Nrros (negative regulator of reactive oxygen species) - Rat Genome Database

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Gene: Nrros (negative regulator of reactive oxygen species) Rattus norvegicus
Analyze
Symbol: Nrros
Name: negative regulator of reactive oxygen species
RGD ID: 1310771
Description: Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface. Orthologous to human NRROS (negative regulator of reactive oxygen species); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Garpl1; leucine rich repeat containing 33; leucine-rich repeat-containing protein 33; leucine-rich repeat-containing protein 33^; LOC303875; Lrrc33; MGC108848; RGD1310771; similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant); transforming growth factor beta activator LRRC33
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,628,641 - 68,646,152 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1168,628,712 - 68,646,142 (+)Ensembl
Rnor_6.01171,872,728 - 71,889,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,872,830 - 71,889,887 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,956,672 - 74,973,823 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,449,116 - 70,466,412 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,506,704 - 70,523,991 (+)NCBI
Celera1168,051,440 - 68,068,647 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:24739962   PMID:28459434   PMID:29909984  


Genomics

Comparative Map Data
Nrros
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,628,641 - 68,646,152 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1168,628,712 - 68,646,142 (+)Ensembl
Rnor_6.01171,872,728 - 71,889,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,872,830 - 71,889,887 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,956,672 - 74,973,823 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,449,116 - 70,466,412 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,506,704 - 70,523,991 (+)NCBI
Celera1168,051,440 - 68,068,647 (+)NCBICelera
Cytogenetic Map11q22NCBI
NRROS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,639,694 - 196,662,004 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3196,639,694 - 196,662,004 (+)EnsemblGRCh38hg38GRCh38
GRCh373196,366,565 - 196,388,875 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,851,053 - 197,873,272 (+)NCBINCBI36hg18NCBI36
Celera3194,948,253 - 194,970,470 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3193,663,748 - 193,685,954 (+)NCBIHuRef
CHM1_13196,337,936 - 196,360,147 (+)NCBICHM1_1
T2T-CHM13v2.03199,359,041 - 199,381,340 (+)NCBI
Nrros
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,961,603 - 31,984,412 (-)NCBIGRCm39mm39
GRCm39 Ensembl1631,961,603 - 31,984,412 (-)Ensembl
GRCm381632,142,785 - 32,165,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,142,785 - 32,165,594 (-)EnsemblGRCm38mm10GRCm38
MGSCv371632,142,911 - 32,165,562 (-)NCBIGRCm37mm9NCBIm37
MGSCv361632,062,572 - 32,085,223 (-)NCBImm8
Celera1632,639,762 - 32,659,142 (-)NCBICelera
Cytogenetic Map16B2NCBI
Nrros
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,792,111 - 12,801,963 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,792,173 - 12,798,645 (+)NCBIChiLan1.0ChiLan1.0
NRROS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13203,925,101 - 203,948,506 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,920,334 - 203,948,506 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03193,984,797 - 194,007,173 (+)NCBIMhudiblu_PPA_v0panPan3
NRROS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,682,182 - 29,699,469 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,692,371 - 29,767,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,699,502 - 29,723,146 (+)NCBI
ROS_Cfam_1.03329,919,288 - 29,942,927 (+)NCBI
ROS_Cfam_1.0 Ensembl3329,919,307 - 29,942,787 (+)Ensembl
UMICH_Zoey_3.13329,696,615 - 29,720,261 (+)NCBI
UNSW_CanFamBas_1.03329,751,932 - 29,775,642 (+)NCBI
UU_Cfam_GSD_1.03330,374,170 - 30,397,856 (+)NCBI
Nrros
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,634,255 - 124,663,044 (-)NCBI
SpeTri2.0NW_0049367841,222,381 - 1,250,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRROS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,470,645 - 133,496,223 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,470,641 - 133,496,218 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,119,166 - 143,143,926 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NRROS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,558,837 - 90,580,291 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,558,770 - 90,579,175 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604164,347,551 - 64,369,085 (-)NCBIVero_WHO_p1.0
Nrros
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,735,134 - 61,742,541 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473061,717,592 - 61,742,374 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
BE097868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,629,587 - 68,629,738 (+)MAPPERmRatBN7.2
Rnor_6.01171,873,706 - 71,873,856NCBIRnor6.0
Rnor_5.01174,957,632 - 74,957,782UniSTSRnor5.0
RGSC_v3.41170,449,992 - 70,450,142UniSTSRGSC3.4
Celera1168,052,316 - 68,052,466UniSTS
RH 3.4 Map11375.53UniSTS
Cytogenetic Map11q22UniSTS
RH144042  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,645,862 - 68,646,045 (+)MAPPERmRatBN7.2
Rnor_6.01171,889,608 - 71,889,790NCBIRnor6.0
Rnor_5.01174,973,534 - 74,973,716UniSTSRnor5.0
RGSC_v3.41170,466,123 - 70,466,305UniSTSRGSC3.4
Celera1168,068,358 - 68,068,540UniSTS
RH 3.4 Map11404.6UniSTS
Cytogenetic Map11q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:106
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000050364
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 28 20 19 20 4 14 18 11
Low 1 34 29 21 21 8 11 70 21 22 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000050364   ⟹   ENSRNOP00000048680
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,628,712 - 68,646,142 (+)Ensembl
Rnor_6.0 Ensembl1171,872,830 - 71,889,887 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095949   ⟹   ENSRNOP00000077154
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,632,029 - 68,646,142 (+)Ensembl
RefSeq Acc Id: NM_001024995   ⟹   NP_001020166
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,628,712 - 68,646,152 (+)NCBI
Rnor_6.01171,872,830 - 71,889,897 (+)NCBI
Rnor_5.01174,956,672 - 74,973,823 (+)NCBI
RGSC_v3.41170,449,116 - 70,466,412 (+)RGD
Celera1168,051,440 - 68,068,647 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248448   ⟹   XP_006248510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,628,641 - 68,646,152 (+)NCBI
Rnor_6.01171,872,728 - 71,889,897 (+)NCBI
Rnor_5.01174,956,672 - 74,973,823 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001020166   ⟸   NM_001024995
- Peptide Label: precursor
- UniProtKB: Q5BK65 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248510   ⟸   XM_006248448
- Peptide Label: isoform X1
- UniProtKB: Q5BK65 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048680   ⟸   ENSRNOT00000050364
RefSeq Acc Id: ENSRNOP00000077154   ⟸   ENSRNOT00000095949
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK65-F1-model_v2 AlphaFold Q5BK65 1-692 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698214
Promoter ID:EPDNEW_R8739
Type:multiple initiation site
Name:Nrros_1
Description:negative regulator of reactive oxygen species
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,872,819 - 71,872,879EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 71888704 71888705 C A snv BBDP/Wor (RGD), MNS/Gib (RGD)
11 71889181 71889182 G C snv WN/N (MCW), F344/NCrl (RGD), LH/MavRrrc (RGD), LL/MavRrrc (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), WAG/Rij (RGD), F344/DuCrl (2019), F344/NCrl (2019), MWF/Hsd (2019), LEXF4/Stm (2020), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WN/N (2020), WAG/RijCrl (2020), F344/NRrrc (MCW), M520/N (MCW), F344/N (2020), LEXF11/Stm (2020), LEXF2B/Stm (2019), LH/MavRrrcAek (2020), LL/MavRrrcAek (2020), M520/NRrrcMcwi (2019), M520/N (2020), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), F344/Stm (2019)


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 74972630 74972631 C A snv MNS/Gib (KNAW), BBDP/WorN (KNAW), ZFDM (KyushuU)
11 74973107 74973108 G C snv LL/MavRrrc (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), M520/N (KNAW), F344/NRrrc (Illumina) (KNAW), SDLEF7/Barth (UDEL), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), F344/Stm (KyushuU), F344/Jcl (KyushuU), LH/MavRrrc (KNAW), WN/N (KNAW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW)


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 70465219 70465220 C A snv BBDP/WorN (ICL), MNS/Gib (ICL)
11 70465696 70465697 G C snv SS/JrHsdMcwi (MDC), F344/NRrrc (KNAW), M520/N (KNAW), WN/N (KNAW), F344/NCrl (ICL), F344/NHsd (ICAHN), LL/MavRrrc (ICL), SR/JrHsd (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), WAG/Rij (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), HCR/2Mco (UMich), LCR/2Mco (UMich), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), LH/MavRrrc (ICL)


Assembly: mRatBN7.2
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 68645436 68645437 G C snv F344/DuCrl (2019), WN/N (2020), F344/N (2020), F344/Stm (2019), LEXF11/Stm (2020), LEXF2B/Stm (2019), LEXF4/Stm (2020), LH/MavRrrcAek (2020), LL/MavRrrcAek (2020), M520/NRrrcMcwi (2019), M520/N (2020), MWF/Hsd (2019), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WAG/RijCrl (2020), F344/NCrl (2019)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310771 AgrOrtholog
BioCyc Gene G2FUF-21082 BioCyc
Ensembl Genes ENSRNOG00000001752 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000048680 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000077154.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050364 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000095949.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7367889 IMAGE-MGC_LOAD
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:303875 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108848 IMAGE-MGC_LOAD
NCBI Gene 303875 ENTREZGENE
Pfam LRR_8 UniProtKB/Swiss-Prot
PhenoGen Nrros PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
SMART LRR_TYP UniProtKB/Swiss-Prot
UniProt A0A8I5Y5F1_RAT UniProtKB/TrEMBL
  LRC33_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-18 Nrros  negative regulator of reactive oxygen species  Lrrc33  leucine rich repeat containing 33  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Lrrc33  leucine rich repeat containing 33  RGD1310771  similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant)  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1310771  similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant)  RGD1310771_predicted  similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310771_predicted  similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant) (predicted)  LOC303875_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303875_predicted  similar to GARP protein precursor (Garpin) (Glycoprotein A repetitions predominant) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL