Ets2 (ETS proto-oncogene 2, transcription factor)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| FTP Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Ets2 (ETS proto-oncogene 2, transcription factor) Rattus norvegicus

Analyze

Symbol:

Ets2

Name:

ETS proto-oncogene 2, transcription factor

RGD ID:

1584977

Description:

Exhibits DNA binding activity and glucocorticoid receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to cytosol; nucleoplasm; and plasma membrane. Orthologous to human ETS2 (ETS proto-oncogene 2, transcription factor); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Avian erythroblastosis virus E26 (v-ets) oncogene homolog 2; E26 avian leukemia oncogene 2, 3' domain; Ets2_mapped; protein C-ets-2; v-ets avian erythroblastosis virus E26 oncogene homolog 2; v-ets erythroblastosis virus E26 oncogene homolog 2; v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)

Orthologs:

Homo sapiens (human) : ETS2 (ETS proto-oncogene 2, transcription factor) HGNC Alliance
Mus musculus (house mouse) : Ets2 (E26 avian leukemia oncogene 2, 3' domain) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ets2 (ETS proto-oncogene 2, transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : ETS2 (ETS proto-oncogene 2, transcription factor)
Canis lupus familiaris (dog) : ETS2 (ETS proto-oncogene 2, transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ets2 (ETS proto-oncogene 2, transcription factor)
Sus scrofa (pig) : ETS2 (ETS proto-oncogene 2, transcription factor)
Chlorocebus sabaeus (African green monkey) : ETS2 (ETS proto-oncogene 2, transcription factor)
Heterocephalus glaber (naked mole-rat) : Ets2 (ETS proto-oncogene 2, transcription factor)

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	11	36,075,709 - 36,092,495 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	36,075,709 - 36,092,495 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	39,606,999 - 39,623,785 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	36,014,047 - 36,030,833 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	11	33,421,839 - 33,438,625 (-)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

Breast Neoplasms (ISO)

Craniofacial Abnormalities (ISO)

Nerve Degeneration (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

ciprofibrate (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (EXP)

curcumin (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dibutyl phthalate (ISO)

dicrotophos (ISO)

diuron (EXP)

doxorubicin (ISO)

ethanol (ISO)

fenhexamid (ISO)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

geraniol (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

irinotecan (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (EXP,ISO)

lipopolysaccharide (ISO)

menadione (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methapyrilene (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

phenobarbital (ISO)

phenol (ISO)

pirinixic acid (ISO)

propanal (ISO)

quercetin (ISO)

reactive oxygen species (ISO)

retinyl acetate (ISO)

rotenone (ISO)

sarin (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

Tanshinone I (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

topotecan (EXP)

trovafloxacin (ISO)

tungsten (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vancomycin (ISO)

vitamin E (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA)

ectodermal cell fate commitment (ISO)

mesoderm development (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of transcription by RNA polymerase II (IMP)

positive regulation of transcription, DNA-templated (ISO)

primitive streak formation (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA)

plasma membrane (IEA,ISO)

Molecular Function

DNA binding (IDA)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

glucocorticoid receptor binding (IDA)

protein binding (ISO)

protein domain specific binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Mullick J, etal., J Biol Chem 2001 May 25;276(21):18007-17. Epub 2001 Feb 21.
3.	RGD automated data pipeline
4.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1300077	PMID:1409581	PMID:11583620	PMID:11909962	PMID:12637547	PMID:16780588	PMID:16799155	PMID:19182667	PMID:20176728	PMID:22247964	PMID:23552073	PMID:25446535

Genomics

Candidate Gene Status

Ets2 is a candidate Gene for QTL Edcs1

Comparative Map Data

Ets2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	11	36,075,709 - 36,092,495 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	36,075,709 - 36,092,495 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	39,606,999 - 39,623,785 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	36,014,047 - 36,030,833 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	11	33,421,839 - 33,438,625 (-)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

ETS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	21	38,805,183 - 38,824,955 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	21	38,805,183 - 38,824,955 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	21	40,177,231 - 40,196,879 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	39,099,719 - 39,118,749 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	21	39,099,718 - 39,118,749	NCBI
Celera	21	25,375,600 - 25,394,615 (+)	NCBI
Cytogenetic Map	21	q22.2	ENTREZGENE
HuRef	21	25,647,131 - 25,666,960 (+)	NCBI		HuRef
CHM1_1	21	39,737,886 - 39,757,463 (+)	NCBI		CHM1_1

Ets2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	95,503,274 - 95,522,093 (+)	NCBI
GRCm38	16	95,702,407 - 95,721,049 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	95,702,075 - 95,721,051 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	95,924,014 - 95,942,656 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	16	95,811,284 - 95,829,847 (+)	NCBI			mm8
Celera	16	96,781,092 - 96,799,213 (+)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	56.64	NCBI

Ets2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	37,747,000 - 37,765,237 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	37,747,152 - 37,764,170 (+)	NCBI	ChiLan1.0	ChiLan1.0

ETS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	21	38,505,685 - 38,527,651 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	38,512,835 - 38,527,651 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	21	25,158,457 - 25,178,035 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

ETS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	31	33,839,010 - 33,860,330 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	31	33,846,821 - 33,861,394 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Ets2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936500	4,244,706 - 4,257,223 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ETS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	202,468,721 - 202,484,610 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	202,464,341 - 202,483,534 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ETS2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	2	82,757,930 - 82,770,165 (+)	Ensembl
ChlSab1.1	2	82,751,196 - 82,770,051 (+)	NCBI

Ets2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624745	25,096,587 - 25,113,953 (-)	NCBI

Position Markers

D11Mit1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	35,900,634 - 35,900,756	NCBI	Rnor6.0
Rnor_6.0	11	35,972,253 - 35,972,375	NCBI	Rnor6.0
Rnor_5.0	11	39,486,246 - 39,486,368	UniSTS	Rnor5.0
RGSC_v3.4	11	35,910,590 - 35,910,713	RGD	RGSC3.4
RGSC_v3.4	11	35,910,591 - 35,910,713	UniSTS	RGSC3.4
RGSC_v3.1	11	35,966,825 - 35,967,133	RGD
Celera	11	33,540,645 - 33,540,767	UniSTS
Cytogenetic Map	11	q11	UniSTS
SHRSP x BN Map	11	11.5599	UniSTS
SHRSP x BN Map	11	11.5599	RGD
FHH x ACI Map	11	13.32	RGD

RH143332

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	36,082,142 - 36,082,398	NCBI	Rnor6.0
Rnor_5.0	11	39,613,432 - 39,613,688	UniSTS	Rnor5.0
RGSC_v3.4	11	36,020,480 - 36,020,736	UniSTS	RGSC3.4
Celera	11	33,431,936 - 33,432,192	UniSTS
Cytogenetic Map	11	q11	UniSTS
RH 3.4 Map	11	263.4	UniSTS

RH140303

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	36,066,098 - 36,066,302	NCBI	Rnor6.0
Rnor_5.0	11	39,597,388 - 39,597,592	UniSTS	Rnor5.0
RGSC_v3.4	11	36,004,436 - 36,004,640	UniSTS	RGSC3.4
Celera	11	33,448,031 - 33,448,235	UniSTS
Cytogenetic Map	11	q11	UniSTS
RH 3.4 Map	11	259.61	UniSTS

AU022856

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	36,092,233 - 36,092,481	NCBI	Rnor6.0
Rnor_6.0	2	211,055,234 - 211,055,482	NCBI	Rnor6.0
Rnor_5.0	11	39,623,523 - 39,623,771	UniSTS	Rnor5.0
Rnor_5.0	2	230,524,571 - 230,524,819	UniSTS	Rnor5.0
RGSC_v3.4	11	36,030,571 - 36,030,819	UniSTS	RGSC3.4
RGSC_v3.4	2	203,829,909 - 203,830,157	UniSTS	RGSC3.4
Celera	11	33,421,853 - 33,422,101	UniSTS
Celera	2	188,546,126 - 188,546,374	UniSTS
Cytogenetic Map	11	q11	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH139731

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	36,091,919 - 36,092,098	NCBI	Rnor6.0
Rnor_5.0	11	39,623,209 - 39,623,388	UniSTS	Rnor5.0
RGSC_v3.4	11	36,030,257 - 36,030,436	UniSTS	RGSC3.4
Celera	11	33,422,236 - 33,422,415	UniSTS
Cytogenetic Map	11	q11	UniSTS
RH 3.4 Map	11	262.7	UniSTS

ETV2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	36,089,281 - 36,090,365	NCBI	Rnor6.0
Rnor_5.0	11	39,620,571 - 39,621,655	UniSTS	Rnor5.0
RGSC_v3.4	11	36,027,619 - 36,028,703	UniSTS	RGSC3.4
Celera	11	33,423,969 - 33,425,053	UniSTS
Cytogenetic Map	11	q11	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	72720192	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	325031	69342559	Rat
1641927	Alcrsp10	Alcohol response QTL 10			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	11	9351274	54351274	Rat
2290451	Scl58	Serum cholesterol level QTL 58	3.48		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	11	11367306	44444347	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	16321973	46583360	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	19016272	90463843	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	19475179	79734728	Rat
1598811	Bp291	Blood pressure QTL 291	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	21944229	66944229	Rat
1598841	Memor7	Memory QTL 7			exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	11	21944229	66944229	Rat
634341	Bw121	Body weight QTL 121	3.56		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	11	22043149	44444112	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	25401129	70401129	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	25720038	70720038	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	25720038	70720038	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	25720038	70720038	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	25720038	70720038	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	28314665	86994795	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	30435339	63186373	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	30435339	86714631	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	32155520	82443118	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	35900634	80900634	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	836
Count of miRNA genes:	323
Interacting mature miRNAs:	446
Transcripts:	ENSRNOT00000002247
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	38	55	39	19	39	8	11	74	35	37	11	8
Low		5	2	2		2					4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHX01068400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC097832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000002247 ⟹ ENSRNOP00000002247

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	11	36,075,709 - 36,092,495 (+)	Ensembl

RefSeq Acc Id:

NM_001107107 ⟹ NP_001100577

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	36,075,709 - 36,092,495 (+)	NCBI
Rnor_5.0	11	39,606,999 - 39,623,785 (+)	NCBI
RGSC_v3.4	11	36,014,047 - 36,030,833 (+)	RGD
Celera	11	33,421,839 - 33,438,625 (-)	RGD

Sequence:

show sequence

CAGCTCCAGAAGAGCGCGCGGCCAGGGGATCGGGCTGGTTACTTCCTCCACCGCGGTGCTGAGC
ACGGAGTGGACACCACTAAGGCCCGCCAGTCCCTGCCACCGTCTCCGACCCCGCGCGCCCGTAT
CGGCCCTACGCCTTCGTCTCGCTGGGCCTTGCCGGCCGGGACCGCCGCGATCTCCTCTCCCCGC
CGCCCTCCGGCTGGCCCTGCTTGCTGCGGCGCGATGAATGATTTTGGAATCAAGAACATGGACC
AAGTGGCTCCTGTTGCCAACAGTTTTCGAGGGACACTCAAGCGCCAGCCAGCCTTCGACACCTT
TGACGGCTCTCTGTTTGCTGTGCTTCCTTCTCTCAGTGAAGAGCAGACGCTCCAAGAAGTACCC
ACAGGCTTGGATTCTGTCTCCCATGACTCGGCCACCTGCGAGCTGCCTTTGCTCACTCCCTGTA
GCAAGGCGGTGATGAGCCAAGCCTTAAAAGCCACCTTCAGTGGCTTCCACAAGGAGCAGCGGCG
TCTTGGCATTCCCAAAAACCCCTGGCTGTGGAATGAGCAGCAGGTGTGCCAGTGGCTGCACTGG
GCCACCAACGAGTTCAGCCTGGTGAATGTGAACCTACAGCGATTTGGCATGAACGGCCAGATGC
TGTGTAACCTCGGCAAGGAGCGCTTTCTGGAGCTGGCGCCCGACTTTGTGGGTGACATCCTCTG
GGAACATCTGGAGCAGATGATCAAAGAGAACCAAGAAAAGACAGAAGACCAATATGAGGAAAAC
TCACACCTCAATGCAGTTCCTCACTGGATCAACAGCAATACATTAGGCTTTGGCGTGGAGCAGG
CTCCATATGGAATGCAGGCACCGAGCTACCTCAAAGACGGCCTCCTGGATGGCATGTGCCCGCC
GTCAGCCACGCCTGCGGCTCTCGGCTCTGAGCAGGAGCTCCAGATGTTGCCCAAGTCTCGGCTC
AACACCGTCAGTGTCAATTACTGTTCCATCAGCCAGGACTTCCCCGGTGGCAACTTGAATTTGC
TCAACAGCAGTTCTGGAAAACCCAAGGAGCACGACTCTCCCGAGAACGGTGGGGACAGCTTCGA
GAGCTCTGACTCGCTGCTGCGGTCCTGGAACAGCCAATCGTCCCTACTGGATGTGCAGCGGGTA
CCTTCCTTCGAGAGCTTCGAGGAGGACTGTAGCCAGTCTCTGTGCCTCAGTAAGCCGACCATGT
CCTTCAAGGACTACATCCAAGAGAGGAGTGACCCAGTTGAGCAAGGCAAACCAGTTATTCCTGC
GGCAGTACTGGCTGGCTTCACTGGAAGTGGACCAATCCAGCTGTGGCAGTTTCTTCTGGAGCTA
CTCTCTGACAAGTCCTGTCAGTCTTTCATCAGCTGGACGGGGGACGGATGGGAATTCAAGCTCG
CTGACCCCGATGAGGTGGCCCGCCGGTGGGGAAAGAGGAAAAACAAACCAAAGATGAACTACGA
GAAGCTGAGCCGGGGCTTACGCTACTACTATGACAAAAACATCATTCACAAGACATCGGGCAAG
CGCTACGTGTACCGTTTCGTGTGCGACCTGCAGAACTTGCTAGGCTTCACTCCGGAGGAACTGC
ATGCCATCCTGGGCGTCCAGCCTGATACGGAAGACTGAAGTCCTCAGGACCACCCTGAGGCAGC
CCCGGGCCCCAGGGACTGAGTGGGAAGCCCGTCCTGACCCACTTGCTCCAAAGACCCATGGGAG
GGCAGGATGAAACCCCTCTGGGGAGAGCCACCAAGCAGCAGTGGCCTTTCATCTCACGCCTCTC
CCACAAGCCAACTCTCCATGGTGGAAACTGACAGGGCCTCTCTGTCCTGTATGAGACTCTGAAG
GGAAGAGTCTCCAGGAAGCCACCGTGGCACCGAGCAGGCCGTGTGCAGATCACAATCGTTGTGG
CTATTTGAGATGCTCCAGGGAGCCAGCATGTGGTGGATACACAAACACTGAAAAACATTGTTTG
GCCACCGGGAGTATCCAGCGCAAACGCCACCTCCGCTTGAGAGGGCTGGGCAGATGGATGGTGT
GATTGCTCCATTTCAGAAGTCAGTTTGTCTGTATATATTATTGTATCTTATAATTGTCCGAATC
CTGCGACAGTTCTATTTAACAGAAGTTGTATATTGTATTTAAAGTAATTATAACTTGTTTGAAT
CAAGAATGCAGATACCTGGTAGGTTATCTTTTTTTTTTTTTTTTTCACTAGCACATAGGAACGC
TATTTTTCACAGATTTGATCTCTTAGGGGCCAACTGAGAGAAATCATAATATTCTGTTTTTGTT
TTATTTGCCAGCAGGAATGGGGTCTGAAGGATGACCCTGGTTTTTACTTTTGTTTTGTTCTGTT
GTTGTTGTTGTTGTTGTTTTTGTTCTGACTGGTTCATTCTCCAGTCAGGACTTTGTATATATAT
TTTTTTATAAGAAACATAATGTTATTATTCGAGGGTCCATGTGGCCTCTCCGCTCTTTCCTGGA
CTGTAAAGCCGTAGAGCAGTATTTTTCTTGACCAATGGCACGTGTTTTCCACTTCCCTGCATGC
CTTAAGCCAGTTTATACACAAATGTATTTTATTTTTTGGCGTAACTGTGTTTTCCAGGCAACGC
CCCTCCCCCACCCCACAGCCAGTCATTCCCTTCCTTCACCCCAAGGTATTCTGTGTGACTACAA
TAAGAAGACTATTTTTGGAAATTTATGACTCCTTTTCAGATATCAGAAGGGATTTATGTAGCAG
CTATTTTTACTGCAAAAGTAACTCACTGGAAAAAAAAATGCAATTTGTACGAAAGCTTTATTTT
TATCTCTGTCGTGTGAAGGGAGGTGTGTCGGGCGGGCAGGGGTGAGGGCAATCAGGAAAGATCT
TCTATCAGCTTTGACCTTAAATGAAGCGTGGTGCTTCCTGTCTCGCTGACCTGCTACGTCTCTT
ACCATCTGGGCTGCATGCTCCTCTTTCTGCTCCGTGTGCTCAGAGAGTTTGCGCCTCTTTTTTG
GGGGGTGGGGTGGGGGTGGGGTGGATACCTAGAAGCACAGACAAGGCAAGCACGCTGGGAAATG
GTGTATTGGAGCAGTCTGTATGAGGTTCTTATGTGGTGAAGGGCTAACTCCCCCATGAGACCCC
CATGCTTTCATCCAGTCATATGGTTTCTAAAGTGAATGGGCTTCTCCATTTACCAGCATGGTGG
CCTCAGACCAGATATTCATAAAGAGCCTTTGAGACCACACAGGGGATGCAGGACCAGCTGGGAC
CTGCTGTGCCAGCCCTGGGTTGCCTTGGCCTGCATGCCCAGAGAGAAATGCTTTGCGGTTTAGC
ACAGGGACCTGTTTGTCGCCGGGACATCTGTGTGTAATATAAACAGACATGGGACTAGGAACAT
ACTCGAGTCAAAAGCTTAATCCACAGTCAATTTATACGCAGTCGAGCCACATGAAATTGCCAAG
TTTAGCCCGAGTTTTGTCAGCTAAGATGACGGTTTTACATGGTTGAATCTAACAGTCATGGAAG
TCCTCAGAAGTCTTAGGCGTGGTCTTAAGTATGAAGGTTTTGTAATTTGGCCTCCTCTTTCTCA
AATAATAAAGTATTTGGTTTATGACAATGC

hide sequence

RefSeq Acc Id:

XM_006248177 ⟹ XP_006248239

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	36,075,950 - 36,092,494 (+)	NCBI
Rnor_5.0	11	39,606,999 - 39,623,785 (+)	NCBI

Sequence:

show sequence

TGCGCGACGTTCCTCGGGAGGGACTCCGCCCGGGGTGGGGTGCAGTGCGGGCGGCCCCTGCTCC
CGCCGGTTGATCGCGCGCCCCGGAGCCTCTCCAGCTGGTTCCTAGGCACCCAGTGGCCTCAGCC
GGGGATCCGGGAACCGGGCCGGGAGCGGGCAGCCCGCTTTTGTTTTAGGGAAGCCAGTGGTCGC
TCTGTGCGGTTCCTGCCTGGGGCGCGGGTCTGTGTTTCTCCAGGGGGCTTGAGACACCTGGAGA
GATGGCCGAAGTAGCCCCAGGTTTGGGGTGACTTGAGTGGGAGAGGAGCTAGGCCTGGGAGGAT
GTGGGGGTGTCCGACGCCTGAAACACCTGGGAAGTTGCGGCTCCCGGGAACATGTCACCTGCTC
GGCCAGCTCTCGGTTCCCCTGGACCCTGGGAAGCCAGTACGGGACACGTCCAAGTAGGGATGAA
TGATTTTGGAATCAAGAACATGGACCAAGTGGCTCCTGTTGCCAACAGTTTTCGAGGGACACTC
AAGCGCCAGCCAGCCTTCGACACCTTTGACGGCTCTCTGTTTGCTGTGCTTCCTTCTCTCAGTG
AAGAGCAGACGCTCCAAGAAGTACCCACAGGCTTGGATTCTGTCTCCCATGACTCGGCCACCTG
CGAGCTGCCTTTGCTCACTCCCTGTAGCAAGGCGGTGATGAGCCAAGCCTTAAAAGCCACCTTC
AGTGGCTTCCACAAGGAGCAGCGGCGTCTTGGCATTCCCAAAAACCCCTGGCTGTGGAATGAGC
AGCAGGTGTGCCAGTGGCTGCACTGGGCCACCAACGAGTTCAGCCTGGTGAATGTGAACCTACA
GCGATTTGGCATGAACGGCCAGATGCTGTGTAACCTCGGCAAGGAGCGCTTTCTGGAGCTGGCG
CCCGACTTTGTGGGTGACATCCTCTGGGAACATCTGGAGCAGATGATCAAAGAGAACCAAGAAA
AGACAGAAGACCAATATGAGGAAAACTCACACCTCAATGCAGTTCCTCACTGGATCAACAGCAA
TACATTAGGCTTTGGCGTGGAGCAGGCTCCATATGGAATGCAGGCACCGAGCTACCTCAAAGAC
GGCCTCCTGGATGGCATGTGCCCGCCGTCAGCCACGCCTGCGGCTCTCGGCTCTGAGCAGGAGC
TCCAGATGTTGCCCAAGTCTCGGCTCAACACCGTCAGTGTCAATTACTGTTCCATCAGCCAGGA
CTTCCCCGGTGGCAACTTGAATTTGCTCAACAGCAGTTCTGGAAAACCCAAGGAGCACGACTCT
CCCGAGAACGGTGGGGACAGCTTCGAGAGCTCTGACTCGCTGCTGCGGTCCTGGAACAGCCAAT
CGTCCCTACTGGATGTGCAGCGGGTACCTTCCTTCGAGAGCTTCGAGGAGGACTGTAGCCAGTC
TCTGTGCCTCAGTAAGCCGACCATGTCCTTCAAGGACTACATCCAAGAGAGGAGTGACCCAGTT
GAGCAAGGCAAACCAGTTATTCCTGCGGCAGTACTGGCTGGCTTCACTGGAAGTGGACCAATCC
AGCTGTGGCAGTTTCTTCTGGAGCTACTCTCTGACAAGTCCTGTCAGTCTTTCATCAGCTGGAC
GGGGGACGGATGGGAATTCAAGCTCGCTGACCCCGATGAGGTGGCCCGCCGGTGGGGAAAGAGG
AAAAACAAACCAAAGATGAACTACGAGAAGCTGAGCCGGGGCTTACGCTACTACTATGACAAAA
ACATCATTCACAAGACATCGGGCAAGCGCTACGTGTACCGTTTCGTGTGCGACCTGCAGAACTT
GCTAGGCTTCACTCCGGAGGAACTGCATGCCATCCTGGGCGTCCAGCCTGATACGGAAGACTGA
AGTCCTCAGGACCACCCTGAGGCAGCCCCGGGCCCCAGGGACTGAGTGGGAAGCCCGTCCTGAC
CCACTTGCTCCAAAGACCCATGGGAGGGCAGGATGAAACCCCTCTGGGGAGAGCCACCAAGCAG
CAGTGGCCTTTCATCTCACGCCTCTCCCACAAGCCAACTCTCCATGGTGGAAACTGACAGGGCC
TCTCTGTCCTGTATGAGACTCTGAAGGGAAGAGTCTCCAGGAAGCCACCGTGGCACCGAGCAGG
CCGTGTGCAGATCACAATCGTTGTGGCTATTTGAGATGCTCCAGGGAGCCAGCATGTGGTGGAT
ACACAAACACTGAAAAACATTGTTTGGCCACCGGGAGTATCCAGCGCAAACGCCACCTCCGCTT
GAGAGGGCTGGGCAGATGGATGGTGTGATTGCTCCATTTCAGAAGTCAGTTTGTCTGTATATAT
TATTGTATCTTATAATTGTCCGAATCCTGCGACAGTTCTATTTAACAGAAGTTGTATATTGTAT
TTAAAGTAATTATAACTTGTTTGAATCAAGAATGCAGATACCTGGTAGGTTATCTTTTTTTTTT
TTTTTTTCACTAGCACATAGGAACGCTATTTTTCACAGATTTGATCTCTTAGGGGCCAACTGAG
AGAAATCATAATATTCTGTTTTTGTTTTATTTGCCAGCAGGAATGGGGTCTGAAGGATGACCCT
GGTTTTTACTTTTGTTTTGTTCTGTTGTTGTTGTTGTTGTTGTTTTTGTTCTGACTGGTTCATT
CTCCAGTCAGGACTTTGTATATATATTTTTTTATAAGAAACATAATGTTATTATTCGAGGGTCC
ATGTGGCCTCTCCGCTCTTTCCTGGACTGTAAAGCCGTAGAGCAGTATTTTTCTTGACCAATGG
CACGTGTTTTCCACTTCCCTGCATGCCTTAAGCCAGTTTATACACAAATGTATTTTATTTTTTG
GCGTAACTGTGTTTTCCAGGCAACGCCCCTCCCCCACCCCACAGCCAGTCATTCCCTTCCTTCA
CCCCAAGGTATTCTGTGTGACTACAATAAGAAGACTATTTTTGGAAATTTATGACTCCTTTTCA
GATATCAGAAGGGATTTATGTAGCAGCTATTTTTACTGCAAAAGTAACTCACTGGAAAAAAAAA
TGCAATTTGTACGAAAGCTTTATTTTTATCTCTGTCGTGTGAAGGGAGGTGTGTCGGGCGGGCA
GGGGTGAGGGCAATCAGGAAAGATCTTCTATCAGCTTTGACCTTAAATGAAGCGTGGTGCTTCC
TGTCTCGCTGACCTGCTACGTCTCTTACCATCTGGGCTGCATGCTCCTCTTTCTGCTCCGTGTG
CTCAGAGAGTTTGCGCCTCTTTTTTGGGGGGTGGGGTGGGGGTGGGGTGGATACCTAGAAGCAC
AGACAAGGCAAGCACGCTGGGAAATGGTGTATTGGAGCAGTCTGTATGAGGTTCTTATGTGGTG
AAGGGCTAACTCCCCCATGAGACCCCCATGCTTTCATCCAGTCATATGGTTTCTAAAGTGAATG
GGCTTCTCCATTTACCAGCATGGTGGCCTCAGACCAGATATTCATAAAGAGCCTTTGAGACCAC
ACAGGGGATGCAGGACCAGCTGGGACCTGCTGTGCCAGCCCTGGGTTGCCTTGGCCTGCATGCC
CAGAGAGAAATGCTTTGCGGTTTAGCACAGGGACCTGTTTGTCGCCGGGACATCTGTGTGTAAT
ATAAACAGACATGGGACTAGGAACATACTCGAGTCAAAAGCTTAATCCACAGTCAATTTATACG
CAGTCGAGCCACATGAAATTGCCAAGTTTAGCCCGAGTTTTGTCAGCTAAGATGACGGTTTTAC
ATGGTTGAATCTAACAGTCATGGAAGTCCTCAGAAGTCTTAGGCGTGGTCTTAAGTATGAAGGT
TTTGTAATTTGGCCTCCTCTTTCTCAAATAATAAAGTATTTGGTTTATGACAATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100577	(Get FASTA)	NCBI Sequence Viewer
	XP_006248239	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76680	(Get FASTA)	NCBI Sequence Viewer
	EDL76681	(Get FASTA)	NCBI Sequence Viewer
	EDL76682	(Get FASTA)	NCBI Sequence Viewer
	EDL76683	(Get FASTA)	NCBI Sequence Viewer
	EDL76684	(Get FASTA)	NCBI Sequence Viewer
	EDL76685	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001100577 ⟸ NM_001107107

- UniProtKB:

D4AAH4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLSEEQTLQEVPTGLDSVSHDSA
TCELPLLTPCSKAVMSQALKATFSGFHKEQRRLGIPKNPWLWNEQQVCQWLHWATNEFSLVNVN
LQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLNAVPHWIN
SNTLGFGVEQAPYGMQAPSYLKDGLLDGMCPPSATPAALGSEQELQMLPKSRLNTVSVNYCSIS
QDFPGGNLNLLNSSSGKPKEHDSPENGGDSFESSDSLLRSWNSQSSLLDVQRVPSFESFEEDCS
QSLCLSKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFIS
WTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQ
NLLGFTPEELHAILGVQPDTED

hide sequence

RefSeq Acc Id:

XP_006248239 ⟸ XM_006248177

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSPARPALGSPGPWEASTGHVQVGMNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVL
PSLSEEQTLQEVPTGLDSVSHDSATCELPLLTPCSKAVMSQALKATFSGFHKEQRRLGIPKNPW
LWNEQQVCQWLHWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIK
ENQEKTEDQYEENSHLNAVPHWINSNTLGFGVEQAPYGMQAPSYLKDGLLDGMCPPSATPAALG
SEQELQMLPKSRLNTVSVNYCSISQDFPGGNLNLLNSSSGKPKEHDSPENGGDSFESSDSLLRS
WNSQSSLLDVQRVPSFESFEEDCSQSLCLSKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTG
SGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRY
YYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED

hide sequence

RefSeq Acc Id:

ENSRNOP00000002247 ⟸ ENSRNOT00000002247

Protein Domains

ETS PNT

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698083

Promoter ID:

EPDNEW_R8608

Type:

initiation region

Name:

Ets2_1

Description:

ETS proto-oncogene 2, transcription factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	36,075,745 - 36,075,805	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1584977	AgrOrtholog
Ensembl Genes	ENSRNOG00000001647	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000002247	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002247	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	1.10.150.50	UniProtKB/TrEMBL
InterPro	Ets	UniProtKB/TrEMBL
	SAM_PNT	UniProtKB/TrEMBL
	SAM_type	UniProtKB/TrEMBL
	Transform_prot_C-ets-2	UniProtKB/TrEMBL
	Transforming_factor_C-ets	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:304063	UniProtKB/TrEMBL
NCBI Gene	304063	ENTREZGENE
Pfam	Ets	UniProtKB/TrEMBL
	SAM_PNT	UniProtKB/TrEMBL
PhenoGen	Ets2	PhenoGen
PIRSF	C-ets-2	UniProtKB/TrEMBL
	Transforming_factor_C-ets	UniProtKB/TrEMBL
PRINTS	ETSDOMAIN	UniProtKB/TrEMBL
PROSITE	ETS_DOMAIN_1	UniProtKB/TrEMBL
	ETS_DOMAIN_2	UniProtKB/TrEMBL
	ETS_DOMAIN_3	UniProtKB/TrEMBL
	PNT	UniProtKB/TrEMBL
SMART	ETS	UniProtKB/TrEMBL
	SAM_PNT	UniProtKB/TrEMBL
Superfamily-SCOP	SAM_homology	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
UniGene	Rn.164554	ENTREZGENE
UniProt	D4AAH4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Ets2	ETS proto-oncogene 2, transcription factor	Ets2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-01	Ets2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	Ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-25	Ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	Ets2	E26 avian leukemia oncogene 2, 3' domain	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Ets2	E26 avian leukemia oncogene 2, 3' domain	Ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-04-13		v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	Ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)	Name updated	737654	APPROVED
2007-04-11	Ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)	Ets2_mapped	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)	Data Merged	737654	APPROVED
2006-11-19	Ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-11-17	Ets2_mapped	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)			Symbol and Name updated	1556543	APPROVED
2002-06-10	Ets2	Avian erythroblastosis virus E26 (v-ets) oncogene homolog 2			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD