Comt (catechol-O-methyltransferase) - Rat Genome Database

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Gene: Comt (catechol-O-methyltransferase) Mus musculus
Analyze
Symbol: Comt
Name: catechol-O-methyltransferase
RGD ID: 10378
MGI Page MGI
Description: Enables catechol O-methyltransferase activity. Involved in neurotransmitter catabolic process. Acts upstream of or within cellular response to phosphate starvation and dopamine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study cognitive disorder and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: catechol O-methyltransferase; catechol-O-methyltransferase 1; Comt1; D16Wsu103; D16Wsu103e; D330014B15Rik
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,225,632 - 18,247,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,225,636 - 18,245,602 (-)EnsemblGRCm39 Ensembl
GRCm381618,406,882 - 18,426,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,406,886 - 18,426,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,406,975 - 18,426,809 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,321,106 - 18,340,078 (-)NCBIMGSCv36mm8
Celera1618,980,657 - 19,001,067 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Pain  (ISO)
alcohol use disorder  (ISO)
amphetamine abuse  (ISO)
Animal Mammary Neoplasms  (IEP,ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bulimia nervosa  (ISO)
Catalepsy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Child Behavior Disorders  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (IAGP,ISO)
DiGeorge syndrome  (ISO)
dilated cardiomyopathy  (ISO)
disease of mental health  (ISO)
Drug-Induced Dyskinesia  (ISO)
Dwarfism  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
eumycotic mycetoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
Fatigue  (ISO)
Fetal Growth Retardation  (ISO)
fibromyalgia  (ISO)
Hearing Loss, Cisplatin-Induced  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (ISO)
intellectual disability  (ISO)
leiomyoma  (ISO)
Lymphatic Metastasis  (ISO)
megacolon  (ISO)
Memory Disorders  (ISO)
Musculoskeletal Pain  (ISO)
Neck Pain  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
ovarian cancer  (ISO)
Pain  (ISO)
panic disorder  (ISO)
Parkinsonism  (ISO)
pheochromocytoma  (ISO)
polycystic ovary syndrome  (ISO)
pre-eclampsia  (IAGP)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
Schizophrenia Spectrum and Other Psychotic Disorders  (ISO)
Temporomandibular Joint Disorders  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
velocardiofacial syndrome  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3',4'-dihydroxyacetophenone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
3,4-dihydroxyacetophenone  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-dihydroxymandelic acid  (ISO)
3,4-dihydroxyphenylethyleneglycol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-methoxycatechol  (ISO)
3-O-methylgallic acid  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-chlorocatechol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylcatechol  (ISO)
4-nitrocatechol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-Hydroxydopamine  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alcohol  (EXP)
all-trans-retinoic acid  (ISO)
alpha-methyl-L-dopa  (ISO)
aminoglutethimide  (ISO)
amitraz  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
anthracene  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (EXP,ISO)
ATP  (ISO)
bathocuproine disulfonic acid  (ISO)
benserazide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
captan  (EXP)
carbidopa  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
catechol  (ISO)
CGP 28014  (EXP)
chlorpyrifos  (EXP,ISO)
ciguatoxin CTX1B  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cyproconazole  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
diuron  (ISO)
dobutamine  (ISO)
dopamine  (EXP,ISO)
edaravone  (EXP)
endosulfan  (ISO)
enilconazole  (ISO)
entacapone  (EXP,ISO)
epoxiconazole  (ISO)
esculetin  (ISO)
estrone  (ISO)
fenbuconazole  (ISO)
fenthion  (EXP)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
fluoranthene  (ISO)
folpet  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
glycidol  (ISO)
guaiacol  (ISO)
hemin  (ISO)
hexachlorobenzene  (ISO)
homocysteine  (ISO)
homovanillic acid  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
kojic acid  (ISO)
lactacystin  (ISO)
lamivudine  (ISO)
megestrol acetate  (ISO)
melevodopa  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Metanephrine  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
mianserin  (EXP)
modafinil  (ISO)
monosodium L-glutamate  (EXP)
morphine  (EXP,ISO)
myricetin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naphthalene  (ISO)
naphthalene-2,3-diol  (ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
Nitecapone  (EXP)
okadaic acid  (ISO)
olanzapine  (ISO)
Oleacein  (ISO)
oxidopamine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
pentachlorobenzene  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenanthrene  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
pyrene  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-3,4-methylenedioxy-N-ethylamphetamine  (ISO)
resveratrol  (ISO)
risperidone  (ISO)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
silicon dioxide  (EXP,ISO)
simazine  (EXP,ISO)
SKF 38393  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachlorocatechol  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
tolcapone  (EXP,ISO)
trans-caffeic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
tropolone  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IEA)
abnormal blood homeostasis  (IAGP)
abnormal cognition  (IAGP)
abnormal fear-related response  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal homeostasis  (IAGP)
abnormal impulsive behavior control  (IAGP)
abnormal locomotor behavior  (IEA)
abnormal maternal decidual layer morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal pregnancy  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal spongiotrophoblast layer morphology  (IAGP)
abnormal xenobiotic pharmacokinetics  (IAGP)
albuminuria  (IAGP)
cognitive inflexibility  (IAGP)
decreased anxiety-related response  (IEA)
decreased circulating fructosamine level  (IEA)
decreased circulating serum albumin level  (IEA)
decreased circulating total protein level  (IEA)
decreased prepulse inhibition  (IAGP)
decreased startle reflex  (IAGP)
decreased thigmotaxis  (IEA)
decreased vertical activity  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
enhanced cued conditioning behavior  (IAGP)
hyperactivity  (IEA)
hypertension  (IAGP)
hypoxia  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired cued conditioning behavior  (IAGP)
increased aggression towards male mice  (IAGP)
increased anxiety-related response  (IAGP)
increased circulating alanine transaminase level  (IEA)
increased circulating phosphate level  (IEA)
increased dopamine level  (IAGP)
increased grip strength  (IEA)
increased interferon-gamma secretion  (IAGP)
increased prepulse inhibition  (IAGP)
increased startle reflex  (IAGP)
increased uterine NK cell number  (IAGP)
increased vertical activity  (IAGP)
short gestation period  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in different ethnic groups. Al-Hendy A and Salama SA, J Soc Gynecol Investig. 2006 Feb;13(2):136-44.
2. Association between the COMT locus and obsessive-compulsive disorder in females but not males. Alsobrook JP 2nd, etal., Am J Med Genet 2002 Jan 8;114(1):116-20.
3. Immunohistochemical localization of catechol methyltransferase in normal and cancerous breast tissues of mice and rats. Amin AM, etal., J Natl Cancer Inst. 1983 Feb;70(2):337-42.
4. Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. Cunningham JM, etal., Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78.
5. The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder. Dickerson FB, etal., Bipolar Disord. 2006 Apr;8(2):124-32.
6. Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. Fernandez-de-las-Penas C, etal., Breast Cancer Res Treat. 2012 Jun;133(2):405-12. doi: 10.1007/s10549-011-1757-y. Epub 2011 Sep 4.
7. Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis. Fernández-de-las-Peñas C, etal., J Pain. 2013 Dec;14(12):1719-23. doi: 10.1016/j.jpain.2013.09.007. Epub 2013 Sep 28.
8. Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer. Garner EI, etal., Cancer Res. 2002 Jun 1;62(11):3058-62.
9. Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk. Gellekink H, etal., Thromb Haemost. 2007 Dec;98(6):1226-31.
10. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Gogos JA, etal., Proc Natl Acad Sci U S A 1998 Aug 18;95(17):9991-6.
11. Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk. Goodman JE, etal., Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1373-6.
12. Measurement of catechol-O-methyltransferase activity in the brain of Dahl salt-sensitive rats. Hirano Y, etal., Biol Pharm Bull. 2007 Nov;30(11):2178-80.
13. Suppression of catechol-O-methyltransferase activity through blunting of alpha2-adrenoceptor can explain hypertension in Dahl salt-sensitive rats. Hirano Y, etal., Hypertens Res. 2007 Mar;30(3):269-78.
14. A multigenic study on breast cancer risk associated with genetic polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 negative Shanghai women with early onset breast cancer or affected relatives. Hu Z, etal., J Cancer Res Clin Oncol. 2007 Dec;133(12):969-78. Epub 2007 Jun 12.
15. Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism. Inanir A, etal., Xenobiotica. 2014 Oct;44(10):952-6. doi: 10.3109/00498254.2014.913083. Epub 2014 Apr 24.
16. Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma -synuclein, and catechol-o-methyltransferase) identified by proteomic analysis. Iwaki H, etal., Cancer Sci. 2004 Dec;95(12):955-61.
17. Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease. Jhun E, etal., Anesth Analg. 2014 Nov;119(5):1201-7. doi: 10.1213/ANE.0000000000000382.
18. Inhibitors of catechol-O-methyltransferase sensitize mice to pain. Kambur O, etal., Br J Pharmacol. 2010 Dec;161(7):1553-65. doi: 10.1111/j.1476-5381.2010.00999.x.
19. Association of genetic polymorphisms of ACADSB and COMT with human hypertension. Kamide K, etal., J Hypertens. 2007 Jan;25(1):103-10.
20. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
21. Microarray analysis of differentially expressed genes associated with human ovarian cancer. Lee BC, etal., Int J Oncol. 2004 Apr;24(4):847-51.
22. A functional single-nucleotide polymorphism in the catechol-O-methyltransferase gene alter vitiligo risk in a Chinese population. Li K, etal., Arch Dermatol Res. 2009 Oct;301(9):681-7. doi: 10.1007/s00403-008-0920-8. Epub 2008 Dec 28.
23. COMT genotype and response to cognitive remediation in schizophrenia. Lindenmayer JP, etal., Schizophr Res. 2015 Oct;168(1-2):279-84. doi: 10.1016/j.schres.2015.07.037. Epub 2015 Aug 6.
24. Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Long JR, etal., Pharmacogenet Genomics. 2007 May;17(5):331-8.
25. Early administration of entacapone prevents levodopa-induced motor fluctuations in hemiparkinsonian rats. Marin C, etal., Exp Neurol. 2005 Mar;192(1):184-93.
26. Coadministration of entacapone with levodopa attenuates the severity of dyskinesias in hemiparkinsonian rats. Marin C, etal., Mov Disord. 2006 May;21(5):646-53.
27. Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase. Matsui A, etal., Cancer Lett. 2000 Mar 13;150(1):23-31.
28. Analysis of oxidative stress status, catalase and catechol-o-methyltransferase polymorphisms in egyptian vitiligo patients. Mehaney DA, etal., PLoS One. 2014 Jun 10;9(6):e99286. doi: 10.1371/journal.pone.0099286. eCollection 2014.
29. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
30. MGDs mouse GO annotations MGD data from the GO Consortium
31. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Nackley AG, etal., Pain. 2007 Apr;128(3):199-208. Epub 2006 Nov 7.
32. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. The Effect of Single Dose Methylphenidate on Neurometabolites according to COMT Gene Val158Met Polymorphism in the Patient with Attention Deficit Hyperactivity Disorder: A Study Using Magnetic Resonance Spectroscopy. Ozturk O, etal., Clin Psychopharmacol Neurosci. 2016 May 31;14(2):184-93. doi: 10.9758/cpn.2016.14.2.184.
35. Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality. Park BL, etal., J Hum Genet. 2009 Dec;54(12):709-12. doi: 10.1038/jhg.2009.102. Epub 2009 Oct 30.
36. Methyl conjugation in uraemia: catechol-O-methyltransferase. Pazmino PA and Weinshilboum RM, Br J Clin Pharmacol. 1980 Nov;10(5):509-18.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
39. The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis. Polak PE, etal., J Neuroimmunol. 2014 Nov 15;276(1-2):135-41. doi: 10.1016/j.jneuroim.2014.09.004. Epub 2014 Sep 16.
40. Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant. Pálmason H, etal., J Neural Transm (Vienna). 2010 Feb;117(2):259-67. doi: 10.1007/s00702-009-0338-2. Epub 2009 Nov 28.
41. Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes. Radoeva PD, etal., Psychiatr Genet. 2014 Dec;24(6):269-72. doi: 10.1097/YPG.0000000000000062.
42. Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia. Redell JB and Dash PK, Neurosci Lett. 2007 Feb 8;413(1):36-41. Epub 2006 Dec 15.
43. Mouse MP Annotation Import Pipeline RGD automated import pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas. Salama SA, etal., Fertil Steril. 2006 Jul;86(1):259-62. Epub 2006 May 26.
47. Lower levels of urinary 2-hydroxyestrogens in polycystic ovary syndrome. Salih S, etal., J Clin Endocrinol Metab. 2007 Aug;92(8):3285-91. Epub 2007 May 29.
48. Multiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer. Sasaki M, etal., Cancer Res. 2003 Jun 15;63(12):3101-6.
49. A highly significant association between a COMT haplotype and schizophrenia. Shifman S, etal., Am J Hum Genet 2002 Dec;71(6):1296-302. Epub 2002 Oct 25.
50. Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition. Singh A, etal., Pharmacology. 2003 Jun;68(2):81-8.
51. Catechol-O-methyltransferase activity in psoriasis patients treated with psoralen plus ultraviolet A therapy. Souteiro P, etal., Photodermatol Photoimmunol Photomed. 2013 Oct;29(5):227-32. doi: 10.1111/phpp.12058.
52. The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate. Suzuki M, etal., Eur Urol. 2005 Nov;48(5):752-9. Epub 2005 Aug 1.
53. Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer. Tanaka Y, etal., Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):238-44.
54. Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer. Tanaka Y, etal., Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):92-7.
55. The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages. Thompson JM, etal., Dev Med Child Neurol. 2012 Feb;54(2):148-54. doi: 10.1111/j.1469-8749.2011.04129.x. Epub 2011 Nov 9.
56. Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats. Tsunoda M, etal., Hypertens Res. 2003 Nov;26(11):923-7.
57. Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility. van de Sande WW, etal., Med Mycol. 2010 Nov;48(7):959-68. doi: 10.3109/13693781003636680.
58. Decrease in catechol-O-methyltransferase activity in the liver of streptozotocin-induced diabetic rats. Wang JP, etal., Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):419-22.
59. Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial. Wang SS, etal., Hum Genet. 2007 Aug;122(1):41-9. Epub 2007 May 12.
60. Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk. Wen W, etal., Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):917-20.
61. Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. Wong LL, etal., Hum Exp Toxicol. 2011 Sep;30(9):1369-81. doi: 10.1177/0960327110391388. Epub 2010 Dec 7.
62. No association between catechol-O-methyltransferase (COMT) genotype and attention deficit hyperactivity disorder (ADHD) in Japanese children. Yatsuga C, etal., Brain Dev. 2014 Aug;36(7):620-5. doi: 10.1016/j.braindev.2013.08.006. Epub 2013 Sep 12.
63. The Vpreb1 and comt genes are closely linked and sublocalized to rat chromosome 11q23. Yeung RS, etal., Mamm Genome 1996 Mar;7(3):246-7.
64. COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa. Yilmaz Z, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):948-52. doi: 10.1016/j.pnpbp.2011.01.012. Epub 2011 Feb 12.
65. [Polymorphism of catechol-O-methyltransferase gene in relation to the risk of endometrial cancer] Zhao XM, etal., Zhonghua Fu Chan Ke Za Zhi. 2007 Feb;42(2):116-9.
66. [Polymorphisms of CYP1B1 and COMT in breast and endometrial cancer]. Zimarina TC, etal., Mol Biol (Mosk). 2004 May-Jun;38(3):386-93.
Additional References at PubMed
PMID:8103600   PMID:8180479   PMID:8401507   PMID:8889548   PMID:9037598   PMID:9244437   PMID:9385360   PMID:9405660   PMID:9520487   PMID:9740669   PMID:10337614   PMID:10349636  
PMID:10486206   PMID:10500251   PMID:10704284   PMID:10725249   PMID:10963672   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11242111   PMID:11849292   PMID:12188925   PMID:12477932  
PMID:14610273   PMID:14614146   PMID:14662705   PMID:14681479   PMID:15716360   PMID:15778864   PMID:15782199   PMID:16109395   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17097888  
PMID:17707921   PMID:17724020   PMID:17881525   PMID:18469803   PMID:18614015   PMID:18674597   PMID:18684228   PMID:18753372   PMID:18834357   PMID:19139376   PMID:19379776   PMID:19426692  
PMID:19770404   PMID:19930170   PMID:20075204   PMID:20374420   PMID:20561508   PMID:20617305   PMID:20618449   PMID:20626558   PMID:20631688   PMID:20659173   PMID:20808911   PMID:20976038  
PMID:21267068   PMID:21677750   PMID:21821099   PMID:21851556   PMID:21873635   PMID:22009725   PMID:22169008   PMID:22192380   PMID:22500608   PMID:22658921   PMID:22688335   PMID:23011431  
PMID:23055483   PMID:23077214   PMID:23169629   PMID:23667712   PMID:23863468   PMID:24145376   PMID:24154693   PMID:24194600   PMID:24357327   PMID:24509724   PMID:24591155   PMID:24639487  
PMID:24658585   PMID:24952961   PMID:25131634   PMID:25452572   PMID:25555360   PMID:26067582   PMID:26893163   PMID:27388330   PMID:27626380   PMID:28556830   PMID:28801594   PMID:28855580  
PMID:30179860   PMID:30237900   PMID:30238463   PMID:31164811   PMID:31505254   PMID:31617665   PMID:32554809   PMID:32892421   PMID:33840199   PMID:34215813   PMID:35128032  


Genomics

Comparative Map Data
Comt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,225,632 - 18,247,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,225,636 - 18,245,602 (-)EnsemblGRCm39 Ensembl
GRCm381618,406,882 - 18,426,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,406,886 - 18,426,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,406,975 - 18,426,809 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,321,106 - 18,340,078 (-)NCBIMGSCv36mm8
Celera1618,980,657 - 19,001,067 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.4NCBI
COMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,941,772 - 19,969,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2219,941,371 - 19,969,975 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,929,295 - 19,957,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,309,309 - 18,336,530 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,324,623 - 18,331,084NCBI
Celera223,780,539 - 3,808,699 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,549,825 - 3,577,976 (+)NCBIHuRef
CHM1_12219,929,027 - 19,957,208 (+)NCBICHM1_1
T2T-CHM13v2.02220,319,463 - 20,347,602 (+)NCBIT2T-CHM13v2.0
Comt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,568,052 - 82,587,642 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,568,025 - 82,587,642 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,296,452 - 91,316,037 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01183,957,676 - 83,977,261 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01183,011,188 - 83,030,773 (+)NCBIRnor_WKY
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBICelera
RH 3.4 Map11712.2RGD
Cytogenetic Map11q23NCBI
Comt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,130,987 - 18,137,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,130,282 - 18,152,153 (-)NCBIChiLan1.0ChiLan1.0
COMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12218,375,434 - 18,402,387 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,375,434 - 18,402,387 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0222,704,015 - 2,731,326 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
COMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,359,930 - 29,381,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,360,356 - 29,366,008 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,318,554 - 29,324,118 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,763,075 - 30,783,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,763,078 - 30,783,978 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,811,616 - 28,817,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,436,974 - 28,442,538 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,522,581 - 29,528,148 (-)NCBIUU_Cfam_GSD_1.0
Comt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,870,188 - 138,906,864 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366193,847,059 - 3,883,866 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,385,738 - 51,403,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,384,729 - 51,403,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,021,681 - 55,040,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,775,829 - 5,803,260 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,773,225 - 5,785,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,128,529 - 1,156,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Comt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747581,832 - 588,333 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747569,127 - 588,479 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
AF076156  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371618,407,647 - 18,407,735UniSTSGRCm37
Celera1618,981,905 - 18,981,993UniSTS
Celera1618,981,099 - 18,981,187UniSTS
Cytogenetic Map16A3UniSTS
cM Map1611.2UniSTS
cM Map1611.18UniSTS
Whitehead/MRC_RH16149.24UniSTS
Comt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
cM Map1611.2UniSTS
D9Mit34.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E3UniSTS
Cytogenetic Map5E1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19D3UniSTS
Cytogenetic Map1H5UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map1H2.1UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map19CUniSTS
Cytogenetic Map17E1.3UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic MapXA1.1UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map3A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map8CUniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map1H1UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map1H2.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map15F2UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map1H4-H6UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map19BUniSTS
cM Map950.0UniSTS
Whitehead Genetic943.7UniSTS
D16Jhu32  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381618,414,626 - 18,415,012UniSTSGRCm38
MGSCv371618,414,719 - 18,415,105UniSTSGRCm37
Celera1618,988,977 - 18,989,363UniSTS
Cytogenetic Map16A3UniSTS
cM Map1611.21UniSTS
RH125710  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371618,407,637 - 18,407,887UniSTSGRCm37
Celera1618,981,895 - 18,982,145UniSTS
Celera1618,981,089 - 18,981,339UniSTS
Cytogenetic Map16A3UniSTS
cM Map1611.2UniSTS
Whitehead/MRC_RH16150.84UniSTS
Comt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
Comt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
Comt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:843
Count of miRNA genes:406
Interacting mature miRNAs:447
Transcripts:ENSMUST00000000335, ENSMUST00000115609, ENSMUST00000147720, ENSMUST00000165430
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001111062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA250343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC003066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC012399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF076156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW908224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB946852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX237493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU324997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU324998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000000335   ⟹   ENSMUSP00000000335
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1618,226,294 - 18,245,354 (-)Ensembl
GRCm38.p6 Ensembl1618,407,544 - 18,426,604 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115609   ⟹   ENSMUSP00000111272
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1618,226,016 - 18,245,602 (-)Ensembl
GRCm38.p6 Ensembl1618,407,266 - 18,426,852 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147720   ⟹   ENSMUSP00000121810
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1618,229,513 - 18,232,244 (-)Ensembl
GRCm38.p6 Ensembl1618,410,763 - 18,413,494 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165430   ⟹   ENSMUSP00000130077
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1618,225,636 - 18,232,244 (-)Ensembl
GRCm38.p6 Ensembl1618,406,886 - 18,413,494 (-)Ensembl
RefSeq Acc Id: NM_001111062   ⟹   NP_001104532
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,225,632 - 18,245,466 (-)NCBI
GRCm381618,406,882 - 18,426,716 (-)ENTREZGENE
MGSCv371618,406,975 - 18,426,809 (-)RGD
Celera1618,980,657 - 19,001,067 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001111063   ⟹   NP_001104533
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,225,632 - 18,232,244 (-)NCBI
GRCm381618,406,882 - 18,413,494 (-)NCBI
MGSCv371618,406,975 - 18,426,809 (-)RGD
Celera1618,980,657 - 19,001,067 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_007744   ⟹   NP_031770
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,225,632 - 18,245,466 (-)NCBI
GRCm381618,406,882 - 18,426,716 (-)ENTREZGENE
MGSCv371618,406,975 - 18,426,809 (-)RGD
Celera1618,980,657 - 19,001,067 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036159764   ⟹   XP_036015657
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,226,279 - 18,247,006 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031770   ⟸   NM_007744
- UniProtKB: Q91XH4 (UniProtKB/Swiss-Prot),   O88587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001104532   ⟸   NM_001111062
- UniProtKB: Q91XH4 (UniProtKB/Swiss-Prot),   O88587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001104533   ⟸   NM_001111063
- UniProtKB: Q91XH4 (UniProtKB/Swiss-Prot),   O88587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000121810   ⟸   ENSMUST00000147720
RefSeq Acc Id: ENSMUSP00000000335   ⟸   ENSMUST00000000335
RefSeq Acc Id: ENSMUSP00000130077   ⟸   ENSMUST00000165430
RefSeq Acc Id: ENSMUSP00000111272   ⟸   ENSMUST00000115609
RefSeq Acc Id: XP_036015657   ⟸   XM_036159764
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88587-F1-model_v2 AlphaFold O88587 1-265 view protein structure

Promoters
RGD ID:6826948
Promoter ID:MM_KWN:20388
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_001111063,   OTTMUST00000064323
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361618,413,201 - 18,413,957 (-)MPROMDB
RGD ID:8685676
Promoter ID:EPDNEW_M20869
Type:single initiation site
Name:Comt_2
Description:Mus musculus catechol-O-methyltransferase , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20870  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381618,413,460 - 18,413,520EPDNEW
RGD ID:8685678
Promoter ID:EPDNEW_M20870
Type:initiation region
Name:Comt_1
Description:Mus musculus catechol-O-methyltransferase , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20869  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381618,426,379 - 18,426,439EPDNEW
RGD ID:6826941
Promoter ID:MM_KWN:20390
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   Brain,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:NM_001111062,   OTTMUST00000064320
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361618,426,416 - 18,426,916 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88470 AgrOrtholog
Ensembl Genes ENSMUSG00000000326 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000000335 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000111272 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000121810.2 UniProtKB/TrEMBL
  ENSMUSP00000130077 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000335 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000115609 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000147720.3 UniProtKB/TrEMBL
  ENSMUST00000165430 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Catechol_O-MeTrfase_euk UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_O-MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12846 UniProtKB/Swiss-Prot
MGD MGI:88470 ENTREZGENE
NCBI Gene 12846 ENTREZGENE
Pfam Methyltransf_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB COMT RGD
PhenoGen Comt PhenoGen
PIRSF Catechol_O-mtfrase_euk UniProtKB/Swiss-Prot
PROSITE SAM_OMT_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt COMT_MOUSE UniProtKB/Swiss-Prot
  D3Z227_MOUSE UniProtKB/TrEMBL
  O88587 ENTREZGENE
  Q91XH4 ENTREZGENE
UniProt Secondary Q91XH4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Comt  catechol-O-methyltransferase  Comt1  catechol-O-methyltransferase 1  Symbol and/or name change 5135510 APPROVED