Adprh (ADP-ribosylarginine hydrolase) - Rat Genome Database

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Gene: Adprh (ADP-ribosylarginine hydrolase) Rattus norvegicus
Analyze
Symbol: Adprh
Name: ADP-ribosylarginine hydrolase
RGD ID: 2052
Description: Enables ADP-ribosylarginine hydrolase activity. Involved in protein modification process. Located in extracellular space. Orthologous to human ADPRH (ADP-ribosylarginine hydrolase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: [Protein ADP-ribosylarginine] hydrolase; ADP-ribose-L-arginine cleaving enzyme; ADP-ribosylhydrolase ARH1; ADPRHA; MGC95225
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21162,299,831 - 62,306,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,299,793 - 62,306,931 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,112,358 - 71,118,697 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,774,605 - 63,780,944 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,825,271 - 62,831,602 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,861,772 - 64,868,112 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,861,768 - 64,868,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,241,824 - 67,248,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,079,175 - 64,085,514 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,136,763 - 64,143,100 (+)NCBI
Celera1161,801,429 - 61,807,769 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ADP-ribosylarginine hydrolase regulates cell proliferation and tumorigenesis. Kato J, etal., Cancer Res. 2011 Aug 1;71(15):5327-35. doi: 10.1158/0008-5472.CAN-10-0733. Epub 2011 Jun 22.
4. Immunohistochemical localization of ADP-ribosylarginine hydrolase in rodent CNS. Miyaoka T, etal., Brain Res. 1997 Jan 23;746(1-2):1-9.
5. Molecular and immunological characterization of ADP-ribosylarginine hydrolases. Moss J, etal., J Biol Chem 1992 May 25;267(15):10481-8.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8349667   PMID:19407395   PMID:30472116  


Genomics

Comparative Map Data
Adprh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21162,299,831 - 62,306,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,299,793 - 62,306,931 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,112,358 - 71,118,697 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,774,605 - 63,780,944 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,825,271 - 62,831,602 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,861,772 - 64,868,112 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,861,768 - 64,868,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,241,824 - 67,248,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,079,175 - 64,085,514 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,136,763 - 64,143,100 (+)NCBI
Celera1161,801,429 - 61,807,769 (+)NCBICelera
Cytogenetic Map11q21NCBI
ADPRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,579,492 - 119,589,945 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,579,268 - 119,589,945 (+)EnsemblGRCh38hg38GRCh38
GRCh373119,298,339 - 119,308,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,781,213 - 120,791,482 (+)NCBINCBI36Build 36hg18NCBI36
Build 343120,781,212 - 120,791,481NCBI
Celera3117,707,084 - 117,717,352 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,674,244 - 116,684,477 (+)NCBIHuRef
CHM1_13119,262,027 - 119,272,296 (+)NCBICHM1_1
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBIT2T-CHM13v2.0
Adprh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391638,265,761 - 38,273,051 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1638,264,392 - 38,273,065 (-)EnsemblGRCm39 Ensembl
GRCm381638,445,399 - 38,452,689 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,444,030 - 38,452,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv371638,445,479 - 38,452,769 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,364,632 - 38,371,922 (-)NCBIMGSCv36mm8
Celera1638,855,860 - 38,863,141 (-)NCBICelera
Cytogenetic Map16B3- B4NCBI
cM Map1626.86NCBI
Adprh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,271,561 - 19,280,288 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,271,734 - 19,280,189 (+)NCBIChiLan1.0ChiLan1.0
ADPRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan13117,561,804 - 117,572,422 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,702,236 - 116,713,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,614,819 - 123,625,353 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,614,819 - 123,625,353 (+)Ensemblpanpan1.1panPan2
ADPRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,218,633 - 23,226,844 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,218,101 - 23,224,667 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,248,543 - 23,257,013 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,456,653 - 23,464,917 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,456,638 - 23,463,631 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,259,063 - 23,267,535 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,294,668 - 23,303,123 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03323,864,155 - 23,872,630 (+)NCBIUU_Cfam_GSD_1.0
Adprh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602131,013,681 - 131,022,687 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,499,256 - 6,508,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,499,316 - 6,508,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADPRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,673,101 - 140,681,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,638,526 - 140,681,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213150,002,965 - 150,023,022 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADPRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12261,230,280 - 61,239,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2261,229,647 - 61,239,472 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,073,025 - 105,083,915 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adprh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,613,773 - 28,620,489 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,611,995 - 28,620,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adprh
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:140
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000038439
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 43 27 19 27 2 5 74 30 40 11 2
Low 7 14 14 14 6 6 5 1 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000038439   ⟹   ENSRNOP00000034815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,299,793 - 62,306,931 (+)Ensembl
Rnor_6.0 Ensembl1164,861,768 - 64,868,108 (+)Ensembl
RefSeq Acc Id: NM_183325   ⟹   NP_899154
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21162,299,831 - 62,306,170 (+)NCBI
Rnor_6.01164,861,772 - 64,868,111 (+)NCBI
Rnor_5.01167,241,824 - 67,248,168 (-)NCBI
RGSC_v3.41164,079,175 - 64,085,514 (+)RGD
Celera1161,801,429 - 61,807,769 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248360   ⟹   XP_006248422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21162,299,964 - 62,306,090 (+)NCBI
Rnor_6.01164,861,883 - 64,868,112 (+)NCBI
Rnor_5.01167,241,824 - 67,248,168 (-)NCBI
Sequence:
RefSeq Acc Id: NP_899154   ⟸   NM_183325
- UniProtKB: Q66H27 (UniProtKB/Swiss-Prot),   Q02589 (UniProtKB/Swiss-Prot),   A6IR67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248422   ⟸   XM_006248360
- Peptide Label: isoform X1
- UniProtKB: Q66H27 (UniProtKB/Swiss-Prot),   Q02589 (UniProtKB/Swiss-Prot),   A6IR67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034815   ⟸   ENSRNOT00000038439

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02589-F1-model_v2 AlphaFold Q02589 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698166
Promoter ID:EPDNEW_R8690
Type:initiation region
Name:Adprh_1
Description:ADP-ribosylarginine hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,861,782 - 64,861,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2052 AgrOrtholog
BioCyc Gene G2FUF-21272 BioCyc
Ensembl Genes ENSRNOG00000027260 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055016270 UniProtKB/Swiss-Prot
  ENSRNOG00060007888 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038439 ENTREZGENE
  ENSRNOT00000038439.5 UniProtKB/Swiss-Prot
  ENSRNOT00055027590 UniProtKB/Swiss-Prot
  ENSRNOT00060013004 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.4080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132643 IMAGE-MGC_LOAD
InterPro ADP-ribosylarg_hydro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosyl_crysJ1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosyl_crysJ1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95225 IMAGE-MGC_LOAD
NCBI Gene 25371 ENTREZGENE
PANTHER [PROTEIN ADP-RIBOSYLARGININE] HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADP-RIBOSYLGLYCOHYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADP_ribosyl_GH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adprh PhenoGen
PIRSF ADP_ribslarg_hdr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027260 RatGTEx
  ENSRNOG00055016270 RatGTEx
  ENSRNOG00060007888 RatGTEx
Superfamily-SCOP ADP-ribosylglycohydrolase UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IR67 ENTREZGENE, UniProtKB/TrEMBL
  A6IR68_RAT UniProtKB/TrEMBL
  ADPRH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66H27 ENTREZGENE
UniProt Secondary Q66H27 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Adprh  ADP-ribosylarginine hydrolase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA and enzyme activity are detected in brain 631707
gene_function catalyzes the removal of mono ADP-ribosylation modification of proteins 631707
gene_protein 39 kDa protein 631707
gene_regulation enzyme activity is dithiothreitol- and magnesium ion dependent 631707