Eif4e (eukaryotic translation initiation factor 4E) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Eif4e (eukaryotic translation initiation factor 4E) Ictidomys tridecemlineatus
Analyze
Symbol: Eif4e
Name: eukaryotic translation initiation factor 4E
RGD ID: 12681935
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); enzyme binding (ortholog); eukaryotic initiation factor 4G binding (ortholog); INVOLVED IN behavioral fear response (ortholog); cellular response to dexamethasone stimulus (ortholog); lung development (ortholog); PARTICIPATES IN CRM1 export pathway; mTOR signaling pathway; translation initiation pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); mantle cell lymphoma (ortholog); FOUND IN cytoplasm (ortholog); eukaryotic translation initiation factor 4F complex (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530120,577,678 - 20,621,269 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365203,922,339 - 3,960,359 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365203,922,457 - 3,964,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Eif4e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530120,577,678 - 20,621,269 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365203,922,339 - 3,960,359 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365203,922,457 - 3,964,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38498,879,276 - 98,929,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl498,879,276 - 98,929,133 (-)EnsemblGRCh38hg38GRCh38
GRCh37499,800,427 - 99,850,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,020,235 - 100,070,139 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,158,390 - 100,208,294NCBI
Celera497,096,811 - 97,149,290 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,536,964 - 95,590,638 (-)NCBIHuRef
CHM1_1499,776,200 - 99,828,797 (-)NCBICHM1_1
T2T-CHM13v2.04102,194,230 - 102,244,088 (-)NCBIT2T-CHM13v2.0
Eif4e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,231,952 - 138,265,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3138,231,940 - 138,265,457 (+)EnsemblGRCm39 Ensembl
GRCm383138,526,191 - 138,559,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,526,179 - 138,559,696 (+)EnsemblGRCm38mm10GRCm38
MGSCv373138,189,155 - 138,220,563 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363139,028,114 - 139,059,540 (+)NCBIMGSCv36mm8
MGSCv363138,463,578 - 138,494,986 (+)NCBIMGSCv36mm8
Celera3144,941,218 - 144,979,363 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.3NCBI
Eif4e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,736,309 - 229,772,628 (+)NCBIGRCr8
mRatBN7.22227,066,519 - 227,099,261 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2227,066,673 - 227,098,683 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,815,680 - 234,847,577 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,715,418 - 232,747,307 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,580,081 - 227,611,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,819,616 - 243,853,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,354,375 - 262,387,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42236,072,748 - 236,104,714 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12236,059,487 - 236,091,453 (+)NCBI
Celera2219,223,372 - 219,255,078 (+)NCBICelera
Cytogenetic Map2q44NCBI
Eif4e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554059,122,228 - 9,159,711 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554059,122,960 - 9,159,095 (-)NCBIChiLan1.0ChiLan1.0
EIF4E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2396,934,680 - 96,996,884 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,210,548 - 97,272,855 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,268,463 - 91,329,800 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14101,941,142 - 101,994,809 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4101,941,142 - 101,994,809 (-)Ensemblpanpan1.1panPan2
EIF4E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,064,202 - 21,108,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,065,270 - 21,124,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,756,689 - 20,865,742 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03221,250,297 - 21,359,208 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13221,216,653 - 21,325,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,042,830 - 21,151,969 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,743,751 - 18,852,925 (+)NCBIUU_Cfam_GSD_1.0
EIF4E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,409,731 - 121,464,471 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,409,633 - 121,464,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,593,991 - 130,647,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,002,522 - 47,053,060 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,001,008 - 47,051,571 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603725,432,821 - 25,482,200 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000002226   ⟹   ENSSTOP00000001986
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365203,945,801 - 3,958,661 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000030975   ⟹   ENSSTOP00000029278
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365203,922,339 - 3,960,359 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000036562   ⟹   ENSSTOP00000025099
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365203,922,529 - 3,959,101 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000037302   ⟹   ENSSTOP00000023996
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365203,922,529 - 3,958,661 (+)Ensembl
RefSeq Acc Id: XM_005325763   ⟹   XP_005325820
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530120,578,929 - 20,621,269 (+)NCBI
SpeTri2.0NW_0049365203,922,457 - 3,964,721 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040293056   ⟹   XP_040148990
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530120,579,640 - 20,621,269 (+)NCBI
RefSeq Acc Id: XM_040293057   ⟹   XP_040148991
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530120,602,899 - 20,621,269 (+)NCBI
RefSeq Acc Id: XM_040293058   ⟹   XP_040148992
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530120,577,678 - 20,621,269 (+)NCBI
RefSeq Acc Id: XM_040293059   ⟹   XP_040148993
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530120,579,383 - 20,621,269 (+)NCBI
RefSeq Acc Id: XM_040293060   ⟹   XP_040148994
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530120,590,798 - 20,621,269 (+)NCBI
RefSeq Acc Id: XP_005325820   ⟸   XM_005325763
- Peptide Label: isoform X3
- UniProtKB: A0A287D6W4 (UniProtKB/TrEMBL),   I3M004 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040148992   ⟸   XM_040293058
- Peptide Label: isoform X3
- UniProtKB: A0A287D6W4 (UniProtKB/TrEMBL),   I3M004 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040148993   ⟸   XM_040293059
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040148990   ⟸   XM_040293056
- Peptide Label: isoform X1
- UniProtKB: I3M004 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040148994   ⟸   XM_040293060
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040148991   ⟸   XM_040293057
- Peptide Label: isoform X2
- UniProtKB: I3M004 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000001986   ⟸   ENSSTOT00000002226
Ensembl Acc Id: ENSSTOP00000029278   ⟸   ENSSTOT00000030975
Ensembl Acc Id: ENSSTOP00000023996   ⟸   ENSSTOT00000037302
Ensembl Acc Id: ENSSTOP00000025099   ⟸   ENSSTOT00000036562


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002230 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002226.3 UniProtKB/TrEMBL
  ENSSTOT00000030975.1 UniProtKB/TrEMBL
  ENSSTOT00000036562.1 UniProtKB/TrEMBL
  ENSSTOT00000037302.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.760.10 UniProtKB/TrEMBL
InterPro TIF_eIF4e-like UniProtKB/TrEMBL
  TIF_eIF_4E UniProtKB/TrEMBL
  TIF_eIF_4E_CS UniProtKB/TrEMBL
NCBI Gene Eif4e ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 4E UniProtKB/TrEMBL
  PTHR11960 UniProtKB/TrEMBL
Pfam IF4E UniProtKB/TrEMBL
PROSITE IF4E UniProtKB/TrEMBL
Superfamily-SCOP SSF55418 UniProtKB/TrEMBL
UniProt A0A287CRT9_ICTTR UniProtKB/TrEMBL
  A0A287CUZ1_ICTTR UniProtKB/TrEMBL
  A0A287D6W4 ENTREZGENE, UniProtKB/TrEMBL
  I3M004 ENTREZGENE, UniProtKB/TrEMBL