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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Comt
Name: catechol-O-methyltransferase
Acc ID: CHEBI:41941
Term: (3,4-dihydroxyphenyl)acetic acid
Definition: A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
Chemical ID: MESH:D015102
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Comtincreases methylationEXP 6480464CTDCOMT protein results in increased methylation of 3, 4-Dihydroxyphenylacetic Acid

PMID:11160877
Comtmultiple interactionsEXP 6480464CTD[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3, 4-Dihydroxyphenylacetic Acid

PMID:15190105, PMID:16012872
Comtincreases methylationISORGD:7371026480464CTDCOMT protein results in increased methylation of 3, 4-Dihydroxyphenylacetic Acid

PMID:11160877
Comtmultiple interactionsISORGD:7371026480464CTD[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3, 4-Dihydroxyphenylacetic Acid

PMID:11793163
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.