Comt (catechol-O-methyltransferase)

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Gene: Comt (catechol-O-methyltransferase) Chinchilla lanigera

Analyze

Symbol:

Comt

Name:

catechol-O-methyltransferase

RGD ID:

8774319

Description:

ENCODES a protein that exhibits catechol O-methyltransferase activity (ortholog); INVOLVED IN positive regulation of lactation; catechol-containing compound metabolic process (ortholog); catecholamine catabolic process (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH Acute Pain (ortholog); alcohol use disorder (ortholog); amphetamine abuse (ortholog); FOUND IN cell body; extracellular space; glial cell projection

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

catechol O-methyltransferase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	18,130,987 - 18,137,412 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	18,130,282 - 18,152,153 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Pain (ISO)

alcohol use disorder (ISO)

amphetamine abuse (ISO)

Animal Mammary Neoplasms (ISO)

attention deficit hyperactivity disorder (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

Bardet-Biedl syndrome (ISO)

bipolar disorder (ISO)

Brain Injuries (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

bulimia nervosa (ISO)

Catalepsy (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Child Behavior Disorders (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

chromosome 22q11.2 microduplication syndrome (ISO)

Cocaine-Related Disorders (ISO)

cognitive disorder (ISO)

DiGeorge syndrome (ISO)

dilated cardiomyopathy (ISO)

disease of mental health (ISO)

Drug-Induced Dyskinesia (ISO)

endometrial cancer (ISO)

epilepsy (ISO)

eumycotic mycetoma (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Diabetes Mellitus (ISO)

familial hypertrophic cardiomyopathy (ISO)

Fatigue (ISO)

Fetal Growth Retardation (ISO)

fibromyalgia (ISO)

genetic disease (ISO)

Glucocorticoid Deficiency 5 (ISO)

Hearing Loss, Cisplatin-Induced (ISO)

hemorrhagic disease (ISO)

hepatocellular carcinoma (ISO)

Hyperalgesia (ISO)

hypertension (ISO)

immunodeficiency 51 (ISO)

intellectual disability (ISO)

leiomyoma (ISO)

Lymphatic Metastasis (ISO)

megacolon (ISO)

Memory Disorders (ISO)

Musculoskeletal Pain (ISO)

Neck Pain (ISO)

Neurodevelopmental Disorders (ISO)

obesity (ISO)

obsessive-compulsive disorder (ISO)

ovarian cancer (ISO)

Pain (ISO)

panic disorder (ISO)

Parkinsonism (ISO)

pheochromocytoma (ISO)

Polyarteritis Nodosa, Childhood-Onset (ISO)

polycystic ovary syndrome (ISO)

pre-eclampsia (ISO)

primary immunodeficiency disease (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

psoriasis (ISO)

renal cell carcinoma (ISO)

schizophrenia (ISO)

Schizophrenia Spectrum and Other Psychotic Disorders (ISO)

Temporomandibular Joint Disorders (ISO)

uremia (ISO)

urinary bladder cancer (ISO)

velocardiofacial syndrome (ISO)

Venous Thrombosis (ISO)

vitiligo (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

catechol-containing compound metabolic process (ISO)

catecholamine catabolic process (ISO)

catecholamine metabolic process (ISO)

cellular response to cocaine (ISO)

cellular response to phosphate starvation (ISO)

cognition (ISO)

detection of temperature stimulus involved in sensory perception of pain (ISO)

dopamine catabolic process (ISO)

dopamine metabolic process (ISO)

dopamine secretion (ISO)

estrogen metabolic process (ISO)

exploration behavior (ISO)

fear response (ISO)

female pregnancy (ISO)

gene expression (ISO)

habituation (ISO)

kidney development (ISO)

learning (ISO)

learning or memory (ISO)

mastication (ISO)

methylation (ISO)

multicellular organismal reproductive process (ISO)

negative regulation of dopamine metabolic process (ISO)

negative regulation of smooth muscle cell proliferation (ISO)

norepinephrine metabolic process (ISO)

norepinephrine secretion (ISO)

positive regulation of homocysteine metabolic process (ISO)

positive regulation of lactation (IDA)

renal albumin absorption (ISO)

renal sodium excretion (ISO)

renin secretion into blood stream (ISO)

response to amphetamine (ISO)

response to angiotensin (ISO)

response to corticosterone (ISO)

response to cytokine (ISO)

response to estrogen (ISO)

response to food (ISO)

response to hypoxia (ISO)

response to inorganic substance (ISO)

response to lipopolysaccharide (ISO)

response to organic cyclic compound (ISO)

response to pain (ISO)

response to salt (ISO)

response to temperature stimulus (ISO)

response to toxic substance (ISO)

response to wounding (ISO)

response to xenobiotic stimulus (ISO)

short-term memory (ISO)

synaptic transmission, dopaminergic (ISO)

visual learning (ISO)

Cellular Component

axon (ISO)

cell body (IDA)

cytosol (ISO)

dendrite (ISO)

dendritic spine (ISO)

extracellular space (IDA)

glial cell projection (IDA)

glutamatergic synapse (ISO)

intracellular membrane-bounded organelle (ISO)

plasma membrane (ISO)

postsynapse (ISO)

postsynaptic membrane (ISO)

Molecular Function

catechol O-methyltransferase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alkaptonuria pathway (ISO)

disulfiram pharmacodynamics pathway (ISO)

dopamine beta-hydroxylase deficiency pathway (ISO)

hawkinsinuria pathway (ISO)

homocysteine metabolic pathway (ISO)

methionine cycle/metabolic pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

tyrosine metabolic pathway (ISO)

tyrosinemia type I pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	Biological and chemical properties of chincilla pituitary prolactin.	Jibson M and Talamantes F, Gen Comp Endocrinol. 1978 Apr;34(4):402-7.
3.	Immunohistochemical demonstration of catechol-o-methyltransferase in mammalian brain.	Kaplan GP, etal., Brain Res. 1979 May 11;167(2):241-50.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data

Comt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	18,130,987 - 18,137,412 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	18,130,282 - 18,152,153 (-)	NCBI	ChiLan1.0	ChiLan1.0

COMT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	19,941,772 - 19,969,975 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	19,941,371 - 19,969,975 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	19,929,295 - 19,957,498 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	18,309,309 - 18,336,530 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	18,324,623 - 18,331,084	NCBI
Celera	22	3,780,539 - 3,808,699 (+)	NCBI		Celera
Cytogenetic Map	22	q11.21	NCBI
HuRef	22	3,549,825 - 3,577,976 (+)	NCBI		HuRef
CHM1_1	22	19,929,027 - 19,957,208 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	20,319,463 - 20,347,602 (+)	NCBI		T2T-CHM13v2.0

Comt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	18,225,632 - 18,247,006 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	18,225,636 - 18,245,602 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	18,406,882 - 18,426,716 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	18,406,886 - 18,426,852 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	18,406,975 - 18,426,809 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	18,321,106 - 18,340,078 (-)	NCBI		MGSCv36	mm8
Celera	16	18,980,657 - 19,001,067 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	11.4	NCBI

Comt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	82,568,052 - 82,587,642 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	82,568,025 - 82,587,642 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	91,296,452 - 91,316,037 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	83,957,676 - 83,977,261 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	83,011,188 - 83,030,773 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	86,715,981 - 86,735,630 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	86,715,981 - 86,735,622 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	89,809,853 - 89,829,568 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	84,561,591 - 84,581,713 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	84,617,363 - 84,622,260 (+)	NCBI
Celera	11	81,345,121 - 81,364,705 (+)	NCBI		Celera
RH 3.4 Map	11	712.2	RGD
Cytogenetic Map	11	q23	NCBI

COMT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	22	32,117,249 - 32,144,549 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	2,704,015 - 2,731,326 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	18,375,434 - 18,402,387 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	18,375,434 - 18,402,387 (+)	Ensembl	panpan1.1		panPan2

COMT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	29,359,930 - 29,381,854 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	29,360,356 - 29,366,008 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	29,318,554 - 29,324,118 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	30,763,075 - 30,783,341 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	30,763,078 - 30,783,978 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	28,811,616 - 28,817,179 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	28,436,974 - 28,442,538 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	29,522,581 - 29,528,148 (-)	NCBI		UU_Cfam_GSD_1.0

Comt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	138,870,188 - 138,906,864 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	3,876,299 - 3,882,747 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936619	3,847,059 - 3,883,866 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COMT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	51,385,738 - 51,403,998 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	51,384,729 - 51,403,997 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	55,021,681 - 55,040,639 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COMT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	5,775,829 - 5,803,260 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	5,773,225 - 5,785,422 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	1,128,529 - 1,156,766 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Comt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	581,832 - 588,333 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	569,127 - 588,479 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005391754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013517802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01037997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01037998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01121489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000020469 ⟹ ENSCLAP00000020273

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955442	18,130,987 - 18,137,412 (-)	Ensembl

RefSeq Acc Id:

XM_005391754 ⟹ XP_005391811

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955442	18,130,282 - 18,152,153 (-)	NCBI

Sequence:

show sequence

GCTGCGGGGCCTCTGAGCGGCCGGGGCTGCCCGCCGCGCTGCCTGCTCCGCCGCGGACGCGTCT
TCCAGGGCGAGTCCCTCGGTCGGATGAAAGGGATCCATTGGGTTCTTGCTGCACCCCGGGAAGG
AACAGCGGTGAGAACGAGGAAAACATAGGCAAGAGACAAAAAGCTGCGATCAGGTGAAGAGCCT
CTCTCCTGAGCAGAGGAAGGGGAACCCTGACCAAGAACAGTAGAGCGTTTATTTATACCCTCAA
GAGATGCTGGGAGCCCCACCTCTGCTGTTGGCAGCTGCCTCATTGGGCATTGCACTGCTGGCCT
TCCTGCTGCTACTAAGACACTGGGGCTGGGGCATGTTACTCATATTCTGGTACGAGCTTGTTGT
GCAGCCCGTCAGAAACCTGGTCATGGGTGACACTAAGGAACAGCGCATCCTGCGCCATGTGCAA
CAGCATGCCAAGCCTGGGGACCCGCAGAGTGTGCTGGAGGCCATCGATACTTACTGCTCACAGA
AGGAATGGGCCATGAACTTGGGCAAAAACAAAGGTGAGATCATGGATGCTGTGATTCGGGAGCA
CAGCCCCTCCCTGGTGCTGGAACTGGGGGCCTACTGTGGCTACTCAGCTGTGCGTATAGCCCGC
CTGCTGCCACCTGCTGGGCGGTTGCTCACCATGGAGATCAACCCCGACTACAGTGCCATCACCC
AACAGATGCTGGACTTCGCAGGCGTGCAGGACAAGGTCACCGTCCTGCTTGGGGCGTCCCACGA
CCTCATCCCCCAGCTGAAGAAGAAGTATGATGTGGACACGCTGGACATGGTCTTCCTCGACCAC
TGGAAAGACCGCTACTTGCCAGACACCCATCTCCTAGAGGAATGTGGCCTGTTGCGGAAGGGGA
CAGTACTCCTGGCTGACAATGTCATCGTCCCAGGAACACCAGACTTCCTGGCATACGTGCGTGG
GAGCAGCAGCTTTGAATGTACACACTACAGCTCATACCTGGAGTACCTGAAGGTGGTGGATGGC
CTAGAGAAGGCTGTCTACAAAGGCCAAGGCAGCACAGAGCAGTCTTAATTGCCCACCCTGCTCT
GGGTTACCCTGCCAAGTCTGGTCTGGAAGGATGAGATGGATGTTTTGCTGCTGAGGTCATATCT
GTGATCCTGGGGTCTTTCCTTACATGTGAAGCATACTTTAGGCAGGAGTCTTCCTCAGGCTGAC
CTTCTGTGTTGCAGTTCCAAATTGTCACACACTGGCACACTTCAAAGTGTAGGGGGATCACCAT
GCAAAACCACTGCAATACATCTGGATGGTATCTGCTGATAAAGACTAAATTGAGGGCTTAGTTA
TAACTCAGTGGTAGAACACTTGCCTAGTATGTACGAGGTATCAGCTCCAAGCCCTAGCACTGCA
AAAAGTAAACAAAAAATTGGAGCCAATGACAGTGTCGCCAGCCAGCAAATGGAACTCCAATAGG
GTGTGTACAACTCAGTGGTCCGCAGGCACTGACAAATCATTAGACCTGGGAAAGACTGAGCAAG
CTGCAGACATCTAGAAACTGCTGGGCTCACTCAGGCCATCCTAGAGGTTTGCTGTCACCAGGTG
GCAGCAGTGTCTCGGTGACAGTACCAGCCACCAACTCATCACACTTCTGACTCAAATTTTTACC
TTTTTAAGACTAACTCATAACCTCTTTACTAAACTCAGCTAGCTGTAATAATCCTCCATACCAA
AACATTTAAAAGACATAAAATGGAAATTAAAGATCTAAACATTTATATA

hide sequence

RefSeq Acc Id:

XM_013517802 ⟹ XP_013373256

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955442	18,130,282 - 18,152,151 (-)	NCBI

Sequence:

show sequence

TGCGGGGCCTCTGAGCGGCCGGGGCTGCCCGCCGCGCTGCCTGCTCCGCCGCGGACGCGTCTTC
CAGGGCGAGTCCCTCGGTCGGATGAAAGGGATCCATTGGGTTCTTGCTGCACCCCGGGAAGGAA
CAGCGGTGAGAACGAGGAAAACATAGGCAAGAGACAAAAAGCTGCGATCAGGTGAAGAGCCTCT
CTCCTGAGCAGAGGAAGGGGAACCCTGACCAAGAACAGTAGAGCGTTTATTTATACCCTCAAGA
GCCCGTCAGAAACCTGGTCATGGGTGACACTAAGGAACAGCGCATCCTGCGCCATGTGCAACAG
CATGCCAAGCCTGGGGACCCGCAGAGTGTGCTGGAGGCCATCGATACTTACTGCTCACAGAAGG
AATGGGCCATGAACTTGGGCAAAAACAAAGGTGAGATCATGGATGCTGTGATTCGGGAGCACAG
CCCCTCCCTGGTGCTGGAACTGGGGGCCTACTGTGGCTACTCAGCTGTGCGTATAGCCCGCCTG
CTGCCACCTGCTGGGCGGTTGCTCACCATGGAGATCAACCCCGACTACAGTGCCATCACCCAAC
AGATGCTGGACTTCGCAGGCGTGCAGGACAAGGTCACCGTCCTGCTTGGGGCGTCCCACGACCT
CATCCCCCAGCTGAAGAAGAAGTATGATGTGGACACGCTGGACATGGTCTTCCTCGACCACTGG
AAAGACCGCTACTTGCCAGACACCCATCTCCTAGAGGAATGTGGCCTGTTGCGGAAGGGGACAG
TACTCCTGGCTGACAATGTCATCGTCCCAGGAACACCAGACTTCCTGGCATACGTGCGTGGGAG
CAGCAGCTTTGAATGTACACACTACAGCTCATACCTGGAGTACCTGAAGGTGGTGGATGGCCTA
GAGAAGGCTGTCTACAAAGGCCAAGGCAGCACAGAGCAGTCTTAATTGCCCACCCTGCTCTGGG
TTACCCTGCCAAGTCTGGTCTGGAAGGATGAGATGGATGTTTTGCTGCTGAGGTCATATCTGTG
ATCCTGGGGTCTTTCCTTACATGTGAAGCATACTTTAGGCAGGAGTCTTCCTCAGGCTGACCTT
CTGTGTTGCAGTTCCAAATTGTCACACACTGGCACACTTCAAAGTGTAGGGGGATCACCATGCA
AAACCACTGCAATACATCTGGATGGTATCTGCTGATAAAGACTAAATTGAGGGCTTAGTTATAA
CTCAGTGGTAGAACACTTGCCTAGTATGTACGAGGTATCAGCTCCAAGCCCTAGCACTGCAAAA
AGTAAACAAAAAATTGGAGCCAATGACAGTGTCGCCAGCCAGCAAATGGAACTCCAATAGGGTG
TGTACAACTCAGTGGTCCGCAGGCACTGACAAATCATTAGACCTGGGAAAGACTGAGCAAGCTG
CAGACATCTAGAAACTGCTGGGCTCACTCAGGCCATCCTAGAGGTTTGCTGTCACCAGGTGGCA
GCAGTGTCTCGGTGACAGTACCAGCCACCAACTCATCACACTTCTGACTCAAATTTTTACCTTT
TTAAGACTAACTCATAACCTCTTTACTAAACTCAGCTAGCTGTAATAATCCTCCATACCAAAAC
ATTTAAAAGACATAAAATGGAAATTAAAGATCTAAACATTTATATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005391811	(Get FASTA)	NCBI Sequence Viewer
	XP_013373256	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005391811 ⟸ XM_005391754
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2YSL6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLGAPPLLLAAASLGIALLAFLLLLRHWGWGMLLIFWYELVVQPVRNLVMGDTKEQRILRHVQQ HAKPGDPQSVLEAIDTYCSQKEWAMNLGKNKGEIMDAVIREHSPSLVLELGAYCGYSAVRIARL LPPAGRLLTMEINPDYSAITQQMLDFAGVQDKVTVLLGASHDLIPQLKKKYDVDTLDMVFLDHW KDRYLPDTHLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYLKVVDGL EKAVYKGQGSTEQS hide sequence

RefSeq Acc Id:

XP_013373256 ⟸ XM_013517802

- Peptide Label:

isoform X2

- Sequence:

show sequence

MGDTKEQRILRHVQQHAKPGDPQSVLEAIDTYCSQKEWAMNLGKNKGEIMDAVIREHSPSLVLE
LGAYCGYSAVRIARLLPPAGRLLTMEINPDYSAITQQMLDFAGVQDKVTVLLGASHDLIPQLKK
KYDVDTLDMVFLDHWKDRYLPDTHLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECT
HYSSYLEYLKVVDGLEKAVYKGQGSTEQS

hide sequence

RefSeq Acc Id:

ENSCLAP00000020273 ⟸ ENSCLAT00000020469

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013891	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCLAP00000020273	ENTREZGENE
	ENSCLAP00000020273.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000020469	ENTREZGENE
	ENSCLAT00000020469.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	Catechol_O-MeTrfase_euk	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
	SAM_O-MeTrfase	UniProtKB/TrEMBL
NCBI Gene	Comt	ENTREZGENE
PANTHER	CATECHOL O-METHYLTRANSFERASE	UniProtKB/TrEMBL
	CATECHOL O-METHYLTRANSFERASE 1-RELATED	UniProtKB/TrEMBL
Pfam	Methyltransf_3	UniProtKB/TrEMBL
PIRSF	Catechol_O-mtfrase_euk	UniProtKB/TrEMBL
PROSITE	SAM_OMT_I	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A8C2YSL6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - SMPDB