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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Comt
Name: catechol-O-methyltransferase
Acc ID: CHEBI:132237
Term: rac-3,4-methylenedioxy-N-ethylamphetamine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-3,4-methylenedioxy-N-ethylamphetamine3,4-methylenedioxy-N-ethylamphetamine.
Chemical ID: MESH:C051800
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Comtincreases methylationISORGD:7371026480464CTDCOMT protein alternative form results in increased methylation of 3, 4-methylenedioxyethamphetamine

PMID:19462939
Comtmultiple interactionsISORGD:7371026480464CTD3, 4-methylenedioxyethamphetamine inhibits the reaction [COMT protein results in increased methylation of Dopamine]

PMID:19462939
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.