Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Comt
Name: catechol-O-methyltransferase
Acc ID: CHEBI:545959
Term: homovanillic acid
Definition: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Chemical ID: MESH:D006719
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Comtmultiple interactionsEXP 6480464CTD[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid

PMID:15190105, PMID:16012872
Comtmultiple interactionsISORGD:7371026480464CTD[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid

PMID:11793163
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.