Stxbp5l (syntaxin binding protein 5L) - Rat Genome Database

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Gene: Stxbp5l (syntaxin binding protein 5L) Rattus norvegicus
Analyze
Symbol: Stxbp5l
Name: syntaxin binding protein 5L
RGD ID: 1311561
Description: Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Predicted to be involved in regulation of protein secretion and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within glucose homeostasis; negative regulation of insulin secretion; and positive regulation of protein secretion. Predicted to be part of SNARE complex. Predicted to be active in neuromuscular junction; neuronal dense core vesicle; and plasma membrane. Orthologous to human STXBP5L (syntaxin binding protein 5L); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC288080; syntaxin binding protein 5-like; syntaxin-binding protein 5-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Stxbp5lTn(sb-T2/Bart3)2.202Mcwi  
Genetic Models: F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21163,334,667 - 63,654,270 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1163,334,667 - 63,657,014 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,147,113 - 72,466,676 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01164,809,343 - 65,128,900 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,858,949 - 64,163,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,246,624 - 66,566,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,316,606 - 66,566,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,337,663 - 69,661,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41165,129,572 - 65,455,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11165,147,137 - 65,512,704 (+)NCBI
Celera1162,831,916 - 63,131,512 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:21330375   PMID:21998599   PMID:24744148   PMID:25002582   PMID:28746398  


Genomics

Comparative Map Data
Stxbp5l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21163,334,667 - 63,654,270 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1163,334,667 - 63,657,014 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,147,113 - 72,466,676 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01164,809,343 - 65,128,900 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,858,949 - 64,163,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,246,624 - 66,566,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,316,606 - 66,566,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,337,663 - 69,661,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41165,129,572 - 65,455,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11165,147,137 - 65,512,704 (+)NCBI
Celera1162,831,916 - 63,131,512 (+)NCBICelera
Cytogenetic Map11q21NCBI
STXBP5L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383120,908,205 - 121,424,761 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3120,908,072 - 121,424,761 (+)EnsemblGRCh38hg38GRCh38
GRCh373120,627,052 - 121,143,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363122,109,609 - 122,621,338 (+)NCBINCBI36Build 36hg18NCBI36
Build 343122,109,772 - 122,621,336NCBI
Celera3119,036,797 - 119,553,405 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3118,001,087 - 118,518,020 (+)NCBIHuRef
CHM1_13120,590,662 - 121,107,318 (+)NCBICHM1_1
T2T-CHM13v2.03123,628,071 - 124,144,685 (+)NCBIT2T-CHM13v2.0
Stxbp5l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391636,927,437 - 37,205,377 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1636,935,304 - 37,205,324 (-)EnsemblGRCm39 Ensembl
GRCm381637,107,075 - 37,385,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1637,114,942 - 37,384,962 (-)EnsemblGRCm38mm10GRCm38
MGSCv371637,107,393 - 37,385,044 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361637,053,135 - 37,304,162 (-)NCBIMGSCv36mm8
Celera1637,516,531 - 37,793,303 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.32NCBI
Stxbp5l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542720,390,060 - 20,760,043 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542720,390,060 - 20,760,043 (+)NCBIChiLan1.0ChiLan1.0
STXBP5L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan13118,881,653 - 119,388,885 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03118,022,061 - 118,529,311 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13124,932,104 - 125,440,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3124,932,110 - 125,434,515 (+)Ensemblpanpan1.1panPan2
STXBP5L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13324,320,625 - 24,702,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3324,320,650 - 24,697,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3324,348,396 - 24,732,582 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03324,559,393 - 24,947,448 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3324,559,417 - 24,940,776 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13324,360,228 - 24,745,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03324,400,286 - 24,781,893 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,964,788 - 25,344,701 (+)NCBIUU_Cfam_GSD_1.0
Stxbp5l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602129,630,023 - 129,958,430 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365367,563,607 - 7,886,038 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365367,563,585 - 7,885,908 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STXBP5L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13139,123,209 - 139,445,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113139,116,931 - 139,491,227 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213148,628,557 - 148,835,696 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STXBP5L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12259,460,278 - 59,938,228 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2259,465,870 - 59,938,129 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041106,369,563 - 106,865,041 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stxbp5l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473126,820,018 - 27,305,447 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473126,815,873 - 27,305,344 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stxbp5l
2020 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:349
Count of miRNA genes:150
Interacting mature miRNAs:176
Transcripts:ENSRNOT00000041715, ENSRNOT00000042630, ENSRNOT00000048936, ENSRNOT00000068059, ENSRNOT00000072159, ENSRNOT00000073264, ENSRNOT00000075613
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

Markers in Region
BF386895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22120,051,216 - 120,051,429 (+)MAPPERmRatBN7.2
Rnor_6.02123,895,153 - 123,895,365NCBIRnor6.0
Rnor_5.02143,507,302 - 143,507,514UniSTSRnor5.0
RGSC_v3.42123,704,313 - 123,704,525UniSTSRGSC3.4
Celera1163,039,059 - 63,039,271UniSTS
Celera2115,006,076 - 115,006,288UniSTS
Cytogenetic Map11q22UniSTS
AU049762  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1162,886,468 - 62,886,675UniSTS
Cytogenetic Map11q22UniSTS
D7S1526  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01166,306,768 - 66,308,201NCBIRnor6.0
Rnor_5.01169,397,807 - 69,399,236UniSTSRnor5.0
Celera2048,035,172 - 48,035,559UniSTS
Celera1162,885,078 - 62,886,503UniSTS
Cytogenetic Map11q22UniSTS


Genetic Models
This gene Stxbp5l is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 44 6
Low 1 21 12 1 12 30 8 15 1
Below cutoff 2 20 16 9 15 9 8 9 26 20 8 8

Sequence


RefSeq Acc Id: ENSRNOT00000041715   ⟹   ENSRNOP00000044583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,334,667 - 63,657,014 (+)Ensembl
Rnor_6.0 Ensembl1166,316,606 - 66,566,331 (+)Ensembl
RefSeq Acc Id: NM_001271250   ⟹   NP_001258179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21163,334,667 - 63,654,270 (+)NCBI
Rnor_6.01166,246,624 - 66,566,331 (+)NCBI
Rnor_5.01169,337,663 - 69,661,463 (+)NCBI
Celera1162,831,916 - 63,131,512 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258179 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11248 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044583
  ENSRNOP00000044583.6
RefSeq Acc Id: NP_001258179   ⟸   NM_001271250
- UniProtKB: A6IR95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044583   ⟸   ENSRNOT00000041715
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZU84-F1-model_v2 AlphaFold D3ZU84 1-1090 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311561 AgrOrtholog
BioCyc Gene G2FUF-21252 BioCyc
Ensembl Genes ENSRNOG00000002496 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041715 ENTREZGENE
  ENSRNOT00000041715.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro Lethal2_giant UniProtKB/TrEMBL
  Lgl_C UniProtKB/TrEMBL
  LLGL2 UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  V_SNARE_CC UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 288080 ENTREZGENE
PANTHER LETHAL 2 GIANT LARVAE PROTEIN UniProtKB/TrEMBL
  SYNTAXIN-BINDING PROTEIN 5-LIKE UniProtKB/TrEMBL
Pfam Lgl_C UniProtKB/TrEMBL
  LLGL UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Stxbp5l PhenoGen
PRINTS LETHAL2GIANT UniProtKB/TrEMBL
PROSITE V_SNARE UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002496 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP Quinoprotein alcohol dehydrogenase-like UniProtKB/TrEMBL
  SNARE fusion complex UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A6IR95 ENTREZGENE, UniProtKB/TrEMBL
  D3ZU84_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-18 Stxbp5l  syntaxin binding protein 5-like  Stxbp5l_predicted  syntaxin binding protein 5-like (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Stxbp5l_predicted  syntaxin binding protein 5-like (predicted)      Symbol and Name status set to approved 70820 APPROVED