Comt (catechol-O-methyltransferase) - Rat Genome Database

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Gene: Comt (catechol-O-methyltransferase) Rattus norvegicus
Symbol: Comt
Name: catechol-O-methyltransferase
RGD ID: 2379
Description: Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of smooth muscle cell proliferation; and regulation of amine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynapse. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (3,4-dihydroxyphenyl)acetic acid; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: catechol O-methyltransferase; catecholamine-O-methyltransferase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Comtem1Mcwi  
Genetic Models: SS-Comtem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21182,568,052 - 82,587,642 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,568,025 - 82,587,642 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,296,452 - 91,316,037 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01183,957,676 - 83,977,261 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01183,011,188 - 83,030,773 (+)NCBIRnor_WKY
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBICelera
RH 3.4 Map11712.2RGD
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Pain  (ISO)
alcohol use disorder  (ISO)
amphetamine abuse  (ISO)
Animal Mammary Neoplasms  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
Bardet-Biedl syndrome  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bulimia nervosa  (ISO)
Catalepsy  (IMP)
Chemical and Drug Induced Liver Injury  (IEP)
Child Behavior Disorders  (ISO)
chromosome 22q11.2 deletion syndrome, distal  (ISO)
chromosome 22q11.2 microduplication syndrome  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
DiGeorge syndrome  (ISO)
dilated cardiomyopathy  (ISO)
disease of mental health  (ISO)
Drug-Induced Dyskinesia  (IMP)
Dwarfism  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
eumycotic mycetoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IDA)
familial hypertrophic cardiomyopathy  (ISO)
Fatigue  (ISO)
Fetal Growth Retardation  (ISO)
fibromyalgia  (ISO)
genetic disease  (ISO)
Glucocorticoid Deficiency 5  (ISO)
Hearing Loss, Cisplatin-Induced  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
hypertension  (IDA,IEP,ISO)
immunodeficiency 51  (ISO)
intellectual disability  (ISO)
leiomyoma  (ISO)
Lymphatic Metastasis  (ISO)
megacolon  (ISO)
Memory Disorders  (ISO)
Musculoskeletal Pain  (ISO)
Neck Pain  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
ovarian cancer  (ISO)
Pain  (IMP,ISO)
panic disorder  (ISO)
Parkinsonism  (IMP)
pheochromocytoma  (ISO)
Polyarteritis Nodosa, Childhood-Onset  (ISO)
polycystic ovary syndrome  (ISO)
pre-eclampsia  (ISS)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
Schizophrenia Spectrum and Other Psychotic Disorders  (ISO)
Temporomandibular Joint Disorders  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
velocardiofacial syndrome  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(3,4-dihydroxyphenyl)acetic acid  (EXP,ISO)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxy-17beta-estradiol  (EXP,ISO)
2-methoxy-17beta-estradiol  (ISO)
3',4'-dihydroxyacetophenone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-dihydroxyacetophenone  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-dihydroxymandelic acid  (ISO)
3,4-dihydroxyphenylethyleneglycol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methoxycatechol  (ISO)
3-O-methylgallic acid  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-chlorocatechol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylcatechol  (EXP,ISO)
4-nitrocatechol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-Hydroxydopamine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alcohol  (ISO)
all-trans-retinoic acid  (ISO)
alpha-methyl-L-dopa  (ISO)
aminoglutethimide  (ISO)
amitraz  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
anthracene  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
bathocuproine disulfonic acid  (ISO)
benserazide  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbidopa  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
catechol  (EXP,ISO)
CGP 28014  (ISO)
chlorpyrifos  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
daidzein  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
diuron  (EXP)
dobutamine  (EXP,ISO)
dopamine  (EXP,ISO)
edaravone  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entacapone  (EXP,ISO)
epoxiconazole  (EXP)
esculetin  (ISO)
estrone  (ISO)
fenbuconazole  (ISO)
fenthion  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
fluoranthene  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
guaiacol  (ISO)
hemin  (ISO)
hexachlorobenzene  (ISO)
homocysteine  (ISO)
homovanillic acid  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
ionomycin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
kojic acid  (EXP)
lactacystin  (ISO)
lamivudine  (ISO)
megestrol acetate  (ISO)
melevodopa  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Metanephrine  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
mianserin  (ISO)
modafinil  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
myricetin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
naphthalene-2,3-diol  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (EXP)
nickel sulfate  (ISO)
Nitecapone  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
Oleacein  (ISO)
oxidopamine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
pentachlorobenzene  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrene  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
rac-3,4-methylenedioxy-N-ethylamphetamine  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
silicon dioxide  (EXP,ISO)
simazine  (EXP,ISO)
SKF 38393  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachlorocatechol  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
tolcapone  (EXP,ISO)
trans-caffeic acid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
tropolone  (EXP)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in different ethnic groups. Al-Hendy A and Salama SA, J Soc Gynecol Investig. 2006 Feb;13(2):136-44.
2. Association between the COMT locus and obsessive-compulsive disorder in females but not males. Alsobrook JP 2nd, etal., Am J Med Genet 2002 Jan 8;114(1):116-20.
3. Immunohistochemical localization of catechol methyltransferase in normal and cancerous breast tissues of mice and rats. Amin AM, etal., J Natl Cancer Inst. 1983 Feb;70(2):337-42.
4. Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development. Chen J, etal., J Biol Chem. 2011 Oct 7;286(40):34752-60. doi: 10.1074/jbc.M111.262790. Epub 2011 Aug 16.
5. Chronic antipsychotics treatment regulates MAOA, MAOB and COMT gene expression in rat frontal cortex. Chen ML and Chen CH, J Psychiatr Res. 2007 Jan-Feb;41(1-2):57-62. Epub 2005 Jun 17.
6. Chronic treatment with aripiprazole induces differential gene expression in the rat frontal cortex. Cheng MC, etal., Int J Neuropsychopharmacol. 2007 Sep 17;:1-10.
7. Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. Cunningham JM, etal., Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78.
8. The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder. Dickerson FB, etal., Bipolar Disord. 2006 Apr;8(2):124-32.
9. Methoxyestradiols mediate the antimitogenic effects of estradiol on vascular smooth muscle cells via estrogen receptor-independent mechanisms. Dubey RK, etal., Biochem Biophys Res Commun. 2000 Nov 11;278(1):27-33.
10. Determination of differential activities of soluble and membrane-bound catechol-O-methyltransferase in tissues and erythrocytes. Ellingson T, etal., J Chromatogr B Biomed Sci Appl. 1999 Jun 11;729(1-2):347-53.
11. Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. Fernandez-de-las-Penas C, etal., Breast Cancer Res Treat. 2012 Jun;133(2):405-12. doi: 10.1007/s10549-011-1757-y. Epub 2011 Sep 4.
12. Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis. Fernández-de-las-Peñas C, etal., J Pain. 2013 Dec;14(12):1719-23. doi: 10.1016/j.jpain.2013.09.007. Epub 2013 Sep 28.
13. Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer. Garner EI, etal., Cancer Res. 2002 Jun 1;62(11):3058-62.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk. Gellekink H, etal., Thromb Haemost. 2007 Dec;98(6):1226-31.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Gogos JA, etal., Proc Natl Acad Sci U S A 1998 Aug 18;95(17):9991-6.
18. Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk. Goodman JE, etal., Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1373-6.
19. Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusion. Helkamaa T, etal., Neurochem Int. 2007 Nov-Dec;51(6-7):412-23. Epub 2007 May 6.
20. Measurement of catechol-O-methyltransferase activity in the brain of Dahl salt-sensitive rats. Hirano Y, etal., Biol Pharm Bull. 2007 Nov;30(11):2178-80.
21. Suppression of catechol-O-methyltransferase activity through blunting of alpha2-adrenoceptor can explain hypertension in Dahl salt-sensitive rats. Hirano Y, etal., Hypertens Res. 2007 Mar;30(3):269-78.
22. A multigenic study on breast cancer risk associated with genetic polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 negative Shanghai women with early onset breast cancer or affected relatives. Hu Z, etal., J Cancer Res Clin Oncol. 2007 Dec;133(12):969-78. Epub 2007 Jun 12.
23. Activation of catechol-O-methyltransferase in astrocytes stimulates homocysteine synthesis and export to neurons. Huang G, etal., Glia. 2005 Jul;51(1):47-55.
24. Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism. Inanir A, etal., Xenobiotica. 2014 Oct;44(10):952-6. doi: 10.3109/00498254.2014.913083. Epub 2014 Apr 24.
25. Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma -synuclein, and catechol-o-methyltransferase) identified by proteomic analysis. Iwaki H, etal., Cancer Sci. 2004 Dec;95(12):955-61.
26. Catechol-O-methyltransferase (COMT) inhibition reduces spinal nociceptive activity. Jacobsen LM, etal., Neurosci Lett. 2010 Apr 12;473(3):212-5. doi: 10.1016/j.neulet.2010.02.049. Epub 2010 Feb 26.
27. Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease. Jhun E, etal., Anesth Analg. 2014 Nov;119(5):1201-7. doi: 10.1213/ANE.0000000000000382.
28. Inhibitors of catechol-O-methyltransferase sensitize mice to pain. Kambur O, etal., Br J Pharmacol. 2010 Dec;161(7):1553-65. doi: 10.1111/j.1476-5381.2010.00999.x.
29. Association of genetic polymorphisms of ACADSB and COMT with human hypertension. Kamide K, etal., J Hypertens. 2007 Jan;25(1):103-10.
30. Catechol-O-methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein. Karhunen T, etal., Neurosci Lett. 1995 Feb 24;187(1):57-60.
31. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
32. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
33. Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition. Laatikainen LM, etal., J Psychopharmacol. 2012 Dec;26(12):1561-8. doi: 10.1177/0269881112454228. Epub 2012 Jul 19.
34. Microarray analysis of differentially expressed genes associated with human ovarian cancer. Lee BC, etal., Int J Oncol. 2004 Apr;24(4):847-51.
35. A functional single-nucleotide polymorphism in the catechol-O-methyltransferase gene alter vitiligo risk in a Chinese population. Li K, etal., Arch Dermatol Res. 2009 Oct;301(9):681-7. doi: 10.1007/s00403-008-0920-8. Epub 2008 Dec 28.
36. COMT genotype and response to cognitive remediation in schizophrenia. Lindenmayer JP, etal., Schizophr Res. 2015 Oct;168(1-2):279-84. doi: 10.1016/j.schres.2015.07.037. Epub 2015 Aug 6.
37. Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Long JR, etal., Pharmacogenet Genomics. 2007 May;17(5):331-8.
38. Early administration of entacapone prevents levodopa-induced motor fluctuations in hemiparkinsonian rats. Marin C, etal., Exp Neurol. 2005 Mar;192(1):184-93.
39. Coadministration of entacapone with levodopa attenuates the severity of dyskinesias in hemiparkinsonian rats. Marin C, etal., Mov Disord. 2006 May;21(5):646-53.
40. Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase. Matsui A, etal., Cancer Lett. 2000 Mar 13;150(1):23-31.
41. Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Matsumoto M, etal., Neuroscience 2003;116(1):127-37.
42. Analysis of oxidative stress status, catalase and catechol-o-methyltransferase polymorphisms in egyptian vitiligo patients. Mehaney DA, etal., PLoS One. 2014 Jun 10;9(6):e99286. doi: 10.1371/journal.pone.0099286. eCollection 2014.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Nackley AG, etal., Pain. 2007 Apr;128(3):199-208. Epub 2006 Nov 7.
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. Regulation of dopamine-induced natriuresisby the dopamine-metabolizing enzyme catechol-O-methyltransferase. Odlind C, etal., Exp Nephrol. 1999 Jul-Aug;7(4):314-22.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
49. The Effect of Single Dose Methylphenidate on Neurometabolites according to COMT Gene Val158Met Polymorphism in the Patient with Attention Deficit Hyperactivity Disorder: A Study Using Magnetic Resonance Spectroscopy. Ozturk O, etal., Clin Psychopharmacol Neurosci. 2016 May 31;14(2):184-93. doi: 10.9758/cpn.2016.14.2.184.
50. Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor. Palma PN, etal., Drug Metab Dispos 2003 Mar;31(3):250-8.
51. Catechol-o-methyltransferase and methoxyestradiols participate in the intraoviductal nongenomic pathway through which estradiol accelerates egg transport in cycling rats. Parada-Bustamante A, etal., Biol Reprod. 2007 Dec;77(6):934-41. Epub 2007 Aug 15.
52. Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality. Park BL, etal., J Hum Genet. 2009 Dec;54(12):709-12. doi: 10.1038/jhg.2009.102. Epub 2009 Oct 30.
53. Developmental changes in the activity of catechol-O-methyl transferase in rat and rabbit fetuses. Parvez H, etal., J Neural Transm. 1979;44(1-2):65-75.
54. Methyl conjugation in uraemia: catechol-O-methyltransferase. Pazmino PA and Weinshilboum RM, Br J Clin Pharmacol. 1980 Nov;10(5):509-18.
55. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
56. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
57. The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis. Polak PE, etal., J Neuroimmunol. 2014 Nov 15;276(1-2):135-41. doi: 10.1016/j.jneuroim.2014.09.004. Epub 2014 Sep 16.
58. Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant. Pálmason H, etal., J Neural Transm (Vienna). 2010 Feb;117(2):259-67. doi: 10.1007/s00702-009-0338-2. Epub 2009 Nov 28.
59. Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes. Radoeva PD, etal., Psychiatr Genet. 2014 Dec;24(6):269-72. doi: 10.1097/YPG.0000000000000062.
60. Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia. Redell JB and Dash PK, Neurosci Lett. 2007 Feb 8;413(1):36-41. Epub 2006 Dec 15.
61. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
62. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
63. Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas. Salama SA, etal., Fertil Steril. 2006 Jul;86(1):259-62. Epub 2006 May 26.
64. Lower levels of urinary 2-hydroxyestrogens in polycystic ovary syndrome. Salih S, etal., J Clin Endocrinol Metab. 2007 Aug;92(8):3285-91. Epub 2007 May 29.
65. Molecular cloning and characterization of rat liver catechol-O-methyltransferase. Salminen M, etal., Gene 1990 Sep 14;93(2):241-7.
66. Multiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer. Sasaki M, etal., Cancer Res. 2003 Jun 15;63(12):3101-6.
67. Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats. Schendzielorz N, etal., J Physiol Pharmacol. 2011 Aug;62(4):483-90.
68. A highly significant association between a COMT haplotype and schizophrenia. Shifman S, etal., Am J Hum Genet 2002 Dec;71(6):1296-302. Epub 2002 Oct 25.
69. Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition. Singh A, etal., Pharmacology. 2003 Jun;68(2):81-8.
70. Catechol-O-methyltransferase activity in psoriasis patients treated with psoralen plus ultraviolet A therapy. Souteiro P, etal., Photodermatol Photoimmunol Photomed. 2013 Oct;29(5):227-32. doi: 10.1111/phpp.12058.
71. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
72. The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate. Suzuki M, etal., Eur Urol. 2005 Nov;48(5):752-9. Epub 2005 Aug 1.
73. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
74. Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer. Tanaka Y, etal., Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):238-44.
75. Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer. Tanaka Y, etal., Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):92-7.
76. Production of rat soluble and membrane-bound catechol O-methyltransferase forms from bifunctional mRNAs. Tenhunen J and Ulmanen I, Biochem J 1993 Dec 15;296 ( Pt 3):595-600.
77. The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages. Thompson JM, etal., Dev Med Child Neurol. 2012 Feb;54(2):148-54. doi: 10.1111/j.1469-8749.2011.04129.x. Epub 2011 Nov 9.
78. Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats. Tsunoda M, etal., Hypertens Res. 2003 Nov;26(11):923-7.
79. Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. Tunbridge EM, etal., J Neurosci. 2004 Jun 9;24(23):5331-5.
80. Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility. van de Sande WW, etal., Med Mycol. 2010 Nov;48(7):959-68. doi: 10.3109/13693781003636680.
81. Decrease in catechol-O-methyltransferase activity in the liver of streptozotocin-induced diabetic rats. Wang JP, etal., Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):419-22.
82. Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial. Wang SS, etal., Hum Genet. 2007 Aug;122(1):41-9. Epub 2007 May 12.
83. Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk. Wen W, etal., Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):917-20.
84. Treatment with an inhibitor of catechol-O-methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats. Wentz MJ, etal., Reproduction. 2007 Dec;134(6):831-9.
85. Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. Wong LL, etal., Hum Exp Toxicol. 2011 Sep;30(9):1369-81. doi: 10.1177/0960327110391388. Epub 2010 Dec 7.
86. No association between catechol-O-methyltransferase (COMT) genotype and attention deficit hyperactivity disorder (ADHD) in Japanese children. Yatsuga C, etal., Brain Dev. 2014 Aug;36(7):620-5. doi: 10.1016/j.braindev.2013.08.006. Epub 2013 Sep 12.
87. COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa. Yilmaz Z, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):948-52. doi: 10.1016/j.pnpbp.2011.01.012. Epub 2011 Feb 12.
88. [Polymorphism of catechol-O-methyltransferase gene in relation to the risk of endometrial cancer] Zhao XM, etal., Zhonghua Fu Chan Ke Za Zhi. 2007 Feb;42(2):116-9.
89. [Polymorphisms of CYP1B1 and COMT in breast and endometrial cancer]. Zimarina TC, etal., Mol Biol (Mosk). 2004 May-Jun;38(3):386-93.
Additional References at PubMed
PMID:1765063   PMID:8127373   PMID:9520487   PMID:10785817   PMID:11559542   PMID:12237326   PMID:15167541   PMID:15489334   PMID:15645182   PMID:16396499   PMID:16508109   PMID:18614015  
PMID:18831714   PMID:19056347   PMID:19056867   PMID:19111934   PMID:19909795   PMID:19930170   PMID:19946888   PMID:19966533   PMID:20374420   PMID:21116937   PMID:21428728   PMID:21851556  
PMID:22071171   PMID:22384243   PMID:23376485   PMID:23533145   PMID:23863468   PMID:24727346   PMID:25560240   PMID:27215035   PMID:33048315   PMID:33503461   PMID:34725639  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21182,568,052 - 82,587,642 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,568,025 - 82,587,642 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,296,452 - 91,316,037 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01183,957,676 - 83,977,261 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01183,011,188 - 83,030,773 (+)NCBIRnor_WKY
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBICelera
RH 3.4 Map11712.2RGD
Cytogenetic Map11q23NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382219,941,772 - 19,969,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2219,941,371 - 19,969,975 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,929,295 - 19,957,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,309,309 - 18,336,530 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,324,623 - 18,331,084NCBI
Celera223,780,539 - 3,808,699 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,549,825 - 3,577,976 (+)NCBIHuRef
CHM1_12219,929,027 - 19,957,208 (+)NCBICHM1_1
T2T-CHM13v2.02220,319,463 - 20,347,602 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391618,225,632 - 18,247,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,225,636 - 18,245,602 (-)EnsemblGRCm39 Ensembl
GRCm381618,406,882 - 18,426,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,406,886 - 18,426,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,406,975 - 18,426,809 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,321,106 - 18,340,078 (-)NCBIMGSCv36mm8
Celera1618,980,657 - 19,001,067 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.4NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544218,130,987 - 18,137,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,130,282 - 18,152,153 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12232,117,249 - 32,144,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,704,015 - 2,731,326 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12218,375,434 - 18,402,387 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,375,434 - 18,402,387 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12629,359,930 - 29,381,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,360,356 - 29,366,008 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,318,554 - 29,324,118 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,763,075 - 30,783,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,763,078 - 30,783,978 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,811,616 - 28,817,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,436,974 - 28,442,538 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,522,581 - 29,528,148 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118138,870,188 - 138,906,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,876,299 - 3,882,747 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366193,847,059 - 3,883,866 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1451,385,738 - 51,403,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,384,729 - 51,403,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,021,681 - 55,040,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1195,775,829 - 5,803,260 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,773,225 - 5,785,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,128,529 - 1,156,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624747581,832 - 588,333 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747569,127 - 588,479 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Comt
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:166
Interacting mature miRNAs:198
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118256654583440803Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,553 - 82,566,702 (+)MAPPERmRatBN7.2
Rnor_6.01186,714,483 - 86,714,631NCBIRnor6.0
Rnor_5.01189,808,355 - 89,808,503UniSTSRnor5.0
RGSC_v3.41184,560,092 - 84,560,241RGDRGSC3.4
RGSC_v3.41184,560,093 - 84,560,241UniSTSRGSC3.4
RGSC_v3.11184,600,689 - 84,600,838RGD
Celera1181,343,623 - 81,343,771UniSTS
SHRSP x BN Map1138.1899UniSTS
SHRSP x BN Map1138.1899RGD
FHH x ACI Map1157.2499RGD
Cytogenetic Map11q23UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,545 - 82,566,718 (+)MAPPERmRatBN7.2
Rnor_6.01186,714,475 - 86,714,647NCBIRnor6.0
Rnor_5.01189,808,347 - 89,808,519UniSTSRnor5.0
RGSC_v3.41184,560,085 - 84,560,257UniSTSRGSC3.4
Celera1181,343,615 - 81,343,787UniSTS
Cytogenetic Map11q23UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01186,725,629 - 86,725,869NCBIRnor6.0
Rnor_5.01189,819,501 - 89,819,807UniSTSRnor5.0
RGSC_v3.41184,571,239 - 84,571,952UniSTSRGSC3.4
Celera1181,354,769 - 81,354,947UniSTS
Cytogenetic Map11q23UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,587,179 - 82,587,373 (+)MAPPERmRatBN7.2
Rnor_6.01186,735,169 - 86,735,362NCBIRnor6.0
Rnor_5.01189,829,107 - 89,829,300UniSTSRnor5.0
RGSC_v3.41184,581,252 - 84,581,445UniSTSRGSC3.4
Celera1181,364,244 - 81,364,437UniSTS
RH 3.4 Map11697.1UniSTS
Cytogenetic Map11q23UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,587,393 - 82,587,563 (+)MAPPERmRatBN7.2
Rnor_6.01186,735,383 - 86,735,551NCBIRnor6.0
Rnor_5.01189,829,321 - 89,829,489UniSTSRnor5.0
RGSC_v3.41184,581,466 - 84,581,634UniSTSRGSC3.4
Celera1181,364,458 - 81,364,626UniSTS
RH 3.4 Map11712.2UniSTS
Cytogenetic Map11q23UniSTS

Genetic Models
This gene Comt is modified in the following models/strains


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 1 1
Medium 3 43 56 40 19 40 7 10 74 35 41 11 7
Low 1 1 1
Below cutoff


Nucleotide Sequences
RefSeq Transcripts NM_012531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK478774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM443074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM443075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M93257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z12651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000050269   ⟹   ENSRNOP00000043148
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,568,025 - 82,587,642 (+)Ensembl
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104392   ⟹   ENSRNOP00000092582
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,579,693 - 82,587,642 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119057   ⟹   ENSRNOP00000086073
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,579,693 - 82,587,642 (+)Ensembl
RefSeq Acc Id: NM_012531   ⟹   NP_036663
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,568,052 - 82,587,642 (+)NCBI
Rnor_6.01186,715,981 - 86,735,630 (+)NCBI
Rnor_5.01189,809,853 - 89,829,568 (+)NCBI
RGSC_v3.41184,561,591 - 84,581,713 (+)RGD
Celera1181,345,121 - 81,364,705 (+)RGD
RefSeq Acc Id: XM_006248603   ⟹   XP_006248665
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,579,756 - 82,587,642 (+)NCBI
Rnor_6.01186,727,725 - 86,735,630 (+)NCBI
Rnor_5.01189,809,853 - 89,829,568 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036663   ⟸   NM_012531
- UniProtKB: P22734 (UniProtKB/Swiss-Prot),   F2W8B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248665   ⟸   XM_006248603
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043148   ⟸   ENSRNOT00000050269
RefSeq Acc Id: ENSRNOP00000092582   ⟸   ENSRNOT00000104392
RefSeq Acc Id: ENSRNOP00000086073   ⟸   ENSRNOT00000119057

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22734-F1-model_v2 AlphaFold P22734 1-264 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698304
Promoter ID:EPDNEW_R8827
Type:initiation region
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,715,939 - 86,715,999EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2379 AgrOrtholog
BioCyc Gene G2FUF-20660 BioCyc
BioCyc Pathway PWY-6334 [L-dopa degradation I (mammalian)] BioCyc
  PWY-6342 [noradrenaline and adrenaline degradation] BioCyc
  PWY18C3-23 [guaiacol biosynthesis] BioCyc
  PWY6666-2 [dopamine degradation] BioCyc
Ensembl Genes ENSRNOG00000001889 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043148 ENTREZGENE
  ENSRNOP00000043148.4 UniProtKB/Swiss-Prot
  ENSRNOP00000086073.1 UniProtKB/TrEMBL
  ENSRNOP00000092582.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050269 ENTREZGENE
  ENSRNOT00000050269.6 UniProtKB/Swiss-Prot
  ENSRNOT00000104392.1 UniProtKB/TrEMBL
  ENSRNOT00000119057.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Catechol_O-MeTrfase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_O-MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Methyltransf_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Comt PhenoGen
PIRSF Catechol_O-mtfrase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COMT_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Comt  catechol-O-methyltransferase    catecholamine-O-methyltransferase  Name updated 629478 APPROVED
2002-06-10 Comt  catecholamine-O-methyltransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function transfers a methyl group from S-adenosylmethionine to catecholamines  
gene_process shortens the biological half-lives of certain neuroactive drugs  
gene_process has a role in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease