Ets2 (ETS proto-oncogene 2, transcription factor) - Rat Genome Database
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Gene: Ets2 (ETS proto-oncogene 2, transcription factor) Rattus norvegicus
Analyze
Symbol: Ets2
Name: ETS proto-oncogene 2, transcription factor
RGD ID: 1584977
Description: Exhibits DNA binding activity and glucocorticoid receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to cytosol; nucleoplasm; and plasma membrane. Orthologous to human ETS2 (ETS proto-oncogene 2, transcription factor); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Avian erythroblastosis virus E26 (v-ets) oncogene homolog 2; E26 avian leukemia oncogene 2, 3' domain; Ets2_mapped; protein C-ets-2; v-ets avian erythroblastosis virus E26 oncogene homolog 2; v-ets erythroblastosis virus E26 oncogene homolog 2; v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)
Orthologs:
Homo sapiens (human) : ETS2 (ETS proto-oncogene 2, transcription factor)  HGNC  Alliance
Mus musculus (house mouse) : Ets2 (E26 avian leukemia oncogene 2, 3' domain)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ets2 (ETS proto-oncogene 2, transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : ETS2 (ETS proto-oncogene 2, transcription factor)
Canis lupus familiaris (dog) : ETS2 (ETS proto-oncogene 2, transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ets2 (ETS proto-oncogene 2, transcription factor)
Sus scrofa (pig) : ETS2 (ETS proto-oncogene 2, transcription factor)
Chlorocebus sabaeus (African green monkey) : ETS2 (ETS proto-oncogene 2, transcription factor)
Heterocephalus glaber (naked mole-rat) : Ets2 (ETS proto-oncogene 2, transcription factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01136,075,709 - 36,092,495 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1136,075,709 - 36,092,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01139,606,999 - 39,623,785 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,014,047 - 36,030,833 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1133,421,839 - 33,438,625 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
fenhexamid  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
sarin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

References

Additional References at PubMed
PMID:1300077   PMID:1409581   PMID:11583620   PMID:11909962   PMID:12637547   PMID:16780588   PMID:16799155   PMID:19182667   PMID:20176728   PMID:22247964   PMID:23552073   PMID:25446535  


Genomics

Candidate Gene Status
Ets2 is a candidate Gene for QTL Edcs1
Comparative Map Data
Ets2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01136,075,709 - 36,092,495 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1136,075,709 - 36,092,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01139,606,999 - 39,623,785 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,014,047 - 36,030,833 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1133,421,839 - 33,438,625 (-)NCBICelera
Cytogenetic Map11q11NCBI
ETS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2138,805,183 - 38,824,955 (+)EnsemblGRCh38hg38GRCh38
GRCh382138,805,183 - 38,824,955 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372140,177,231 - 40,196,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362139,099,719 - 39,118,749 (+)NCBINCBI36hg18NCBI36
Build 342139,099,718 - 39,118,749NCBI
Celera2125,375,600 - 25,394,615 (+)NCBI
Cytogenetic Map21q22.2ENTREZGENE
HuRef2125,647,131 - 25,666,960 (+)NCBIHuRef
CHM1_12139,737,886 - 39,757,463 (+)NCBICHM1_1
Ets2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391695,503,274 - 95,522,093 (+)NCBI
GRCm381695,702,407 - 95,721,049 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1695,702,075 - 95,721,051 (+)EnsemblGRCm38mm10GRCm38
MGSCv371695,924,014 - 95,942,656 (+)NCBIGRCm37mm9NCBIm37
MGSCv361695,811,284 - 95,829,847 (+)NCBImm8
Celera1696,781,092 - 96,799,213 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1656.64NCBI
Ets2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540737,747,000 - 37,765,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540737,747,152 - 37,764,170 (+)NCBIChiLan1.0ChiLan1.0
ETS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12138,505,685 - 38,527,651 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2138,512,835 - 38,527,651 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02125,158,457 - 25,178,035 (+)NCBIMhudiblu_PPA_v0panPan3
ETS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3133,839,010 - 33,860,330 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13133,846,821 - 33,861,394 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ets2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365004,244,706 - 4,257,223 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ETS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13202,468,721 - 202,484,610 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113202,464,341 - 202,483,534 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ETS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl282,757,930 - 82,770,165 (+)Ensembl
ChlSab1.1282,751,196 - 82,770,051 (+)NCBI
Ets2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474525,096,587 - 25,113,953 (-)NCBI

Position Markers
D11Mit1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01135,900,634 - 35,900,756NCBIRnor6.0
Rnor_6.01135,972,253 - 35,972,375NCBIRnor6.0
Rnor_5.01139,486,246 - 39,486,368UniSTSRnor5.0
RGSC_v3.41135,910,590 - 35,910,713RGDRGSC3.4
RGSC_v3.41135,910,591 - 35,910,713UniSTSRGSC3.4
RGSC_v3.11135,966,825 - 35,967,133RGD
Celera1133,540,645 - 33,540,767UniSTS
Cytogenetic Map11q11UniSTS
SHRSP x BN Map1111.5599UniSTS
SHRSP x BN Map1111.5599RGD
FHH x ACI Map1113.32RGD
RH143332  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01136,082,142 - 36,082,398NCBIRnor6.0
Rnor_5.01139,613,432 - 39,613,688UniSTSRnor5.0
RGSC_v3.41136,020,480 - 36,020,736UniSTSRGSC3.4
Celera1133,431,936 - 33,432,192UniSTS
Cytogenetic Map11q11UniSTS
RH 3.4 Map11263.4UniSTS
RH140303  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01136,066,098 - 36,066,302NCBIRnor6.0
Rnor_5.01139,597,388 - 39,597,592UniSTSRnor5.0
RGSC_v3.41136,004,436 - 36,004,640UniSTSRGSC3.4
Celera1133,448,031 - 33,448,235UniSTS
Cytogenetic Map11q11UniSTS
RH 3.4 Map11259.61UniSTS
AU022856  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01136,092,233 - 36,092,481NCBIRnor6.0
Rnor_6.02211,055,234 - 211,055,482NCBIRnor6.0
Rnor_5.01139,623,523 - 39,623,771UniSTSRnor5.0
Rnor_5.02230,524,571 - 230,524,819UniSTSRnor5.0
RGSC_v3.41136,030,571 - 36,030,819UniSTSRGSC3.4
RGSC_v3.42203,829,909 - 203,830,157UniSTSRGSC3.4
Celera1133,421,853 - 33,422,101UniSTS
Celera2188,546,126 - 188,546,374UniSTS
Cytogenetic Map11q11UniSTS
Cytogenetic Map2q34UniSTS
RH139731  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01136,091,919 - 36,092,098NCBIRnor6.0
Rnor_5.01139,623,209 - 39,623,388UniSTSRnor5.0
RGSC_v3.41136,030,257 - 36,030,436UniSTSRGSC3.4
Celera1133,422,236 - 33,422,415UniSTS
Cytogenetic Map11q11UniSTS
RH 3.4 Map11262.7UniSTS
ETV2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01136,089,281 - 36,090,365NCBIRnor6.0
Rnor_5.01139,620,571 - 39,621,655UniSTSRnor5.0
RGSC_v3.41136,027,619 - 36,028,703UniSTSRGSC3.4
Celera1133,423,969 - 33,425,053UniSTS
Cytogenetic Map11q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)1132503169342559Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11935127454351274Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111136730644444347Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111632197346583360Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)112194422966944229Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)112194422966944229Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)112204314944444112Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112540112970401129Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112572003870720038Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112572003870720038Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113043533963186373Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113215552082443118Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113590063480900634Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:836
Count of miRNA genes:323
Interacting mature miRNAs:446
Transcripts:ENSRNOT00000002247
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 55 39 19 39 8 11 74 35 37 11 8
Low 5 2 2 2 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002247   ⟹   ENSRNOP00000002247
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1136,075,709 - 36,092,495 (+)Ensembl
RefSeq Acc Id: NM_001107107   ⟹   NP_001100577
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01136,075,709 - 36,092,495 (+)NCBI
Rnor_5.01139,606,999 - 39,623,785 (+)NCBI
RGSC_v3.41136,014,047 - 36,030,833 (+)RGD
Celera1133,421,839 - 33,438,625 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248177   ⟹   XP_006248239
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01136,075,950 - 36,092,494 (+)NCBI
Rnor_5.01139,606,999 - 39,623,785 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001100577   ⟸   NM_001107107
- UniProtKB: D4AAH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248239   ⟸   XM_006248177
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000002247   ⟸   ENSRNOT00000002247
Protein Domains
ETS   PNT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698083
Promoter ID:EPDNEW_R8608
Type:initiation region
Name:Ets2_1
Description:ETS proto-oncogene 2, transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01136,075,745 - 36,075,805EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584977 AgrOrtholog
Ensembl Genes ENSRNOG00000001647 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002247 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002247 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.150.50 UniProtKB/TrEMBL
InterPro Ets UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
  Transform_prot_C-ets-2 UniProtKB/TrEMBL
  Transforming_factor_C-ets UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:304063 UniProtKB/TrEMBL
NCBI Gene 304063 ENTREZGENE
Pfam Ets UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
PhenoGen Ets2 PhenoGen
PIRSF C-ets-2 UniProtKB/TrEMBL
  Transforming_factor_C-ets UniProtKB/TrEMBL
PRINTS ETSDOMAIN UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_1 UniProtKB/TrEMBL
  ETS_DOMAIN_2 UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/TrEMBL
  PNT UniProtKB/TrEMBL
SMART ETS UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
Superfamily-SCOP SAM_homology UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniGene Rn.164554 ENTREZGENE
UniProt D4AAH4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Ets2  ETS proto-oncogene 2, transcription factor  Ets2  v-ets avian erythroblastosis virus E26 oncogene homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Ets2  v-ets avian erythroblastosis virus E26 oncogene homolog 2  Ets2  v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-25 Ets2  v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)  Ets2  E26 avian leukemia oncogene 2, 3' domain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ets2  E26 avian leukemia oncogene 2, 3' domain  Ets2  v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)  Ets2  v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)  Name updated 737654 APPROVED
2007-04-11 Ets2  v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)  Ets2_mapped  v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)  Data Merged 737654 APPROVED
2006-11-19 Ets2  v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ets2_mapped  v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Ets2  Avian erythroblastosis virus E26 (v-ets) oncogene homolog 2      Symbol and Name status set to approved 70586 APPROVED