Comt (catechol-O-methyltransferase) - Rat Genome Database

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Gene: Comt (catechol-O-methyltransferase) Rattus norvegicus
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Symbol: Comt
Name: catechol-O-methyltransferase
RGD ID: 2379
Description: Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of smooth muscle cell proliferation; and regulation of cellular amine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (3,4-dihydroxyphenyl)acetic acid; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: catechol O-methyltransferase; catecholamine-O-methyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Comtem1Mcwi  
Genetic Models: SS-Comtem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,568,052 - 82,587,642 (+)NCBI
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBICelera
RH 3.4 Map11712.2RGD
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Pain  (ISO)
alcohol use disorder  (ISO)
amphetamine abuse  (ISO)
Animal Mammary Neoplasms  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bulimia nervosa  (ISO)
Catalepsy  (IMP)
Chemical and Drug Induced Liver Injury  (IEP)
Child Behavior Disorders  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
DiGeorge syndrome  (ISO)
dilated cardiomyopathy  (ISO)
disease of mental health  (ISO)
Drug-Induced Dyskinesia  (IMP)
endometrial cancer  (ISO)
epilepsy  (ISO)
eumycotic mycetoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IDA)
familial hypertrophic cardiomyopathy  (ISO)
Fatigue  (ISO)
Fetal Growth Retardation  (ISO)
fibromyalgia  (ISO)
Hearing Loss, Cisplatin-Induced  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
hypertension  (IDA,IEP,ISO)
intellectual disability  (ISO)
leiomyoma  (ISO)
Lymphatic Metastasis  (ISO)
Memory Disorders  (ISO)
Musculoskeletal Pain  (ISO)
Neck Pain  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
ovarian cancer  (ISO)
Pain  (IMP,ISO)
panic disorder  (ISO)
Parkinsonism  (IMP)
pheochromocytoma  (ISO)
polycystic ovary syndrome  (ISO)
pre-eclampsia  (ISS)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
Schizophrenia Spectrum and Other Psychotic Disorders  (ISO)
Temporomandibular Joint Disorders  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(3,4-dihydroxyphenyl)acetic acid  (EXP,ISO)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxy-17beta-estradiol  (EXP,ISO)
2-methoxy-17beta-estradiol  (ISO)
3',4'-dihydroxyacetophenone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-dihydroxyacetophenone  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-dihydroxymandelic acid  (ISO)
3,4-dihydroxyphenylethyleneglycol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methoxycatechol  (ISO)
3-O-methylgallic acid  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-chlorocatechol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylcatechol  (EXP,ISO)
4-nitrocatechol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-Hydroxydopamine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
alcohol  (ISO)
all-trans-retinoic acid  (ISO)
alpha-methyl-L-dopa  (ISO)
aminoglutethimide  (ISO)
amitraz  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
anthracene  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (EXP,ISO)
ATP  (ISO)
bathocuproine disulfonic acid  (ISO)
benserazide  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbidopa  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
catechol  (EXP,ISO)
CGP 28014  (ISO)
chlorpyrifos  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
diuron  (EXP)
dobutamine  (EXP,ISO)
dopamine  (EXP,ISO)
edaravone  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entacapone  (EXP,ISO)
epoxiconazole  (EXP)
esculetin  (ISO)
estrone  (ISO)
fenbuconazole  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
fluoranthene  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
guaiacol  (ISO)
hemin  (ISO)
hexachlorobenzene  (ISO)
homocysteine  (ISO)
homovanillic acid  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
kojic acid  (EXP)
lactacystin  (ISO)
lamivudine  (ISO)
megestrol acetate  (ISO)
melevodopa  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Metanephrine  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
mianserin  (ISO)
modafinil  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
myricetin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
naphthalene-2,3-diol  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (EXP)
nickel sulfate  (ISO)
Nitecapone  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
Oleacein  (ISO)
oxidopamine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorobenzene  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrene  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
rac-3,4-methylenedioxy-N-ethylamphetamine  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
S-adenosyl-L-homocysteine  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
silicon dioxide  (EXP,ISO)
simazine  (EXP,ISO)
SKF 38393  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachlorocatechol  (ISO)
tetrachloromethane  (EXP,ISO)
tolcapone  (EXP,ISO)
trans-caffeic acid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
tropolone  (EXP)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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Additional References at PubMed
PMID:1765063   PMID:8127373   PMID:9520487   PMID:10785817   PMID:11559542   PMID:12237326   PMID:15167541   PMID:15489334   PMID:15645182   PMID:16396499   PMID:16508109   PMID:18614015  
PMID:18831714   PMID:19056347   PMID:19056867   PMID:19111934   PMID:19909795   PMID:19930170   PMID:19946888   PMID:19966533   PMID:20374420   PMID:21116937   PMID:21428728   PMID:21851556  
PMID:22071171   PMID:22384243   PMID:23376485   PMID:23533145   PMID:23863468   PMID:24727346   PMID:25560240   PMID:27215035   PMID:33503461  


Genomics

Comparative Map Data
Comt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,568,052 - 82,587,642 (+)NCBI
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBICelera
RH 3.4 Map11712.2RGD
Cytogenetic Map11q23NCBI
COMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2219,941,371 - 19,969,975 (+)EnsemblGRCh38hg38GRCh38
GRCh382219,941,772 - 19,969,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,929,295 - 19,957,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,309,309 - 18,336,530 (+)NCBINCBI36hg18NCBI36
Build 342218,324,623 - 18,331,084NCBI
Celera223,780,539 - 3,808,699 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,549,825 - 3,577,976 (+)NCBIHuRef
CHM1_12219,929,027 - 19,957,208 (+)NCBICHM1_1
Comt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,225,632 - 18,247,006 (-)NCBIGRCm39mm39
GRCm39 Ensembl1618,225,636 - 18,245,602 (-)Ensembl
GRCm381618,406,882 - 18,426,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,406,886 - 18,426,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,406,975 - 18,426,809 (-)NCBIGRCm37mm9NCBIm37
MGSCv361618,321,106 - 18,340,078 (-)NCBImm8
Celera1618,980,657 - 19,001,067 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.4NCBI
Comt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,130,987 - 18,137,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,130,282 - 18,152,153 (-)NCBIChiLan1.0ChiLan1.0
COMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12218,375,434 - 18,402,387 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,375,434 - 18,402,387 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0222,704,015 - 2,731,326 (+)NCBIMhudiblu_PPA_v0panPan3
COMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,359,930 - 29,381,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,360,356 - 29,366,008 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,318,554 - 29,324,118 (-)NCBI
ROS_Cfam_1.02630,763,075 - 30,783,341 (-)NCBI
UMICH_Zoey_3.12628,811,616 - 28,817,179 (-)NCBI
UNSW_CanFamBas_1.02628,436,974 - 28,442,538 (-)NCBI
UU_Cfam_GSD_1.02629,522,581 - 29,528,148 (-)NCBI
Comt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,870,188 - 138,906,864 (-)NCBI
SpeTri2.0NW_0049366193,847,059 - 3,883,866 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,385,133 - 51,403,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,384,729 - 51,403,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,021,681 - 55,040,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,775,829 - 5,803,260 (-)NCBI
ChlSab1.1 Ensembl195,773,225 - 5,785,422 (-)Ensembl
Vero_WHO_p1.0NW_0236660851,128,529 - 1,156,766 (+)NCBI
Comt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624747569,127 - 588,479 (+)NCBI

Position Markers
D11Mgh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,553 - 82,566,702 (+)MAPPER
Rnor_6.01186,714,483 - 86,714,631NCBIRnor6.0
Rnor_5.01189,808,355 - 89,808,503UniSTSRnor5.0
RGSC_v3.41184,560,092 - 84,560,241RGDRGSC3.4
RGSC_v3.41184,560,093 - 84,560,241UniSTSRGSC3.4
RGSC_v3.11184,600,689 - 84,600,838RGD
Celera1181,343,623 - 81,343,771UniSTS
SHRSP x BN Map1138.1899UniSTS
SHRSP x BN Map1138.1899RGD
FHH x ACI Map1157.2499RGD
Cytogenetic Map11q23UniSTS
D11Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,545 - 82,566,718 (+)MAPPER
Rnor_6.01186,714,475 - 86,714,647NCBIRnor6.0
Rnor_5.01189,808,347 - 89,808,519UniSTSRnor5.0
RGSC_v3.41184,560,085 - 84,560,257UniSTSRGSC3.4
Celera1181,343,615 - 81,343,787UniSTS
Cytogenetic Map11q23UniSTS
D11Mgh8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01186,725,629 - 86,725,869NCBIRnor6.0
Rnor_5.01189,819,501 - 89,819,807UniSTSRnor5.0
RGSC_v3.41184,571,239 - 84,571,952UniSTSRGSC3.4
Celera1181,354,769 - 81,354,947UniSTS
Cytogenetic Map11q23UniSTS
RH128045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,587,179 - 82,587,373 (+)MAPPER
Rnor_6.01186,735,169 - 86,735,362NCBIRnor6.0
Rnor_5.01189,829,107 - 89,829,300UniSTSRnor5.0
RGSC_v3.41184,581,252 - 84,581,445UniSTSRGSC3.4
Celera1181,364,244 - 81,364,437UniSTS
RH 3.4 Map11697.1UniSTS
Cytogenetic Map11q23UniSTS
RH94723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,587,393 - 82,587,563 (+)MAPPER
Rnor_6.01186,735,383 - 86,735,551NCBIRnor6.0
Rnor_5.01189,829,321 - 89,829,489UniSTSRnor5.0
RGSC_v3.41184,581,466 - 84,581,634UniSTSRGSC3.4
Celera1181,364,458 - 81,364,626UniSTS
RH 3.4 Map11712.2UniSTS
Cytogenetic Map11q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117272002986994795Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)118035840887200449Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118671447587444587Rat


Genetic Models
This gene Comt is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:166
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000050269
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 1 1
Medium 3 43 56 40 19 40 7 10 74 35 41 11 7
Low 1 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK478774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM443074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM443075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M93257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z12651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000050269   ⟹   ENSRNOP00000043148
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)Ensembl
RefSeq Acc Id: NM_012531   ⟹   NP_036663
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,568,052 - 82,587,642 (+)NCBI
Rnor_6.01186,715,981 - 86,735,630 (+)NCBI
Rnor_5.01189,809,853 - 89,829,568 (+)NCBI
RGSC_v3.41184,561,591 - 84,581,713 (+)RGD
Celera1181,345,121 - 81,364,705 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248603   ⟹   XP_006248665
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,579,756 - 82,587,642 (+)NCBI
Rnor_6.01186,727,725 - 86,735,630 (+)NCBI
Rnor_5.01189,809,853 - 89,829,568 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036663   ⟸   NM_012531
- UniProtKB: P22734 (UniProtKB/Swiss-Prot),   F2W8B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248665   ⟸   XM_006248603
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000043148   ⟸   ENSRNOT00000050269

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698304
Promoter ID:EPDNEW_R8827
Type:initiation region
Name:Comt_1
Description:catechol-O-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,715,939 - 86,715,999EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2379 AgrOrtholog
Ensembl Genes ENSRNOG00000001889 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000043148 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050269 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191956 IMAGE-MGC_LOAD
InterPro Catechol_O-MeTrfase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_O-MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93639 IMAGE-MGC_LOAD
NCBI Gene 24267 ENTREZGENE
Pfam Methyltransf_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB COMT RGD
PhenoGen Comt PhenoGen
PIRSF Catechol_O-mtfrase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SAM_OMT_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt COMT_RAT UniProtKB/Swiss-Prot
  F2W8B0 ENTREZGENE, UniProtKB/TrEMBL
  P22734 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Comt  catechol-O-methyltransferase    catecholamine-O-methyltransferase  Name updated 629478 APPROVED
2002-06-10 Comt  catecholamine-O-methyltransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function transfers a methyl group from S-adenosylmethionine to catecholamines  
gene_process shortens the biological half-lives of certain neuroactive drugs  
gene_process has a role in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease