(-)-epigallocatechin 3-gallate affects binding ISO Comt (Rattus norvegicus) 6480464 epigallocatechin gallate binds to COMT protein CTD PMID:23010222 (3,4-dihydroxyphenyl)acetic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-Dihydroxyphenylacetic Acid CTD PMID:11160877 (3,4-dihydroxyphenyl)acetic acid multiple interactions ISO Comt (Rattus norvegicus) 6480464 [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3 and 4-Dihydroxyphenylacetic Acid CTD PMID:15190105 and PMID:16012872 (3,4-dihydroxyphenyl)acetic acid increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of 3 and 4-Dihydroxyphenylacetic Acid CTD PMID:11160877 (3,4-dihydroxyphenyl)acetic acid multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3 and 4-Dihydroxyphenylacetic Acid CTD PMID:11793163 (R)-adrenaline increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Epinephrine CTD PMID:11160877 (R)-adrenaline multiple interactions ISO Comt (Rattus norvegicus) 6480464 [COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine and tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] CTD PMID:10064789 and PMID:8821542 (R)-adrenaline increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of Epinephrine CTD PMID:10064789 (R)-adrenaline multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine CTD PMID:11248589 (R)-noradrenaline multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine CTD PMID:11248589 (R)-noradrenaline increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Norepinephrine CTD PMID:11160877 (S)-amphetamine affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene SNP affects the susceptibility to Dextroamphetamine CTD PMID:12716966 1,2,4-trimethylbenzene decreases expression ISO Comt (Rattus norvegicus) 6480464 pseudocumene results in decreased expression of COMT protein CTD PMID:17337753 1,2-dichloroethane decreases expression EXP 6480464 ethylene dichloride results in decreased expression of COMT mRNA CTD PMID:28189721 and PMID:28960355 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMT mRNA CTD PMID:17942748 17beta-estradiol decreases activity ISO COMT (Homo sapiens) 6480464 Estradiol results in decreased activity of COMT protein CTD PMID:18192686 and PMID:18497090 17beta-estradiol decreases expression ISO Comt (Rattus norvegicus) 6480464 Estradiol results in decreased expression of COMT mRNA CTD PMID:32145629 17beta-estradiol decreases expression ISO COMT (Homo sapiens) 6480464 Estradiol results in decreased expression of COMT mRNA CTD PMID:18497090 more ... 17beta-estradiol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Estradiol metabolite and Estradiol results in increased methylation of COMT promoter CTD PMID:22285433 and PMID:30684530 17beta-estradiol increases activity ISO Comt (Rattus norvegicus) 6480464 Estradiol results in increased activity of COMT protein CTD PMID:20600213 17beta-estradiol multiple interactions ISO Comt (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Estradiol results in increased activity of COMT protein] CTD PMID:20600213 17beta-estradiol multiple interactions ISO COMT (Homo sapiens) 6480464 [Estradiol results in increased methylation of COMT promoter] which results in decreased expression of COMT mRNA more ... CTD PMID:18192686 more ... 17beta-estradiol decreases abundance ISO COMT (Homo sapiens) 6480464 COMT protein polymorphism results in decreased abundance of Estradiol analog CTD PMID:15288375 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 2 more ... CTD PMID:32352317 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO COMT (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of COMT mRNA CTD PMID:20702594 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Comt (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of COMT mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Comt (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of COMT mRNA CTD PMID:20959002 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Comt (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of COMT mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of COMT mRNA CTD PMID:18796159 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of COMT mRNA more ... CTD PMID:16214954 more ... 2,3,7,8-Tetrachlorodibenzofuran affects expression EXP 6480464 2 more ... CTD PMID:20702594 2,4,6-tribromophenol decreases expression ISO COMT (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 2-hydroxy-17beta-estradiol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 2-hydroxyestradiol CTD PMID:11160877 2-hydroxy-17beta-estradiol increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of 2-hydroxyestradiol CTD PMID:11160877 2-hydroxy-17beta-estradiol affects metabolic processing ISO COMT (Homo sapiens) 6480464 COMT protein affects the metabolism of 2-hydroxyestradiol CTD PMID:15377160 2-methoxy-17beta-estradiol affects chemical synthesis ISO COMT (Homo sapiens) 6480464 COMT protein affects the chemical synthesis of 2-Methoxyestradiol CTD PMID:15377160 3',4'-dihydroxyacetophenone increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-dihydroxyacetophenone CTD PMID:11160877 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO Comt (Rattus norvegicus) 6480464 [3 more ... CTD PMID:30744511 3,3',5,5'-tetrabromobisphenol A decreases expression ISO Comt (Rattus norvegicus) 6480464 tetrabromobisphenol A results in decreased expression of COMT mRNA CTD PMID:26988606 3,3',5,5'-tetrabromobisphenol A decreases expression ISO COMT (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of COMT protein CTD PMID:31675489 3,4,5,3',4',5'-Hexachlorobiphenyl multiple interactions ISO Comt (Rattus norvegicus) 6480464 [3 more ... CTD PMID:30744511 3,4-dihydroxyacetophenone increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-dihydroxyacetophenone CTD PMID:11160877 3,4-dihydroxybenzoic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of protocatechuic acid CTD PMID:11160877 3,4-dihydroxybenzoic acid increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of protocatechuic acid CTD PMID:11160877 3,4-dihydroxymandelic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-dihydroxymandelic acid CTD PMID:11160877 3,4-dihydroxyphenylethyleneglycol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 and 4-dihydroxyphenylglycol CTD PMID:11160877 3,4-methylenedioxymethamphetamine multiple interactions EXP 6480464 COMT protein affects the metabolism of and affects the susceptibility to N-Methyl-3 and 4-methylenedioxyamphetamine CTD PMID:24591155 3,4-methylenedioxymethamphetamine multiple interactions ISO Comt (Rattus norvegicus) 6480464 COMT protein affects the metabolism of and affects the susceptibility to N-Methyl-3 and 4-methylenedioxyamphetamine CTD PMID:24591155 3-chloropropane-1,2-diol decreases expression ISO Comt (Rattus norvegicus) 6480464 alpha-Chlorohydrin analog results in decreased expression of COMT protein and alpha-Chlorohydrin results in decreased expression of COMT protein CTD PMID:26597043 3-methoxycatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3-methoxycatechol CTD PMID:11160877 3-O-methylgallic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3-O-methylgallic acid CTD PMID:11160877 4-amino-2,6-dinitrotoluene affects expression ISO Comt (Rattus norvegicus) 6480464 4-amino-2 and 6-dinitrotoluene affects the expression of COMT mRNA CTD PMID:21346803 4-chlorocatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 4-chlorocatechol CTD PMID:11160877 4-chlorocatechol increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of 4-chlorocatechol CTD PMID:11160877 4-hydroxy-17beta-estradiol affects metabolic processing ISO COMT (Homo sapiens) 6480464 COMT protein affects the metabolism of 4-hydroxyestradiol CTD PMID:15377160 4-hydroxy-17beta-estradiol multiple interactions ISO COMT (Homo sapiens) 6480464 daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol] more ... CTD PMID:18192686 4-hydroxy-17beta-estradiol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 4-hydroxyestradiol CTD PMID:18192686 4-hydroxynon-2-enal decreases expression ISO COMT (Homo sapiens) 6480464 4-hydroxy-2-nonenal results in decreased expression of COMT mRNA CTD PMID:12419474 4-methylcatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 4-methylcatechol CTD PMID:11160877 4-methylcatechol increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of 4-methylcatechol CTD PMID:11160877 4-nitrocatechol increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of 4-nitrocatechol CTD PMID:11160877 4-nitrocatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 4-nitrocatechol CTD PMID:11160877 5-aza-2'-deoxycytidine multiple interactions ISO COMT (Homo sapiens) 6480464 Decitabine inhibits the reaction [Estradiol results in decreased expression of COMT mRNA] and Decitabine inhibits the reaction [Estradiol results in increased methylation of COMT promoter] CTD PMID:30684530 5-Hydroxydopamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 5-hydroxydopamine CTD PMID:11160877 6-propyl-2-thiouracil decreases expression ISO Comt (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of COMT mRNA CTD PMID:36843608 acetamide decreases expression ISO Comt (Rattus norvegicus) 6480464 acetamide results in decreased expression of COMT mRNA CTD PMID:31881176 aflatoxin B1 affects methylation ISO COMT (Homo sapiens) 6480464 Aflatoxin B1 affects the methylation of COMT intron CTD PMID:30157460 Aflatoxin B2 alpha affects methylation ISO COMT (Homo sapiens) 6480464 aflatoxin B2 affects the methylation of COMT intron CTD PMID:30157460 alcohol affects response to substance EXP 6480464 COMT affects the susceptibility to Alcohols CTD PMID:18684228 all-trans-retinoic acid increases expression ISO COMT (Homo sapiens) 6480464 Tretinoin results in increased expression of COMT mRNA CTD PMID:21934132 alpha-methyl-L-dopa increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Methyldopa CTD PMID:11160877 alpha-methyl-L-dopa decreases activity ISO COMT (Homo sapiens) 6480464 Methyldopa results in decreased activity of COMT protein CTD PMID:7053299 aminoglutethimide increases expression ISO COMT (Homo sapiens) 6480464 Aminoglutethimide results in increased expression of COMT protein CTD PMID:26102013 amitraz multiple interactions ISO Comt (Rattus norvegicus) 6480464 Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA] and Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein] CTD PMID:28463726 amitraz affects expression ISO Comt (Rattus norvegicus) 6480464 amitraz affects the expression of COMT mRNA and amitraz affects the expression of COMT protein CTD PMID:28463726 ammonium chloride affects expression ISO Comt (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of COMT mRNA CTD PMID:16483693 ammonium chloride increases expression ISO Comt (Rattus norvegicus) 6480464 Ammonium Chloride results in increased expression of COMT mRNA CTD PMID:12420312 amphetamine multiple interactions ISO Comt (Rattus norvegicus) 6480464 COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine] CTD PMID:14574438 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of COMT mRNA CTD PMID:16916582 amphotericin B increases expression ISO COMT (Homo sapiens) 6480464 Amphotericin B analog results in increased expression of COMT mRNA CTD PMID:28534445 anthracene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 antirheumatic drug decreases expression ISO COMT (Homo sapiens) 6480464 Antirheumatic Agents results in decreased expression of COMT mRNA CTD PMID:24449571 aripiprazole increases expression ISO Comt (Rattus norvegicus) 6480464 Aripiprazole results in increased expression of COMT mRNA CTD PMID:17868501 aristolochic acid A increases expression ISO COMT (Homo sapiens) 6480464 aristolochic acid I results in increased expression of COMT mRNA CTD PMID:33212167 arsenite(3-) decreases expression EXP 6480464 arsenite results in decreased expression of COMT protein CTD PMID:29982692 arsenite(3-) increases expression ISO COMT (Homo sapiens) 6480464 arsenite results in increased expression of COMT mRNA CTD PMID:31646340 arsenite(3-) decreases expression ISO Comt (Rattus norvegicus) 6480464 arsenite results in decreased expression of COMT protein CTD PMID:29982692 ATP multiple interactions ISO COMT (Homo sapiens) 6480464 [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate and [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate CTD PMID:14975680 bathocuproine disulfonic acid multiple interactions ISO COMT (Homo sapiens) 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] CTD PMID:15477007 benserazide increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Benserazide CTD PMID:11160877 benserazide increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of Benserazide CTD PMID:11160877 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of COMT mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO COMT (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of COMT intron CTD PMID:30157460 benzo[a]pyrene decreases methylation ISO COMT (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of COMT 5' UTR CTD PMID:27901495 benzo[a]pyrene increases methylation ISO COMT (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of COMT 3' UTR and Benzo(a)pyrene results in increased methylation of COMT promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions EXP 6480464 [lipopolysaccharide and E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of COMT mRNA CTD PMID:28987381 benzo[e]pyrene decreases methylation ISO COMT (Homo sapiens) 6480464 benzo(e)pyrene results in decreased methylation of COMT intron CTD PMID:30157460 bexarotene decreases expression ISO Comt (Rattus norvegicus) 6480464 bexarotene results in decreased expression of COMT mRNA CTD PMID:16648578 bexarotene increases expression ISO Comt (Rattus norvegicus) 6480464 bexarotene results in increased expression of COMT mRNA CTD PMID:16648578 bis(2-ethylhexyl) phthalate increases expression ISO COMT (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of COMT mRNA CTD PMID:31163220 bisphenol A increases methylation ISO COMT (Homo sapiens) 6480464 bisphenol A results in increased methylation of COMT promoter CTD PMID:24214726 bisphenol A increases expression ISO COMT (Homo sapiens) 6480464 bisphenol A results in increased expression of COMT protein CTD PMID:34186270 bisphenol A affects expression ISO Comt (Rattus norvegicus) 6480464 bisphenol A affects the expression of COMT mRNA CTD PMID:30903817 bisphenol A increases expression ISO Comt (Rattus norvegicus) 6480464 bisphenol A results in increased expression of COMT mRNA CTD PMID:25181051 and PMID:29552716 bisphenol A multiple interactions ISO COMT (Homo sapiens) 6480464 fulvestrant inhibits the reaction [bisphenol A results in decreased expression of COMT mRNA] CTD PMID:24040167 bisphenol A decreases expression ISO COMT (Homo sapiens) 6480464 bisphenol A analog results in decreased expression of COMT mRNA more ... CTD PMID:24040167 more ... bisphenol A decreases expression ISO Comt (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of COMT mRNA CTD PMID:26186136 more ... Bisphenol B increases expression ISO COMT (Homo sapiens) 6480464 bisphenol B results in increased expression of COMT protein CTD PMID:34186270 bisphenol F decreases expression ISO Comt (Rattus norvegicus) 6480464 4 and 4'-bisphenol F results in decreased expression of COMT mRNA CTD PMID:26186136 bisphenol F increases expression ISO COMT (Homo sapiens) 6480464 bisphenol F results in increased expression of COMT protein CTD PMID:34186270 Butylbenzyl phthalate decreases expression ISO COMT (Homo sapiens) 6480464 butylbenzyl phthalate results in decreased expression of COMT mRNA CTD PMID:24040167 Butylbenzyl phthalate multiple interactions ISO COMT (Homo sapiens) 6480464 fulvestrant inhibits the reaction [butylbenzyl phthalate results in decreased expression of COMT mRNA] CTD PMID:24040167 butyric acid decreases expression ISO COMT (Homo sapiens) 6480464 Butyric Acid results in decreased expression of COMT mRNA CTD PMID:30439556 cadmium atom multiple interactions ISO COMT (Homo sapiens) 6480464 Fulvestrant inhibits the reaction [Cadmium results in decreased expression of COMT mRNA] CTD PMID:31646340 cadmium atom decreases expression ISO COMT (Homo sapiens) 6480464 Cadmium results in decreased expression of COMT mRNA CTD PMID:31646340 cadmium dichloride decreases expression ISO Comt (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of COMT mRNA CTD PMID:33453195 caffeine multiple interactions EXP 6480464 [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 calcitriol multiple interactions ISO COMT (Homo sapiens) 6480464 [Calcitriol co-treated with VDR protein] results in increased expression of COMT mRNA and Calcitriol promotes the reaction [VDR protein binds to COMT promoter] CTD PMID:27450565 captan increases expression EXP 6480464 Captan results in increased expression of COMT mRNA CTD PMID:31558096 carbidopa increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Carbidopa CTD PMID:11160877 carbidopa increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of Carbidopa CTD PMID:11160877 carbon nanotube decreases expression EXP 6480464 Nanotubes more ... CTD PMID:25620056 carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases activity ISO COMT (Homo sapiens) 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein CTD PMID:14975680 carbonyl cyanide p-trifluoromethoxyphenylhydrazone multiple interactions ISO COMT (Homo sapiens) 6480464 [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate CTD PMID:14975680 catechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of catechol CTD PMID:11160877 catechol multiple interactions ISO COMT (Homo sapiens) 6480464 COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA] more ... CTD PMID:24141029 catechol increases response to substance ISO COMT (Homo sapiens) 6480464 COMT mutant form results in increased susceptibility to catechol CTD PMID:24141029 catechol increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of catechol CTD PMID:11160877 CGP 28014 decreases activity EXP 6480464 N-(2-pyridone-6-yl)-N' and N'-di-n-propylformamidine results in decreased activity of COMT protein CTD PMID:20726980 chlorpyrifos increases expression ISO Comt (Rattus norvegicus) 6480464 Chlorpyrifos results in increased expression of COMT mRNA CTD PMID:18812211 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of COMT mRNA CTD PMID:37019170 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of COMT mRNA CTD PMID:32715474 ciguatoxin CTX1B affects expression EXP 6480464 Ciguatoxins affects the expression of COMT mRNA CTD PMID:18353800 cis-caffeic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of caffeic acid CTD PMID:11160877 cisplatin increases expression ISO Comt (Rattus norvegicus) 6480464 Cisplatin results in increased expression of COMT protein CTD PMID:22023808 cisplatin affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene SNP affects the susceptibility to Cisplatin CTD PMID:19898482 clonidine increases expression ISO Comt (Rattus norvegicus) 6480464 Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 clonidine (amino form) increases expression ISO Comt (Rattus norvegicus) 6480464 Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 clonidine (imino form) increases expression ISO Comt (Rattus norvegicus) 6480464 Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 clozapine multiple interactions ISO Comt (Rattus norvegicus) 6480464 [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] CTD PMID:15190105 clozapine affects response to substance ISO COMT (Homo sapiens) 6480464 COMT protein affects the susceptibility to Clozapine CTD PMID:17123785 clozapine increases response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism results in increased susceptibility to Clozapine CTD PMID:17123785 cobalt dichloride decreases expression ISO COMT (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of COMT mRNA CTD PMID:19320972 and PMID:19376846 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of COMT mRNA CTD PMID:31344373 corticosterone multiple interactions EXP 6480464 Edaravone inhibits the reaction [Corticosterone results in decreased expression of COMT mRNA] CTD PMID:31344373 coumestrol decreases expression ISO COMT (Homo sapiens) 6480464 Coumestrol results in decreased expression of COMT mRNA CTD PMID:19167446 coumestrol multiple interactions ISO COMT (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of COMT mRNA CTD PMID:19167446 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of COMT mRNA CTD PMID:21041162 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of COMT mRNA CTD PMID:19770486 cyproconazole multiple interactions ISO Comt (Rattus norvegicus) 6480464 [cyproconazole co-treated with epoxiconazole] results in increased expression of COMT mRNA CTD PMID:29038839 daidzein decreases activity ISO COMT (Homo sapiens) 6480464 daidzein results in decreased activity of COMT protein CTD PMID:18192686 and PMID:18497090 daidzein multiple interactions ISO COMT (Homo sapiens) 6480464 daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol] and fulvestrant inhibits the reaction [daidzein results in decreased expression of COMT mRNA] CTD PMID:18192686 and PMID:18497090 daidzein decreases expression ISO COMT (Homo sapiens) 6480464 daidzein results in decreased expression of COMT mRNA CTD PMID:18192686 and PMID:18497090 decabromodiphenyl ether increases expression ISO Comt (Rattus norvegicus) 6480464 decabromobiphenyl ether results in increased expression of COMT mRNA CTD PMID:23914054 decabromodiphenyl ether decreases expression ISO COMT (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of COMT protein CTD PMID:31675489 deguelin increases expression ISO COMT (Homo sapiens) 6480464 deguelin results in increased expression of COMT mRNA CTD PMID:33512557 deoxynivalenol decreases phosphorylation EXP 6480464 deoxynivalenol results in decreased phosphorylation of COMT protein CTD PMID:23811945 dexamethasone multiple interactions ISO Comt (Rattus norvegicus) 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of COMT mRNA] CTD PMID:20032058 dexamethasone increases expression ISO Comt (Rattus norvegicus) 6480464 Dexamethasone results in increased expression of COMT mRNA CTD PMID:16962226 and PMID:20032058 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of COMT mRNA CTD PMID:21041162 diazinon decreases expression ISO Comt (Rattus norvegicus) 6480464 Diazinon results in decreased expression of COMT mRNA and Diazinon results in decreased expression of COMT protein CTD PMID:18812211 and PMID:26721910 dibenzofurans increases expression EXP 6480464 Dibenzofurans results in increased expression of COMT mRNA CTD PMID:34254344 dibutyl phthalate multiple interactions ISO COMT (Homo sapiens) 6480464 fulvestrant inhibits the reaction [Dibutyl Phthalate results in decreased expression of COMT mRNA] CTD PMID:24040167 dibutyl phthalate decreases expression ISO COMT (Homo sapiens) 6480464 Dibutyl Phthalate results in decreased expression of COMT mRNA CTD PMID:24040167 dieldrin increases expression ISO Comt (Rattus norvegicus) 6480464 Dieldrin results in increased expression of COMT mRNA CTD PMID:18812211 diethyl maleate decreases expression ISO Comt (Rattus norvegicus) 6480464 diethyl maleate results in decreased expression of COMT mRNA CTD PMID:21161181 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of COMT mRNA CTD PMID:21041162 diuron decreases expression ISO Comt (Rattus norvegicus) 6480464 Diuron results in decreased expression of COMT mRNA CTD PMID:21551480 diuron decreases expression ISO COMT (Homo sapiens) 6480464 Diuron results in decreased expression of COMT mRNA CTD PMID:35967413 dobutamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Dobutamine CTD PMID:11160877 dobutamine increases expression ISO Comt (Rattus norvegicus) 6480464 Dobutamine results in increased expression of COMT mRNA CTD PMID:12423672 dopamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Dopamine CTD PMID:11160877 dopamine increases metabolic processing EXP 6480464 COMT protein results in increased metabolism of Dopamine CTD PMID:20626558 dopamine increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of Dopamine CTD PMID:11160877 dopamine multiple interactions ISO Comt (Rattus norvegicus) 6480464 [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] and COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine] CTD PMID:14574438 and PMID:15190105 dopamine multiple interactions ISO COMT (Homo sapiens) 6480464 3 more ... CTD PMID:11248589 more ... edaravone multiple interactions EXP 6480464 Edaravone inhibits the reaction [Corticosterone results in decreased expression of COMT mRNA] CTD PMID:31344373 endosulfan decreases expression ISO Comt (Rattus norvegicus) 6480464 Endosulfan results in decreased expression of COMT mRNA CTD PMID:29391264 enilconazole increases expression ISO COMT (Homo sapiens) 6480464 enilconazole results in increased expression of COMT protein CTD PMID:32201337 entacapone decreases activity ISO COMT (Homo sapiens) 6480464 entacapone results in decreased activity of COMT protein CTD PMID:23206800 and PMID:29688484 entacapone affects binding ISO Comt (Rattus norvegicus) 6480464 entacapone binds to COMT protein CTD PMID:19783845 entacapone decreases activity ISO Comt (Rattus norvegicus) 6480464 entacapone results in decreased activity of COMT protein CTD PMID:19783845 and PMID:20334432 entacapone decreases activity EXP 6480464 entacapone results in decreased activity of COMT protein CTD PMID:15566291 and PMID:20334432 entacapone multiple interactions ISO COMT (Homo sapiens) 6480464 [entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine and entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa] CTD PMID:12898346 and PMID:23206800 epoxiconazole multiple interactions ISO Comt (Rattus norvegicus) 6480464 [cyproconazole co-treated with epoxiconazole] results in increased expression of COMT mRNA CTD PMID:29038839 esculetin increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of esculetin CTD PMID:11160877 estrone increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Estrone metabolite CTD PMID:22285433 fenbuconazole increases expression ISO COMT (Homo sapiens) 6480464 fenbuconazole results in increased expression of COMT mRNA CTD PMID:15942997 fenthion increases expression EXP 6480464 Fenthion results in increased expression of COMT mRNA CTD PMID:34813904 fingolimod hydrochloride increases expression ISO COMT (Homo sapiens) 6480464 Fingolimod Hydrochloride results in increased expression of COMT mRNA CTD PMID:29654831 fisetin multiple interactions ISO COMT (Homo sapiens) 6480464 [fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 fluoranthene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 folpet increases expression EXP 6480464 folpet results in increased expression of COMT mRNA CTD PMID:31558096 FR900359 increases phosphorylation ISO COMT (Homo sapiens) 6480464 FR900359 results in increased phosphorylation of COMT protein CTD PMID:37730182 fulvestrant multiple interactions ISO COMT (Homo sapiens) 6480464 Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of COMT mRNA] more ... CTD PMID:18192686 more ... fulvestrant increases expression ISO COMT (Homo sapiens) 6480464 Fulvestrant results in increased expression of COMT mRNA CTD PMID:31646340 furan decreases expression ISO Comt (Rattus norvegicus) 6480464 furan results in decreased expression of COMT mRNA CTD PMID:26194646 genistein decreases activity ISO COMT (Homo sapiens) 6480464 Genistein results in decreased activity of COMT protein CTD PMID:18192686 and PMID:18497090 genistein increases methylation ISO COMT (Homo sapiens) 6480464 Genistein results in increased methylation of COMT promoter CTD PMID:30684530 genistein decreases expression ISO COMT (Homo sapiens) 6480464 Genistein results in decreased expression of COMT mRNA CTD PMID:18192686 more ... genistein multiple interactions ISO COMT (Homo sapiens) 6480464 [Genistein results in increased methylation of COMT promoter] which results in decreased expression of COMT mRNA more ... CTD PMID:18192686 more ... glycidol increases expression ISO Comt (Rattus norvegicus) 6480464 glycidol results in increased expression of COMT mRNA CTD PMID:24915197 guaiacol multiple interactions ISO COMT (Homo sapiens) 6480464 COMT mutant form inhibits the reaction [catechol results in increased abundance of Guaiacol] CTD PMID:24141029 hemin multiple interactions ISO COMT (Homo sapiens) 6480464 COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA] more ... CTD PMID:24141029 hexachlorobenzene increases expression ISO COMT (Homo sapiens) 6480464 Hexachlorobenzene results in increased expression of COMT protein CTD PMID:24365113 homocysteine multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine] CTD PMID:16758261 homovanillic acid multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid CTD PMID:11793163 homovanillic acid multiple interactions ISO Comt (Rattus norvegicus) 6480464 [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid CTD PMID:15190105 and PMID:16012872 hydrazine decreases expression ISO Comt (Rattus norvegicus) 6480464 hydrazine results in decreased expression of COMT protein CTD PMID:15370871 hydrogen peroxide decreases expression ISO COMT (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of COMT mRNA and Hydrogen Peroxide results in decreased expression of COMT protein CTD PMID:12419474 and PMID:34581912 hydrogen peroxide increases expression ISO COMT (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of COMT mRNA CTD PMID:18951874 inulin multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of COMT mRNA CTD PMID:36331819 ionomycin multiple interactions ISO COMT (Homo sapiens) 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] and [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA CTD PMID:15477007 isoprenaline increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Isoproterenol CTD PMID:11160877 ivermectin decreases expression ISO COMT (Homo sapiens) 6480464 Ivermectin results in decreased expression of COMT protein CTD PMID:32959892 ketamine increases expression ISO Comt (Rattus norvegicus) 6480464 Ketamine results in increased expression of COMT mRNA CTD PMID:20080153 kojic acid multiple interactions ISO Comt (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA CTD PMID:18544905 lactacystin multiple interactions ISO COMT (Homo sapiens) 6480464 lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein] CTD PMID:17138778 lamivudine multiple interactions ISO COMT (Homo sapiens) 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA CTD PMID:15784690 megestrol acetate increases expression ISO COMT (Homo sapiens) 6480464 Megestrol Acetate results in increased expression of COMT protein CTD PMID:16939895 melevodopa increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of levodopa methyl ester CTD PMID:11160877 mercury atom affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism affects the susceptibility to Mercury and COMT gene SNP affects the susceptibility to Mercury CTD PMID:19296409 and PMID:24593143 mercury(0) affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism affects the susceptibility to Mercury and COMT gene SNP affects the susceptibility to Mercury CTD PMID:19296409 and PMID:24593143 Metanephrine increases chemical synthesis ISO COMT (Homo sapiens) 6480464 COMT protein results in increased chemical synthesis of Metanephrine CTD PMID:22569243 Metanephrine multiple interactions ISO Comt (Rattus norvegicus) 6480464 [COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine and tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] CTD PMID:10064789 and PMID:8821542 methamphetamine increases response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism results in increased susceptibility to Methamphetamine CTD PMID:15274053 methamphetamine affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism affects the susceptibility to Methamphetamine CTD PMID:19462300 methapyrilene decreases methylation ISO COMT (Homo sapiens) 6480464 Methapyrilene results in decreased methylation of COMT intron CTD PMID:30157460 methotrexate increases expression ISO Comt (Rattus norvegicus) 6480464 Methotrexate results in increased expression of COMT mRNA CTD PMID:15120968 mianserin multiple interactions EXP 6480464 [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 modafinil affects response to substance ISO COMT (Homo sapiens) 6480464 COMT gene polymorphism affects the susceptibility to modafinil and COMT protein affects the susceptibility to modafinil CTD PMID:20815183 monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of COMT mRNA CTD PMID:22078008 morphine affects response to substance EXP 6480464 COMT protein affects the susceptibility to Morphine CTD PMID:18834357 morphine multiple interactions ISO COMT (Homo sapiens) 6480464 [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine CTD PMID:21127283 myricetin multiple interactions ISO COMT (Homo sapiens) 6480464 [myricetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 N-methyl-4-phenylpyridinium multiple interactions ISO COMT (Homo sapiens) 6480464 U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of COMT mRNA] CTD PMID:12710931 N-nitrosodiethylamine multiple interactions ISO Comt (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA CTD PMID:18544905 N-nitrosomorpholine decreases expression ISO Comt (Rattus norvegicus) 6480464 N-nitrosomorpholine results in decreased expression of COMT protein CTD PMID:19716841 naphthalene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 naphthalene-2,3-diol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 2 and 3-dihydroxynaphthalene CTD PMID:11160877 naphthalene-2,3-diol increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of 2 and 3-dihydroxynaphthalene CTD PMID:11160877 naphthalenes decreases expression ISO Comt (Rattus norvegicus) 6480464 Naphthalenes results in decreased expression of COMT protein CTD PMID:17337753 nickel atom decreases expression ISO Comt (Rattus norvegicus) 6480464 Nickel results in decreased expression of COMT mRNA CTD PMID:18812211 nickel sulfate increases expression ISO COMT (Homo sapiens) 6480464 nickel sulfate results in increased expression of COMT mRNA CTD PMID:18651567 Nitecapone decreases activity EXP 6480464 nitecapone results in decreased activity of COMT protein CTD PMID:20726980 okadaic acid decreases expression ISO COMT (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of COMT protein CTD PMID:19397276 okadaic acid multiple interactions ISO COMT (Homo sapiens) 6480464 [Okadaic Acid co-treated with gambierol] results in decreased expression of COMT protein CTD PMID:19397276 olanzapine increases expression ISO Comt (Rattus norvegicus) 6480464 olanzapine results in increased expression of COMT mRNA CTD PMID:15964593 Oleacein decreases activity ISO COMT (Homo sapiens) 6480464 oleacein results in decreased activity of COMT protein CTD PMID:30935952 oxidopamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Oxidopamine CTD PMID:11160877 paracetamol decreases expression ISO Comt (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of COMT mRNA CTD PMID:17202762 more ... paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of COMT mRNA CTD PMID:17562736 paraquat increases expression ISO Comt (Rattus norvegicus) 6480464 Paraquat results in increased expression of COMT mRNA CTD PMID:17935786 parathion decreases expression EXP 6480464 Parathion results in decreased expression of COMT mRNA CTD PMID:34813904 pentachlorobenzene decreases expression ISO COMT (Homo sapiens) 6480464 pentachlorobenzene results in decreased expression of COMT protein CTD PMID:24365113 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of COMT mRNA CTD PMID:36331819 perfluorooctane-1-sulfonic acid increases expression ISO COMT (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in increased expression of COMT mRNA CTD PMID:33772556 perfluorooctanoic acid multiple interactions EXP 6480464 [perfluorooctanoic acid co-treated with Dietary Fats more ... CTD PMID:20118188 and PMID:23626681 perfluorooctanoic acid increases expression ISO COMT (Homo sapiens) 6480464 perfluorooctanoic acid results in increased expression of COMT mRNA CTD PMID:33772556 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of COMT mRNA CTD PMID:20118188 and PMID:23626681 permethrin decreases expression EXP 6480464 Permethrin results in decreased expression of COMT mRNA CTD PMID:30629241 phenanthrene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 phenobarbital decreases expression ISO Comt (Rattus norvegicus) 6480464 Phenobarbital results in decreased expression of COMT mRNA CTD PMID:16510358 PhIP affects response to substance ISO Comt (Rattus norvegicus) 6480464 COMT protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine CTD PMID:12901791 phorbol 13-acetate 12-myristate multiple interactions ISO COMT (Homo sapiens) 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] and [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA CTD PMID:15477007 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of COMT mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO Comt (Rattus norvegicus) 6480464 pirinixic acid results in decreased expression of COMT mRNA CTD PMID:16940010 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of COMT mRNA CTD PMID:18445702 and PMID:20813756 potassium bromate increases expression ISO Comt (Rattus norvegicus) 6480464 potassium bromate results in increased expression of COMT mRNA CTD PMID:23588252 potassium dichromate increases expression ISO COMT (Homo sapiens) 6480464 Potassium Dichromate results in increased expression of COMT mRNA CTD PMID:18332044 pregnenolone 16alpha-carbonitrile decreases expression ISO Comt (Rattus norvegicus) 6480464 Pregnenolone Carbonitrile results in decreased expression of COMT mRNA CTD PMID:19162173 progesterone decreases expression ISO COMT (Homo sapiens) 6480464 Progesterone results in decreased expression of COMT protein CTD PMID:17138778 pyrene multiple interactions ISO COMT (Homo sapiens) 6480464 [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA and [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 pyrogallol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of Pyrogallol CTD PMID:11160877 pyrrolidine dithiocarbamate multiple interactions ISO COMT (Homo sapiens) 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] CTD PMID:15477007 quercetin multiple interactions ISO COMT (Homo sapiens) 6480464 [Quercetin co-treated with COMT protein] results in decreased activity of DNMT1 protein CTD PMID:16037419 quercetin decreases activity ISO Comt (Rattus norvegicus) 6480464 Quercetin results in decreased activity of COMT protein CTD PMID:20600213 quercetin multiple interactions ISO Comt (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Estradiol results in increased activity of COMT protein] CTD PMID:20600213 rac-3,4-methylenedioxy-N-ethylamphetamine multiple interactions ISO COMT (Homo sapiens) 6480464 3 and 4-methylenedioxyethamphetamine inhibits the reaction [COMT protein results in increased methylation of Dopamine] CTD PMID:19462939 rac-3,4-methylenedioxy-N-ethylamphetamine increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein alternative form results in increased methylation of 3 and 4-methylenedioxyethamphetamine CTD PMID:19462939 resveratrol multiple interactions ISO COMT (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of COMT mRNA CTD PMID:19167446 risperidone increases expression ISO Comt (Rattus norvegicus) 6480464 Risperidone results in increased expression of COMT mRNA CTD PMID:15964593 rotenone increases expression ISO COMT (Homo sapiens) 6480464 Rotenone results in increased expression of COMT mRNA CTD PMID:33512557 S-adenosyl-L-homocysteine decreases activity ISO Comt (Rattus norvegicus) 6480464 S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 S-adenosyl-L-methioninate multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 S-adenosyl-L-methionine multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of COMT mRNA CTD PMID:23221170 silicon dioxide increases expression ISO Comt (Rattus norvegicus) 6480464 Silicon Dioxide results in increased expression of COMT mRNA CTD PMID:32721576 simazine decreases expression EXP 6480464 Simazine results in decreased expression of COMT mRNA and Simazine results in decreased expression of COMT protein CTD PMID:29137186 simazine increases expression ISO Comt (Rattus norvegicus) 6480464 Simazine results in increased expression of COMT mRNA CTD PMID:29115391 SKF 38393 increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 2 more ... CTD PMID:11160877 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of COMT protein CTD PMID:29044176 sodium arsenite increases expression ISO Comt (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of COMT protein CTD PMID:29459688 sodium dichromate increases expression ISO Comt (Rattus norvegicus) 6480464 sodium bichromate results in increased expression of COMT mRNA CTD PMID:12325037 sulforaphane multiple interactions ISO COMT (Homo sapiens) 6480464 sulforaphane inhibits the reaction [DNMT3B protein binds to COMT promoter] more ... CTD PMID:30684530 sunitinib increases expression ISO COMT (Homo sapiens) 6480464 Sunitinib results in increased expression of COMT mRNA CTD PMID:31533062 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of COMT mRNA CTD PMID:25123088 tamoxifen affects expression ISO Comt (Rattus norvegicus) 6480464 Tamoxifen affects the expression of COMT mRNA and Tamoxifen affects the expression of COMT protein CTD PMID:28463726 tamoxifen multiple interactions ISO Comt (Rattus norvegicus) 6480464 Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA] and Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein] CTD PMID:28463726 tamoxifen affects metabolic processing ISO COMT (Homo sapiens) 6480464 COMT protein affects the metabolism of Tamoxifen CTD PMID:15288375 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of COMT mRNA CTD PMID:20937368 tert-butyl hydroperoxide decreases expression ISO COMT (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of COMT mRNA CTD PMID:12419474 tert-butyl hydroperoxide decreases expression ISO Comt (Rattus norvegicus) 6480464 tert-Butylhydroperoxide results in decreased expression of COMT protein CTD PMID:24394546 testosterone multiple interactions ISO Comt (Rattus norvegicus) 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of COMT mRNA] CTD PMID:20032058 tetrachlorocatechol increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of 3 more ... CTD PMID:11160877 tetrachloromethane decreases expression ISO Comt (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of COMT mRNA CTD PMID:16239168 and PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of COMT mRNA CTD PMID:31919559 thioacetamide decreases expression ISO Comt (Rattus norvegicus) 6480464 Thioacetamide results in decreased expression of COMT mRNA CTD PMID:34492290 tolcapone increases methylation ISO Comt (Rattus norvegicus) 6480464 COMT protein results in increased methylation of tolcapone CTD PMID:12584150 tolcapone decreases activity ISO COMT (Homo sapiens) 6480464 tolcapone results in decreased activity of COMT protein CTD PMID:11248589 more ... tolcapone multiple interactions ISO COMT (Homo sapiens) 6480464 [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine] more ... CTD PMID:10047930 more ... tolcapone affects binding ISO Comt (Rattus norvegicus) 6480464 tolcapone binds to COMT protein CTD PMID:19783845 tolcapone decreases activity EXP 6480464 tolcapone results in decreased activity of COMT protein CTD PMID:15566291 and PMID:20334432 tolcapone decreases activity ISO Comt (Rattus norvegicus) 6480464 tolcapone results in decreased activity of COMT protein CTD PMID:10064789 more ... tolcapone multiple interactions ISO Comt (Rattus norvegicus) 6480464 [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] more ... CTD PMID:15190105 more ... trans-caffeic acid increases methylation ISO COMT (Homo sapiens) 6480464 COMT protein results in increased methylation of caffeic acid CTD PMID:11160877 trichloroethene decreases expression ISO Comt (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of COMT mRNA CTD PMID:19448997 trichloroethene increases expression ISO Comt (Rattus norvegicus) 6480464 Trichloroethylene results in increased expression of COMT mRNA CTD PMID:33387578 trichostatin A multiple interactions ISO COMT (Homo sapiens) 6480464 trichostatin A inhibits the reaction [Estradiol results in decreased expression of COMT mRNA] CTD PMID:30684530 Triptolide decreases expression ISO Comt (Rattus norvegicus) 6480464 triptolide results in decreased expression of COMT protein CTD PMID:32519852 tropolone decreases activity ISO Comt (Rattus norvegicus) 6480464 Tropolone results in decreased activity of COMT protein CTD PMID:10064789 trovafloxacin multiple interactions EXP 6480464 [trovafloxacin co-treated with lipopolysaccharide and E coli O55-B5] results in decreased expression of COMT mRNA CTD PMID:18930950 valproic acid affects expression ISO COMT (Homo sapiens) 6480464 Valproic Acid affects the expression of COMT mRNA CTD PMID:25979313 valproic acid increases expression ISO COMT (Homo sapiens) 6480464 Valproic Acid results in increased expression of COMT mRNA CTD PMID:28001369 valproic acid increases methylation ISO COMT (Homo sapiens) 6480464 Valproic Acid results in increased methylation of COMT gene CTD PMID:29154799 valproic acid decreases expression ISO COMT (Homo sapiens) 6480464 Valproic Acid results in decreased expression of COMT mRNA CTD PMID:29154799 vinclozolin affects expression ISO Comt (Rattus norvegicus) 6480464 vinclozolin affects the expression of COMT mRNA CTD PMID:19015723 zidovudine multiple interactions ISO COMT (Homo sapiens) 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA CTD PMID:15784690