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Gene: Comt (catechol-O-methyltransferase) Rattus norvegicus
Symbol: Comt
Name: catechol-O-methyltransferase
Description: Exhibits catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of smooth muscle cell proliferation; and regulation of cellular amine metabolic process. Localizes to several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Used to study hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; bulimia nervosa; cognitive disorder (multiple); eumycotic mycetoma; and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (3,4-dihydroxyphenyl)acetic acid; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: catechol O-methyltransferase; catecholamine-O-methyltransferase
Homo sapiens (human) : COMT (catechol-O-methyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Comt (catechol-O-methyltransferase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Comt (catechol-O-methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : COMT (catechol-O-methyltransferase)
Canis lupus familiaris (dog) : COMT (catechol-O-methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Comt (catechol-O-methyltransferase)
Sus scrofa (pig) : COMT (catechol-O-methyltransferase)
Chlorocebus sabaeus (African green monkey) : COMT (catechol-O-methyltransferase)
Heterocephalus glaber (naked mole-rat) : Comt (catechol-O-methyltransferase)
more info ...
Allele / Splice: Comtem1Mcwi  
Genetic Models: SS-Comtem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBICelera
Cytogenetic Map11q23NCBI
RH 3.4 Map11712.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Comt
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2379
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.