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Gene: Kng2 (kininogen 2) Rattus norvegicus
Symbol: Kng2
Name: kininogen 2
Description: Exhibits cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of T cell proliferation; positive regulation of cell population proliferation; and regulation of protein metabolic process. Localizes to extracellular space; intracellular membrane-bounded organelle; and perikaryon. Human ortholog(s) of this gene implicated in high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1); PARTICIPATES IN kallikrein-kinin cascade pathway; kinin signaling pathway; syndecan signaling pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 1-octadec-9-enoylglycero-3-phosphate.
Type: protein-coding
Also known as: alpha-1-MAP; K-kininogen; K-kininogen, differential splicing leads to HMW Kngk; kininogen 1; kininogen 1, variant 1; kininogen II; KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1; Kng_v1; Kngk; Kngt; Kngt1; LMW T-kininogen I; Map1; T-kininogen; T-kininogen 1; T-kininogen I; thiostatin; Tkg; TKG6
Homo sapiens (human) : KNG1 (kininogen 1)  HGNC  Alliance
Mus musculus (house mouse) : Kng2 (kininogen 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kng1 (kininogen 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KNG1 (kininogen 1)
Canis lupus familiaris (dog) : KNG1 (kininogen 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kng1 (kininogen 1)
Sus scrofa (pig) : KNG1 (kininogen 1)
Chlorocebus sabaeus (African green monkey) : KNG1 (kininogen 1)
Heterocephalus glaber (naked mole-rat) : Kng1 (kininogen 1)
more info ...
Allele / Splice: Kng1_v1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01181,509,185 - 81,516,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01184,605,412 - 84,612,986 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,109,499 - 80,131,887 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11180,167,317 - 80,189,475 (+)NCBI
Celera1176,789,106 - 76,811,459 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Kng2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2980
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.