RGD Reference Report - The association between high-activity COMT allele and alcoholism. - Rat Genome Database

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The association between high-activity COMT allele and alcoholism.

Authors: Serý, Omar  Didden, William  Mikes, Vladimír  Pitelová, Renáta  Znojil, Vladimír  Zvolský, Petr 
Citation: Serý O, etal., Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):231-5.
RGD ID: 401940155
Pubmed: PMID:16648777   (View Abstract at PubMed)


OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. The Val158Met polymorphism of the COMT gene has been previously associated with a variability of the COMT activity, and alcoholism. The aim of the present association study was to examine the relationship between the Val158Met polymorphism of the COMT gene and dispositions to alcoholism.
METHODS: In our case control study we analyzed DNA samples from 799 subjects in total (279 male alcoholics and 120 female alcoholics, 151 male controls and 249 female controls). The restriction analysis for the detection of the Val158Met polymorphism was used.
RESULTS: We found a relationship between the Val158Met polymorphism of the COMT gene and alcoholism in male subjects. We found the significant difference between male alcoholics and male controls in allele and genotype frequencies (p<0,007; and p<0,04 respectively).
CONCLUSIONS: Our study confirmed the relationship between the COMT polymorphism and alcoholism in the Czech male population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
COMTHumanalcohol dependence susceptibilityIAGP DNA:SNP:cd: p.V158M (human)RGD 
ComtRatalcohol dependence susceptibilityISOCOMT (Homo sapiens)DNA:SNP:cd: p.V158M (human)RGD 
ComtMousealcohol dependence susceptibilityISOCOMT (Homo sapiens)DNA:SNP:cd: p.V158M (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
COMTHumanAddictive alcohol use susceptibilityIAGP DNA:SNP:cd: p.V158M (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Comt  (catechol-O-methyltransferase)

Genes (Mus musculus)
Comt  (catechol-O-methyltransferase)

Genes (Homo sapiens)
COMT  (catechol-O-methyltransferase)


Additional Information