Tigit (T cell immunoreceptor with Ig and ITIM domains) - Rat Genome Database

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Gene: Tigit (T cell immunoreceptor with Ig and ITIM domains) Rattus norvegicus
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Symbol: Tigit
Name: T cell immunoreceptor with Ig and ITIM domains
RGD ID: 1563191
Description: Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in negative regulation of T cell activation; negative regulation of interleukin-12 production; and positive regulation of interleukin-10 production. Predicted to be located in membrane. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; glyphosate; vinclozolin.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC363784; RGD1563191; similar to hypothetical protein; T-cell immunoreceptor with Ig and ITIM domains
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21157,029,024 - 57,046,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1157,029,118 - 57,045,994 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01161,966,780 - 61,987,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,970,976 - 61,987,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01161,100,049 - 61,120,824 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,618,187 - 58,635,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1156,581,374 - 56,598,622 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IBA,ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19011627   PMID:21199897   PMID:21416464   PMID:27978489  


Genomics

Comparative Map Data
Tigit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21157,029,024 - 57,046,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1157,029,118 - 57,045,994 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01161,966,780 - 61,987,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,970,976 - 61,987,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01161,100,049 - 61,120,824 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,618,187 - 58,635,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1156,581,374 - 56,598,622 (+)NCBICelera
Cytogenetic Map11q21NCBI
TIGIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383114,294,028 - 114,310,288 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3114,276,913 - 114,310,288 (+)EnsemblGRCh38hg38GRCh38
GRCh373114,012,875 - 114,029,135 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,495,565 - 115,511,038 (+)NCBINCBI36Build 36hg18NCBI36
Celera3112,420,299 - 112,436,499 (+)NCBICelera
Cytogenetic Map3q13.31NCBI
HuRef3111,385,681 - 111,401,895 (+)NCBIHuRef
CHM1_13113,975,847 - 113,992,048 (+)NCBICHM1_1
T2T-CHM13v2.03117,014,923 - 117,031,081 (+)NCBIT2T-CHM13v2.0
Tigit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,469,224 - 43,485,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1643,469,230 - 43,484,509 (-)EnsemblGRCm39 Ensembl
GRCm381643,626,137 - 43,665,125 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,648,867 - 43,664,146 (-)EnsemblGRCm38mm10GRCm38
MGSCv371643,648,974 - 43,664,297 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361643,649,114 - 43,664,297 (-)NCBIMGSCv36mm8
Celera1644,003,410 - 44,018,650 (-)NCBICelera
Cytogenetic Map16B4NCBI
Tigit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542714,360,272 - 14,382,524 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542714,358,326 - 14,381,074 (+)NCBIChiLan1.0ChiLan1.0
TIGIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13118,344,588 - 118,360,939 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3118,344,459 - 118,360,939 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03111,424,940 - 111,441,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TIGIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13318,484,106 - 18,501,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3318,485,955 - 18,499,440 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3318,592,840 - 18,608,590 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03318,731,173 - 18,746,925 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3318,731,359 - 18,746,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13318,538,986 - 18,554,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03318,585,866 - 18,601,612 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03319,131,089 - 19,146,839 (+)NCBIUU_Cfam_GSD_1.0
Tigit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602135,775,157 - 135,790,568 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365361,731,352 - 1,746,763 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365361,731,352 - 1,746,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIGIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13145,673,658 - 145,692,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113145,673,646 - 145,799,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213155,180,469 - 155,200,775 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIGIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12266,555,560 - 66,572,206 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604199,892,201 - 99,907,826 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tigit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473134,203,346 - 34,220,389 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473134,203,313 - 34,220,389 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tigit
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000059622
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 1
Low 1 7 15 3 17 3 2 8 9
Below cutoff 1 16 14 10 10 6 7 23 11 9 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078921   ⟹   ENSRNOP00000074881
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1157,029,118 - 57,045,994 (+)Ensembl
Rnor_6.0 Ensembl1161,970,976 - 61,987,760 (+)Ensembl
RefSeq Acc Id: XM_008768765   ⟹   XP_008766987
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21157,029,024 - 57,046,627 (+)NCBI
Rnor_6.01161,970,617 - 61,987,749 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008766987 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008766987   ⟸   XM_008768765
- Sequence:
RefSeq Acc Id: ENSRNOP00000074881   ⟸   ENSRNOT00000078921
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTQ2-F1-model_v2 AlphaFold D3ZTQ2 1-242 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563191 AgrOrtholog
BioCyc Gene G2FUF-21328 BioCyc
Ensembl Genes ENSRNOG00000056574 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074881 ENTREZGENE
  ENSRNOP00000074881.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078921 ENTREZGENE
  ENSRNOT00000078921.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  TIGIT UniProtKB/TrEMBL
NCBI Gene 363784 ENTREZGENE
PANTHER PTHR47734 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Tigit PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt D3ZTQ2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Tigit  T cell immunoreceptor with Ig and ITIM domains  RGD1563191  similar to hypothetical protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563191  similar to hypothetical protein   RGD1563191_predicted  similar to hypothetical protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563191_predicted  similar to hypothetical protein (predicted)  LOC363784  similar to hypothetical protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363784  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL