Cd200r1 (CD200 receptor 1) - Rat Genome Database

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Gene: Cd200r1 (CD200 receptor 1) Rattus norvegicus
Analyze
Symbol: Cd200r1
Name: CD200 receptor 1
RGD ID: 61837
Description: Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including negative regulation of interleukin-6 production; negative regulation of mononuclear cell migration; and negative regulation of neuroinflammatory response. Located in cell surface. Orthologous to human CD200R1 (CD200 receptor 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1; Mox2r; OX102 antigen; OX2 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,392,943 - 69,427,213 (-)NCBIGRCr8
mRatBN7.21155,886,937 - 55,921,217 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,887,717 - 55,921,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,701,896 - 64,734,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,363,755 - 57,396,462 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,434,097 - 56,466,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,848,161 - 60,882,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,848,131 - 60,882,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,962,558 - 64,994,987 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,427,237 - 57,459,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,484,825 - 57,517,305 (-)NCBI
Celera1155,452,759 - 55,484,520 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. Meuth SG, etal., J Neuroimmunol. 2008 Feb;194(1-2):62-9. doi: 10.1016/j.jneuroim.2007.11.013.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Wright GJ, etal., Immunity 2000 Aug;13(2):233-42.
8. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. Wright GJ, etal., Immunology. 2001 Feb;102(2):173-9.
Additional References at PubMed
PMID:15274657   PMID:19151626   PMID:21471232   PMID:22053982   PMID:22342946   PMID:23382219   PMID:25569356   PMID:30006626   PMID:30032349   PMID:31078691   PMID:32394288   PMID:32473633  
PMID:32664639   PMID:36565856   PMID:36591265   PMID:37971567   PMID:38237226  


Genomics

Comparative Map Data
Cd200r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,392,943 - 69,427,213 (-)NCBIGRCr8
mRatBN7.21155,886,937 - 55,921,217 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,887,717 - 55,921,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,701,896 - 64,734,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,363,755 - 57,396,462 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,434,097 - 56,466,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,848,161 - 60,882,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,848,131 - 60,882,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,962,558 - 64,994,987 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,427,237 - 57,459,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,484,825 - 57,517,305 (-)NCBI
Celera1155,452,759 - 55,484,520 (-)NCBICelera
Cytogenetic Map11q21NCBI
CD200R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383112,921,205 - 112,975,103 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3112,921,205 - 112,975,103 (-)EnsemblGRCh38hg38GRCh38
GRCh373112,640,052 - 112,693,950 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363114,124,222 - 114,176,627 (-)NCBINCBI36Build 36hg18NCBI36
Celera3111,049,870 - 111,102,275 (-)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3110,025,071 - 110,077,471 (-)NCBIHuRef
CHM1_13112,605,064 - 112,657,469 (-)NCBICHM1_1
T2T-CHM13v2.03115,642,153 - 115,696,046 (-)NCBIT2T-CHM13v2.0
Cd200r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391644,586,141 - 44,615,341 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1644,586,099 - 44,615,341 (+)EnsemblGRCm39 Ensembl
GRCm381644,765,736 - 44,794,977 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1644,765,736 - 44,794,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv371644,765,849 - 44,795,090 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361644,685,124 - 44,714,310 (+)NCBIMGSCv36mm8
Celera1645,131,563 - 45,160,813 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1629.08NCBI
Cd200r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542713,143,695 - 13,148,743 (-)NCBIChiLan1.0ChiLan1.0
LOC487977
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13317,332,986 - 17,357,301 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3317,436,279 - 17,460,591 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03317,577,294 - 17,601,611 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13317,381,692 - 17,406,001 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03317,429,158 - 17,453,448 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03317,978,760 - 18,003,078 (-)NCBIUU_Cfam_GSD_1.0
LOC103228312
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12267,862,368 - 67,902,875 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2267,862,783 - 67,901,872 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604198,576,511 - 98,618,733 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cd200r1
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:66
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000002799
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 6 10 6 2 2
Low 3 41 50 35 9 35 8 8 56 32 34 11 8
Below cutoff 2 3 16 1 3

Sequence


RefSeq Acc Id: ENSRNOT00000002799   ⟹   ENSRNOP00000002799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,887,717 - 55,921,285 (-)Ensembl
Rnor_6.0 Ensembl1160,848,131 - 60,882,379 (-)Ensembl
RefSeq Acc Id: NM_023953   ⟹   NP_076443
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,975 - 69,427,128 (-)NCBI
mRatBN7.21155,886,969 - 55,921,130 (-)NCBI
Rnor_6.01160,849,447 - 60,882,153 (-)NCBI
Rnor_5.01164,962,558 - 64,994,987 (-)NCBI
RGSC_v3.41157,427,237 - 57,459,716 (-)RGD
Celera1155,452,759 - 55,484,520 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248347   ⟹   XP_006248409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,943 - 69,427,212 (-)NCBI
mRatBN7.21155,886,937 - 55,921,217 (-)NCBI
Rnor_6.01160,848,161 - 60,882,470 (-)NCBI
Rnor_5.01164,962,558 - 64,994,987 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768743   ⟹   XP_008766965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,943 - 69,427,212 (-)NCBI
mRatBN7.21155,886,937 - 55,921,217 (-)NCBI
Rnor_6.01160,848,161 - 60,882,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088611   ⟹   XP_038944539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,943 - 69,427,211 (-)NCBI
mRatBN7.21155,886,937 - 55,921,215 (-)NCBI
RefSeq Acc Id: XM_039088612   ⟹   XP_038944540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,392,943 - 69,427,213 (-)NCBI
mRatBN7.21155,886,937 - 55,921,217 (-)NCBI
RefSeq Acc Id: NP_076443   ⟸   NM_023953
- Peptide Label: precursor
- UniProtKB: Q6PS97 (UniProtKB/Swiss-Prot),   Q9ES58 (UniProtKB/Swiss-Prot),   A6IQZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248409   ⟸   XM_006248347
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008766965   ⟸   XM_008768743
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000002799   ⟸   ENSRNOT00000002799
RefSeq Acc Id: XP_038944540   ⟸   XM_039088612
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038944539   ⟸   XM_039088611
- Peptide Label: isoform X2
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES58-F1-model_v2 AlphaFold Q9ES58 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698146
Promoter ID:EPDNEW_R8670
Type:initiation region
Name:Cd200r1_1
Description:CD200 receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,882,342 - 60,882,402EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61837 AgrOrtholog
BioCyc Gene G2FUF-21358 BioCyc
Ensembl Genes ENSRNOG00000039048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055003530 UniProtKB/Swiss-Prot
  ENSRNOG00060007303 UniProtKB/Swiss-Prot
  ENSRNOG00065008594 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002799 ENTREZGENE
  ENSRNOT00000002799.6 UniProtKB/Swiss-Prot
  ENSRNOT00055005496 UniProtKB/Swiss-Prot
  ENSRNOT00060012001 UniProtKB/Swiss-Prot
  ENSRNOT00065013660 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD200R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD80_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64357 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64357 ENTREZGENE
PANTHER CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL SURFACE GLYCOPROTEIN OX2 RECEPTOR PRECURSOR UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam C2-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd200r1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039048 RatGTEx
  ENSRNOG00055003530 RatGTEx
  ENSRNOG00060007303 RatGTEx
  ENSRNOG00065008594 RatGTEx
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IQZ7 ENTREZGENE, UniProtKB/TrEMBL
  MO2R1_RAT UniProtKB/Swiss-Prot
  Q6PS97 ENTREZGENE
  Q9ES58 ENTREZGENE
UniProt Secondary Q6PS97 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Cd200r1  CD200 receptor 1  Mox2r  antigen identified by monoclonal antibody MRC OX-2 receptor   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mox2r  antigen identified by monoclonal antibody MRC OX-2 receptor       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function receptor for OX2 61663
gene_physical_interaction interacts with OX2 61663
gene_regulation phosphorylated on tyrosine residues 61663