GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Comt | affects binding | EXP | | 6480464 | CTD | tolcapone binds to COMT protein | PMID:19783845 | Comt | decreases activity | EXP | | 6480464 | CTD | tolcapone results in decreased activity of COMT protein | PMID:10064789 PMID:15190105 PMID:16012872 PMID:19783845 PMID:20334432 PMID:2089102 | Comt | increases methylation | EXP | | 6480464 | CTD | COMT protein results in increased methylation of tolcapone | PMID:12584150 | Comt | multiple interactions | EXP | | 6480464 | CTD | [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] | PMID:15190105 PMID:16012872 PMID:8821542 | Comt | decreases activity | ISO | Comt (Mus musculus) | 6480464 | CTD | tolcapone results in decreased activity of COMT protein | PMID:15566291 PMID:20334432 | Comt | decreases activity | ISO | COMT (Homo sapiens) | 6480464 | CTD | tolcapone results in decreased activity of COMT protein | PMID:11248589 PMID:11432539 PMID:11793426 PMID:16758261 PMID:23206800 PMID:29688484 PMID:7768073 | Comt | multiple interactions | ISO | COMT (Homo sapiens) | 6480464 | CTD | [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa] | PMID:10047930 PMID:10809409 PMID:10872643 PMID:11248589 PMID:11432539 PMID:11793163 PMID:12898346 PMID:14975680 PMID:16758261 PMID:23206800 PMID:7566641 PMID:9333106 | | ||||||||||||||||||||||
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