P2rx6 (purinergic receptor P2X 6) - Rat Genome Database

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Gene: P2rx6 (purinergic receptor P2X 6) Rattus norvegicus
Analyze
Symbol: P2rx6
Name: purinergic receptor P2X 6
RGD ID: 3243
Description: Exhibits extracellularly ATP-gated cation channel activity. Predicted to be involved in cation transmembrane transport; cell surface receptor signaling pathway; and response to ATP. Localizes to several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic specialization. Orthologous to human P2RX6 (purinergic receptor P2X 6); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP receptor; P2rxl1; P2X purinoceptor 6; P2x6; P2X6 receptor; P2XM; purinergic receptor P2X, ligand-gated ion channel, 6; purinergic receptor P2X-like 1; purinergic receptor P2X-like 1 orphan receptor; purinergic receptor P2X-like 1, orphan receptor; purinergic receptor P2X6; Rnap2x6; RNRNAP2X6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,439,922 - 83,450,449 (-)NCBI
Rnor_6.0 Ensembl1187,435,185 - 87,445,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01187,434,929 - 87,445,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01190,485,985 - 90,496,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,431,257 - 85,441,293 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,471,855 - 85,481,771 (-)NCBI
Celera1182,208,493 - 82,218,517 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12088286   PMID:15313628   PMID:15657042   PMID:19946698   PMID:20617399   PMID:21669492   PMID:22230887   PMID:25680470   PMID:27545450  


Genomics

Comparative Map Data
P2rx6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,439,922 - 83,450,449 (-)NCBI
Rnor_6.0 Ensembl1187,435,185 - 87,445,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01187,434,929 - 87,445,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01190,485,985 - 90,496,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,431,257 - 85,441,293 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,471,855 - 85,481,771 (-)NCBI
Celera1182,208,493 - 82,218,517 (-)NCBICelera
Cytogenetic Map11q23NCBI
P2RX6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2221,009,808 - 21,028,830 (+)EnsemblGRCh38hg38GRCh38
GRCh382221,009,699 - 21,028,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372221,369,442 - 21,382,302 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,699,464 - 19,712,302 (+)NCBINCBI36hg18NCBI36
Build 342219,694,002 - 19,707,673NCBI
Celera224,860,745 - 4,873,604 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef224,637,727 - 4,650,586 (+)NCBIHuRef
CHM1_12221,369,657 - 21,382,503 (+)NCBICHM1_1
P2rx6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,379,729 - 17,389,879 (+)NCBIGRCm39mm39
GRCm39 Ensembl1617,379,749 - 17,395,664 (+)Ensembl
GRCm381617,561,867 - 17,572,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,561,885 - 17,577,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,561,978 - 17,572,105 (+)NCBIGRCm37mm9NCBIm37
MGSCv361617,475,563 - 17,484,828 (+)NCBImm8
Celera1618,135,205 - 18,145,330 (+)NCBICelera
Cytogenetic Map16A3NCBI
P2rx6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,264,790 - 19,271,537 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,263,544 - 19,272,231 (-)NCBIChiLan1.0ChiLan1.0
P2RX6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12219,728,644 - 19,741,078 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,728,644 - 19,741,078 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0223,239,019 - 3,251,966 (+)NCBIMhudiblu_PPA_v0panPan3
P2RX6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,456,231 - 30,467,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,457,014 - 30,466,152 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,417,349 - 30,428,575 (-)NCBI
ROS_Cfam_1.02631,867,789 - 31,879,013 (-)NCBI
UMICH_Zoey_3.12629,913,614 - 29,924,837 (-)NCBI
UNSW_CanFamBas_1.02629,537,801 - 29,549,022 (-)NCBI
UU_Cfam_GSD_1.02630,626,779 - 30,638,005 (-)NCBI
P2rx6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,186,450 - 140,193,553 (-)NCBI
SpeTri2.0NW_0049366192,560,685 - 2,567,612 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,623,708 - 50,632,260 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,595,876 - 50,633,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,043,227 - 54,082,269 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,958,713 - 4,969,443 (+)NCBI
ChlSab1.1 Ensembl194,958,671 - 4,969,724 (+)Ensembl
P2rx6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624945646,361 - 687,901 (-)NCBI

Position Markers
D11Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,440,555 - 83,440,803 (-)MAPPER
Rnor_6.01187,444,342 - 87,444,587NCBIRnor6.0
Rnor_5.01190,495,636 - 90,495,881UniSTSRnor5.0
RGSC_v3.41185,431,891 - 85,432,136UniSTSRGSC3.4
Celera1182,209,127 - 82,209,372UniSTS
Cytogenetic Map11q23UniSTS
AI059538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,439,926 - 83,440,169 (-)MAPPER
Rnor_6.01187,444,974 - 87,445,216NCBIRnor6.0
Rnor_5.01190,496,268 - 90,496,510UniSTSRnor5.0
RGSC_v3.41185,431,262 - 85,431,504UniSTSRGSC3.4
Celera1182,208,498 - 82,208,740UniSTS
RH 3.4 Map11712.6UniSTS
Cytogenetic Map11q23UniSTS
AI059538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,440,066 - 83,440,271 (-)MAPPER
Rnor_6.01187,444,872 - 87,445,076NCBIRnor6.0
Rnor_5.01190,496,166 - 90,496,370UniSTSRnor5.0
RGSC_v3.41185,431,402 - 85,431,606UniSTSRGSC3.4
Celera1182,208,638 - 82,208,842UniSTS
RH 3.4 Map11712.6UniSTS
Cytogenetic Map11q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118671447587444587Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:207
Interacting mature miRNAs:234
Transcripts:ENSRNOT00000002558
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 3 3 1
Low 2 11 10 4 7 9 62 3 26 8 7
Below cutoff 1 32 22 16 15 16 10 30 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002558   ⟹   ENSRNOP00000002558
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1187,435,185 - 87,445,219 (+)Ensembl
RefSeq Acc Id: NM_012721   ⟹   NP_036853
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,439,922 - 83,449,960 (-)NCBI
Rnor_6.01187,435,185 - 87,445,221 (+)NCBI
Rnor_5.01190,485,985 - 90,496,515 (+)NCBI
RGSC_v3.41185,431,257 - 85,441,293 (-)RGD
Celera1182,208,493 - 82,218,517 (-)RGD
Sequence:
RefSeq Acc Id: XM_017597882   ⟹   XP_017453371
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,434,929 - 87,445,221 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597883   ⟹   XP_017453372
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,435,092 - 87,445,221 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087988   ⟹   XP_038943916
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,439,922 - 83,450,192 (-)NCBI
RefSeq Acc Id: XM_039087989   ⟹   XP_038943917
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,439,922 - 83,450,449 (-)NCBI
RefSeq Acc Id: XM_039087990   ⟹   XP_038943918
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,443,150 - 83,450,011 (-)NCBI
RefSeq Acc Id: XM_039087991   ⟹   XP_038943919
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,439,922 - 83,450,172 (-)NCBI
RefSeq Acc Id: XM_039087992   ⟹   XP_038943920
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,439,922 - 83,450,073 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036853   ⟸   NM_012721
- UniProtKB: P51579 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017453371   ⟸   XM_017597882
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453372   ⟸   XM_017597883
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000002558   ⟸   ENSRNOT00000002558
RefSeq Acc Id: XP_038943917   ⟸   XM_039087989
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038943916   ⟸   XM_039087988
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943919   ⟸   XM_039087991
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038943920   ⟸   XM_039087992
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038943918   ⟸   XM_039087990
- Peptide Label: isoform X3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 90492933 90492934 G T snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (KNAW), ZFDM (KyushuU), MNS/Gib (KNAW), BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), FHL/EurMcwi (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 87441639 87441640 G T snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), MNS/Gib (RGD), FHL/EurMcwi (RGD), FHH/EurMcwi (RGD), CDR


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 85434839 85434840 C A snv FHH/EurMcwi (MDC), FHH/EurMcwi (MCW), MNS/Gib (ICL), FHH/EurMcwi (ICL), FHL/EurMcwi (ICL), FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3243 AgrOrtholog
Ensembl Genes ENSRNOG00000001873 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000002558 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002558 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot
InterPro P2X6_purnocptor UniProtKB/Swiss-Prot
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot
  P2X_purnocptor UniProtKB/Swiss-Prot
KEGG Report rno:25041 UniProtKB/Swiss-Prot
NCBI Gene 25041 ENTREZGENE
PANTHER PTHR10125:SF21 UniProtKB/Swiss-Prot
PhenoGen P2rx6 PhenoGen
PIRSF P2X_purinoceptor UniProtKB/Swiss-Prot
PRINTS P2X6RECEPTOR UniProtKB/Swiss-Prot
  P2XRECEPTOR UniProtKB/Swiss-Prot
PROSITE P2X_RECEPTOR UniProtKB/Swiss-Prot
TIGR TC210320
TIGRFAMs P2X UniProtKB/Swiss-Prot
UniProt P2RX6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary R9PXR5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2rx6  purinergic receptor P2X 6  P2rx6  purinergic receptor P2X, ligand-gated ion channel, 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 P2rx6  purinergic receptor P2X, ligand-gated ion channel, 6  P2rxl1  purinergic receptor P2X-like 1, orphan receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 P2rxl1  purinergic receptor P2X-like 1, orphan receptor    purinergic receptor P2X-like 1  Name updated 1299863 APPROVED
2002-11-06 P2rxl1  purinergic receptor P2X-like 1  P2x6  P2X6 receptor  Symbol and Name updated 625702 APPROVED
2002-06-10 P2x6  P2X6 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the P2X receptor family of ATP-gated ion channels 729425