Heg1 (heart development protein with EGF-like domains 1) - Rat Genome Database

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Gene: Heg1 (heart development protein with EGF-like domains 1) Rattus norvegicus
Analyze
Symbol: Heg1
Name: heart development protein with EGF-like domains 1
RGD ID: 1564641
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; and negative regulation of membrane permeability. Predicted to act upstream of or within several processes, including circulatory system development; endothelial cell morphogenesis; and lymph circulation. Predicted to be located in cell-cell junction and external side of plasma membrane. Orthologous to human HEG1 (heart development protein with EGF like domains 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HEG homolog 1; HEG homolog 1 (zebrafish); hypothetical protein LOC689710; LOC303891; LOC689710; RGD1564641; similar to Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21167,006,954 - 67,095,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,957,190 - 67,095,051 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01170,234,248 - 70,322,966 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,236,888 - 70,322,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,322,608 - 73,410,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,828,748 - 68,912,073 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.41168,828,748 - 68,889,177 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1166,457,252 - 66,545,180 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fulvestrant  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18418349   PMID:19151727   PMID:22898778   PMID:26780829  


Genomics

Comparative Map Data
Heg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21167,006,954 - 67,095,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,957,190 - 67,095,051 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01170,234,248 - 70,322,966 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,236,888 - 70,322,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,322,608 - 73,410,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,828,748 - 68,912,073 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.41168,828,748 - 68,889,177 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1166,457,252 - 66,545,180 (-)NCBICelera
Cytogenetic Map11q22NCBI
HEG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383124,965,710 - 125,055,997 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3124,965,710 - 125,055,997 (-)EnsemblGRCh38hg38GRCh38
GRCh373124,684,554 - 124,774,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363126,167,244 - 126,257,492 (-)NCBINCBI36Build 36hg18NCBI36
Celera3123,091,267 - 123,182,155 (-)NCBICelera
Cytogenetic Map3q21.2NCBI
HuRef3122,058,734 - 122,148,741 (-)NCBIHuRef
CHM1_13124,647,692 - 124,738,018 (-)NCBICHM1_1
T2T-CHM13v2.03127,691,280 - 127,781,663 (-)NCBIT2T-CHM13v2.0
Heg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391633,504,754 - 33,591,946 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1633,504,740 - 33,591,946 (+)EnsemblGRCm39 Ensembl
GRCm381633,684,384 - 33,771,576 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1633,684,370 - 33,771,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv371633,684,552 - 33,768,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361633,645,203 - 33,687,942 (+)NCBIMGSCv36mm8
Celera1634,168,044 - 34,252,062 (+)NCBICelera
Cytogenetic Map16B3NCBI
Heg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542724,035,193 - 24,115,483 (-)NCBIChiLan1.0ChiLan1.0
HEG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13128,964,878 - 129,028,313 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3128,969,817 - 129,028,317 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03122,091,832 - 122,204,436 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HEG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13327,982,127 - 28,044,379 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3327,987,252 - 28,044,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3328,005,028 - 28,093,824 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03328,214,315 - 28,303,777 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3328,216,310 - 28,278,479 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13328,013,569 - 28,102,848 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03328,058,048 - 28,147,010 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03328,677,414 - 28,766,962 (-)NCBIUU_Cfam_GSD_1.0
Heg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602126,352,183 - 126,427,942 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936725261,712 - 336,414 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936725261,809 - 336,390 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13135,298,377 - 135,358,670 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113135,268,566 - 135,358,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213144,767,453 - 144,829,493 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12255,782,039 - 55,874,679 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2255,809,901 - 55,871,402 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041110,440,982 - 110,530,309 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Heg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,020,805 - 1,092,995 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,015,889 - 1,092,875 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Heg1
540 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:91
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000002443, ENSRNOT00000064403, ENSRNOT00000074189
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
RH131176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21167,047,762 - 67,047,965 (+)MAPPERmRatBN7.2
Rnor_6.01170,275,450 - 70,275,652NCBIRnor6.0
Rnor_5.01173,363,161 - 73,363,363UniSTSRnor5.0
RGSC_v3.41168,864,685 - 68,864,887UniSTSRGSC3.4
Celera1166,497,926 - 66,498,128UniSTS
RH 3.4 Map11409.4UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 42 15 4 14 4 5 5 65 32 33 11 5
Low 2 1 42 37 5 37 3 6 9 3 8 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002443   ⟹   ENSRNOP00000002443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,006,985 - 67,095,007 (-)Ensembl
Rnor_6.0 Ensembl1170,236,888 - 70,322,690 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100733   ⟹   ENSRNOP00000091844
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,957,190 - 67,095,051 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103922   ⟹   ENSRNOP00000090829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,957,190 - 67,095,051 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114458   ⟹   ENSRNOP00000093083
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,957,190 - 67,094,866 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117204   ⟹   ENSRNOP00000097884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,957,190 - 67,095,051 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117458   ⟹   ENSRNOP00000095467
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,957,190 - 67,094,866 (-)Ensembl
RefSeq Acc Id: XM_006248443   ⟹   XP_006248505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21167,006,954 - 67,095,019 (-)NCBI
Rnor_6.01170,234,248 - 70,322,965 (-)NCBI
Rnor_5.01173,322,608 - 73,410,501 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598169   ⟹   XP_017453658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21167,006,954 - 67,095,020 (-)NCBI
Rnor_6.01170,234,248 - 70,322,966 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006248505 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453658 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11356 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_006248505   ⟸   XM_006248443
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AEF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453658   ⟸   XM_017598169
- Peptide Label: isoform X2
- UniProtKB: F1M9I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002443   ⟸   ENSRNOT00000002443
RefSeq Acc Id: ENSRNOP00000090829   ⟸   ENSRNOT00000103922
RefSeq Acc Id: ENSRNOP00000093083   ⟸   ENSRNOT00000114458
RefSeq Acc Id: ENSRNOP00000091844   ⟸   ENSRNOT00000100733
RefSeq Acc Id: ENSRNOP00000097884   ⟸   ENSRNOT00000117204
RefSeq Acc Id: ENSRNOP00000095467   ⟸   ENSRNOT00000117458
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M9I4-F1-model_v2 AlphaFold F1M9I4 1-1317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698204
Promoter ID:EPDNEW_R8723
Type:single initiation site
Name:Heg1_1
Description:heart development protein with EGF-like domains 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01170,322,686 - 70,322,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564641 AgrOrtholog
BioCyc Gene G2FUF-21131 BioCyc
Ensembl Genes ENSRNOG00000001793 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002443 ENTREZGENE
  ENSRNOP00000002443.8 UniProtKB/TrEMBL
  ENSRNOP00000090829.1 UniProtKB/TrEMBL
  ENSRNOP00000091844 ENTREZGENE
  ENSRNOP00000091844.1 UniProtKB/TrEMBL
  ENSRNOP00000093083.1 UniProtKB/TrEMBL
  ENSRNOP00000095467.1 UniProtKB/TrEMBL
  ENSRNOP00000097884.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002443 ENTREZGENE
  ENSRNOT00000002443.9 UniProtKB/TrEMBL
  ENSRNOT00000100733 ENTREZGENE
  ENSRNOT00000100733.1 UniProtKB/TrEMBL
  ENSRNOT00000103922.1 UniProtKB/TrEMBL
  ENSRNOT00000114458.1 UniProtKB/TrEMBL
  ENSRNOT00000117204.1 UniProtKB/TrEMBL
  ENSRNOT00000117458.1 UniProtKB/TrEMBL
InterPro EG-like_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  HEG UniProtKB/TrEMBL
NCBI Gene 689710 ENTREZGENE
PANTHER PTHR24037 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
PhenoGen Heg1 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
UniProt A0A8I6AAY6_RAT UniProtKB/TrEMBL
  A0A8I6AEF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATG9_RAT UniProtKB/TrEMBL
  A0A8I6B2N1_RAT UniProtKB/TrEMBL
  A0A8I6GKH9_RAT UniProtKB/TrEMBL
  F1M9I4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-20 Heg1  heart development protein with EGF-like domains 1  Heg1  HEG homolog 1 (zebrafish)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-12 Heg1  HEG homolog 1 (zebrafish)  RGD1564641  similar to Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-09-08 RGD1564641  similar to Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)  LOC689710  hypothetical protein LOC689710  Data Merged 737654 APPROVED
2008-04-30 RGD1564641  similar to Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)   RGD1564641_predicted  similar to Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC689710  hypothetical protein LOC689710      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1564641_predicted  similar to Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) (predicted)  LOC303891  similar to Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC303891  similar to Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2)      Symbol and Name status set to provisional 70820 PROVISIONAL