Igf2bp2 (insulin-like growth factor 2 mRNA binding protein 2) - Rat Genome Database

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Gene: Igf2bp2 (insulin-like growth factor 2 mRNA binding protein 2) Rattus norvegicus
Analyze
Symbol: Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
RGD ID: 1305614
Description: Predicted to have mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to be involved in nervous system development; regulation of RNA metabolic process; and regulation of gene expression. Predicted to localize to cytoskeleton; cytosol; and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2); INTERACTS WITH 17beta-estradiol; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: insulin-like growth factor 2 mRNA-binding protein 2; LOC303824; RGD1305614; similar to IGF-II mRNA-binding protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21178,874,402 - 78,974,392 (+)NCBI
Rnor_6.0 Ensembl1182,466,071 - 82,621,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01182,466,071 - 82,621,105 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01185,557,265 - 85,711,768 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,115,320 - 81,216,170 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11181,172,908 - 81,271,988 (+)NCBI
Celera1177,737,081 - 77,836,862 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytoskeleton  (ISO)
cytosol  (IBA,ISO)
nucleus  (IBA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:9891060   PMID:15618018   PMID:20080952   PMID:22427968   PMID:22513850   PMID:22658674   PMID:22681889  


Genomics

Candidate Gene Status
Igf2bp2 is a candidate Gene for QTL Niddm22
Comparative Map Data
Igf2bp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21178,874,402 - 78,974,392 (+)NCBI
Rnor_6.0 Ensembl1182,466,071 - 82,621,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01182,466,071 - 82,621,105 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01185,557,265 - 85,711,768 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,115,320 - 81,216,170 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11181,172,908 - 81,271,988 (+)NCBI
Celera1177,737,081 - 77,836,862 (+)NCBICelera
Cytogenetic Map11q23NCBI
IGF2BP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3185,643,130 - 185,825,042 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3185,643,739 - 185,825,056 (-)EnsemblGRCh38hg38GRCh38
GRCh383185,643,130 - 185,825,046 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373185,360,918 - 185,542,830 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363186,844,221 - 187,025,521 (-)NCBINCBI36hg18NCBI36
Celera3183,799,612 - 183,980,726 (-)NCBI
Cytogenetic Map3q27.2NCBI
HuRef3182,771,322 - 182,953,823 (-)NCBIHuRef
CHM1_13185,324,446 - 185,505,780 (-)NCBICHM1_1
Igf2bp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391621,877,759 - 21,982,049 (-)NCBIGRCm39mm39
GRCm39 Ensembl1621,877,759 - 21,982,049 (-)Ensembl
GRCm381622,059,009 - 22,163,299 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1622,059,009 - 22,163,299 (-)EnsemblGRCm38mm10GRCm38
MGSCv371622,059,082 - 22,163,372 (-)NCBIGRCm37mm9NCBIm37
MGSCv361621,974,311 - 22,078,275 (-)NCBImm8
Celera1622,626,468 - 22,730,584 (-)NCBICelera
Cytogenetic Map16B1NCBI
Igf2bp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542021,818,972 - 21,958,440 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542021,818,970 - 21,957,295 (+)NCBIChiLan1.0ChiLan1.0
IGF2BP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13191,141,289 - 191,320,426 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3191,142,063 - 191,320,221 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03182,667,557 - 182,848,528 (-)NCBIMhudiblu_PPA_v0panPan3
IGF2BP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13418,368,509 - 18,522,233 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3418,369,684 - 18,522,157 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3422,454,233 - 22,609,748 (-)NCBI
ROS_Cfam_1.03418,278,310 - 18,433,934 (-)NCBI
UMICH_Zoey_3.13418,313,763 - 18,469,277 (-)NCBI
UNSW_CanFamBas_1.03418,310,091 - 18,465,396 (-)NCBI
UU_Cfam_GSD_1.03418,539,538 - 18,694,889 (-)NCBI
Igf2bp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602117,979,147 - 118,130,531 (+)NCBI
SpeTri2.0NW_0049365784,070,997 - 4,222,661 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2BP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13123,485,624 - 123,650,039 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113123,485,619 - 123,650,050 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213133,022,551 - 133,065,869 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGF2BP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1153,607,764 - 3,793,386 (+)NCBI
ChlSab1.1 Ensembl153,607,849 - 3,791,631 (+)Ensembl
Igf2bp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473070,914,763 - 71,061,313 (+)NCBI

Position Markers
AW535442  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21178,974,107 - 78,974,258 (+)MAPPER
Rnor_6.01182,620,821 - 82,620,971NCBIRnor6.0
Rnor_5.01185,711,484 - 85,711,634UniSTSRnor5.0
RGSC_v3.41181,215,886 - 81,216,036UniSTSRGSC3.4
Celera1177,836,578 - 77,836,728UniSTS
RH 3.4 Map11650.3UniSTS
Cytogenetic Map11q23UniSTS
RH135376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21178,888,010 - 78,888,210 (+)MAPPER
Rnor_6.01182,479,954 - 82,480,153NCBIRnor6.0
Rnor_5.01185,571,148 - 85,571,347UniSTSRnor5.0
RGSC_v3.41181,128,997 - 81,129,196UniSTSRGSC3.4
Celera1177,750,663 - 77,750,862UniSTS
RH 3.4 Map11650.7UniSTS
Cytogenetic Map11q23UniSTS
RH141735  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21178,973,674 - 78,973,872 (+)MAPPER
Rnor_6.01182,620,388 - 82,620,585NCBIRnor6.0
Rnor_5.01185,711,051 - 85,711,248UniSTSRnor5.0
RGSC_v3.41181,215,453 - 81,215,650UniSTSRGSC3.4
Celera1177,836,145 - 77,836,342UniSTS
RH 3.4 Map11650.9UniSTS
Cytogenetic Map11q23UniSTS
BE117128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21178,886,281 - 78,886,444 (+)MAPPER
Rnor_6.01182,478,226 - 82,478,388NCBIRnor6.0
Rnor_5.01185,569,420 - 85,569,582UniSTSRnor5.0
RGSC_v3.41181,127,269 - 81,127,431UniSTSRGSC3.4
Celera1177,748,954 - 77,749,116UniSTS
RH 3.4 Map11650.7UniSTS
Cytogenetic Map11q23UniSTS
BF408297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21178,928,429 - 78,928,524 (+)MAPPER
Rnor_6.01182,575,535 - 82,575,629NCBIRnor6.0
Rnor_6.01182,520,255 - 82,520,349NCBIRnor6.0
Rnor_5.01185,666,198 - 85,666,292UniSTSRnor5.0
Rnor_5.01185,610,918 - 85,611,012UniSTSRnor5.0
RGSC_v3.41181,169,814 - 81,169,908UniSTSRGSC3.4
Celera1177,791,173 - 77,791,267UniSTS
RH 3.4 Map11651.8UniSTS
Cytogenetic Map11q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116934231986312439Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117272002986994795Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)118035840887200449Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:330
Count of miRNA genes:181
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000036958
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 24 22 20 20 45 22 28 4
Low 1 19 24 10 16 10 6 8 23 13 5 7 6
Below cutoff 11 11 3 11 2 3 6 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036958   ⟹   ENSRNOP00000037578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1182,466,071 - 82,621,079 (+)Ensembl
RefSeq Acc Id: NM_001270598   ⟹   NP_001257527
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21178,874,402 - 78,974,392 (+)NCBI
Rnor_6.01182,466,071 - 82,621,105 (+)NCBI
Rnor_5.01185,557,265 - 85,711,768 (+)NCBI
Celera1177,737,081 - 77,836,862 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270599   ⟹   NP_001257528
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21178,874,402 - 78,974,392 (+)NCBI
Rnor_6.01182,466,071 - 82,621,105 (+)NCBI
Rnor_5.01185,557,265 - 85,711,768 (+)NCBI
Celera1177,737,081 - 77,836,862 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257527 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257528 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78047 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001257527   ⟸   NM_001270598
- Peptide Label: isoform 1
- UniProtKB: D3ZWZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257528   ⟸   NM_001270599
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: ENSRNOP00000037578   ⟸   ENSRNOT00000036958
Protein Domains
RRM

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698258
Promoter ID:EPDNEW_R8783
Type:initiation region
Name:Igf2bp2_1
Description:insulin-like growth factor 2 mRNA binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01182,466,079 - 82,466,139EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 82616415 82616416 T A snv F344/NRrrc (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305614 AgrOrtholog
Ensembl Genes ENSRNOG00000025946 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000037578 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036958 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.10 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro IGF2BP2 UniProtKB/TrEMBL
  IGF2BP2_RRM1 UniProtKB/TrEMBL
  IPR004087 UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/TrEMBL
  KH_type_1 UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
KEGG Report rno:303824 UniProtKB/TrEMBL
NCBI Gene 303824 ENTREZGENE
PANTHER PTHR10288:SF93 UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
PhenoGen Igf2bp2 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
  SM00322 UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt D3ZWZ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Igf2bp2  insulin-like growth factor 2 mRNA binding protein 2  RGD1305614_predicted  similar to IGF-II mRNA-binding protein 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305614_predicted  similar to IGF-II mRNA-binding protein 2 (predicted)  LOC303824_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303824_predicted  similar to IGF-II mRNA-binding protein 2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL