P2rx6 (purinergic receptor P2X 6) - Rat Genome Database

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Gene: P2rx6 (purinergic receptor P2X 6) Rattus norvegicus
Analyze
Symbol: P2rx6
Name: purinergic receptor P2X 6
RGD ID: 3243
Description: Enables extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transmembrane transport. Located in dendritic spine and neuronal cell body. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic specialization membrane. Orthologous to human P2RX6 (purinergic receptor P2X 6); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP receptor; P2rxl1; P2X purinoceptor 6; P2x6; P2X6 receptor; P2XM; purinergic receptor P2X, ligand-gated ion channel, 6; purinergic receptor P2X-like 1; purinergic receptor P2X-like 1 orphan receptor; purinergic receptor P2X-like 1, orphan receptor; purinergic receptor P2X6; Rnap2x6; RNRNAP2X6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,944,167 - 96,956,424 (-)NCBIGRCr8
mRatBN7.21183,439,922 - 83,450,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,439,924 - 83,450,481 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,167,552 - 92,177,610 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,828,716 - 84,838,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,882,324 - 83,892,380 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,434,929 - 87,445,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,435,185 - 87,445,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,485,985 - 90,496,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,431,257 - 85,441,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,471,855 - 85,481,771 (-)NCBI
Celera1182,208,493 - 82,218,517 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging. Antonio LS, etal., FEBS Lett. 2014 Jun 5;588(12):2125-8. doi: 10.1016/j.febslet.2014.04.048. Epub 2014 May 8.
2. The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Barrera NP, etal., Biophys J. 2007 Jul 15;93(2):505-12. Epub 2007 Apr 20.
3. Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. Collo G, etal., J Neurosci 1996 Apr 15;16(8):2495-507.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Distinct Localization of P2X receptors at excitatory postsynaptic specializations. Rubio ME and Soto F, J Neurosci. 2001 Jan 15;21(2):641-53.
11. Cloning and tissue distribution of a novel P2X receptor from rat brain. Soto F, etal., Biochem Biophys Res Commun 1996 Jun 14;223(2):456-60.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12088286   PMID:15313628   PMID:15657042   PMID:19946698   PMID:20617399   PMID:21669492   PMID:22230887   PMID:25680470   PMID:27545450  


Genomics

Comparative Map Data
P2rx6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,944,167 - 96,956,424 (-)NCBIGRCr8
mRatBN7.21183,439,922 - 83,450,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,439,924 - 83,450,481 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,167,552 - 92,177,610 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,828,716 - 84,838,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,882,324 - 83,892,380 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,434,929 - 87,445,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,435,185 - 87,445,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,485,985 - 90,496,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,431,257 - 85,441,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,471,855 - 85,481,771 (-)NCBI
Celera1182,208,493 - 82,218,517 (-)NCBICelera
Cytogenetic Map11q23NCBI
P2RX6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,009,799 - 21,028,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,009,808 - 21,028,013 (+)EnsemblGRCh38hg38GRCh38
GRCh372221,369,454 - 21,382,297 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,699,464 - 19,712,302 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,694,002 - 19,707,673NCBI
Celera224,860,745 - 4,873,604 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,637,727 - 4,650,586 (+)NCBIHuRef
CHM1_12221,369,657 - 21,382,503 (+)NCBICHM1_1
T2T-CHM13v2.02221,423,939 - 21,436,767 (+)NCBIT2T-CHM13v2.0
P2rx6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,379,749 - 17,389,879 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,379,749 - 17,395,664 (+)EnsemblGRCm39 Ensembl
GRCm381617,561,867 - 17,572,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,561,885 - 17,577,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,561,978 - 17,572,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,475,563 - 17,484,828 (+)NCBIMGSCv36mm8
Celera1618,135,205 - 18,145,330 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.88NCBI
P2rx6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,264,790 - 19,271,537 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,263,544 - 19,272,231 (-)NCBIChiLan1.0ChiLan1.0
P2RX6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,721,153 - 30,735,310 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,270,081 - 33,284,233 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,239,019 - 3,251,966 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12219,728,644 - 19,741,078 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,728,644 - 19,741,078 (+)Ensemblpanpan1.1panPan2
P2RX6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,456,231 - 30,467,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,457,014 - 30,466,152 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,417,349 - 30,428,575 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,867,789 - 31,879,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,869,314 - 31,879,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,913,614 - 29,924,837 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,537,801 - 29,549,022 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,626,779 - 30,638,005 (-)NCBIUU_Cfam_GSD_1.0
P2rx6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,186,450 - 140,193,553 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,560,759 - 2,566,355 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,560,685 - 2,567,612 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,622,938 - 50,633,535 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,595,876 - 50,633,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,043,227 - 54,082,269 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,958,713 - 4,969,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,958,671 - 4,969,724 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,001,874 - 2,015,701 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2rx6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945648,499 - 656,075 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945646,361 - 687,901 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2rx6
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:207
Interacting mature miRNAs:234
Transcripts:ENSRNOT00000002558
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118256654583440803Rat

Markers in Region
D11Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,440,555 - 83,440,803 (-)MAPPERmRatBN7.2
Rnor_6.01187,444,342 - 87,444,587NCBIRnor6.0
Rnor_5.01190,495,636 - 90,495,881UniSTSRnor5.0
RGSC_v3.41185,431,891 - 85,432,136UniSTSRGSC3.4
Celera1182,209,127 - 82,209,372UniSTS
Cytogenetic Map11q23UniSTS
AI059538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,439,926 - 83,440,169 (-)MAPPERmRatBN7.2
Rnor_6.01187,444,974 - 87,445,216NCBIRnor6.0
Rnor_5.01190,496,268 - 90,496,510UniSTSRnor5.0
RGSC_v3.41185,431,262 - 85,431,504UniSTSRGSC3.4
Celera1182,208,498 - 82,208,740UniSTS
RH 3.4 Map11712.6UniSTS
Cytogenetic Map11q23UniSTS
AI059538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,440,066 - 83,440,271 (-)MAPPERmRatBN7.2
Rnor_6.01187,444,872 - 87,445,076NCBIRnor6.0
Rnor_5.01190,496,166 - 90,496,370UniSTSRnor5.0
RGSC_v3.41185,431,402 - 85,431,606UniSTSRGSC3.4
Celera1182,208,638 - 82,208,842UniSTS
RH 3.4 Map11712.6UniSTS
Cytogenetic Map11q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 3 3 1
Low 2 11 10 4 7 9 62 3 26 8 7
Below cutoff 1 32 22 16 15 16 10 30 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO554543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X92070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000002558   ⟹   ENSRNOP00000002558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,439,924 - 83,449,960 (-)Ensembl
Rnor_6.0 Ensembl1187,435,185 - 87,445,219 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100698   ⟹   ENSRNOP00000096439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,439,924 - 83,450,481 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116608   ⟹   ENSRNOP00000090158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,439,924 - 83,449,960 (-)Ensembl
RefSeq Acc Id: NM_012721   ⟹   NP_036853
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,944,167 - 96,954,203 (-)NCBI
mRatBN7.21183,439,922 - 83,449,960 (-)NCBI
Rnor_6.01187,435,185 - 87,445,221 (+)NCBI
Rnor_5.01190,485,985 - 90,496,515 (+)NCBI
RGSC_v3.41185,431,257 - 85,441,293 (-)RGD
Celera1182,208,493 - 82,218,517 (-)RGD
Sequence:
RefSeq Acc Id: XM_039087988   ⟹   XP_038943916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,944,167 - 96,954,435 (-)NCBI
mRatBN7.21183,439,922 - 83,450,192 (-)NCBI
RefSeq Acc Id: XM_039087989   ⟹   XP_038943917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,944,167 - 96,954,595 (-)NCBI
mRatBN7.21183,439,922 - 83,450,449 (-)NCBI
RefSeq Acc Id: XM_039087990   ⟹   XP_038943918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,947,393 - 96,954,247 (-)NCBI
mRatBN7.21183,443,150 - 83,450,011 (-)NCBI
RefSeq Acc Id: XM_039087991   ⟹   XP_038943919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,944,167 - 96,954,420 (-)NCBI
mRatBN7.21183,439,922 - 83,450,172 (-)NCBI
RefSeq Acc Id: XM_063270291   ⟹   XP_063126361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,946,215 - 96,954,247 (-)NCBI
RefSeq Acc Id: XM_063270292   ⟹   XP_063126362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,944,167 - 96,954,595 (-)NCBI
RefSeq Acc Id: XM_063270293   ⟹   XP_063126363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,947,393 - 96,954,243 (-)NCBI
RefSeq Acc Id: XM_063270294   ⟹   XP_063126364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,944,167 - 96,956,424 (-)NCBI
RefSeq Acc Id: NP_036853   ⟸   NM_012721
- UniProtKB: R9PXR5 (UniProtKB/Swiss-Prot),   P51579 (UniProtKB/Swiss-Prot),   A0A8I6ADW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002558   ⟸   ENSRNOT00000002558
RefSeq Acc Id: XP_038943917   ⟸   XM_039087989
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038943916   ⟸   XM_039087988
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943919   ⟸   XM_039087991
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038943918   ⟸   XM_039087990
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000090158   ⟸   ENSRNOT00000116608
RefSeq Acc Id: ENSRNOP00000096439   ⟸   ENSRNOT00000100698
RefSeq Acc Id: XP_063126364   ⟸   XM_063270294
- Peptide Label: isoform X7
- UniProtKB: A0A8I6ADW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126362   ⟸   XM_063270292
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ADW0 (UniProtKB/TrEMBL),   A0A8I6ATC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126361   ⟸   XM_063270291
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063126363   ⟸   XM_063270293
- Peptide Label: isoform X6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51579-F1-model_v2 AlphaFold P51579 1-389 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3243 AgrOrtholog
BioCyc Gene G2FUF-20595 BioCyc
Ensembl Genes ENSRNOG00000001873 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003773 UniProtKB/Swiss-Prot
  ENSRNOG00060011274 UniProtKB/Swiss-Prot
  ENSRNOG00065008032 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002558 ENTREZGENE
  ENSRNOT00000002558.7 UniProtKB/Swiss-Prot
  ENSRNOT00000100698.1 UniProtKB/TrEMBL
  ENSRNOT00000116608.1 UniProtKB/TrEMBL
  ENSRNOT00055005942 UniProtKB/Swiss-Prot
  ENSRNOT00060019063 UniProtKB/Swiss-Prot
  ENSRNOT00065012681 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  atp-gated p2x4 ion channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P2X6_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25041 UniProtKB/Swiss-Prot
NCBI Gene 25041 ENTREZGENE
PANTHER P2X PURINOCEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10125:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P2X_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2rx6 PhenoGen
PIRSF P2X_purinoceptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS P2X6RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P2X_RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001873 RatGTEx
  ENSRNOG00055003773 RatGTEx
  ENSRNOG00060011274 RatGTEx
  ENSRNOG00065008032 RatGTEx
TIGR TC210320
UniProt A0A8I6ADW0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATC1 ENTREZGENE, UniProtKB/TrEMBL
  P2RX6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXR5 ENTREZGENE
UniProt Secondary R9PXR5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2rx6  purinergic receptor P2X 6  P2rx6  purinergic receptor P2X, ligand-gated ion channel, 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 P2rx6  purinergic receptor P2X, ligand-gated ion channel, 6  P2rxl1  purinergic receptor P2X-like 1, orphan receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 P2rxl1  purinergic receptor P2X-like 1, orphan receptor    purinergic receptor P2X-like 1  Name updated 1299863 APPROVED
2002-11-06 P2rxl1  purinergic receptor P2X-like 1  P2x6  P2X6 receptor  Symbol and Name updated 625702 APPROVED
2002-06-10 P2x6  P2X6 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the P2X receptor family of ATP-gated ion channels 729425