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Gene: Eif4g1 (eukaryotic translation initiation factor 4, gamma 1) Mus musculus
Symbol: Eif4g1
Name: eukaryotic translation initiation factor 4, gamma 1
Description: This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E030015G23Rik; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; eIF4GI; eukaryotic translation initiation factor 4 gamma 1; MGC37551; MGC90776
Related Pseudogenes: Gm13517   Gm8847  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381620,672,720 - 20,692,883 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371620,672,822 - 20,692,956 (+)NCBIGRCm37mm9NCBIm37
MGSCv361620,586,292 - 20,606,426 (+)NCBImm8
Celera1621,237,424 - 21,258,239 (+)NCBICelera
Cytogenetic Map16 B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Eif4g1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1550408
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-05-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.