Dynlt2b (dynein light chain Tctex-type 2B) - Rat Genome Database

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Gene: Dynlt2b (dynein light chain Tctex-type 2B) Rattus norvegicus
Analyze
Symbol: Dynlt2b
Name: dynein light chain Tctex-type 2B
RGD ID: 1563597
Description: Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in cilium organization; regulation of cilium assembly; and regulation of intraciliary retrograde transport. Predicted to be located in ciliary base and cytoskeleton. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dynein light chain Tctex-type protein 2B; LOC498095; RGD1563597; similar to RIKEN cDNA 0610012D17; Tctex1 domain containing 2; tctex1 domain-containing protein 2; Tctex1d2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,864,195 - 81,872,555 (-)NCBIGRCr8
mRatBN7.21168,359,138 - 68,367,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,358,263 - 68,367,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,196,193 - 77,204,553 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,860,905 - 69,869,271 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,885,307 - 68,893,667 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,593,302 - 71,601,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,593,302 - 71,601,662 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,678,025 - 74,686,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,175,484 - 70,183,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1167,791,755 - 67,800,115 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25205765   PMID:25830415   PMID:26044572  


Genomics

Comparative Map Data
Dynlt2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,864,195 - 81,872,555 (-)NCBIGRCr8
mRatBN7.21168,359,138 - 68,367,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,358,263 - 68,367,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,196,193 - 77,204,553 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,860,905 - 69,869,271 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,885,307 - 68,893,667 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,593,302 - 71,601,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,593,302 - 71,601,662 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,678,025 - 74,686,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,175,484 - 70,183,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1167,791,755 - 67,800,115 (-)NCBICelera
Cytogenetic Map11q22NCBI
DYNLT2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,291,219 - 196,318,240 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,291,219 - 196,318,299 (-)EnsemblGRCh38hg38GRCh38
GRCh373196,018,090 - 196,045,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,502,495 - 197,529,542 (-)NCBINCBI36Build 36hg18NCBI36
Celera3194,599,369 - 194,625,623 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,315,227 - 193,342,065 (-)NCBIHuRef
CHM1_13195,988,915 - 196,015,992 (-)NCBICHM1_1
T2T-CHM13v2.03199,010,707 - 199,037,779 (-)NCBIT2T-CHM13v2.0
Dynlt2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,238,520 - 32,247,917 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,238,520 - 32,247,917 (+)EnsemblGRCm39 Ensembl
GRCm381632,419,702 - 32,429,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,419,702 - 32,429,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,419,788 - 32,428,978 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,339,491 - 32,348,845 (+)NCBIMGSCv36mm8
Celera1632,903,898 - 32,913,071 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1622.69NCBI
Dynlt2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,515,195 - 12,528,861 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,515,195 - 12,528,863 (-)NCBIChiLan1.0ChiLan1.0
DYNLT2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,162,023 - 194,190,929 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,166,741 - 194,195,647 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,636,238 - 193,665,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,580,040 - 203,607,193 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,580,040 - 203,607,189 (-)Ensemblpanpan1.1panPan2
DYNLT2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,414,484 - 29,430,439 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,438,720 - 29,458,096 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,647,899 - 29,667,241 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,647,895 - 29,667,239 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,435,103 - 29,454,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,488,952 - 29,508,396 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,111,622 - 30,131,184 (-)NCBIUU_Cfam_GSD_1.0
Dynlt2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,930,228 - 124,944,969 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784940,168 - 955,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936784940,300 - 954,959 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNLT2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,774,574 - 133,800,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,774,548 - 133,798,920 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DYNLT2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,867,250 - 90,902,064 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,867,322 - 90,902,667 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604164,689,281 - 64,716,174 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dynlt2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,467,510 - 61,479,756 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,467,262 - 61,479,848 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dynlt2b
329 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:201
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000002397
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002397   ⟹   ENSRNOP00000002397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,359,138 - 68,367,499 (-)Ensembl
Rnor_6.0 Ensembl1171,593,302 - 71,601,662 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102459   ⟹   ENSRNOP00000095089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,359,339 - 68,367,499 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106782   ⟹   ENSRNOP00000078257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,358,263 - 68,367,499 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109280   ⟹   ENSRNOP00000097992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,359,339 - 68,367,499 (-)Ensembl
RefSeq Acc Id: NM_001109054   ⟹   NP_001102524
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,864,195 - 81,872,555 (-)NCBI
mRatBN7.21168,359,138 - 68,367,499 (-)NCBI
Rnor_6.01171,593,302 - 71,601,662 (-)NCBI
Rnor_5.01174,678,025 - 74,686,385 (-)NCBI
RGSC_v3.41170,175,484 - 70,183,844 (-)RGD
Celera1167,791,755 - 67,800,115 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102524 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11419 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002397
  ENSRNOP00000002397.5
  ENSRNOP00000078257.1
  ENSRNOP00000095089.1
  ENSRNOP00000097992.1
RefSeq Acc Id: NP_001102524   ⟸   NM_001109054
- UniProtKB: D4ADI6 (UniProtKB/TrEMBL),   A6IRR7 (UniProtKB/TrEMBL),   A0A8I6ASY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002397   ⟸   ENSRNOT00000002397
Ensembl Acc Id: ENSRNOP00000078257   ⟸   ENSRNOT00000106782
Ensembl Acc Id: ENSRNOP00000097992   ⟸   ENSRNOT00000109280
Ensembl Acc Id: ENSRNOP00000095089   ⟸   ENSRNOT00000102459

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698211
Promoter ID:EPDNEW_R8735
Type:initiation region
Name:Tctex1d2_1
Description:Tctex1 domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,601,668 - 71,601,728EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563597 AgrOrtholog
BioCyc Gene G2FUF-21093 BioCyc
Ensembl Genes ENSRNOG00000001758 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002397 ENTREZGENE
  ENSRNOT00000002397.6 UniProtKB/TrEMBL
  ENSRNOT00000102459.1 UniProtKB/TrEMBL
  ENSRNOT00000106782.1 UniProtKB/TrEMBL
  ENSRNOT00000109280.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1140.40 UniProtKB/TrEMBL
InterPro Tctex UniProtKB/TrEMBL
  Tctex-1-like_sf UniProtKB/TrEMBL
KEGG Report rno:498095 UniProtKB/TrEMBL
NCBI Gene 498095 ENTREZGENE
PANTHER DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B UniProtKB/TrEMBL
  Tctex UniProtKB/TrEMBL
Pfam Tctex-1 UniProtKB/TrEMBL
PhenoGen Dynlt2b PhenoGen
RatGTEx ENSRNOG00000001758 RatGTEx
UniProt A0A8I6APP9_RAT UniProtKB/TrEMBL
  A0A8I6ASY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G2I0_RAT UniProtKB/TrEMBL
  A6IRR7 ENTREZGENE, UniProtKB/TrEMBL
  A6IRR8_RAT UniProtKB/TrEMBL
  D4ADI6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-08 Dynlt2b  dynein light chain Tctex-type 2B  Tctex1d2  Tctex1 domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Tctex1d2  Tctex1 domain containing 2  RGD1563597_predicted  similar to RIKEN cDNA 0610012D17 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563597_predicted  similar to RIKEN cDNA 0610012D17 (predicted)  LOC498095  similar to RIKEN cDNA 0610012D17  Symbol and Name status set to approved 1299863 APPROVED