Gene: Comt (catechol-O-methyltransferase) Rattus norvegicus
Symbol: Comt
Name: catechol-O-methyltransferase
Description: ENCODES a protein that exhibits catechol O-methyltransferase activity; INVOLVED IN developmental process; estrogen metabolic process; female pregnancy; PARTICIPATES IN alkaptonuria disease pathway; disulfiram pharmacodynamics pathway; dopamine beta hydroxylase deficiency pathway; ASSOCIATED WITH abnormal dopamine level; ASSOCIATED WITH Brain Injuries; Catalepsy; Diabetes Mellitus, Experimental; FOUND IN axon; cell body; cytosol; INTERACTS WITH (-)-epigallocatechin 3-gallate; (3,4-dihydroxyphenyl)acetic acid; (R)-adrenaline
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: catechol O-methyltransferase; catecholamine-O-methyltransferase
Homo sapiens (human) : COMT (catechol-O-methyltransferase)  HGNC  AGR
Mus musculus (house mouse) : Comt (catechol-O-methyltransferase)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Comt (catechol-O-methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : COMT (catechol-O-methyltransferase)
Canis lupus familiaris (dog) : COMT (catechol-O-methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Comt (catechol-O-methyltransferase)
more info ...
Allele / Splice: Comtem1Mcwi  
Genetic Models: SS-Comtem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBICelera
Cytogenetic Map11q23NCBI
RH 3.4 Map11712.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Comt
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2379
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-28
Status: ACTIVE