Gene: Eif4g1 (eukaryotic translation initiation factor 4 gamma, 1) Rattus norvegicus
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Symbol:
Eif4g1
Name:
eukaryotic translation initiation factor 4 gamma, 1
RGD ID:
1306144
Description:
Exhibits eukaryotic initiation factor 4E binding activity. Involved in lung development and response to ethanol. Localizes to eukaryotic translation initiation factor 4F complex and postsynapse. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to human EIF4G1 (eukaryotic translation initiation factor 4 gamma 1); PARTICIPATES IN translation initiation pathway; myocarditis pathway; RNA transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bis(2-ethylhexyl) phthalate.
Type:
protein-coding
RefSeq Status:
MODEL
Also known as:
eukaryotic translation initiation factor 4 gamma 1; LOC102550847; LOC287986; voltage-dependent P/Q-type calcium channel subunit alpha-1A-like
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 11 83,907,659 - 83,927,683 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 83,908,109 - 83,926,524 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 11 86,979,577 - 86,999,605 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 11 82,451,555 - 82,471,735 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 11 82,509,144 - 82,529,350 (-) NCBI Celera 11 79,061,657 - 79,081,657 (-) NCBI Celera Cytogenetic Map 11 q23 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Currarino syndrome ISO RGD:1314591 8554872 ClinVar Annotator: match by term: Currarino triad ClinVar PMID:21681106 , PMID:27549440 late onset Parkinson's disease ISO RGD:1314591 8554872 ClinVar Annotator: match by term: PARKINSON DISEASE 18, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO ClinVar late onset Parkinson's disease ISO RGD:1314591 8554872 ClinVar Annotator: match by OMIM:614251 ClinVar PMID:21907011 , PMID:25368108 late onset Parkinson's disease ISO RGD:1314591 8554872 ClinVar Annotator: match by OMIM:614251 ClinVar PMID:21907011 more ...
Imported Annotations - CTD
autistic disorder ISO RGD:1314591 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20957522 Imported Annotations - OMIM
late onset Parkinson's disease ISO RGD:1314591 7240710 OMIM
1,2-dimethylhydrazine increases expression ISO RGD:1550408 6480464 1, 2-Dimethylhydrazine results in increased expression of EIF4G1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:1550408 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EIF4G1 mRNA CTD PMID:22206623 17beta-estradiol multiple interactions ISO RGD:1314591 6480464 everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein] CTD PMID:16033851 17beta-estradiol increases phosphorylation ISO RGD:1314591 6480464 Estradiol results in increased phosphorylation of EIF4G1 protein CTD PMID:16033851 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550408 6480464 Tetrachlorodibenzodioxin affects the expression of EIF4G1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of EIF4G1 mRNA CTD PMID:32109520 2-methylcholine affects expression ISO RGD:1314591 6480464 beta-methylcholine affects the expression of EIF4G1 mRNA CTD PMID:21179406 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1550408 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of EIF4G1 mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1314591 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EIF4G1 mRNA more ... CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1314591 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EIF4G1 mRNA CTD PMID:28628672 4-vinylcyclohexene dioxide affects expression ISO RGD:1550408 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of EIF4G1 mRNA CTD PMID:20829426 5-aza-2'-deoxycytidine increases expression ISO RGD:1314591 6480464 Decitabine results in increased expression of EIF4G1 mRNA CTD PMID:17908484 7-methyl-GTP affects binding ISO RGD:1314591 6480464 EIF4G1 protein binds to 7-methylguanosine triphosphate CTD PMID:25940091 7-methyl-GTP multiple interactions ISO RGD:1314591 6480464 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1 more ... CTD PMID:25940091 aflatoxin B1 increases methylation ISO RGD:1314591 6480464 Aflatoxin B1 results in increased methylation of EIF4G1 gene CTD PMID:27153756 aflatoxin B1 decreases methylation ISO RGD:1314591 6480464 Aflatoxin B1 results in decreased methylation of EIF4G1 exon CTD PMID:30157460 aldehydo-D-glucose multiple interactions ISO RGD:1550408 6480464 Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein], resveratrol inhibits the reaction [Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein]] CTD PMID:19765649 all-trans-retinoic acid increases expression ISO RGD:1314591 6480464 Tretinoin results in increased expression of EIF4G1 mRNA CTD PMID:15894607 all-trans-retinoic acid multiple interactions ISO RGD:1314591 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of EIF4G1 mRNA CTD PMID:15894607 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of EIF4G1 mRNA CTD PMID:30779732 arsenite(3-) multiple interactions ISO RGD:1314591 6480464 arsenite promotes the reaction [EIF4E protein binds to EIF4G1 protein], MAPK14 protein affects the reaction [arsenite promotes the reaction [EIF4E protein binds to EIF4G1 protein]] CTD PMID:12781867 arsenous acid decreases expression ISO RGD:1314591 6480464 Arsenic Trioxide results in decreased expression of EIF4G1 mRNA CTD PMID:23911876 arsenous acid increases expression ISO RGD:1314591 6480464 Arsenic Trioxide results in increased expression of EIF4G1 mRNA CTD PMID:15894607 arsenous acid multiple interactions ISO RGD:1314591 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of EIF4G1 mRNA CTD PMID:15894607 benzo[a]pyrene increases mutagenesis ISO RGD:1314591 6480464 Benzo(a)pyrene results in increased mutagenesis of EIF4G1 gene CTD PMID:25435355 benzo[a]pyrene increases methylation ISO RGD:1314591 6480464 Benzo(a)pyrene results in increased methylation of EIF4G1 3' UTR CTD PMID:27901495 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:1314591 6480464 Mustard Gas results in increased phosphorylation of EIF4G1 protein CTD PMID:19845377 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of EIF4G1 promoter CTD PMID:23359474 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of EIF4G1 promoter CTD PMID:23359474 bisphenol A decreases expression ISO RGD:1314591 6480464 bisphenol A results in decreased expression of EIF4G1 mRNA CTD PMID:29275510 bisphenol A multiple interactions ISO RGD:1314591 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EIF4G1 mRNA CTD PMID:28628672 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of EIF4G1 mRNA CTD PMID:30816183 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EIF4G1 mRNA CTD PMID:25181051 bisphenol F multiple interactions ISO RGD:1314591 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF4G1 mRNA CTD PMID:28628672 bleomycin A5 increases expression ISO RGD:1314591 6480464 bleomycetin results in increased expression of EIF4G1 mRNA CTD PMID:21040473 captan decreases expression ISO RGD:1550408 6480464 Captan results in decreased expression of EIF4G1 mRNA CTD PMID:31558096 carbamazepine affects expression ISO RGD:1314591 6480464 Carbamazepine affects the expression of EIF4G1 mRNA CTD PMID:24752500 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of EIF4G1 mRNA CTD PMID:23125180 chrysene increases expression ISO RGD:1550408 6480464 chrysene results in increased expression of EIF4G1 mRNA CTD PMID:26377693 cisplatin decreases expression ISO RGD:1314591 6480464 Cisplatin results in decreased expression of EIF4G1 mRNA CTD PMID:27594783 clofibrate decreases expression ISO RGD:1550408 6480464 Clofibrate results in decreased expression of EIF4G1 mRNA CTD PMID:17585979 cobalt dichloride decreases expression ISO RGD:1314591 6480464 cobaltous chloride results in decreased expression of EIF4G1 mRNA CTD PMID:19320972 curcumin decreases phosphorylation ISO RGD:1314591 6480464 Curcumin results in decreased phosphorylation of EIF4G1 protein CTD PMID:18790744 cycloheximide multiple interactions EXP 6480464 Cycloheximide promotes the reaction [EIF4EBP1 protein binds to EIF4G1 protein] CTD PMID:22689575 D-glucose multiple interactions ISO RGD:1550408 6480464 Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein], resveratrol inhibits the reaction [Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein]] CTD PMID:19765649 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of EIF4G1 mRNA CTD PMID:23640034 deoxynivalenol increases phosphorylation ISO RGD:1550408 6480464 deoxynivalenol results in increased phosphorylation of EIF4G1 protein CTD PMID:23352502 dexamethasone multiple interactions ISO RGD:1314591 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EIF4G1 mRNA more ... CTD PMID:28628672 diarsenic trioxide increases expression ISO RGD:1314591 6480464 Arsenic Trioxide results in increased expression of EIF4G1 mRNA CTD PMID:15894607 diarsenic trioxide decreases expression ISO RGD:1314591 6480464 Arsenic Trioxide results in decreased expression of EIF4G1 mRNA CTD PMID:23911876 diarsenic trioxide multiple interactions ISO RGD:1314591 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of EIF4G1 mRNA CTD PMID:15894607 dibutyl phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of EIF4G1 promoter CTD PMID:23359474 diclofenac affects expression ISO RGD:1314591 6480464 Diclofenac affects the expression of EIF4G1 mRNA CTD PMID:24752500 dicrotophos increases expression ISO RGD:1314591 6480464 dicrotophos results in increased expression of EIF4G1 mRNA CTD PMID:28302478 dioxygen increases expression ISO RGD:1550408 6480464 Oxygen deficiency results in increased expression of EIF4G1 mRNA CTD PMID:24205000 dioxygen affects methylation ISO RGD:1550408 6480464 Oxygen deficiency affects the methylation of EIF4G1 promoter CTD PMID:24205000 disodium selenite increases expression ISO RGD:1314591 6480464 Sodium Selenite results in increased expression of EIF4G1 mRNA CTD PMID:18175754 diuron decreases expression EXP 6480464 Diuron results in decreased expression of EIF4G1 mRNA CTD PMID:25152437 doxorubicin decreases phosphorylation EXP 6480464 Doxorubicin results in decreased phosphorylation of EIF4G1 protein CTD PMID:19801490 doxorubicin decreases expression ISO RGD:1314591 6480464 Doxorubicin results in decreased expression of EIF4G1 mRNA CTD PMID:29803840 doxorubicin multiple interactions EXP 6480464 NRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of EIF4G1 protein] CTD PMID:19801490 elemental selenium multiple interactions ISO RGD:1314591 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of EIF4G1 mRNA CTD PMID:19244175 elemental selenium increases expression ISO RGD:1314591 6480464 Selenium results in increased expression of EIF4G1 mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO RGD:1314591 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EIF4G1 protein CTD PMID:23301498 ethanol affects splicing ISO RGD:1550408 6480464 Ethanol affects the splicing of EIF4G1 mRNA CTD PMID:30319688 everolimus multiple interactions ISO RGD:1314591 6480464 Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein] CTD PMID:16033851 finasteride increases expression EXP 6480464 Finasteride results in increased expression of EIF4G1 mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of EIF4G1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1550408 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EIF4G1 mRNA CTD PMID:22206623 folpet decreases expression ISO RGD:1550408 6480464 folpet results in decreased expression of EIF4G1 mRNA CTD PMID:31558096 genistein multiple interactions ISO RGD:1314591 6480464 ESR2 promotes the reaction [Genistein results in decreased expression of EIF4G1 protein] CTD PMID:20884965 genistein decreases expression ISO RGD:1314591 6480464 Genistein results in decreased expression of EIF4G1 protein CTD PMID:20884965 glafenine increases expression EXP 6480464 Glafenine results in increased expression of EIF4G1 mRNA CTD PMID:24136188 glucose multiple interactions ISO RGD:1550408 6480464 Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein], resveratrol inhibits the reaction [Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein]] CTD PMID:19765649 hydrogen peroxide multiple interactions ISO RGD:1550408 6480464 [Hydrogen Peroxide co-treated with N-(oxo-5 more ... CTD PMID:31494107 indometacin multiple interactions ISO RGD:1314591 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EIF4G1 mRNA more ... CTD PMID:28628672 josamycin affects response to substance ISO RGD:1314591 6480464 EIF4G1 protein affects the susceptibility to Josamycin CTD PMID:31915244 LY294002 multiple interactions ISO RGD:1314591 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4G1 protein] CTD PMID:12781867 lycopene increases expression ISO RGD:1314591 6480464 lycopene results in increased expression of EIF4G1 mRNA CTD PMID:16886892 mercury atom decreases expression ISO RGD:1550408 6480464 Mercury analog results in decreased expression of EIF4G1 mRNA CTD PMID:25056781 mercury(0) decreases expression ISO RGD:1550408 6480464 Mercury analog results in decreased expression of EIF4G1 mRNA CTD PMID:25056781 methyl methanesulfonate decreases expression ISO RGD:1314591 6480464 Methyl Methanesulfonate results in decreased expression of EIF4G1 mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:1314591 6480464 methylmercuric chloride results in increased expression of EIF4G1 mRNA CTD PMID:23179753 , PMID:26272509 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of EIF4G1 mRNA CTD PMID:24136188 nickel sulfate increases expression ISO RGD:1314591 6480464 nickel sulfate results in increased expression of EIF4G1 mRNA CTD PMID:18651567 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of EIF4G1 mRNA CTD PMID:24136188 paracetamol decreases expression ISO RGD:1314591 6480464 Acetaminophen results in decreased expression of EIF4G1 mRNA CTD PMID:21420995 paracetamol increases expression ISO RGD:1550408 6480464 Acetaminophen results in increased expression of EIF4G1 mRNA CTD PMID:17585979 paracetamol affects expression ISO RGD:1550408 6480464 Acetaminophen affects the expression of EIF4G1 mRNA CTD PMID:17562736 phenethyl isothiocyanate decreases expression EXP 6480464 phenethyl isothiocyanate results in decreased expression of EIF4G1 mRNA CTD PMID:17616710 phenobarbital decreases expression ISO RGD:1550408 6480464 Phenobarbital results in decreased expression of EIF4G1 mRNA CTD PMID:23091169 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1314591 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4G1 protein] more ... CTD PMID:12781867 pyrogallol increases expression ISO RGD:1550408 6480464 Pyrogallol results in increased expression of EIF4G1 mRNA CTD PMID:20362636 resveratrol multiple interactions ISO RGD:1550408 6480464 resveratrol inhibits the reaction [Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein]] CTD PMID:19765649 SB 203580 multiple interactions ISO RGD:1314591 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4G1 protein] CTD PMID:12781867 selenium atom multiple interactions ISO RGD:1314591 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of EIF4G1 mRNA CTD PMID:19244175 selenium atom increases expression ISO RGD:1314591 6480464 Selenium results in increased expression of EIF4G1 mRNA CTD PMID:19244175 sirolimus multiple interactions ISO RGD:1314591 6480464 Sirolimus inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate] more ... CTD PMID:25940091 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of EIF4G1 mRNA CTD PMID:21297353 Soman increases expression EXP 6480464 Soman results in increased expression of EIF4G1 mRNA CTD PMID:19281266 testosterone enanthate affects expression ISO RGD:1314591 6480464 testosterone enanthate affects the expression of EIF4G1 mRNA CTD PMID:17440010 thimerosal decreases expression ISO RGD:1314591 6480464 Thimerosal results in decreased expression of EIF4G1 mRNA CTD PMID:27188386 titanium dioxide increases expression ISO RGD:1550408 6480464 titanium dioxide results in increased expression of EIF4G1 mRNA CTD PMID:29264374 torcetrapib increases expression ISO RGD:1314591 6480464 torcetrapib results in increased expression of EIF4G1 mRNA CTD PMID:23228038 torin 1 multiple interactions ISO RGD:1314591 6480464 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1 more ... CTD PMID:25940091 Tributyltin oxide decreases expression ISO RGD:1550408 6480464 bis(tri-n-butyltin)oxide results in decreased expression of EIF4G1 protein CTD PMID:19552622 Tributyltin oxide decreases phosphorylation ISO RGD:1550408 6480464 bis(tri-n-butyltin)oxide results in decreased phosphorylation of EIF4G1 protein CTD PMID:22174045 trimellitic anhydride increases expression ISO RGD:1550408 6480464 trimellitic anhydride results in increased expression of EIF4G1 mRNA CTD PMID:19042947 tungsten decreases expression ISO RGD:1550408 6480464 Tungsten results in decreased expression of EIF4G1 mRNA CTD PMID:30912803 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of EIF4G1 mRNA CTD PMID:24136188 valproic acid decreases methylation ISO RGD:1314591 6480464 Valproic Acid results in decreased methylation of EIF4G1 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:1314591 6480464 Valproic Acid affects the expression of EIF4G1 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1314591 6480464 Valproic Acid results in increased expression of EIF4G1 mRNA CTD PMID:23179753 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of EIF4G1 mRNA CTD PMID:20566332 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of EIF4G1 mRNA CTD PMID:18042343 , PMID:23034163 vitamin E multiple interactions ISO RGD:1314591 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of EIF4G1 mRNA CTD PMID:19244175 vitamin E increases expression ISO RGD:1314591 6480464 Vitamin E results in increased expression of EIF4G1 mRNA CTD PMID:19244175 vitamin E decreases expression ISO RGD:1314591 6480464 Vitamin E results in decreased expression of EIF4G1 mRNA CTD PMID:19244175 vorinostat decreases expression ISO RGD:1314591 6480464 vorinostat results in decreased expression of EIF4G1 mRNA CTD PMID:27188386
Gene-Chemical Interaction Annotations
