Kng2 (kininogen 2) - Rat Genome Database

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Gene: Kng2 (kininogen 2) Rattus norvegicus
Analyze
Symbol: Kng2 (Ensembl: Kng2l1)
Name: kininogen 2
RGD ID: 2980
Description: Enables cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including negative regulation of T cell proliferation; positive regulation of cell population proliferation; and regulation of protein metabolic process. Located in extracellular space; intracellular membrane-bounded organelle; and perikaryon. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1); PARTICIPATES IN kallikrein-kinin cascade pathway; kinin signaling pathway; syndecan signaling pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 1-octadec-9-enoylglycero-3-phosphate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-1-MAP; K-kininogen; K-kininogen, differential splicing leads to HMW Kngk; kininogen 1; kininogen 1, variant 1; kininogen II; KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1; Kng_v1; Kngk; Kngt; Kngt1; LMW T-kininogen I; Map1; T-kininogen; T-kininogen 1; T-kininogen I; thiostatin; Tkg; TKG6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kng1_v1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21177,913,876 - 77,936,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,909,612 - 78,002,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,664,319 - 86,686,690 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01179,302,200 - 79,324,460 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01178,378,641 - 78,401,008 (+)NCBIRnor_WKY
Rnor_6.01181,509,185 - 81,516,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01184,605,412 - 84,612,986 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,109,499 - 80,131,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11180,167,317 - 80,189,475 (+)NCBI
Celera1176,789,106 - 76,811,459 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-oxoprostaglandin F1alpha  (EXP)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
acetylsalicylic acid  (EXP)
aconitine  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
alpha-linolenic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
ampicillin  (EXP)
arachidonic acid  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (EXP)
cadmium atom  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium trinitrate  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
compound 48/80  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
enalapril  (EXP)
flurbiprofen  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
fructose  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
GW 4064  (ISO)
Hexachloro-1,3-butadiene  (EXP)
histamine  (EXP)
icatibant  (EXP,ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
isoflavones  (EXP)
kainic acid  (EXP)
ketamine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP)
m-xylene  (EXP)
manganese(II) chloride  (EXP)
meloxicam  (EXP)
menadione  (ISO)
mepyramine  (ISO)
methidathion  (ISO)
methotrexate  (EXP)
methyltestosterone  (ISO)
metronidazole  (EXP)
N,O-dimethyltyramine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nafamostat  (ISO)
nefazodone  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
nitroprusside  (EXP)
O-methyleugenol  (ISO)
olanzapine  (ISO)
oryzalin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PD123319  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
Pranoprofen  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
propofol  (ISO)
prostaglandin E2  (EXP)
prostaglandin I2  (EXP)
quartz  (EXP)
quercetin  (ISO)
ramipril  (EXP)
ramiprilat  (EXP)
serotonin  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
staurosporine  (EXP)
stigmasterol  (ISO)
streptozocin  (EXP)
sulforaphane  (EXP)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
Triptolide  (EXP)
U-73122  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (EXP)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
wortmannin  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. T-kininogen, a cystatin-like molecule, inhibits ERK-dependent lymphocyte proliferation. Acuna-Castillo C, etal., Mech Ageing Dev. 2005 Dec;126(12):1284-91. Epub 2005 Sep 2.
2. Correlation between genetic and cytogenetic maps of the rat. Andoh Y, etal., Mamm Genome 1998 Apr;9(4):287-93.
3. T-kininogen can either induce or inhibit proliferation in Balb/c 3T3 fibroblasts, depending on the route of administration. Aravena M, etal., Mech Ageing Dev. 2005 Mar;126(3):399-406.
4. Involvement of endogenous kinins in the pathogenesis of peptidoglycan-induced arthritis in the Lewis rat. Blais C Jr, etal., Arthritis Rheum. 1997 Jul;40(7):1327-33.
5. Activation of factor XII in human plasma: protection by benzamidine of the cofactor function of high molecular weight kininogen. Briseid K and Johansen HT, Acta Pharmacol Toxicol (Copenh). 1983 Oct;53(4):344-52.
6. Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors. Bruzelius M, etal., J Thromb Haemost. 2015 Feb;13(2):219-27. doi: 10.1111/jth.12808. Epub 2015 Jan 12.
7. Genetic basis of total kininogen deficiency in Williams' trait. Cheung PP, etal., J Biol Chem. 1993 Nov 5;268(31):23361-5.
8. Distribution of immunoreactive T-kininogen in rat nervous tissues. Damas J, etal., Brain Res. 1992 Jan 8;569(1):63-70.
9. P2X3 and P2X2/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE(2) or dopamine. de Oliveira Fusaro MC, etal., Eur J Pharmacol. 2010 Dec 15;649(1-3):177-82. doi: 10.1016/j.ejphar.2010.09.037. Epub 2010 Sep 21.
10. Role of kallikrein-kinin system in pathogenesis of bacterial cell wall-induced inflammation. DeLa Cadena RA, etal., Am J Physiol. 1991 Feb;260(2 Pt 1):G213-9.
11. Purification and characterization of two isoforms of T-kininogens from rat liver microsomes. Enjyoji K and Kato H, J Biochem (Tokyo). 1992 May;111(5):670-5.
12. Primary structures of the mRNAs encoding the rat precursors for bradykinin and T-kinin. Structural relationship of kininogens with major acute phase protein and alpha 1-cysteine proteinase inhibitor. Furuto-Kato S, etal., J Biol Chem 1985 Oct 5;260(22):12054-9.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Higher Serum Angiotensinogen Is an Indicator of IgA Vasculitis with Nephritis Revealed by Comparative Proteomes Analysis. He X, etal., PLoS One. 2015 Jun 22;10(6):e0130536. doi: 10.1371/journal.pone.0130536. eCollection 2015.
15. Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect and Epistatic Interactions in a Chinese Population. Hu Z, etal., J Stroke Cerebrovasc Dis. 2015 Sep;24(9):2060-8. doi: 10.1016/j.jstrokecerebrovasdis.2015.04.036. Epub 2015 Jul 7.
16. Differing utilization of homologous transcription initiation sites of rat K and T kininogen genes under inflammation condition. Kageyama R, etal., J Biol Chem 1987 Feb 15;262(5):2345-51.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
19. Cysteine-proteinase-inhibiting function of T kininogen and of its proteolytic fragments. Moreau T, etal., Eur J Biochem. 1988 Apr 5;173(1):185-90.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Effect of plant neutrophil elastase inhibitor on leucocyte migration, adhesion and cytokine release in inflammatory conditions. Oliveira C, etal., Br J Pharmacol. 2010 Oct;161(4):899-910. doi: 10.1111/j.1476-5381.2010.00924.x.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Bradykinin induces eosinophil accumulation in the rat pleural cavity. Pasquale CP, etal., Int Arch Allergy Appl Immunol. 1991;95(2-3):244-7.
24. T-kininogen induces endothelial cell proliferation. Perez V, etal., Mech Ageing Dev. 2006 Mar;127(3):282-9. Epub 2005 Dec 27.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Role of the adrenal gland in the leucocytosis caused by bradykinin or cellulose sulphate in the rat. Rothschild AM Br J Pharmacol. 1971 Aug;42(4):631-3.
31. Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk. Sotoodehnia N, etal., Heart Rhythm. 2009 Sep;6(9):1306-14. doi: 10.1016/j.hrthm.2009.06.013. Epub 2009 Jun 9.
32. Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene. Vionnet N, etal., Diabetes. 2006 Nov;55(11):3166-74.
33. Kininogen 1 and insulin-like growth factor binding protein 6: candidate serum biomarkers of proliferative vitreoretinopathy. Yu J, etal., Clin Exp Optom. 2014 Jan;97(1):72-9. doi: 10.1111/cxo.12088. Epub 2013 Jul 1.
Additional References at PubMed
PMID:1653251   PMID:2108948   PMID:2413019   PMID:2439509   PMID:2578992   PMID:2579644   PMID:2806908   PMID:3029068   PMID:3121623   PMID:3335530   PMID:3488317   PMID:7574705  
PMID:11290596   PMID:11970955   PMID:12074933   PMID:12118089   PMID:12477932   PMID:12842992   PMID:15238617   PMID:16014619   PMID:16059911   PMID:16502470   PMID:17293494   PMID:18580444  
PMID:19056867   PMID:20220009   PMID:22516433   PMID:22865451   PMID:23376485   PMID:23533145   PMID:27068509   PMID:27559042  


Genomics

Comparative Map Data
Kng2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21177,913,876 - 77,936,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,909,612 - 78,002,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,664,319 - 86,686,690 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01179,302,200 - 79,324,460 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01178,378,641 - 78,401,008 (+)NCBIRnor_WKY
Rnor_6.01181,509,185 - 81,516,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01184,605,412 - 84,612,986 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,109,499 - 80,131,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11180,167,317 - 80,189,475 (+)NCBI
Celera1176,789,106 - 76,811,459 (+)NCBICelera
Cytogenetic Map11q23NCBI
KNG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383186,717,359 - 186,744,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3186,717,348 - 186,744,410 (+)EnsemblGRCh38hg38GRCh38
GRCh373186,435,148 - 186,462,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363187,917,814 - 187,944,437 (+)NCBINCBI36Build 36hg18NCBI36
Celera3184,871,536 - 184,898,662 (+)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3183,844,775 - 183,871,713 (+)NCBIHuRef
CHM1_13186,399,036 - 186,425,781 (+)NCBICHM1_1
T2T-CHM13v2.03189,539,122 - 189,566,165 (+)NCBIT2T-CHM13v2.0
Kng2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391622,804,602 - 22,847,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1622,804,604 - 22,848,232 (-)EnsemblGRCm39 Ensembl
GRCm381622,985,852 - 23,029,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1622,985,854 - 23,029,482 (-)EnsemblGRCm38mm10GRCm38
MGSCv371622,985,925 - 23,029,174 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361622,902,680 - 22,944,351 (-)NCBIMGSCv36mm8
Celera1623,545,793 - 23,588,919 (-)NCBICelera
Cytogenetic Map16B1NCBI
Kng1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542020,989,197 - 21,016,084 (-)NCBIChiLan1.0ChiLan1.0
KNG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13192,219,675 - 192,245,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3192,219,462 - 192,245,149 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03183,751,598 - 183,778,655 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KNG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13419,288,629 - 19,318,096 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3419,287,109 - 19,318,081 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3423,373,992 - 23,403,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03419,199,856 - 19,229,431 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3419,199,904 - 19,229,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13419,231,763 - 19,260,578 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03419,231,843 - 19,260,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03419,460,203 - 19,488,753 (+)NCBIUU_Cfam_GSD_1.0
Kng1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602117,161,767 - 117,189,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365783,253,749 - 3,281,296 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365783,255,335 - 3,281,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KNG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13124,521,340 - 124,557,958 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113124,521,276 - 124,557,384 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213133,911,227 - 133,947,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KNG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,002,287 - 81,027,893 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604154,492,596 - 54,518,121 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kng1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473070,022,449 - 70,065,115 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kng2
90 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat

Markers in Region
D11Elh1   No map positions available.
D11Mit8  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11642.9RGD
RH 3.4 Map11642.9UniSTS
RH 2.0 Map1164.4RGD
SHRSP x BN Map1135.7599RGD
FHH x ACI Map1155.0699RGD
Cytogenetic Map11q23UniSTS
RH127328  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11643.0UniSTS
Cytogenetic Map11q23UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC087028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000080562   ⟹   ENSRNOP00000075573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,936,246 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080949   ⟹   ENSRNOP00000069578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,934,579 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096169   ⟹   ENSRNOP00000077820
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,002,971 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100483   ⟹   ENSRNOP00000093913
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,909,612 - 77,936,254 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102748   ⟹   ENSRNOP00000086253
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,978,923 - 78,001,486 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103089   ⟹   ENSRNOP00000084194
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,001,323 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109164   ⟹   ENSRNOP00000076561
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,936,139 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115073   ⟹   ENSRNOP00000081425
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,978,824 - 78,001,323 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116873   ⟹   ENSRNOP00000091640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,001,396 (+)Ensembl
RefSeq Acc Id: NM_012696   ⟹   NP_036828
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21177,913,876 - 77,936,247 (+)NCBI
Rnor_6.01181,509,185 - 81,516,759 (+)NCBI
Rnor_5.01184,605,412 - 84,612,986 (+)NCBI
RGSC_v3.41180,109,499 - 80,131,887 (+)RGD
Celera1176,789,106 - 76,811,459 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036828   ⟸   NM_012696
- Peptide Label: precursor
- UniProtKB: Q5PQU1 (UniProtKB/TrEMBL),   A0A0G2KAY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000086253   ⟸   ENSRNOT00000102748
RefSeq Acc Id: ENSRNOP00000081425   ⟸   ENSRNOT00000115073
RefSeq Acc Id: ENSRNOP00000075573   ⟸   ENSRNOT00000080562
RefSeq Acc Id: ENSRNOP00000093913   ⟸   ENSRNOT00000100483
RefSeq Acc Id: ENSRNOP00000076561   ⟸   ENSRNOT00000109164
RefSeq Acc Id: ENSRNOP00000091640   ⟸   ENSRNOT00000116873
RefSeq Acc Id: ENSRNOP00000077820   ⟸   ENSRNOT00000096169
RefSeq Acc Id: ENSRNOP00000069578   ⟸   ENSRNOT00000080949
RefSeq Acc Id: ENSRNOP00000084194   ⟸   ENSRNOT00000103089
Protein Domains
Cystatin kininogen-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01048-F1-model_v2 AlphaFold P01048 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2980 AgrOrtholog
BioCyc Gene G2FUF-20840 BioCyc
Ensembl Genes ENSRNOG00000065935 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069578.2 UniProtKB/TrEMBL
  ENSRNOP00000075573 ENTREZGENE
  ENSRNOP00000075573.2 UniProtKB/TrEMBL
  ENSRNOP00000076561.1 UniProtKB/TrEMBL
  ENSRNOP00000077820.1 UniProtKB/TrEMBL
  ENSRNOP00000081425.1 UniProtKB/TrEMBL
  ENSRNOP00000084194.1 UniProtKB/TrEMBL
  ENSRNOP00000086253.1 UniProtKB/TrEMBL
  ENSRNOP00000091640.1 UniProtKB/TrEMBL
  ENSRNOP00000093913.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080562 ENTREZGENE
  ENSRNOT00000080562.2 UniProtKB/TrEMBL
  ENSRNOT00000080949.2 UniProtKB/TrEMBL
  ENSRNOT00000096169.1 UniProtKB/TrEMBL
  ENSRNOT00000100483.1 UniProtKB/TrEMBL
  ENSRNOT00000102748.1 UniProtKB/TrEMBL
  ENSRNOT00000103089.1 UniProtKB/TrEMBL
  ENSRNOT00000109164.1 UniProtKB/TrEMBL
  ENSRNOT00000115073.1 UniProtKB/TrEMBL
  ENSRNOT00000116873.1 UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kininogen UniProtKB/TrEMBL
  Kininogen-type_cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24903 UniProtKB/TrEMBL
NCBI Gene 24903 ENTREZGENE
Pfam Cystatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KNG1 RGD
PhenoGen Kng2 PhenoGen
PRINTS KININOGEN UniProtKB/TrEMBL
PROSITE CYSTATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTATIN_KININOGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVQ5_RAT UniProtKB/TrEMBL
  A0A0G2KAY3 ENTREZGENE
  A0A8I5Y6S4_RAT UniProtKB/TrEMBL
  A0A8I5ZK39_RAT UniProtKB/TrEMBL
  A0A8I5ZRM0_RAT UniProtKB/TrEMBL
  A0A8I5ZWQ0_RAT UniProtKB/TrEMBL
  A0A8I6ACG6_RAT UniProtKB/TrEMBL
  A0A8I6AXR2_RAT UniProtKB/TrEMBL
  A0A8I6GER1_RAT UniProtKB/TrEMBL
  KNT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5PQU1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2KAY3 UniProtKB/TrEMBL
  P04081 UniProtKB/Swiss-Prot
  Q6LDW3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-18 Kng2  kininogen 2  Kng1  kininogen 1  Name and Symbol changed 629549 APPROVED
2004-09-10 Kng1  kininogen 1  Kng  T-kininogen  Symbol and Name updated 1299863 APPROVED
2001-11-02 Kng  kininogen      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency in BN rats promotes the formation of aneurysms in the abdominal aorta but does not promote the development of atherosclerosis when rats were fed a high-cholesterol diet 1302825
gene_process cysteine protease inhibitor and a major acute phase reactant 1298975
gene_regulation resistant to cleavage with trypsin or kallikreins 633117
gene_regulation expression increases under acute inflammation conditions 633118