Comt Rat (-)-epigallocatechin 3-gallate affects binding EXP 6480464 epigallocatechin gallate binds to COMT protein CTD PMID:23010222 Comt Rat (3,4-dihydroxyphenyl)acetic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-Dihydroxyphenylacetic Acid CTD PMID:11160877 Comt Rat (3,4-dihydroxyphenyl)acetic acid multiple interactions EXP 6480464 [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3 and 4-Dihydroxyphenylacetic Acid CTD PMID:15190105 and PMID:16012872 Comt Rat (3,4-dihydroxyphenyl)acetic acid increases methylation EXP 6480464 COMT protein results in increased methylation of 3 and 4-Dihydroxyphenylacetic Acid CTD PMID:11160877 Comt Rat (3,4-dihydroxyphenyl)acetic acid multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3 and 4-Dihydroxyphenylacetic Acid CTD PMID:11793163 Comt Rat (R)-adrenaline increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Epinephrine CTD PMID:11160877 Comt Rat (R)-adrenaline multiple interactions EXP 6480464 [COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine and tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] CTD PMID:10064789 and PMID:8821542 Comt Rat (R)-adrenaline increases methylation EXP 6480464 COMT protein results in increased methylation of Epinephrine CTD PMID:10064789 Comt Rat (R)-adrenaline multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine CTD PMID:11248589 Comt Rat (R)-noradrenaline multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine CTD PMID:11248589 Comt Rat (R)-noradrenaline increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Norepinephrine CTD PMID:11160877 Comt Rat (S)-amphetamine affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene SNP affects the susceptibility to Dextroamphetamine CTD PMID:12716966 Comt Rat 1,2,4-trimethylbenzene decreases expression EXP 6480464 pseudocumene results in decreased expression of COMT protein CTD PMID:17337753 Comt Rat 1,2-dichloroethane decreases expression ISO Comt (Mus musculus) 6480464 ethylene dichloride results in decreased expression of COMT mRNA CTD PMID:28189721 and PMID:28960355 Comt Rat 17alpha-ethynylestradiol multiple interactions ISO Comt (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMT mRNA CTD PMID:17942748 Comt Rat 17beta-estradiol decreases activity ISO COMT (Homo sapiens) 6480464 Estradiol results in decreased activity of COMT protein CTD PMID:18192686 and PMID:18497090 Comt Rat 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of COMT mRNA CTD PMID:32145629 Comt Rat 17beta-estradiol decreases expression ISO COMT (Homo sapiens) 6480464 Estradiol results in decreased expression of COMT mRNA and Estradiol results in decreased expression of COMT protein CTD PMID:18497090 more ... Comt Rat 17beta-estradiol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Estradiol metabolite and Estradiol results in increased methylation of COMT promoter CTD PMID:22285433 and PMID:30684530 Comt Rat 17beta-estradiol increases activity EXP 6480464 Estradiol results in increased activity of COMT protein CTD PMID:20600213 Comt Rat 17beta-estradiol multiple interactions EXP 6480464 Quercetin inhibits the reaction [Estradiol results in increased activity of COMT protein] CTD PMID:20600213 Comt Rat 17beta-estradiol multiple interactions ISO COMT (Homo sapiens) 6480464 [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of COMT protein more ... CTD PMID:18192686 more ... Comt Rat 17beta-estradiol decreases abundance ISO COMT (Homo sapiens) 6480464 COMT protein polymorphism results in decreased abundance of Estradiol analog CTD PMID:15288375 Comt Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Comt (Mus musculus) 6480464 2 more ... CTD PMID:32352317 Comt Rat 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO COMT (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 Comt Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Comt (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of COMT mRNA CTD PMID:20702594 Comt Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of COMT mRNA CTD PMID:34747641 Comt Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of COMT mRNA CTD PMID:20959002 Comt Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of COMT mRNA CTD PMID:21215274 Comt Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Comt (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of COMT mRNA CTD PMID:18796159 more ... Comt Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Comt (Mus musculus) 6480464 [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of COMT mRNA more ... CTD PMID:16214954 more ... Comt Rat 2,3,7,8-Tetrachlorodibenzofuran affects expression ISO Comt (Mus musculus) 6480464 2 more ... CTD PMID:20702594 Comt Rat 2,4,6-tribromophenol decreases expression ISO COMT (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 Comt Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Comt (Mus musculus) 6480464 2 more ... CTD PMID:38648751 Comt Rat 2-hydroxy-17beta-estradiol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 2-hydroxyestradiol CTD PMID:11160877 Comt Rat 2-hydroxy-17beta-estradiol increases methylation EXP 6480464 COMT protein results in increased methylation of 2-hydroxyestradiol CTD PMID:11160877 Comt Rat 2-hydroxy-17beta-estradiol affects metabolic processing ISO COMT (Homo sapiens) 6480464 COMT protein affects the metabolism of 2-hydroxyestradiol CTD PMID:15377160 Comt Rat 2-methoxy-17beta-estradiol affects chemical synthesis ISO COMT (Homo sapiens) 6480464 COMT protein affects the chemical synthesis of 2-Methoxyestradiol CTD PMID:15377160 Comt Rat 3',4'-dihydroxyacetophenone increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-dihydroxyacetophenone CTD PMID:11160877 Comt Rat 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:30744511 Comt Rat 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of COMT mRNA CTD PMID:26988606 Comt Rat 3,3',5,5'-tetrabromobisphenol A decreases expression ISO COMT (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of COMT protein CTD PMID:31675489 Comt Rat 3,4,5,3',4',5'-Hexachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:30744511 Comt Rat 3,4-dihydroxyacetophenone increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-dihydroxyacetophenone CTD PMID:11160877 Comt Rat 3,4-dihydroxybenzoic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of protocatechuic acid CTD PMID:11160877 Comt Rat 3,4-dihydroxybenzoic acid increases methylation EXP 6480464 COMT protein results in increased methylation of protocatechuic acid CTD PMID:11160877 Comt Rat 3,4-dihydroxymandelic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-dihydroxymandelic acid CTD PMID:11160877 Comt Rat 3,4-dihydroxyphenylethyleneglycol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-dihydroxyphenylglycol CTD PMID:11160877 Comt Rat 3,4-methylenedioxymethamphetamine multiple interactions ISO Comt (Mus musculus) 6480464 COMT protein affects the metabolism of and affects the susceptibility to N-Methyl-3 and 4-methylenedioxyamphetamine CTD PMID:24591155 Comt Rat 3,4-methylenedioxymethamphetamine multiple interactions EXP 6480464 COMT protein affects the metabolism of and affects the susceptibility to N-Methyl-3 and 4-methylenedioxyamphetamine CTD PMID:24591155 Comt Rat 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin analog results in decreased expression of COMT protein and alpha-Chlorohydrin results in decreased expression of COMT protein CTD PMID:26597043 Comt Rat 3-methoxycatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3-methoxycatechol CTD PMID:11160877 Comt Rat 3-O-methylgallic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3-O-methylgallic acid CTD PMID:11160877 Comt Rat 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2 and 6-dinitrotoluene affects the expression of COMT mRNA CTD PMID:21346803 Comt Rat 4-chlorocatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 4-chlorocatechol CTD PMID:11160877 Comt Rat 4-chlorocatechol increases methylation EXP 6480464 COMT protein results in increased methylation of 4-chlorocatechol CTD PMID:11160877 Comt Rat 4-hydroxy-17beta-estradiol affects metabolic processing ISO COMT (Homo sapiens) 6480464 COMT protein affects the metabolism of 4-hydroxyestradiol CTD PMID:15377160 Comt Rat 4-hydroxy-17beta-estradiol multiple interactions ISO COMT (Homo sapiens) 6480464 daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol] more ... CTD PMID:18192686 Comt Rat 4-hydroxy-17beta-estradiol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 4-hydroxyestradiol CTD PMID:18192686 Comt Rat 4-hydroxynon-2-enal decreases expression ISO COMT (Homo sapiens) 6480464 4-hydroxy-2-nonenal results in decreased expression of COMT mRNA CTD PMID:12419474 Comt Rat 4-methylcatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 4-methylcatechol CTD PMID:11160877 Comt Rat 4-methylcatechol increases methylation EXP 6480464 COMT protein results in increased methylation of 4-methylcatechol CTD PMID:11160877 Comt Rat 4-nitrocatechol increases methylation EXP 6480464 COMT protein results in increased methylation of 4-nitrocatechol CTD PMID:11160877 Comt Rat 4-nitrocatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 4-nitrocatechol CTD PMID:11160877 Comt Rat 5-aza-2'-deoxycytidine multiple interactions ISO COMT (Homo sapiens) 6480464 Decitabine inhibits the reaction [Estradiol results in decreased expression of COMT mRNA] and Decitabine inhibits the reaction [Estradiol results in increased methylation of COMT promoter] CTD PMID:30684530 Comt Rat 5-Hydroxydopamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 5-hydroxydopamine CTD PMID:11160877 Comt Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of COMT mRNA CTD PMID:36843608 Comt Rat 7,12-dimethyltetraphene decreases expression ISO Comt (Mus musculus) 6480464 9 more ... CTD PMID:38307155 Comt Rat acetamide decreases expression EXP 6480464 acetamide results in decreased expression of COMT mRNA CTD PMID:31881176 Comt Rat aflatoxin B1 affects methylation ISO COMT (Homo sapiens) 6480464 Aflatoxin B1 affects the methylation of COMT intron CTD PMID:30157460 Comt Rat Aflatoxin B2 alpha affects methylation ISO COMT (Homo sapiens) 6480464 aflatoxin B2 affects the methylation of COMT intron CTD PMID:30157460 Comt Rat alcohol affects response to substance ISO Comt (Mus musculus) 6480464 COMT affects the susceptibility to Alcohols CTD PMID:18684228 Comt Rat all-trans-retinoic acid increases expression ISO COMT (Homo sapiens) 6480464 Tretinoin results in increased expression of COMT mRNA CTD PMID:21934132 Comt Rat alpha-methyl-L-dopa increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Methyldopa CTD PMID:11160877 Comt Rat alpha-methyl-L-dopa decreases activity ISO COMT (Homo sapiens) 6480464 Methyldopa results in decreased activity of COMT protein CTD PMID:7053299 Comt Rat aminoglutethimide increases expression ISO COMT (Homo sapiens) 6480464 Aminoglutethimide results in increased expression of COMT protein CTD PMID:26102013 Comt Rat amitraz multiple interactions EXP 6480464 Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA] and Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein] CTD PMID:28463726 Comt Rat amitraz affects expression EXP 6480464 amitraz affects the expression of COMT mRNA and amitraz affects the expression of COMT protein CTD PMID:28463726 Comt Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of COMT mRNA CTD PMID:16483693 Comt Rat ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of COMT mRNA CTD PMID:12420312 Comt Rat amphetamine increases expression ISO Comt (Mus musculus) 6480464 Amphetamine results in increased expression of COMT mRNA CTD PMID:16916582 Comt Rat amphetamine multiple interactions EXP 6480464 COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine] CTD PMID:14574438 Comt Rat amphotericin B increases expression ISO COMT (Homo sapiens) 6480464 Amphotericin B analog results in increased expression of COMT mRNA CTD PMID:28534445 Comt Rat anthracene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 Comt Rat antirheumatic drug decreases expression ISO COMT (Homo sapiens) 6480464 Antirheumatic Agents results in decreased expression of COMT mRNA CTD PMID:24449571 Comt Rat aripiprazole increases expression EXP 6480464 Aripiprazole results in increased expression of COMT mRNA CTD PMID:17868501 Comt Rat aristolochic acid A increases expression ISO COMT (Homo sapiens) 6480464 aristolochic acid I results in increased expression of COMT mRNA CTD PMID:33212167 Comt Rat arsane multiple interactions ISO COMT (Homo sapiens) 6480464 [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of COMT protein CTD PMID:35747940 Comt Rat arsenic atom multiple interactions ISO COMT (Homo sapiens) 6480464 [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of COMT protein CTD PMID:35747940 Comt Rat arsenite(3-) decreases expression ISO Comt (Mus musculus) 6480464 arsenite results in decreased expression of COMT protein CTD PMID:29982692 Comt Rat arsenite(3-) increases expression ISO COMT (Homo sapiens) 6480464 arsenite results in increased expression of COMT mRNA CTD PMID:31646340 Comt Rat arsenite(3-) decreases expression EXP 6480464 arsenite results in decreased expression of COMT protein CTD PMID:29982692 Comt Rat ATP multiple interactions ISO COMT (Homo sapiens) 6480464 [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate and [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate CTD PMID:14975680 Comt Rat bathocuproine disulfonic acid multiple interactions ISO COMT (Homo sapiens) 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] CTD PMID:15477007 Comt Rat benserazide increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Benserazide CTD PMID:11160877 Comt Rat benserazide increases methylation EXP 6480464 COMT protein results in increased methylation of Benserazide CTD PMID:11160877 Comt Rat benzo[a]pyrene increases expression ISO Comt (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of COMT mRNA CTD PMID:19770486 Comt Rat benzo[a]pyrene decreases methylation ISO COMT (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of COMT 5' UTR CTD PMID:27901495 Comt Rat benzo[a]pyrene increases methylation ISO COMT (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of COMT 3' UTR and Benzo(a)pyrene results in increased methylation of COMT promoter CTD PMID:27901495 Comt Rat benzo[a]pyrene affects methylation ISO COMT (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of COMT intron CTD PMID:30157460 Comt Rat benzo[a]pyrene multiple interactions ISO Comt (Mus musculus) 6480464 [lipopolysaccharide and E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of COMT mRNA CTD PMID:28987381 Comt Rat benzo[e]pyrene decreases methylation ISO COMT (Homo sapiens) 6480464 benzo(e)pyrene results in decreased methylation of COMT intron CTD PMID:30157460 Comt Rat beta-lapachone decreases expression ISO COMT (Homo sapiens) 6480464 beta-lapachone results in decreased expression of COMT mRNA CTD PMID:38218311 Comt Rat bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of COMT mRNA CTD PMID:16648578 Comt Rat bexarotene increases expression EXP 6480464 bexarotene results in increased expression of COMT mRNA CTD PMID:16648578 Comt Rat bis(2-ethylhexyl) phthalate increases expression ISO COMT (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of COMT mRNA CTD PMID:31163220 Comt Rat bisphenol A increases methylation ISO COMT (Homo sapiens) 6480464 bisphenol A results in increased methylation of COMT promoter CTD PMID:24214726 Comt Rat bisphenol A increases expression ISO COMT (Homo sapiens) 6480464 bisphenol A results in increased expression of COMT protein CTD PMID:34186270 Comt Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of COMT mRNA CTD PMID:30903817 Comt Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of COMT mRNA CTD PMID:25181051 and PMID:29552716 Comt Rat bisphenol A multiple interactions ISO COMT (Homo sapiens) 6480464 fulvestrant inhibits the reaction [bisphenol A results in decreased expression of COMT mRNA] CTD PMID:24040167 Comt Rat bisphenol A decreases expression ISO COMT (Homo sapiens) 6480464 bisphenol A analog results in decreased expression of COMT mRNA more ... CTD PMID:24040167 more ... Comt Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of COMT mRNA CTD PMID:26186136 more ... Comt Rat Bisphenol B increases expression ISO COMT (Homo sapiens) 6480464 bisphenol B results in increased expression of COMT protein CTD PMID:34186270 Comt Rat bisphenol F decreases expression EXP 6480464 4 and 4'-bisphenol F results in decreased expression of COMT mRNA CTD PMID:26186136 Comt Rat bisphenol F increases expression ISO COMT (Homo sapiens) 6480464 bisphenol F results in increased expression of COMT protein CTD PMID:34186270 Comt Rat Butylbenzyl phthalate decreases expression ISO COMT (Homo sapiens) 6480464 butylbenzyl phthalate results in decreased expression of COMT mRNA CTD PMID:24040167 Comt Rat Butylbenzyl phthalate multiple interactions ISO COMT (Homo sapiens) 6480464 fulvestrant inhibits the reaction [butylbenzyl phthalate results in decreased expression of COMT mRNA] CTD PMID:24040167 Comt Rat butyric acid decreases expression ISO COMT (Homo sapiens) 6480464 Butyric Acid results in decreased expression of COMT mRNA CTD PMID:30439556 Comt Rat cadmium atom multiple interactions ISO COMT (Homo sapiens) 6480464 Fulvestrant inhibits the reaction [Cadmium results in decreased expression of COMT mRNA] CTD PMID:31646340 Comt Rat cadmium atom decreases expression ISO COMT (Homo sapiens) 6480464 Cadmium results in decreased expression of COMT mRNA CTD PMID:31646340 Comt Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of COMT mRNA CTD PMID:33453195 Comt Rat caffeine multiple interactions ISO Comt (Mus musculus) 6480464 [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 Comt Rat calcitriol multiple interactions ISO COMT (Homo sapiens) 6480464 [Calcitriol co-treated with VDR protein] results in increased expression of COMT mRNA and Calcitriol promotes the reaction [VDR protein binds to COMT promoter] CTD PMID:27450565 Comt Rat captan increases expression ISO Comt (Mus musculus) 6480464 Captan results in increased expression of COMT mRNA CTD PMID:31558096 Comt Rat carbidopa increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Carbidopa CTD PMID:11160877 Comt Rat carbidopa increases methylation EXP 6480464 COMT protein results in increased methylation of Carbidopa CTD PMID:11160877 Comt Rat carbon nanotube decreases expression ISO Comt (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25620056 Comt Rat carbonyl cyanide p-trifluoromethoxyphenylhydrazone multiple interactions ISO COMT (Homo sapiens) 6480464 [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate CTD PMID:14975680 Comt Rat carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases activity ISO COMT (Homo sapiens) 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein CTD PMID:14975680 Comt Rat catechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of catechol CTD PMID:11160877 Comt Rat catechol multiple interactions ISO COMT (Homo sapiens) 6480464 COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA] more ... CTD PMID:24141029 Comt Rat catechol increases response to substance ISO COMT (Homo sapiens) 6480464 COMT mutant form results in increased susceptibility to catechol CTD PMID:24141029 Comt Rat catechol increases methylation EXP 6480464 COMT protein results in increased methylation of catechol CTD PMID:11160877 Comt Rat CGP 28014 decreases activity ISO Comt (Mus musculus) 6480464 N-(2-pyridone-6-yl)-N' and N'-di-n-propylformamidine results in decreased activity of COMT protein CTD PMID:20726980 Comt Rat chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of COMT mRNA CTD PMID:18812211 Comt Rat chlorpyrifos increases expression ISO Comt (Mus musculus) 6480464 Chlorpyrifos results in increased expression of COMT mRNA CTD PMID:37019170 Comt Rat chlorpyrifos decreases expression ISO Comt (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of COMT mRNA CTD PMID:32715474 Comt Rat ciguatoxin CTX1B affects expression ISO Comt (Mus musculus) 6480464 Ciguatoxins affects the expression of COMT mRNA CTD PMID:18353800 Comt Rat cis-caffeic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of caffeic acid CTD PMID:11160877 Comt Rat cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of COMT protein CTD PMID:22023808 Comt Rat cisplatin affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene SNP affects the susceptibility to Cisplatin CTD PMID:19898482 Comt Rat clonidine increases expression EXP 6480464 Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 Comt Rat clonidine (amino form) increases expression EXP 6480464 Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 Comt Rat clonidine (imino form) increases expression EXP 6480464 Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 Comt Rat clozapine multiple interactions EXP 6480464 [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] CTD PMID:15190105 Comt Rat clozapine affects response to substance ISO COMT (Homo sapiens) 6480464 COMT protein affects the susceptibility to Clozapine CTD PMID:17123785 Comt Rat clozapine increases response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism results in increased susceptibility to Clozapine CTD PMID:17123785 Comt Rat cobalt dichloride decreases expression ISO COMT (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of COMT mRNA CTD PMID:19320972 and PMID:19376846 Comt Rat corticosterone multiple interactions ISO Comt (Mus musculus) 6480464 Edaravone inhibits the reaction [Corticosterone results in decreased expression of COMT mRNA] CTD PMID:31344373 Comt Rat corticosterone decreases expression ISO Comt (Mus musculus) 6480464 Corticosterone results in decreased expression of COMT mRNA CTD PMID:31344373 Comt Rat coumestrol decreases expression ISO COMT (Homo sapiens) 6480464 Coumestrol results in decreased expression of COMT mRNA CTD PMID:19167446 Comt Rat coumestrol multiple interactions ISO COMT (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of COMT mRNA CTD PMID:19167446 Comt Rat cyclophosphamide increases expression ISO Comt (Mus musculus) 6480464 Cyclophosphamide results in increased expression of COMT mRNA CTD PMID:21041162 Comt Rat cyclosporin A decreases expression ISO Comt (Mus musculus) 6480464 Cyclosporine results in decreased expression of COMT mRNA CTD PMID:19770486 Comt Rat cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole] results in increased expression of COMT mRNA CTD PMID:29038839 Comt Rat daidzein decreases activity ISO COMT (Homo sapiens) 6480464 daidzein results in decreased activity of COMT protein CTD PMID:18192686 and PMID:18497090 Comt Rat daidzein multiple interactions ISO COMT (Homo sapiens) 6480464 daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol] and fulvestrant inhibits the reaction [daidzein results in decreased expression of COMT mRNA] CTD PMID:18192686 and PMID:18497090 Comt Rat daidzein decreases expression ISO COMT (Homo sapiens) 6480464 daidzein results in decreased expression of COMT mRNA CTD PMID:18192686 and PMID:18497090 Comt Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of COMT mRNA CTD PMID:23914054 Comt Rat decabromodiphenyl ether decreases expression ISO COMT (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of COMT protein CTD PMID:31675489 Comt Rat deguelin increases expression ISO COMT (Homo sapiens) 6480464 deguelin results in increased expression of COMT mRNA CTD PMID:33512557 Comt Rat deoxynivalenol decreases phosphorylation ISO Comt (Mus musculus) 6480464 deoxynivalenol results in decreased phosphorylation of COMT protein CTD PMID:23811945 Comt Rat dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of COMT mRNA] CTD PMID:20032058 Comt Rat dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of COMT mRNA CTD PMID:16962226 and PMID:20032058 Comt Rat dexamethasone increases expression ISO Comt (Mus musculus) 6480464 Dexamethasone results in increased expression of COMT mRNA CTD PMID:21041162 Comt Rat diazinon decreases expression EXP 6480464 Diazinon results in decreased expression of COMT mRNA and Diazinon results in decreased expression of COMT protein CTD PMID:18812211 and PMID:26721910 Comt Rat dibenzofurans increases expression ISO Comt (Mus musculus) 6480464 Dibenzofurans results in increased expression of COMT mRNA CTD PMID:34254344 Comt Rat Dibutyl phosphate affects expression ISO COMT (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of COMT mRNA CTD PMID:37042841 Comt Rat dibutyl phthalate multiple interactions ISO COMT (Homo sapiens) 6480464 fulvestrant inhibits the reaction [Dibutyl Phthalate results in decreased expression of COMT mRNA] CTD PMID:24040167 Comt Rat dibutyl phthalate decreases expression ISO COMT (Homo sapiens) 6480464 Dibutyl Phthalate results in decreased expression of COMT mRNA CTD PMID:24040167 Comt Rat dieldrin increases expression EXP 6480464 Dieldrin results in increased expression of COMT mRNA CTD PMID:18812211 Comt Rat diethyl maleate decreases expression EXP 6480464 diethyl maleate results in decreased expression of COMT mRNA CTD PMID:21161181 Comt Rat diethylstilbestrol increases expression ISO Comt (Mus musculus) 6480464 Diethylstilbestrol results in increased expression of COMT mRNA CTD PMID:21041162 Comt Rat diuron decreases expression EXP 6480464 Diuron results in decreased expression of COMT mRNA CTD PMID:21551480 Comt Rat diuron decreases expression ISO COMT (Homo sapiens) 6480464 Diuron results in decreased expression of COMT mRNA CTD PMID:35967413 Comt Rat dobutamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Dobutamine CTD PMID:11160877 Comt Rat dobutamine increases expression EXP 6480464 Dobutamine results in increased expression of COMT mRNA CTD PMID:12423672 Comt Rat dopamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Dopamine CTD PMID:11160877 Comt Rat dopamine increases metabolic processing ISO Comt (Mus musculus) 6480464 COMT protein results in increased metabolism of Dopamine CTD PMID:20626558 Comt Rat dopamine increases methylation EXP 6480464 COMT protein results in increased methylation of Dopamine CTD PMID:11160877 Comt Rat dopamine multiple interactions EXP 6480464 [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] and COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine] CTD PMID:14574438 and PMID:15190105 Comt Rat dopamine multiple interactions ISO COMT (Homo sapiens) 6480464 3 more ... CTD PMID:11248589 more ... Comt Rat edaravone multiple interactions ISO Comt (Mus musculus) 6480464 Edaravone inhibits the reaction [Corticosterone results in decreased expression of COMT mRNA] CTD PMID:31344373 Comt Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of COMT mRNA CTD PMID:29391264 Comt Rat enilconazole increases expression ISO COMT (Homo sapiens) 6480464 enilconazole results in increased expression of COMT protein CTD PMID:32201337 Comt Rat entacapone decreases activity ISO COMT (Homo sapiens) 6480464 entacapone results in decreased activity of COMT protein CTD PMID:23206800 and PMID:29688484 Comt Rat entacapone affects binding EXP 6480464 entacapone binds to COMT protein CTD PMID:19783845 Comt Rat entacapone decreases activity EXP 6480464 entacapone results in decreased activity of COMT protein CTD PMID:19783845 and PMID:20334432 Comt Rat entacapone decreases activity ISO Comt (Mus musculus) 6480464 entacapone results in decreased activity of COMT protein CTD PMID:15566291 and PMID:20334432 Comt Rat entacapone multiple interactions ISO COMT (Homo sapiens) 6480464 [entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine and entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa] CTD PMID:12898346 and PMID:23206800 Comt Rat epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole] results in increased expression of COMT mRNA CTD PMID:29038839 Comt Rat esculetin increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of esculetin CTD PMID:11160877 Comt Rat estrone increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Estrone metabolite CTD PMID:22285433 Comt Rat fenbuconazole increases expression ISO COMT (Homo sapiens) 6480464 fenbuconazole results in increased expression of COMT mRNA CTD PMID:15942997 Comt Rat fenthion increases expression ISO Comt (Mus musculus) 6480464 Fenthion results in increased expression of COMT mRNA CTD PMID:34813904 Comt Rat fingolimod hydrochloride increases expression ISO COMT (Homo sapiens) 6480464 Fingolimod Hydrochloride results in increased expression of COMT mRNA CTD PMID:29654831 Comt Rat fisetin multiple interactions ISO COMT (Homo sapiens) 6480464 [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 Comt Rat fluoranthene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 Comt Rat folpet increases expression ISO Comt (Mus musculus) 6480464 folpet results in increased expression of COMT mRNA CTD PMID:31558096 Comt Rat FR900359 increases phosphorylation ISO COMT (Homo sapiens) 6480464 FR900359 results in increased phosphorylation of COMT protein CTD PMID:37730182 Comt Rat fulvestrant multiple interactions ISO COMT (Homo sapiens) 6480464 Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of COMT mRNA] more ... CTD PMID:18192686 more ... Comt Rat fulvestrant increases expression ISO COMT (Homo sapiens) 6480464 Fulvestrant results in increased expression of COMT mRNA CTD PMID:31646340 Comt Rat furan decreases expression EXP 6480464 furan results in decreased expression of COMT mRNA CTD PMID:26194646 Comt Rat genistein decreases activity ISO COMT (Homo sapiens) 6480464 Genistein results in decreased activity of COMT protein CTD PMID:18192686 and PMID:18497090 Comt Rat genistein increases methylation ISO COMT (Homo sapiens) 6480464 Genistein results in increased methylation of COMT promoter CTD PMID:30684530 Comt Rat genistein decreases expression ISO COMT (Homo sapiens) 6480464 Genistein results in decreased expression of COMT mRNA CTD PMID:18192686 more ... Comt Rat genistein multiple interactions ISO COMT (Homo sapiens) 6480464 [Genistein results in increased methylation of COMT promoter] which results in decreased expression of COMT mRNA more ... CTD PMID:18192686 more ... Comt Rat glycidol increases expression EXP 6480464 glycidol results in increased expression of COMT mRNA CTD PMID:24915197 Comt Rat guaiacol multiple interactions ISO COMT (Homo sapiens) 6480464 COMT mutant form inhibits the reaction [catechol results in increased abundance of Guaiacol] CTD PMID:24141029 Comt Rat hemin multiple interactions ISO COMT (Homo sapiens) 6480464 COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA] more ... CTD PMID:24141029 Comt Rat hexachlorobenzene increases expression ISO COMT (Homo sapiens) 6480464 Hexachlorobenzene results in increased expression of COMT protein CTD PMID:24365113 Comt Rat homocysteine multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine] CTD PMID:16758261 Comt Rat homovanillic acid multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid CTD PMID:11793163 Comt Rat homovanillic acid multiple interactions EXP 6480464 [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid CTD PMID:15190105 and PMID:16012872 Comt Rat hydrazine decreases expression EXP 6480464 hydrazine results in decreased expression of COMT protein CTD PMID:15370871 Comt Rat hydrogen peroxide decreases expression ISO COMT (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of COMT mRNA and Hydrogen Peroxide results in decreased expression of COMT protein CTD PMID:12419474 and PMID:34581912 Comt Rat hydrogen peroxide increases expression ISO COMT (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of COMT mRNA CTD PMID:18951874 Comt Rat inulin multiple interactions ISO Comt (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of COMT mRNA CTD PMID:36331819 Comt Rat ionomycin multiple interactions ISO COMT (Homo sapiens) 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] and [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA CTD PMID:15477007 Comt Rat isoprenaline increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Isoproterenol CTD PMID:11160877 Comt Rat ivermectin decreases expression ISO COMT (Homo sapiens) 6480464 Ivermectin results in decreased expression of COMT protein CTD PMID:32959892 Comt Rat ketamine increases expression EXP 6480464 Ketamine results in increased expression of COMT mRNA CTD PMID:20080153 Comt Rat kojic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA CTD PMID:18544905 Comt Rat lactacystin multiple interactions ISO COMT (Homo sapiens) 6480464 lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein] CTD PMID:17138778 Comt Rat lamivudine multiple interactions ISO COMT (Homo sapiens) 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA CTD PMID:15784690 Comt Rat megestrol acetate increases expression ISO COMT (Homo sapiens) 6480464 Megestrol Acetate results in increased expression of COMT protein CTD PMID:16939895 Comt Rat melevodopa increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of levodopa methyl ester CTD PMID:11160877 Comt Rat mercury atom affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism affects the susceptibility to Mercury and COMT gene SNP affects the susceptibility to Mercury CTD PMID:19296409 and PMID:24593143 Comt Rat mercury(0) affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism affects the susceptibility to Mercury and COMT gene SNP affects the susceptibility to Mercury CTD PMID:19296409 and PMID:24593143 Comt Rat Metanephrine increases chemical synthesis ISO COMT (Homo sapiens) 6480464 COMT protein results in increased chemical synthesis of Metanephrine CTD PMID:22569243 Comt Rat Metanephrine multiple interactions EXP 6480464 [COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine and tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] CTD PMID:10064789 and PMID:8821542 Comt Rat methamphetamine increases response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism results in increased susceptibility to Methamphetamine CTD PMID:15274053 Comt Rat methamphetamine affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism affects the susceptibility to Methamphetamine CTD PMID:19462300 Comt Rat methapyrilene decreases methylation ISO COMT (Homo sapiens) 6480464 Methapyrilene results in decreased methylation of COMT intron CTD PMID:30157460 Comt Rat methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of COMT mRNA CTD PMID:15120968 Comt Rat mianserin multiple interactions ISO Comt (Mus musculus) 6480464 [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 Comt Rat modafinil affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism affects the susceptibility to modafinil and COMT protein affects the susceptibility to modafinil CTD PMID:20815183 Comt Rat monosodium L-glutamate increases expression ISO Comt (Mus musculus) 6480464 Sodium Glutamate results in increased expression of COMT mRNA CTD PMID:22078008 Comt Rat morphine affects response to substance ISO Comt (Mus musculus) 6480464 COMT protein affects the susceptibility to Morphine CTD PMID:18834357 Comt Rat morphine multiple interactions ISO COMT (Homo sapiens) 6480464 [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine CTD PMID:21127283 Comt Rat myricetin multiple interactions ISO COMT (Homo sapiens) 6480464 [myricetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 Comt Rat N-methyl-4-phenylpyridinium multiple interactions ISO COMT (Homo sapiens) 6480464 U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of COMT mRNA] CTD PMID:12710931 Comt Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA CTD PMID:18544905 Comt Rat N-nitrosomorpholine decreases expression EXP 6480464 N-nitrosomorpholine results in decreased expression of COMT protein CTD PMID:19716841 Comt Rat naphthalene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 Comt Rat naphthalene-2,3-diol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 2 and 3-dihydroxynaphthalene CTD PMID:11160877 Comt Rat naphthalene-2,3-diol increases methylation EXP 6480464 COMT protein results in increased methylation of 2 and 3-dihydroxynaphthalene CTD PMID:11160877 Comt Rat naphthalenes decreases expression EXP 6480464 Naphthalenes results in decreased expression of COMT protein CTD PMID:17337753 Comt Rat nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of COMT mRNA CTD PMID:18812211 Comt Rat nickel sulfate increases expression ISO COMT (Homo sapiens) 6480464 nickel sulfate results in increased expression of COMT mRNA CTD PMID:18651567 Comt Rat Nitecapone decreases activity ISO Comt (Mus musculus) 6480464 nitecapone results in decreased activity of COMT protein CTD PMID:20726980 Comt Rat okadaic acid decreases expression ISO COMT (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of COMT protein CTD PMID:19397276 Comt Rat okadaic acid multiple interactions ISO COMT (Homo sapiens) 6480464 [Okadaic Acid co-treated with gambierol] results in decreased expression of COMT protein CTD PMID:19397276 Comt Rat olanzapine increases expression EXP 6480464 olanzapine results in increased expression of COMT mRNA CTD PMID:15964593 Comt Rat Oleacein decreases activity ISO COMT (Homo sapiens) 6480464 oleacein results in decreased activity of COMT protein CTD PMID:30935952 Comt Rat oxidopamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Oxidopamine CTD PMID:11160877 Comt Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of COMT mRNA CTD PMID:17202762 more ... Comt Rat paracetamol affects expression ISO Comt (Mus musculus) 6480464 Acetaminophen affects the expression of COMT mRNA CTD PMID:17562736 Comt Rat paraquat increases expression EXP 6480464 Paraquat results in increased expression of COMT mRNA CTD PMID:17935786 Comt Rat parathion decreases expression ISO Comt (Mus musculus) 6480464 Parathion results in decreased expression of COMT mRNA CTD PMID:34813904 Comt Rat pentachlorobenzene decreases expression ISO COMT (Homo sapiens) 6480464 pentachlorobenzene results in decreased expression of COMT protein CTD PMID:24365113 Comt Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Comt (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of COMT mRNA CTD PMID:36331819 Comt Rat perfluorooctane-1-sulfonic acid increases expression ISO COMT (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in increased expression of COMT mRNA CTD PMID:33772556 Comt Rat perfluorooctanoic acid multiple interactions ISO Comt (Mus musculus) 6480464 [perfluorooctanoic acid co-treated with Dietary Fats more ... CTD PMID:20118188 and PMID:23626681 Comt Rat perfluorooctanoic acid increases expression ISO COMT (Homo sapiens) 6480464 perfluorooctanoic acid results in increased expression of COMT mRNA CTD PMID:33772556 Comt Rat perfluorooctanoic acid decreases expression ISO Comt (Mus musculus) 6480464 perfluorooctanoic acid results in decreased expression of COMT mRNA CTD PMID:20118188 and PMID:23626681 Comt Rat permethrin decreases expression ISO Comt (Mus musculus) 6480464 Permethrin results in decreased expression of COMT mRNA CTD PMID:30629241 Comt Rat phenanthrene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 Comt Rat phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of COMT mRNA CTD PMID:16510358 Comt Rat PhIP affects response to substance EXP 6480464 COMT protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine CTD PMID:12901791 Comt Rat phorbol 13-acetate 12-myristate multiple interactions ISO COMT (Homo sapiens) 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] and [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA CTD PMID:15477007 Comt Rat pirinixic acid multiple interactions ISO Comt (Mus musculus) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of COMT mRNA CTD PMID:19710929 Comt Rat pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of COMT mRNA CTD PMID:16940010 Comt Rat pirinixic acid decreases expression ISO Comt (Mus musculus) 6480464 pirinixic acid results in decreased expression of COMT mRNA CTD PMID:18445702 and PMID:20813756 Comt Rat potassium bromate increases expression EXP 6480464 potassium bromate results in increased expression of COMT mRNA CTD PMID:23588252 Comt Rat potassium dichromate increases expression ISO COMT (Homo sapiens) 6480464 Potassium Dichromate results in increased expression of COMT mRNA CTD PMID:18332044 Comt Rat pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of COMT mRNA CTD PMID:19162173 Comt Rat progesterone decreases expression ISO COMT (Homo sapiens) 6480464 Progesterone results in decreased expression of COMT protein CTD PMID:17138778 Comt Rat pyrene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 Comt Rat pyrogallol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Pyrogallol CTD PMID:11160877 Comt Rat pyrrolidine dithiocarbamate multiple interactions ISO COMT (Homo sapiens) 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] CTD PMID:15477007 Comt Rat quercetin multiple interactions ISO COMT (Homo sapiens) 6480464 [Quercetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 Comt Rat quercetin decreases activity EXP 6480464 Quercetin results in decreased activity of COMT protein CTD PMID:20600213 Comt Rat quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Estradiol results in increased activity of COMT protein] CTD PMID:20600213 Comt Rat rac-3,4-methylenedioxy-N-ethylamphetamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein alternative form results in increased methylation of 3 and 4-methylenedioxyethamphetamine CTD PMID:19462939 Comt Rat rac-3,4-methylenedioxy-N-ethylamphetamine multiple interactions ISO COMT (Homo sapiens) 6480464 3 and 4-methylenedioxyethamphetamine inhibits the reaction [COMT protein results in increased methylation of Dopamine] CTD PMID:19462939 Comt Rat resveratrol multiple interactions ISO COMT (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of COMT mRNA CTD PMID:19167446 Comt Rat risperidone increases expression EXP 6480464 Risperidone results in increased expression of COMT mRNA CTD PMID:15964593 Comt Rat rotenone increases expression ISO COMT (Homo sapiens) 6480464 Rotenone results in increased expression of COMT mRNA CTD PMID:33512557 Comt Rat S-adenosyl-L-homocysteine decreases activity EXP 6480464 S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 Comt Rat S-adenosyl-L-methioninate multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 Comt Rat S-adenosyl-L-methionine multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 Comt Rat silicon dioxide decreases expression ISO Comt (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of COMT mRNA CTD PMID:23221170 Comt Rat silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of COMT mRNA CTD PMID:32721576 Comt Rat simazine increases expression EXP 6480464 Simazine results in increased expression of COMT mRNA CTD PMID:29115391 Comt Rat simazine decreases expression ISO Comt (Mus musculus) 6480464 Simazine results in decreased expression of COMT mRNA and Simazine results in decreased expression of COMT protein CTD PMID:29137186 Comt Rat SKF 38393 increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 2 more ... CTD PMID:11160877 Comt Rat sodium arsenite increases expression ISO Comt (Mus musculus) 6480464 sodium arsenite results in increased expression of COMT protein CTD PMID:29044176 Comt Rat sodium arsenite multiple interactions ISO COMT (Homo sapiens) 6480464 [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of COMT protein CTD PMID:35747940 Comt Rat sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of COMT protein CTD PMID:29459688 Comt Rat sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of COMT mRNA CTD PMID:12325037 Comt Rat sulforaphane multiple interactions ISO COMT (Homo sapiens) 6480464 sulforaphane inhibits the reaction [DNMT3B protein binds to COMT promoter] more ... CTD PMID:30684530 Comt Rat sunitinib increases expression ISO COMT (Homo sapiens) 6480464 Sunitinib results in increased expression of COMT mRNA CTD PMID:31533062 Comt Rat tamoxifen decreases expression ISO Comt (Mus musculus) 6480464 Tamoxifen results in decreased expression of COMT mRNA CTD PMID:25123088 Comt Rat tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of COMT mRNA and Tamoxifen affects the expression of COMT protein CTD PMID:28463726 Comt Rat tamoxifen multiple interactions EXP 6480464 Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA] and Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein] CTD PMID:28463726 Comt Rat tamoxifen affects metabolic processing ISO COMT (Homo sapiens) 6480464 COMT protein affects the metabolism of Tamoxifen CTD PMID:15288375 Comt Rat tamoxifen affects expression ISO Comt (Mus musculus) 6480464 Tamoxifen affects the expression of COMT mRNA CTD PMID:20937368 Comt Rat tert-butyl hydroperoxide decreases expression ISO COMT (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of COMT mRNA CTD PMID:12419474 Comt Rat tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of COMT protein CTD PMID:24394546 Comt Rat testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of COMT mRNA] CTD PMID:20032058 Comt Rat tetrachlorocatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 more ... CTD PMID:11160877 Comt Rat tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of COMT mRNA CTD PMID:16239168 and PMID:31150632 Comt Rat tetrachloromethane decreases expression ISO Comt (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of COMT mRNA CTD PMID:31919559 Comt Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of COMT mRNA CTD PMID:34492290 Comt Rat tolcapone multiple interactions EXP 6480464 [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] more ... CTD PMID:15190105 more ... Comt Rat tolcapone decreases activity ISO COMT (Homo sapiens) 6480464 tolcapone results in decreased activity of COMT protein CTD PMID:11248589 more ... Comt Rat tolcapone multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine] more ... CTD PMID:10047930 more ... Comt Rat tolcapone decreases activity EXP 6480464 tolcapone results in decreased activity of COMT protein CTD PMID:10064789 more ... Comt Rat tolcapone affects binding EXP 6480464 tolcapone binds to COMT protein CTD PMID:19783845 Comt Rat tolcapone increases methylation EXP 6480464 COMT protein results in increased methylation of tolcapone CTD PMID:12584150 Comt Rat tolcapone decreases activity ISO Comt (Mus musculus) 6480464 tolcapone results in decreased activity of COMT protein CTD PMID:15566291 and PMID:20334432 Comt Rat trans-caffeic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of caffeic acid CTD PMID:11160877 Comt Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of COMT mRNA CTD PMID:19448997 Comt Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of COMT mRNA CTD PMID:33387578 Comt Rat trichostatin A multiple interactions ISO COMT (Homo sapiens) 6480464 trichostatin A inhibits the reaction [Estradiol results in decreased expression of COMT mRNA] CTD PMID:30684530 Comt Rat Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of COMT protein CTD PMID:32519852 Comt Rat tropolone decreases activity EXP 6480464 Tropolone results in decreased activity of COMT protein CTD PMID:10064789 Comt Rat trovafloxacin multiple interactions ISO Comt (Mus musculus) 6480464 [trovafloxacin co-treated with lipopolysaccharide and E coli O55-B5] results in decreased expression of COMT mRNA CTD PMID:18930950 Comt Rat valproic acid decreases expression ISO COMT (Homo sapiens) 6480464 Valproic Acid results in decreased expression of COMT mRNA CTD PMID:29154799 Comt Rat valproic acid increases expression ISO COMT (Homo sapiens) 6480464 Valproic Acid results in increased expression of COMT mRNA CTD PMID:28001369 Comt Rat valproic acid increases methylation ISO COMT (Homo sapiens) 6480464 Valproic Acid results in increased methylation of COMT gene CTD PMID:29154799 Comt Rat valproic acid affects expression ISO COMT (Homo sapiens) 6480464 Valproic Acid affects the expression of COMT mRNA CTD PMID:25979313 Comt Rat vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of COMT mRNA CTD PMID:19015723 Comt Rat zidovudine multiple interactions ISO COMT (Homo sapiens) 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA CTD PMID:15784690