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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Experimental Liver Cirrhosis | | ISO | RGD:1602040 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:25380136 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Experimental Liver Cirrhosis | | ISO | RGD:1602040 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:25380136 | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
3. | GOA pipeline | RGD automated data pipeline |
4. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
PMID:12477932 | PMID:15489334 | PMID:24739962 | PMID:28459434 | PMID:29909984 |
Nrros (Rattus norvegicus - Norway rat) |
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NRROS (Homo sapiens - human) |
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Nrros (Mus musculus - house mouse) |
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Nrros (Chinchilla lanigera - long-tailed chinchilla) |
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NRROS (Pan paniscus - bonobo/pygmy chimpanzee) |
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NRROS (Canis lupus familiaris - dog) |
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Nrros (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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NRROS (Sus scrofa - pig) |
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NRROS (Chlorocebus sabaeus - green monkey) |
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Nrros (Heterocephalus glaber - naked mole-rat) |
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BE097868 |
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RH144042 |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 2 | 9 | 28 | 20 | 19 | 20 | 4 | 14 | 18 | 11 | |||
Low | 1 | 34 | 29 | 21 | 21 | 8 | 11 | 70 | 21 | 22 | 8 | ||
Below cutoff | 1 |
RefSeq Acc Id: | ENSRNOT00000050364 ⟹ ENSRNOP00000048680 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000095949 ⟹ ENSRNOP00000077154 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001024995 ⟹ NP_001020166 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006248448 ⟹ XP_006248510 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NP_001020166 ⟸ NM_001024995 |
- Peptide Label: | precursor |
- UniProtKB: | Q5BK65 (UniProtKB/Swiss-Prot) |
- Sequence: |
RefSeq Acc Id: | XP_006248510 ⟸ XM_006248448 |
- Peptide Label: | isoform X1 |
- UniProtKB: | Q5BK65 (UniProtKB/Swiss-Prot) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000048680 ⟸ ENSRNOT00000050364 |
RefSeq Acc Id: | ENSRNOP00000077154 ⟸ ENSRNOT00000095949 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q5BK65-F1-model_v2 | AlphaFold | Q5BK65 | 1-692 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13698214 | ||||||||
Promoter ID: | EPDNEW_R8739 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Nrros_1 | ||||||||
Description: | negative regulator of reactive oxygen species | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
11 | 71888704 | 71888705 | C | A | snv | BBDP/Wor (RGD), MNS/Gib (RGD) |
11 | 71889181 | 71889182 | G | C | snv | WN/N (MCW), F344/NCrl (RGD), LH/MavRrrc (RGD), LL/MavRrrc (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), WAG/Rij (RGD), F344/DuCrl (2019), F344/NCrl (2019), MWF/Hsd (2019), LEXF4/Stm (2020), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WN/N (2020), WAG/RijCrl (2020), F344/NRrrc (MCW), M520/N (MCW), F344/N (2020), LEXF11/Stm (2020), LEXF2B/Stm (2019), LH/MavRrrcAek (2020), LL/MavRrrcAek (2020), M520/NRrrcMcwi (2019), M520/N (2020), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), F344/Stm (2019) |
Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
11 | 74972630 | 74972631 | C | A | snv | MNS/Gib (KNAW), BBDP/WorN (KNAW), ZFDM (KyushuU) |
11 | 74973107 | 74973108 | G | C | snv | LL/MavRrrc (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), M520/N (KNAW), F344/NRrrc (Illumina) (KNAW), SDLEF7/Barth (UDEL), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), F344/Stm (KyushuU), F344/Jcl (KyushuU), LH/MavRrrc (KNAW), WN/N (KNAW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW) |
Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
11 | 70465219 | 70465220 | C | A | snv | BBDP/WorN (ICL), MNS/Gib (ICL) |
11 | 70465696 | 70465697 | G | C | snv | SS/JrHsdMcwi (MDC), F344/NRrrc (KNAW), M520/N (KNAW), WN/N (KNAW), F344/NCrl (ICL), F344/NHsd (ICAHN), LL/MavRrrc (ICL), SR/JrHsd (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), WAG/Rij (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), HCR/2Mco (UMich), LCR/2Mco (UMich), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), LH/MavRrrc (ICL) |
Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
11 | 68645436 | 68645437 | G | C | snv | F344/DuCrl (2019), WN/N (2020), F344/N (2020), F344/Stm (2019), LEXF11/Stm (2020), LEXF2B/Stm (2019), LEXF4/Stm (2020), LH/MavRrrcAek (2020), LL/MavRrrcAek (2020), M520/NRrrcMcwi (2019), M520/N (2020), MWF/Hsd (2019), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WAG/RijCrl (2020), F344/NCrl (2019) |
Database | Acc Id | Source(s) |
AGR Gene | RGD:1310771 | AgrOrtholog |
BioCyc Gene | G2FUF-21082 | BioCyc |
Ensembl Genes | ENSRNOG00000001752 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000048680 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOP00000077154.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000050364 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOT00000095949.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.80.10.10 | UniProtKB/Swiss-Prot |
IMAGE_CLONE | IMAGE:7367889 | IMAGE-MGC_LOAD |
InterPro | Leu-rich_rpt | UniProtKB/Swiss-Prot |
Leu-rich_rpt_typical-subtyp | UniProtKB/Swiss-Prot | |
LRR_dom_sf | UniProtKB/Swiss-Prot | |
KEGG Report | rno:303875 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:108848 | IMAGE-MGC_LOAD |
NCBI Gene | 303875 | ENTREZGENE |
Pfam | LRR_8 | UniProtKB/Swiss-Prot |
PhenoGen | Nrros | PhenoGen |
PROSITE | LRR | UniProtKB/Swiss-Prot |
SMART | LRR_TYP | UniProtKB/Swiss-Prot |
UniProt | A0A8I5Y5F1_RAT | UniProtKB/TrEMBL |
LRC33_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2013-07-18 | Nrros | negative regulator of reactive oxygen species | Lrrc33 | leucine rich repeat containing 33 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2006-03-30 | Lrrc33 | leucine rich repeat containing 33 | RGD1310771 | similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant) | Symbol and Name updated | 1299863 | APPROVED |
2005-12-06 | RGD1310771 | similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant) | RGD1310771_predicted | similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant) (predicted) | Symbol and Name updated | 1559027 | APPROVED |
2005-01-20 | RGD1310771_predicted | similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant) (predicted) | LOC303875_predicted | Symbol and Name status set to approved | 1331353 | APPROVED | |
2005-01-12 | LOC303875_predicted | similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant) (predicted) | Symbol and Name status set to provisional | 70820 | PROVISIONAL |