Cbr1l1 (carbonyl reductase 1 like 1) - Rat Genome Database

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Gene: Cbr1l1 (carbonyl reductase 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cbr1l1 (Ensembl: Cbr1)
Name: carbonyl reductase 1 like 1 (Ensembl:carbonyl reductase)
RGD ID: 2286
Description: Enables carbonyl reductase (NADPH) activity. Involved in several processes, including ovulation from ovarian follicle; phylloquinone catabolic process; and prostaglandin catabolic process. Located in microvillus; nucleus; and plasma membrane. Biomarker of chronic kidney disease. Orthologous to human CBR1 (carbonyl reductase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; .
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 15-hydroxyprostaglandin dehydrogenase; 20-beta-hydroxysteroid dehydrogenase; alcohol dehydrogenase [NAD(P)+] CBR1; carbonyl reductase; carbonyl reductase 1; carbonyl reductase [NADPH] 1; Cbr; Cbr 1; Cbr1; MGC124927; NADPH-dependent carbonyl reductase 1; PG-9-KR; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21132,860,618 - 32,862,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,908,950 - 32,911,393 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1132,857,991 - 32,895,275 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,554,857 - 41,557,234 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01134,226,398 - 34,228,775 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01133,387,189 - 33,389,552 (+)NCBIRnor_WKY
Rnor_6.01133,813,041 - 33,815,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1133,845,463 - 33,847,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01137,436,992 - 37,439,368 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41133,787,957 - 33,790,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11133,844,199 - 33,846,562 (+)NCBI
Celera1132,503,106 - 32,505,469 (+)NCBICelera
RH 3.4 Map11248.5RGD
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Effect of experimental kidney disease on the functional expression of hepatic reductases. Alshogran OY, etal., Drug Metab Dispos. 2015 Jan;43(1):100-6. doi: 10.1124/dmd.114.061150. Epub 2014 Oct 20.
2. Identification of two closely related genes, inducible and noninducible carbonyl reductases in the rat ovary. Aoki H, etal., Biochem Biophys Res Commun 1997 Jan 23;230(3):518-23.
3. Effects of gonadectomy and steroid treatment on renal prostaglandin 9-ketoreductase activity in the rat. Cagen LM and Baer PG, Life Sci. 1987 Jan 5;40(1):95-100.
4. Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat. Espey LL and Richards JS, Biol Reprod. 2002 Dec;67(6):1662-70.
5. Characterization of ovarian carbonyl reductase gene expression during ovulation in the gonadotropin-primed immature Rat. Espey LL, etal., Biol Reprod 2000 Feb;62(2):390-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Differential hormonal regulation of carbonyl reductase activities in liver and kidney microsomes of rat. Imamura Y, etal., Xenobiotica 2002 Sep;32(9):729-37.
9. Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever. Ivanov AI, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Mar;284(3):R698-706. Epub 2002 Oct 24.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Proteomic and transcriptomic analysis for streptozotocin-induced diabetic rat pancreas in response to fungal polysaccharide treatments. Kim SW, etal., Proteomics. 2008 Jun;8(11):2344-61.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
15. New developments in anthracycline-induced cardiotoxicity. Mordente A, etal., Curr Med Chem. 2009;16(13):1656-72.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Mutation of threonine-241 to proline eliminates autocatalytic modification of human carbonyl reductase. Sciotti MA, etal., Biochem J. 2000 Aug 15;350 Pt 1:89-92.
21. Differences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acids. Sciotti MA, etal., FEBS Lett. 2006 Jan 9;580(1):67-71. Epub 2005 Dec 6.
22. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
23. Prostaglandin F synthase. Watanabe K, Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:401-7.
24. Cloning and expression of carbonyl reductase from rat testis. Wermuth B, etal., Eur J Biochem 1995 Mar 1;228(2):473-9.
25. Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions. Yuan H, etal., J Proteome Res. 2006 Feb;5(2):299-307.
Additional References at PubMed
PMID:1597188   PMID:8198567   PMID:12477932   PMID:15489334   PMID:16855179   PMID:18449627   PMID:19056867   PMID:19199708   PMID:19442656   PMID:21492153   PMID:23376485   PMID:23533145  
PMID:24769233   PMID:25931508  


Genomics

Variants

.
Variants in Cbr1l1
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:54
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000041838, ENSRNOT00000072384
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

Markers in Region
RH129182  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01137,407,584 - 37,407,747NCBIRnor5.0
Rnor_5.01137,457,286 - 37,457,456NCBIRnor5.0
Rnor_5.01137,439,156 - 37,439,319NCBIRnor5.0
RGSC_v3.41133,790,109 - 33,790,271UniSTSRGSC3.4
RGSC_v3.41133,807,779 - 33,807,941UniSTSRGSC3.4
Celera1132,505,258 - 32,505,420UniSTS
Cytogenetic Map11q11UniSTS
RH142185  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01137,438,302 - 37,438,475NCBIRnor5.0
Rnor_5.01137,406,730 - 37,406,903NCBIRnor5.0
Rnor_5.01137,456,432 - 37,456,605NCBIRnor5.0
RGSC_v3.41133,806,925 - 33,807,097UniSTSRGSC3.4
RGSC_v3.41133,789,255 - 33,789,427UniSTSRGSC3.4
Celera1132,504,404 - 32,504,576UniSTS
RH 3.4 Map11248.5UniSTS
Cytogenetic Map11q11UniSTS
BE099783  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01137,437,874 - 37,438,929NCBIRnor5.0
Rnor_5.01137,406,301 - 37,407,357NCBIRnor5.0
Rnor_5.01137,456,003 - 37,457,059NCBIRnor5.0
RGSC_v3.41133,806,497 - 33,807,551UniSTSRGSC3.4
RGSC_v3.41133,788,826 - 33,789,881UniSTSRGSC3.4
Celera1132,503,975 - 32,505,030UniSTS
RH 3.4 Map3208.9UniSTS
Cytogenetic Map11q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 1 44 20
Low 41 33 18 19 18 2 4 30 30 21 11 2
Below cutoff 1 22 22 1 22 6 7 1 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000041838   ⟹   ENSRNOP00000051107
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,985,707 - 32,992,000 (+)Ensembl
Rnor_6.0 Ensembl1133,845,463 - 33,847,793 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000042283   ⟹   ENSRNOP00000043385
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1133,812,989 - 33,815,418 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075985   ⟹   ENSRNOP00000067964
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1133,813,043 - 33,815,418 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112111
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,908,950 - 32,911,393 (+)Ensembl
RefSeq Acc Id: NM_019170   ⟹   NP_062043
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21132,860,618 - 32,862,981 (+)NCBI
Rnor_6.01133,813,041 - 33,815,418 (+)NCBI
Rnor_5.01137,436,992 - 37,439,368 (+)NCBI
RGSC_v3.41133,787,957 - 33,790,320 (+)RGD
Celera1132,503,106 - 32,505,469 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062043   ⟸   NM_019170
- UniProtKB: Q3KR58 (UniProtKB/Swiss-Prot),   P47727 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051107   ⟸   ENSRNOT00000041838
RefSeq Acc Id: ENSRNOP00000043385   ⟸   ENSRNOT00000042283
RefSeq Acc Id: ENSRNOP00000067964   ⟸   ENSRNOT00000075985

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47727-F1-model_v2 AlphaFold P47727 1-277 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2286 AgrOrtholog
BioCyc Gene G2FUF-21812 BioCyc
Ensembl Genes ENSRNOG00000047848 Ensembl
  ENSRNOG00000049693 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000049911 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051107.5 UniProtKB/TrEMBL
  ENSRNOP00000064050.2 UniProtKB/TrEMBL
  ENSRNOP00000067964.2 UniProtKB/TrEMBL
  ENSRNOP00000077145 ENTREZGENE
  ENSRNOP00000077145.1 UniProtKB/TrEMBL
  ENSRNOP00000081570.1 UniProtKB/TrEMBL
  ENSRNOP00000082202.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041838.6 UniProtKB/TrEMBL
  ENSRNOT00000072384.3 UniProtKB/TrEMBL
  ENSRNOT00000075105.3 UniProtKB/TrEMBL
  ENSRNOT00000075985.2 UniProtKB/TrEMBL
  ENSRNOT00000096883 ENTREZGENE
  ENSRNOT00000096883.1 UniProtKB/TrEMBL
  ENSRNOT00000114595.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7366019 IMAGE-MGC_LOAD
InterPro CBR1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29224 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124927 IMAGE-MGC_LOAD
NCBI Gene 29224 ENTREZGENE
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CBR1 RGD
PhenoGen Cbr1l1 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJ24_RAT UniProtKB/TrEMBL
  A0A0G2JSW9_RAT UniProtKB/TrEMBL
  A0A8I5XVU2_RAT UniProtKB/TrEMBL
  A0A8I5ZT21_RAT UniProtKB/TrEMBL
  A0A8I5ZUP5_RAT UniProtKB/TrEMBL
  CBR1_RAT UniProtKB/Swiss-Prot
  M0R3X6_RAT UniProtKB/TrEMBL
  P47727 ENTREZGENE
  Q3KR58 ENTREZGENE
UniProt Secondary O08558 UniProtKB/Swiss-Prot
  Q3KR58 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-18 Cbr1l1  carbonyl reductase 1 like 1  Cbr1  carbonyl reductase 1  Name and Symbol changed 629549 APPROVED
2002-06-10 Cbr1  carbonyl reductase 1      Symbol and Name status set to approved 70586 APPROVED
2001-12-06 Cbr 1  carbonyl reductase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis and ovaries 634702
gene_expression expressed in liver and kidneys 634703
gene_function NADPH-dependent oxidoreductase 69801
gene_function recombinant enzyme catalyzes its own modification by 2-oxoglutarate 69801
gene_process may be involved in ovarian follicular development 634702
gene_process may be involved in ovarian follicular development 1299856