RGD Reference Report - Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase. - Rat Genome Database

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Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase.

Authors: Matsui, A  Ikeda, T  Enomoto, K  Nakashima, H  Omae, K  Watanabe, M  Hibi, T  Kitajima, M 
Citation: Matsui A, etal., Cancer Lett. 2000 Mar 13;150(1):23-31.
RGD ID: 8662330
Pubmed: PMID:10755383   (View Abstract at PubMed)

There is increasing evidence that catecholestrogens may contribute to the development of breast cancer. Specifically, inactivation of catecholestrogens may prevent the genesis and arrest the progression of the disease. Catechol-O-methyltransferase (COMT), Glutathione S-transferase (GST) M1 and GSTP1 are responsible for the detoxification of catecholestrogens, and are polymorphic in the human population. In this study, a PCR-based restriction fragment length polymorphism analysis was performed to determine genotypes of the COMT, GSTM1 and GSTP1 genes. We investigated the relationship between the germline polymorphism of these genes and clinico-pathological characteristics in 140 patients with breast cancer. Among 73 patients with the low activity COMT allele, 49 (67%) had regional lymph node metastasis. On the other hand, only 27 (40%) of 67 patients without the low activity allele had lymph node metastasis. The COMT genotype was significantly associated with clinical stage and the extent of regional lymph node metastasis of breast cancer (P<0.05). However, polymorphisms of the GSTM1 and GSTP1 gene were not associated with clinico-pathological factors. Our findings suggest that the allele encoding for low activity COMT may contribute to the progression of breast cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lymphatic Metastasis  IAGP 8662330associated with breast cancer and DNA:missense mutation:cds:p.V108/158M (human)RGD 
Lymphatic Metastasis  ISOCOMT (Homo sapiens)8662330; 8662330associated with breast cancer and DNA:missense mutation:cds:p.V108/158M (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal lymphatic vessel morphology  IAGP 8662330associated with breast cancer and DNA:missense mutation:cds:p.V108/158MRGD 
Objects Annotated

Genes (Rattus norvegicus)
Comt  (catechol-O-methyltransferase)

Genes (Mus musculus)
Comt  (catechol-O-methyltransferase)

Genes (Homo sapiens)
COMT  (catechol-O-methyltransferase)


Additional Information