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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Comt
Name: catechol-O-methyltransferase
Acc ID: CHEBI:16318
Term: 4-nitrocatechol
Definition: A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.
Chemical ID: MESH:C001833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Comtincreases methylationEXP 6480464CTDCOMT protein results in increased methylation of 4-nitrocatechol

PMID:11160877
Comtincreases methylationISORGD:7371026480464CTDCOMT protein results in increased methylation of 4-nitrocatechol

PMID:11160877
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.