RGD Reference Report - Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. - Rat Genome Database

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Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers.

Authors: Guo, Song  Chen, Da Fang  Zhou, Dong Feng  Sun, Hong Qiang  Wu, Gui Ying  Haile, Colin N  Kosten, Therese A  Kosten, Thomas R  Zhang, Xiang Yang 
Citation: Guo S, etal., Psychopharmacology (Berl). 2007 Mar;190(4):449-56. doi: 10.1007/s00213-006-0628-4. Epub 2007 Jan 6.
RGD ID: 401959230
Pubmed: PMID:17206495   (View Abstract at PubMed)
DOI: DOI:10.1007/s00213-006-0628-4   (Journal Full-text)


RATIONALE: Catechol-O-methyltransferase (COMT) is an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, which is important in mediating drug reward such as nicotine in tobacco smoke. Different COMT alleles encode enzyme whose activity varies from three- to fourfold that may affect dopamine levels and alter subjective effects of nicotine. Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual's predisposition to developing nicotine dependence.
SUBJECTS AND METHODS: We studied the COMT Val108Met polymorphism in a male population of 203 current smokers, 66 former smokers, and 102 non-smokers. The age-adjusted odds ratios were estimated by multiple logistic regression models.
RESULTS: The results showed no significant association of the COMT Val108Met with initiation, persistent smoking, or smoking cessation. However, current smokers with the Met allele had significantly higher Fagerstrom Test for Nicotine Dependence scores (7.5 +/- 2.1 vs 6.8 +/- 1.8, p = 0.018) and started smoking significantly earlier (18.4 +/- 4.9 vs 20.1 +/- 5.9 years, p = 0.036).
CONCLUSIONS: These results suggest that the COMT Val108Met polymorphism may not influence smoking status in a Chinese male population but may influence the age at which smoking started and smoking severity among smokers. However, the findings must be regarded as preliminary because of the relatively small sample size and marginal associations and should be replicated in a larger cohort.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nicotine dependence onsetIAGP 401959230DNA:SNP:exon 3: G1947A and p.V158M (rs4680) (human)RGD 
nicotine dependence onsetISOCOMT (Homo sapiens)401959230; 401959230DNA:SNP:exon 3: G1947A and p.V158M (rs4680) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Addictive nicotine use onsetIAGP 401959230DNA:SNP:exon 3: G1947A and p.V158M (rs4680) (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Comt  (catechol-O-methyltransferase)

Genes (Mus musculus)
Comt  (catechol-O-methyltransferase)

Genes (Homo sapiens)
COMT  (catechol-O-methyltransferase)


Additional Information