Eif4e (eukaryotic translation initiation factor 4E) - Rat Genome Database
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Gene: Eif4e (eukaryotic translation initiation factor 4E) Rattus norvegicus
Analyze
Symbol: Eif4e
Name: eukaryotic translation initiation factor 4E
RGD ID: 69647
Description: Exhibits eukaryotic initiation factor 4G binding activity. Involved in lung development. Localizes to eukaryotic translation initiation factor 4F complex; glutamatergic synapse; and postsynaptic cytosol. Biomarker of vascular dementia. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E); PARTICIPATES IN CRM1 export pathway; mTOR signaling pathway; translation initiation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: eIF-4E; eIF-4F 25 kDa subunit; eukaryotic initiation factor 4E; MGC93265; mRNA cap-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22227,066,519 - 227,099,261 (+)NCBI
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02243,819,616 - 243,853,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02262,354,375 - 262,387,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42236,072,748 - 236,104,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12236,059,487 - 236,091,453 (+)NCBI
Celera2219,223,372 - 219,255,078 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
7-methyl-7,8-dihydroguanosine-5'-diphosphate  (ISO)
7-methyl-GTP  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (EXP,ISO)
cypermethrin  (ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
everolimus  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guanosine  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
jaspamide  (ISO)
kojic acid  (ISO)
lactacystin  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
orlistat  (ISO)
perfluorooctanoic acid  (EXP)
perhexiline  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolone  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
rottlerin  (ISO)
SB 203580  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thapsigargin  (ISO)
thiophenes  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Asaki C, etal., Brain Res. 2003 May 16;972(1-2):168-76.
2. Connolly EP, etal., Cell Death Differ. 2006 Sep;13(9):1586-94. Epub 2006 Jan 27.
3. Fingar DC, etal., Genes Dev 2002 Jun 15;16(12):1472-87.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. GOA data from the GO Consortium
6. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
7. Makhlouf AA, etal., Gene 2001 Apr 4;267(1):1-12.
8. MGD data from the GO Consortium
9. Miyagi Y, etal., Lab Invest 1995 Dec;73(6):890-8.
10. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
11. NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline
13. Otulakowski G, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):555-67. Epub 2008 Oct 23.
14. Petegnief V, etal., J Biol Chem 2003 Aug 8;278(32):29552-9. Epub 2003 May 27.
15. Pipeline to import KEGG annotations from KEGG into RGD
16. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. RGD automated data pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Tang SJ, etal., Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72. doi: 10.1073/pnas.012605299. Epub 2001 Dec 26.
21. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Vary TC J Nutr. 2007 Sep;137(9):2074-9.
23. Vary TC, etal., Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H121-8. Epub 2004 Sep 23.
24. Zhu Y, etal., Neurol Sci. 2013 Jul;34(7):1093-7. doi: 10.1007/s10072-012-1209-4. Epub 2012 Oct 9.
Additional References at PubMed
PMID:7939721   PMID:9204908   PMID:10100614   PMID:11319880   PMID:12388085   PMID:12441348   PMID:12477932   PMID:14673156   PMID:15489334   PMID:15545827   PMID:15919658   PMID:16010989  
PMID:16236269   PMID:16271312   PMID:16289705   PMID:16306159   PMID:17556672   PMID:17634255   PMID:18337562   PMID:18426977   PMID:18805096   PMID:19074679   PMID:19393246   PMID:19750007  
PMID:20458337   PMID:20616046   PMID:21289279   PMID:21883093   PMID:22578813   PMID:22681889   PMID:22792342   PMID:23263185   PMID:23359369   PMID:23814182   PMID:24990923   PMID:25304210  
PMID:25456498   PMID:25822952   PMID:30361391  


Genomics

Comparative Map Data
Eif4e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22227,066,519 - 227,099,261 (+)NCBI
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02243,819,616 - 243,853,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02262,354,375 - 262,387,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42236,072,748 - 236,104,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12236,059,487 - 236,091,453 (+)NCBI
Celera2219,223,372 - 219,255,078 (+)NCBICelera
Cytogenetic Map2q44NCBI
EIF4E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl498,879,276 - 98,929,133 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl498,871,684 - 98,930,637 (-)EnsemblGRCh38hg38GRCh38
GRCh38498,879,276 - 98,929,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37499,800,427 - 99,850,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,020,235 - 100,070,139 (-)NCBINCBI36hg18NCBI36
Build 344100,158,390 - 100,208,294NCBI
Celera497,096,811 - 97,149,290 (-)NCBI
Cytogenetic Map4q23NCBI
HuRef495,536,964 - 95,590,638 (-)NCBIHuRef
CHM1_1499,776,200 - 99,828,797 (-)NCBICHM1_1
Eif4e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,231,952 - 138,265,457 (+)NCBIGRCm39mm39
GRCm39 Ensembl3138,231,940 - 138,265,457 (+)Ensembl
GRCm383138,526,191 - 138,559,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,526,179 - 138,559,696 (+)EnsemblGRCm38mm10GRCm38
MGSCv373138,189,155 - 138,220,563 (+)NCBIGRCm37mm9NCBIm37
MGSCv363139,028,114 - 139,059,540 (+)NCBImm8
MGSCv363138,463,578 - 138,494,986 (+)NCBImm8
Celera3144,941,218 - 144,979,363 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.3NCBI
Eif4e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554059,122,228 - 9,159,711 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554059,122,960 - 9,159,095 (-)NCBIChiLan1.0ChiLan1.0
EIF4E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14101,941,142 - 101,994,809 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4101,941,142 - 101,994,809 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0491,268,463 - 91,329,800 (-)NCBIMhudiblu_PPA_v0panPan3
EIF4E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3221,065,270 - 21,124,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13221,064,202 - 21,108,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Eif4e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365203,922,457 - 3,964,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,409,731 - 121,466,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,409,633 - 121,464,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,593,991 - 130,647,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4E
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,002,522 - 47,053,060 (-)NCBI
ChlSab1.1 Ensembl747,001,008 - 47,051,571 (-)Ensembl

Position Markers
PMC56953P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02160,278,303 - 160,278,975NCBIRnor5.0
Rnor_5.01110,873,480 - 10,874,161NCBIRnor5.0
RGSC_v3.4118,684,445 - 8,685,125UniSTSRGSC3.4
RGSC_v3.42141,098,844 - 141,099,515UniSTSRGSC3.4
Celera118,630,255 - 8,630,935UniSTS
Celera2130,778,183 - 130,778,854UniSTS
Cytogenetic Map2q44UniSTS
Eif4e  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02262,385,948 - 262,386,705NCBIRnor5.0
Rnor_5.02160,279,340 - 160,279,850NCBIRnor5.0
RGSC_v3.42236,103,383 - 236,103,907UniSTSRGSC3.4
RGSC_v3.42141,099,881 - 141,100,390UniSTSRGSC3.4
Celera2219,253,747 - 219,254,271UniSTS
Celera2130,779,220 - 130,779,729UniSTS
Cytogenetic Map2q44UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2236318496264899009Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2236318496264899009Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2235289967257110527Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2228712271266435125Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2229793522266435125Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2199380312244380312Rat
631514Scl8Serum cholesterol level QTL84.4blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)2231621666266435125Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2229606682264899009Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2155965557254121739Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)2214870793251212353Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2217743855262743855Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2217498545254132424Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283819608243901375Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2221488355254121739Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2228712271266435125Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2177680772243901375Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2231224020254132424Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2208594330263179188Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2204585642249585642Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2204585642249585642Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2237712398257579826Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2240679103266435125Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2228712271266435125Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2240679103266435125Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2228712271266435125Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2228712271266435125Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2233013605253626471Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:120
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000068613
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000089744
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2243,829,781 - 243,850,864 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090526   ⟹   ENSRNOP00000073799
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093355   ⟹   ENSRNOP00000076114
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2243,840,134 - 243,850,928 (+)Ensembl
RefSeq Acc Id: NM_053974   ⟹   NP_446426
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22227,067,384 - 227,099,261 (+)NCBI
Rnor_6.02243,820,696 - 243,852,631 (+)NCBI
Rnor_5.02262,354,375 - 262,387,512 (+)NCBI
RGSC_v3.42236,072,748 - 236,104,714 (+)RGD
Celera2219,223,372 - 219,255,078 (+)RGD
Sequence:
RefSeq Acc Id: XM_008761488   ⟹   XP_008759710
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02243,819,616 - 243,853,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590592   ⟹   XP_017446081
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22227,066,519 - 227,099,261 (+)NCBI
Rnor_6.02243,820,532 - 243,853,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101586   ⟹   XP_038957514
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22227,068,535 - 227,099,261 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446426   ⟸   NM_053974
- UniProtKB: P63074 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008759710   ⟸   XM_008761488
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446081   ⟸   XM_017590592
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000073799   ⟸   ENSRNOT00000090526
RefSeq Acc Id: ENSRNOP00000076114   ⟸   ENSRNOT00000093355
RefSeq Acc Id: XP_038957514   ⟸   XM_039101586
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691791
Promoter ID:EPDNEW_R2315
Type:multiple initiation site
Name:Eif4e_1
Description:eukaryotic translation initiation factor 4E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02243,820,696 - 243,820,756EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69647 AgrOrtholog
Ensembl Genes ENSRNOG00000052343 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073799 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000076114 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090526 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000093355 UniProtKB/TrEMBL
Gene3D-CATH 3.30.760.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122606 IMAGE-MGC_LOAD
InterPro TIF_eIF4e-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIF_eIF_4E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIF_eIF_4E_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117045 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93265 IMAGE-MGC_LOAD
NCBI Gene 117045 ENTREZGENE
PANTHER PTHR11960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IF4E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif4e PhenoGen
PROSITE IF4E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229222
UniProt A0A1W2Q627_RAT UniProtKB/TrEMBL
  IF4E_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P20415 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Eif4e  eukaryotic translation initiation factor 4E      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to the 7-methylguanosine cap of mRNA and facilitates binding of mRNA to the 40 S ribosome during translation initiation 68706
gene_function binds to the 7-methylguanosine cap of mRNA and facilitates binding of mRNA to the 40 S ribosome during translation initiation 68886
gene_process regulates translational efficiency of mRNAs 68706
gene_process regulates translational efficiency of mRNAs 68886
gene_process may function in cell growth 68706
gene_process may function in cell growth 68886