Tiam1 (TIAM Rac1 associated GEF 1) - Rat Genome Database
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Gene: Tiam1 (TIAM Rac1 associated GEF 1) Rattus norvegicus
Analyze
Symbol: Tiam1
Name: TIAM Rac1 associated GEF 1
RGD ID: 1307455
Description: Exhibits Rac GTPase binding activity; microtubule binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; positive regulation of neurogenesis; and regulation of MAPK cascade. Localizes to several cellular components, including axon; extrinsic component of postsynaptic density membrane; and ruffle membrane. Colocalizes with microtubule. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1
Orthologs:
Homo sapiens (human) : TIAM1 (TIAM Rac1 associated GEF 1)  HGNC  Alliance
Mus musculus (house mouse) : Tiam1 (T cell lymphoma invasion and metastasis 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tiam1 (TIAM Rac1 associated GEF 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TIAM1 (TIAM Rac1 associated GEF 1)
Canis lupus familiaris (dog) : TIAM1 (TIAM Rac1 associated GEF 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tiam1 (TIAM Rac1 associated GEF 1)
Sus scrofa (pig) : TIAM1 (TIAM Rac1 associated GEF 1)
Chlorocebus sabaeus (African green monkey) : TIAM1 (TIAM Rac1 associated GEF 1)
Heterocephalus glaber (naked mole-rat) : Tiam1 (TIAM Rac1 associated GEF 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01129,931,083 - 30,061,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,551,577 - 33,681,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,123,752 - 30,252,936 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11130,128,732 - 30,252,936 (+)NCBI
Celera1128,721,403 - 28,849,496 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
1. Chandra R, etal., Front Mol Neurosci. 2013 May 24;6:13. doi: 10.3389/fnmol.2013.00013. eCollection 2013.
2. Connolly BA, etal., Mol Cell Biol. 2005 Jun;25(11):4602-14.
3. Duman JG, etal., J Neurosci. 2013 Apr 17;33(16):6964-78. doi: 10.1523/JNEUROSCI.3978-12.2013.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. GOA data from the GO Consortium
6. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
7. Henriquez DR, etal., PLoS One. 2012;7(12):e53123. doi: 10.1371/journal.pone.0053123. Epub 2012 Dec 27.
8. Kunda P, etal., J Neurosci. 2001 Apr 1;21(7):2361-72.
9. MGD data from the GO Consortium
10. Miyamoto Y, etal., Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10444-9. Epub 2006 Jun 26.
11. Otsuki Y, etal., J Biol Chem 2003 Feb 14;278(7):5132-40.
12. Pipeline to import KEGG annotations from KEGG into RGD
13. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Qi H, etal., Cell Growth Differ. 2001 Dec;12(12):603-11.
15. RGD automated data pipeline
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
19. Shirazi Fard S, etal., PLoS One. 2010 Mar 19;5(3):e9647. doi: 10.1371/journal.pone.0009647.
20. Tolias KF, etal., Neuron. 2005 Feb 17;45(4):525-38.
21. Veluthakal R, etal., Biochem Pharmacol. 2009 Jan 1;77(1):101-13. doi: 10.1016/j.bcp.2008.09.021. Epub 2008 Sep 27.
22. Vettel C, etal., J Mol Cell Cardiol. 2012 Aug;53(2):165-75. doi: 10.1016/j.yjmcc.2012.04.015. Epub 2012 May 4.
23. Xiao L, etal., Glia. 2013 Dec;61(12):2078-99. doi: 10.1002/glia.22578. Epub 2013 Oct 7.
24. Yamauchi J, etal., Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14889-94. Epub 2005 Oct 3.
25. Zhang H and Macara IG, Nat Cell Biol. 2006 Mar;8(3):227-37. Epub 2006 Feb 12.
Additional References at PubMed
PMID:8889548   PMID:12024021   PMID:12525493   PMID:14988728   PMID:15723051   PMID:17440041   PMID:18006851   PMID:18805958   PMID:20332120   PMID:20361982   PMID:20826792   PMID:22750946  
PMID:23109420   PMID:23533177   PMID:25032858   PMID:25248834   PMID:25931508   PMID:31597723  


Genomics

Comparative Map Data
Tiam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01129,931,083 - 30,061,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,551,577 - 33,681,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,123,752 - 30,252,936 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11130,128,732 - 30,252,936 (+)NCBI
Celera1128,721,403 - 28,849,496 (-)NCBICelera
Cytogenetic Map11q11NCBI
TIAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2131,118,416 - 31,559,977 (-)EnsemblGRCh38hg38GRCh38
GRCh382131,118,418 - 31,559,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372132,490,736 - 32,931,290 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,412,607 - 31,853,161 (-)NCBINCBI36hg18NCBI36
Build 342131,238,437 - 31,853,161NCBI
Celera2117,673,700 - 18,114,602 (-)NCBI
Cytogenetic Map21q22.11ENTREZGENE
HuRef2117,900,683 - 18,341,390 (-)NCBIHuRef
CHM1_12132,052,512 - 32,493,303 (-)NCBICHM1_1
Tiam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391689,583,999 - 89,942,488 (-)NCBI
GRCm381689,787,111 - 90,145,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1689,787,111 - 90,143,769 (-)EnsemblGRCm38mm10GRCm38
MGSCv371689,787,356 - 89,974,944 (-)NCBIGRCm37mm9NCBIm37
MGSCv361689,675,971 - 89,849,686 (-)NCBImm8
Celera1689,988,286 - 90,179,618 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.5NCBI
Tiam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540730,803,653 - 30,942,854 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540730,804,769 - 31,178,420 (-)NCBIChiLan1.0ChiLan1.0
TIAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12130,868,308 - 31,213,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2130,868,308 - 31,016,883 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02117,483,273 - 17,925,301 (-)NCBI
TIAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3125,932,697 - 26,202,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13126,058,858 - 26,440,059 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tiam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493650010,451,599 - 10,812,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13194,745,850 - 195,234,325 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113194,774,495 - 195,235,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,172,464 - 205,307,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIAM1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl260,865,819 - 61,017,191 (+)Ensembl
ChlSab1.1260,573,187 - 61,015,599 (+)NCBI
Tiam1
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
D11Got22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01130,119,772 - 30,119,937NCBIRnor6.0
Rnor_5.01133,740,395 - 33,740,560UniSTSRnor5.0
RGSC_v3.41130,064,375 - 30,064,541RGDRGSC3.4
RGSC_v3.41130,064,376 - 30,064,541UniSTSRGSC3.4
RGSC_v3.11130,064,376 - 30,064,541RGD
Celera1128,907,774 - 28,907,939UniSTS
Cytogenetic Map11q11UniSTS
RH 3.4 Map11195.7RGD
RH 3.4 Map11195.7UniSTS
RH 2.0 Map11480.6RGD
RH132417  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,932,318 - 29,932,521NCBIRnor6.0
Rnor_5.01133,552,812 - 33,553,015UniSTSRnor5.0
RGSC_v3.41130,251,498 - 30,251,701UniSTSRGSC3.4
Celera1128,722,640 - 28,722,843UniSTS
Cytogenetic Map11q11UniSTS
RH 3.4 Map11165.0UniSTS
RH132792  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,931,304 - 29,931,492NCBIRnor6.0
Rnor_5.01133,551,798 - 33,551,986UniSTSRnor5.0
RGSC_v3.41130,252,527 - 30,252,715UniSTSRGSC3.4
Celera1128,721,624 - 28,721,812UniSTS
Cytogenetic Map11q11UniSTS
RH 3.4 Map11165.0UniSTS
RH141943  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01130,036,774 - 30,036,965NCBIRnor6.0
Rnor_5.01133,656,825 - 33,657,016UniSTSRnor5.0
RGSC_v3.41130,149,500 - 30,149,691UniSTSRGSC3.4
Celera1128,825,226 - 28,825,417UniSTS
Cytogenetic Map11q11UniSTS
RH 3.4 Map11165.5UniSTS
AW532393  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01130,051,658 - 30,051,849NCBIRnor6.0
Rnor_5.01133,672,451 - 33,672,642UniSTSRnor5.0
RGSC_v3.41130,132,891 - 30,133,082UniSTSRGSC3.4
Celera1128,840,124 - 28,840,315UniSTS
Cytogenetic Map11q11UniSTS
RH 3.4 Map11169.3UniSTS
TIAM1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01129,933,435 - 29,933,622NCBIRnor6.0
Rnor_5.01133,553,929 - 33,554,116UniSTSRnor5.0
RGSC_v3.41130,250,397 - 30,250,584UniSTSRGSC3.4
Celera1128,723,757 - 28,723,944UniSTS
Cytogenetic Map11q11UniSTS
ha2436  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01130,040,126 - 30,040,865NCBIRnor6.0
Rnor_6.01572,750,995 - 72,751,679NCBIRnor6.0
Rnor_5.01133,660,708 - 33,661,447UniSTSRnor5.0
Rnor_5.01576,323,888 - 76,324,572UniSTSRnor5.0
Celera1128,828,579 - 28,829,318UniSTS
Celera1564,851,043 - 64,851,727UniSTS
Cytogenetic Map11q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11133867429Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)1132503169342559Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11935127454351274Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111136730644444347Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111632197346583360Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)112194422966944229Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)112194422966944229Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)112204314944444112Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112540112970401129Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112572003870720038Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112572003870720038Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:218
Interacting mature miRNAs:258
Transcripts:ENSRNOT00000046486
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 2 2 2 72 4 29
Low 3 29 41 25 19 25 7 7 2 31 12 11 7
Below cutoff 8 14 14 14 1 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046486   ⟹   ENSRNOP00000044001
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)Ensembl
RefSeq Acc Id: NM_001100558   ⟹   NP_001094028
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01129,931,083 - 30,061,173 (-)NCBI
Rnor_5.01133,551,577 - 33,681,966 (-)NCBI
RGSC_v3.41130,123,752 - 30,252,936 (+)RGD
Celera1128,721,403 - 28,849,496 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD91170 (Get FASTA)   NCBI Sequence Viewer  
  EDM10680 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001094028   ⟸   NM_001100558
- Sequence:
RefSeq Acc Id: ENSRNOP00000044001   ⟸   ENSRNOT00000046486
Protein Domains
DH   PDZ   PH   RBD

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307455 AgrOrtholog
Ensembl Genes ENSRNOG00000021569 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044001 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046486 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Raf-like_ras-bd UniProtKB/TrEMBL
  TIAM1 UniProtKB/TrEMBL
  Tiam1/Tiam2/Sif UniProtKB/TrEMBL
  TIAM1_CC-Ex UniProtKB/TrEMBL
NCBI Gene 304109 ENTREZGENE
PANTHER PTHR46001 UniProtKB/TrEMBL
  PTHR46001:SF1 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  Tiam_CC_Ex UniProtKB/TrEMBL
PhenoGen Tiam1 PhenoGen
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
UniGene Rn.35587 ENTREZGENE
UniProt D3ZWV8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Tiam1  TIAM Rac1 associated GEF 1  Tiam1  T-cell lymphoma invasion and metastasis 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tiam1  T-cell lymphoma invasion and metastasis 1  Tiam1_predicted  T-cell lymphoma invasion and metastasis 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tiam1_predicted  T-cell lymphoma invasion and metastasis 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.