5b | Rat | arsane | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SEMA5B mRNA | CTD | PMID:32525701 | Sema5b | Rat | arsane | decreases methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | Arsenic results in decreased methylation of SEMA5B gene | CTD | PMID:31135185 | Sema5b | Rat | arsenic atom | decreases methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | Arsenic results in decreased methylation of SEMA5B gene | CTD | PMID:31135185 | Sema5b | Rat | arsenic atom | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SEMA5B mRNA | CTD | PMID:32525701 | Sema5b | Rat | atrazine | increases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Atrazine results in increased expression of SEMA5B mRNA | CTD | PMID:18585445 | Sema5b | Rat | benzo[a]pyrene | decreases methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SEMA5B promoter | CTD | PMID:27901495 | Sema5b | Rat | benzo[a]pyrene | affects methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SEMA5B 5' UTR and Benzo(a)pyrene affects the methylation of SEMA5B intron | CTD | PMID:27901495 and PMID:30157460 | Sema5b | Rat | benzo[e]pyrene | increases methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of SEMA5B intron | CTD | PMID:30157460 | Sema5b | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SEMA5B mRNA | CTD | PMID:25181051 | Sema5b | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SEMA5B gene | CTD | PMID:28505145 | Sema5b | Rat | cadmium atom | multiple interactions | ISO | Sema5b (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SEMA5B mRNA | CTD | PMID:37325564 | Sema5b | Rat | cadmium dichloride | multiple interactions | ISO | Sema5b (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SEMA5B mRNA | CTD | PMID:37325564 | Sema5b | Rat | carbamazepine | affects expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SEMA5B mRNA | CTD | PMID:25979313 | Sema5b | Rat | CGP 52608 | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SEMA5B gene] | CTD | PMID:28238834 | Sema5b | Rat | choline | multiple interactions | ISO | Sema5b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA5B gene | CTD | PMID:20938992 | Sema5b | Rat | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of SEMA5B mRNA | CTD | PMID:15691709 | Sema5b | Rat | cytarabine | increases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Cytarabine results in increased expression of SEMA5B mRNA | CTD | PMID:21198554 | Sema5b | Rat | dibutyl phthalate | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of SEMA5B mRNA | CTD | PMID:21266533 | Sema5b | Rat | dichloroacetic acid | increases expression | ISO | Sema5b (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of SEMA5B mRNA | CTD | PMID:28962523 | Sema5b | Rat | dorsomorphin | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5B mRNA | CTD | PMID:27188386 | Sema5b | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of SEMA5B mRNA | CTD | PMID:29391264 | Sema5b | Rat | entinostat | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | entinostat results in decreased expression of SEMA5B mRNA | CTD | PMID:27188386 | Sema5b | Rat | ethanol | increases expression | ISO | Sema5b (Mus musculus) | 6480464 | Ethanol results in increased expression of SEMA5B mRNA | CTD | PMID:30319688 | Sema5b | Rat | ethanol | affects splicing | ISO | Sema5b (Mus musculus) | 6480464 | Ethanol affects the splicing of SEMA5B mRNA | CTD | PMID:30319688 | Sema5b | Rat | folic acid | multiple interactions | ISO | Sema5b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA5B gene | CTD | PMID:20938992 | Sema5b | Rat | folic acid | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SEMA5B mRNA | CTD | PMID:25629700 | Sema5b | Rat | GW 4064 | increases expression | ISO | Sema5b (Mus musculus) | 6480464 | GW 4064 results in increased expression of SEMA5B mRNA | CTD | PMID:26655953 | Sema5b | Rat | hexane | decreases methylation | EXP | | 6480464 | n-hexane results in decreased methylation of SEMA5B promoter | CTD | PMID:23740543 | Sema5b | Rat | inulin | multiple interactions | ISO | Sema5b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SEMA5B mRNA | CTD | PMID:36331819 | Sema5b | Rat | L-methionine | multiple interactions | ISO | Sema5b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SEMA5B gene | CTD | PMID:20938992 | Sema5b | Rat | lidocaine | increases expression | EXP | | 6480464 | Lidocaine results in increased expression of SEMA5B mRNA | CTD | PMID:35283115 | Sema5b | Rat | lipopolysaccharide | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SEMA5B mRNA | CTD | PMID:35811015 | Sema5b | Rat | methapyrilene | increases methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of SEMA5B intron | CTD | PMID:30157460 | Sema5b | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of SEMA5B gene | CTD | PMID:35440735 | Sema5b | Rat | methylmercury chloride | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | methylmercuric chloride results in decreased expression of SEMA5B mRNA | CTD | PMID:29261810 | Sema5b | Rat | O-methyleugenol | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of SEMA5B mRNA | CTD | PMID:32234424 | Sema5b | Rat | ozone | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | Ozone results in decreased expression of SEMA5B mRNA | CTD | PMID:31626304 | Sema5b | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SEMA5B mRNA | CTD | PMID:33387578 | Sema5b | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Sema5b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SEMA5B mRNA | CTD | PMID:36331819 | Sema5b | Rat | permethrin | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Permethrin results in decreased expression of SEMA5B mRNA | CTD | PMID:37047231 | Sema5b | Rat | phenylmercury acetate | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of SEMA5B mRNA | CTD | PMID:26272509 | Sema5b | Rat | phenylmercury acetate | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5B mRNA | CTD | PMID:27188386 | Sema5b | Rat | pirinixic acid | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of SEMA5B mRNA | CTD | PMID:25270620 | Sema5b | Rat | pirinixic acid | increases expression | ISO | Sema5b (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SEMA5B mRNA | CTD | PMID:18301758 more ... | Sema5b | Rat | resveratrol | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of SEMA5B mRNA | CTD | PMID:23557933 | Sema5b | Rat | rotenone | increases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Rotenone results in increased expression of SEMA5B mRNA | CTD | PMID:29955902 | Sema5b | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SEMA5B mRNA | CTD | PMID:35811015 | Sema5b | Rat | SB 431542 | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA5B mRNA | CTD | PMID:27188386 | Sema5b | Rat | silicon dioxide | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SEMA5B mRNA | CTD | PMID:25895662 | Sema5b | Rat | silver atom | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | Silver results in decreased expression of SEMA5B mRNA | CTD | PMID:27131904 | Sema5b | Rat | silver(0) | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | Silver results in decreased expression of SEMA5B mRNA | CTD | PMID:27131904 | Sema5b | Rat | sodium arsenate | multiple interactions | ISO | SEMA5B (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SEMA5B mRNA | CTD | PMID:32525701 | Sema5b | Rat | sodium arsenite | increases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SEMA5B mRNA | CTD | PMID:38568856 | Sema5b | Rat | sunitinib | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of SEMA5B mRNA | CTD | PMID:31533062 | Sema5b | Rat | tetrachloroethene | increases expression | ISO | Sema5b (Mus musculus) | 6480464 | Tetrachloroethylene results in increased expression of SEMA5B mRNA | CTD | PMID:28973375 | Sema5b | Rat | titanium dioxide | decreases methylation | ISO | Sema5b (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SEMA5B gene | CTD | PMID:35295148 | Sema5b | Rat | trichloroethene | increases expression | ISO | Sema5b (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of SEMA5B mRNA | CTD | PMID:25549359 | Sema5b | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SEMA5B mRNA | CTD | PMID:33387578 | Sema5b | Rat | triptonide | increases expression | ISO | Sema5b (Mus musculus) | 6480464 | triptonide results in increased expression of SEMA5B mRNA | CTD | PMID:33045310 | Sema5b | Rat | valproic acid | decreases methylation | ISO | SEMA5B (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of SEMA5B gene | CTD | PMID:29154799 | Sema5b | Rat | valproic acid | decreases expression | ISO | Sema5b (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of SEMA5B mRNA | CTD | PMID:29261810 | Sema5b | Rat | valproic acid | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SEMA5B mRNA | CTD | PMID:28001369 | Sema5b | Rat | valproic acid | affects expression | ISO | SEMA5B (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SEMA5B mRNA | CTD | PMID:25979313 | Sema5b | Rat | zoledronic acid | decreases expression | ISO | SEMA5B (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of SEMA5B mRNA | CTD | PMID:24714768 | |