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Gene: Comt (catechol-O-methyltransferase) Mus musculus
Symbol: Comt
Name: catechol-O-methyltransferase
Description: Exhibits catechol O-methyltransferase activity. Involved in cellular response to phosphate starvation and dopamine catabolic process. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study cognitive disorder and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; bulimia nervosa; cognitive disorder (multiple); eumycotic mycetoma; and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: catechol O-methyltransferase; catechol-O-methyltransferase 1; Comt1; D16Wsu103; D16Wsu103e; D330014B15Rik
Homo sapiens (human) : COMT (catechol-O-methyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Comt (catechol-O-methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Comt (catechol-O-methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : COMT (catechol-O-methyltransferase)
Canis lupus familiaris (dog) : COMT (catechol-O-methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Comt (catechol-O-methyltransferase)
Sus scrofa (pig) : COMT (catechol-O-methyltransferase)
Chlorocebus sabaeus (African green monkey) : COMT (catechol-O-methyltransferase)
Heterocephalus glaber (naked mole-rat) : Comt (catechol-O-methyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1618,406,886 - 18,426,852 (-)EnsemblGRCm38mm10GRCm38
GRCm381618,406,882 - 18,426,716 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371618,406,975 - 18,426,809 (-)NCBIGRCm37mm9NCBIm37
MGSCv361618,321,106 - 18,340,078 (-)NCBImm8
Celera1618,980,657 - 19,001,067 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Comt
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10378
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.