Comt (catechol-O-methyltransferase) - Rat Genome Database

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Gene: Comt (catechol-O-methyltransferase) Heterocephalus glaber
Analyze
Symbol: Comt
Name: catechol-O-methyltransferase
RGD ID: 18931757
Description: ENCODES a protein that exhibits catechol O-methyltransferase activity (ortholog); INVOLVED IN artery development (ortholog); behavioral fear response (ortholog); catecholamine metabolic process (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH Acute Pain (ortholog); alcohol dependence (ortholog); alcohol use disorder (ortholog); FOUND IN axon (ortholog); cell body (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: catechol O-methyltransferase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747581,832 - 588,333 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747569,127 - 588,479 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Pain  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
amphetamine abuse  (ISO)
Animal Mammary Neoplasms  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
Bardet-Biedl syndrome  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bulimia nervosa  (ISO)
cannabis abuse  (ISO)
cannabis dependence  (ISO)
Catalepsy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Child Behavior Disorders  (ISO)
chromosome 22q11.2 deletion syndrome, distal  (ISO)
chromosome 22q11.2 microduplication syndrome  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
DiGeorge syndrome  (ISO)
dilated cardiomyopathy  (ISO)
disease of mental health  (ISO)
drug dependence  (ISO)
Drug-Induced Dyskinesia  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
eumycotic mycetoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
Fatigue  (ISO)
Fetal Growth Retardation  (ISO)
fibromyalgia  (ISO)
Glucocorticoid Deficiency 5  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
heroin dependence  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
immunodeficiency 51  (ISO)
intellectual disability  (ISO)
intermittent explosive disorder  (ISO)
leiomyoma  (ISO)
lung cancer  (ISO)
Lymphatic Metastasis  (ISO)
megacolon  (ISO)
Memory Disorders  (ISO)
morphine dependence  (ISO)
Musculoskeletal Pain  (ISO)
Neck Pain  (ISO)
neonatal abstinence syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
nicotine dependence  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
opiate dependence  (ISO)
ovarian cancer  (ISO)
Pain  (ISO)
panic disorder  (ISO)
Paranoid Disorders  (ISO)
Parkinsonism  (ISO)
pathological gambling  (ISO)
pheochromocytoma  (ISO)
Polyarteritis Nodosa, Childhood-Onset  (ISO)
polycystic ovary syndrome  (ISO)
pre-eclampsia  (ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
Schizophrenia Spectrum and Other Psychotic Disorders  (ISO)
Temporomandibular Joint Disorders  (ISO)
Tobacco Use Disorder  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
velocardiofacial syndrome  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
artery development  (ISO)
behavioral fear response  (ISO)
catecholamine catabolic process  (IEA)
catecholamine metabolic process  (IEA,ISO)
cellular response to cocaine  (ISO)
cellular response to phosphate starvation  (ISO)
cerebellar cortex morphogenesis  (ISO)
cholesterol efflux  (ISO)
cognition  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
developmental process  (IEA)
dopamine catabolic process  (ISO)
dopamine metabolic process  (IEA,ISO)
dopamine secretion  (ISO)
estrogen metabolic process  (ISO)
exploration behavior  (ISO)
fear response  (ISO)
female pregnancy  (ISO)
gene expression  (ISO)
glomerulus development  (ISO)
glycogen metabolic process  (ISO)
habituation  (ISO)
kidney development  (ISO)
learning  (ISO)
learning or memory  (ISO)
mastication  (ISO)
memory  (ISO)
methylation  (IEA)
multicellular organism growth  (ISO)
multicellular organismal reproductive process  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of dopamine metabolic process  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
norepinephrine metabolic process  (ISO)
norepinephrine secretion  (ISO)
positive regulation of homocysteine metabolic process  (ISO)
positive regulation of lactation  (ISO)
prostaglandin metabolic process  (ISO)
protein methylation  (ISO)
protein phosphorylation  (ISO)
regulation of blood pressure  (ISO)
renal albumin absorption  (ISO)
renal filtration  (ISO)
renal sodium excretion  (ISO)
renin secretion into blood stream  (ISO)
response to amphetamine  (ISO)
response to angiotensin  (ISO)
response to corticosterone  (ISO)
response to cytokine  (ISO)
response to dopamine  (ISO)
response to estrogen  (ISO)
response to food  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to pain  (ISO)
response to salt  (ISO)
response to stress  (ISO)
response to temperature stimulus  (ISO)
response to toxic substance  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
short-term memory  (ISO)
startle response  (ISO)
synaptic transmission, dopaminergic  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Comt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747581,832 - 588,333 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747569,127 - 588,479 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
COMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,941,772 - 19,969,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,941,371 - 19,969,975 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,929,295 - 19,957,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,309,309 - 18,336,530 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,324,623 - 18,331,084NCBI
Celera223,780,539 - 3,808,699 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,549,825 - 3,577,976 (+)NCBIHuRef
CHM1_12219,929,027 - 19,957,208 (+)NCBICHM1_1
T2T-CHM13v2.02220,319,463 - 20,347,602 (+)NCBIT2T-CHM13v2.0
Comt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,225,632 - 18,247,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,225,636 - 18,245,602 (-)EnsemblGRCm39 Ensembl
GRCm381618,406,882 - 18,426,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,406,886 - 18,426,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,406,975 - 18,426,809 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,321,106 - 18,340,078 (-)NCBIMGSCv36mm8
Celera1618,980,657 - 19,001,067 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.4NCBI
Comt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,072,371 - 96,091,956 (+)NCBIGRCr8
mRatBN7.21182,568,052 - 82,587,642 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,568,025 - 82,587,642 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,296,452 - 91,316,037 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,957,676 - 83,977,261 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,011,188 - 83,030,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,715,981 - 86,735,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBICelera
RH 3.4 Map11712.2RGD
Cytogenetic Map11q23NCBI
Comt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,130,987 - 18,137,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,130,282 - 18,152,153 (-)NCBIChiLan1.0ChiLan1.0
COMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22329,569,904 - 29,597,129 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,117,249 - 32,144,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,704,015 - 2,731,326 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12218,375,434 - 18,402,387 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,375,434 - 18,402,387 (+)Ensemblpanpan1.1panPan2
COMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,359,930 - 29,381,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,360,356 - 29,366,008 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,318,554 - 29,324,118 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,763,075 - 30,783,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,763,078 - 30,783,978 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,811,616 - 28,817,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,436,974 - 28,442,538 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,522,581 - 29,528,148 (-)NCBIUU_Cfam_GSD_1.0
Comt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,870,188 - 138,906,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,876,299 - 3,882,747 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,847,059 - 3,883,866 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,385,738 - 51,403,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,384,729 - 51,403,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,021,681 - 55,040,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,775,829 - 5,803,260 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,773,225 - 5,785,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,128,529 - 1,156,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000011353   ⟹   ENSHGLP00000011228
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624747581,832 - 588,333 (+)Ensembl
RefSeq Acc Id: XM_013071947   ⟹   XP_012927401
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624747574,420 - 588,479 (+)NCBI
RefSeq Acc Id: XM_013071949   ⟹   XP_012927403
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624747569,127 - 588,479 (+)NCBI
RefSeq Acc Id: XM_013071950   ⟹   XP_012927404
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624747574,417 - 588,479 (+)NCBI
RefSeq Acc Id: XM_013071951   ⟹   XP_012927405
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624747577,565 - 588,479 (+)NCBI
RefSeq Acc Id: XR_001183380
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624747574,415 - 588,231 (+)NCBI
Protein Sequences
Protein RefSeqs XP_012927401 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927403 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927404 (Get FASTA)   NCBI Sequence Viewer  
  XP_012927405 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011228
RefSeq Acc Id: XP_012927403   ⟸   XM_013071949
- Peptide Label: isoform X2
- UniProtKB: G5CA23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927404   ⟸   XM_013071950
- Peptide Label: isoform X2
- UniProtKB: G5CA23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927401   ⟸   XM_013071947
- Peptide Label: isoform X1
- UniProtKB: G5CA23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927405   ⟸   XM_013071951
- Peptide Label: isoform X2
- UniProtKB: G5CA23 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011228   ⟸   ENSHGLT00000011353


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008056 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000011353 ENTREZGENE
Gene3D-CATH Vaccinia Virus protein VP39 UniProtKB/TrEMBL
InterPro Catechol_O-MeTrfase_euk UniProtKB/TrEMBL
  SAM-dependent_MTases_sf UniProtKB/TrEMBL
  SAM_O-MeTrfase UniProtKB/TrEMBL
NCBI Gene Comt ENTREZGENE
PANTHER CATECHOL O-METHYLTRANSFERASE UniProtKB/TrEMBL
  CATECHOL O-METHYLTRANSFERASE 1-RELATED UniProtKB/TrEMBL
Pfam Methyltransf_3 UniProtKB/TrEMBL
PIRSF Catechol_O-mtfrase_euk UniProtKB/TrEMBL
PROSITE SAM_OMT_I UniProtKB/TrEMBL
Superfamily-SCOP S-adenosyl-L-methionine-dependent methyltransferases UniProtKB/TrEMBL
UniProt G5CA23 ENTREZGENE, UniProtKB/TrEMBL