EIF4E (eukaryotic translation initiation factor 4E) - Rat Genome Database

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Gene: EIF4E (eukaryotic translation initiation factor 4E) Homo sapiens
Analyze
Symbol: EIF4E
Name: eukaryotic translation initiation factor 4E
RGD ID: 732833
HGNC Page HGNC
Description: Enables several functions, including DNA-binding transcription factor binding activity; RNA binding activity; and eukaryotic initiation factor 4G binding activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of mitotic cell cycle; and regulation of translation. Located in cytoplasmic ribonucleoprotein granule; cytosol; and perinuclear region of cytoplasm. Part of RISC complex; eukaryotic translation initiation factor 4F complex; and mRNA cap binding activity complex. Implicated in autistic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AUTS19; CBP; eIF-4E; eIF-4F 25 kDa subunit; EIF4E1; EIF4EL1; EIF4F; eukaryotic translation initiation factor 4E-like 1; MGC111573; mRNA cap-binding protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: EIF4EP1   EIF4EP2   EIF4EP3   EIF4EP4   EIF4EP5  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl498,879,276 - 98,929,133 (-)EnsemblGRCh38hg38GRCh38
GRCh38498,879,276 - 98,929,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37499,800,427 - 99,850,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,020,235 - 100,070,139 (-)NCBINCBI36hg18NCBI36
Build 344100,158,390 - 100,208,294NCBI
Celera497,096,811 - 97,149,290 (-)NCBI
Cytogenetic Map4q23NCBI
HuRef495,536,964 - 95,590,638 (-)NCBIHuRef
CHM1_1499,776,200 - 99,828,797 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
7-methyl-7,8-dihydroguanosine-5'-diphosphate  (EXP)
7-methyl-GTP  (EXP)
acetylleucyl-leucyl-norleucinal  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (EXP,ISO)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cycloheximide  (EXP,ISO)
cypermethrin  (ISO)
D-glucitol  (EXP)
D-glucose  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
Dictamnine  (EXP)
Dihydrotanshinone I  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP)
ethyl methanesulfonate  (EXP)
everolimus  (EXP)
flavonoids  (ISO)
fluoxetine  (ISO)
flurbiprofen  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (EXP)
glucose  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
guanosine  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
indometacin  (EXP)
irinotecan  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
jaspamide  (EXP)
kojic acid  (EXP)
lactacystin  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
LY294002  (EXP)
metformin  (EXP)
methapyrilene  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
naphthalene  (ISO)
nefazodone  (ISO)
niclosamide  (EXP)
nicotine  (EXP,ISO)
orlistat  (EXP)
perfluorooctanoic acid  (ISO)
perhexiline  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pioglitazone  (EXP)
piroxicam  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
quinolone  (EXP)
resveratrol  (EXP,ISO)
ribavirin  (EXP)
rottlerin  (EXP)
SB 203580  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP)
sorafenib  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiophenes  (EXP)
triadimefon  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1384058   PMID:1672854   PMID:1674733   PMID:1736299   PMID:1916814   PMID:1993647   PMID:2016328   PMID:3112145   PMID:3469651   PMID:7590282   PMID:7651417   PMID:7665584  
PMID:7782323   PMID:7935836   PMID:8449919   PMID:8505316   PMID:8521827   PMID:8662663   PMID:8816458   PMID:8939971   PMID:9155017   PMID:9330633   PMID:9372926   PMID:9418880  
PMID:9593750   PMID:9607624   PMID:9628874   PMID:9878069   PMID:10022874   PMID:10364159   PMID:10394359   PMID:10405182   PMID:10600798   PMID:10648556   PMID:10698949   PMID:10753870  
PMID:10772338   PMID:10856257   PMID:10870064   PMID:10880459   PMID:10910074   PMID:11072066   PMID:11154262   PMID:11401917   PMID:11408474   PMID:11500381   PMID:11553333   PMID:11575918  
PMID:11605658   PMID:11771728   PMID:11847216   PMID:11879179   PMID:11959093   PMID:12071973   PMID:12089333   PMID:12105188   PMID:12138083   PMID:12151318   PMID:12167712   PMID:12169454  
PMID:12186496   PMID:12189553   PMID:12239292   PMID:12374671   PMID:12438698   PMID:12477932   PMID:12482586   PMID:12554669   PMID:12588972   PMID:12588975   PMID:12691746   PMID:12747804  
PMID:12775419   PMID:12781867   PMID:12867426   PMID:12897141   PMID:12918105   PMID:12975586   PMID:14558943   PMID:14645512   PMID:14673156   PMID:14702039   PMID:14732354   PMID:14990584  
PMID:15094042   PMID:15122903   PMID:15153109   PMID:15220445   PMID:15247416   PMID:15355912   PMID:15361857   PMID:15371741   PMID:15375804   PMID:15487973   PMID:15489334   PMID:15542544  
PMID:15767663   PMID:15809305   PMID:15840819   PMID:15878868   PMID:15897904   PMID:15956551   PMID:15961545   PMID:16023599   PMID:16112647   PMID:16124648   PMID:16157702   PMID:16189514  
PMID:16242075   PMID:16271312   PMID:16281055   PMID:16332685   PMID:16341674   PMID:16467844   PMID:16504179   PMID:16540463   PMID:16541103   PMID:16648488   PMID:16699599   PMID:16720573  
PMID:16739988   PMID:16756390   PMID:16798736   PMID:16824195   PMID:17010208   PMID:17074885   PMID:17203162   PMID:17245113   PMID:17254965   PMID:17316564   PMID:17353931   PMID:17357517  
PMID:17524464   PMID:17601486   PMID:17631896   PMID:17638893   PMID:17667941   PMID:17689990   PMID:17724079   PMID:17786246   PMID:17855553   PMID:18234281   PMID:18250159   PMID:18337562  
PMID:18343217   PMID:18423201   PMID:18426977   PMID:18479935   PMID:18593934   PMID:18614538   PMID:18719964   PMID:18789325   PMID:18805096   PMID:18955708   PMID:18957614   PMID:19020722  
PMID:19060904   PMID:19114552   PMID:19122207   PMID:19134194   PMID:19188486   PMID:19244480   PMID:19261348   PMID:19262567   PMID:19289374   PMID:19367274   PMID:19383915   PMID:19393246  
PMID:19440045   PMID:19483468   PMID:19556253   PMID:19560264   PMID:19603014   PMID:19615732   PMID:19750007   PMID:19776122   PMID:19834456   PMID:19850923   PMID:19850929   PMID:20053821  
PMID:20101233   PMID:20212144   PMID:20224576   PMID:20347422   PMID:20359850   PMID:20360068   PMID:20379614   PMID:20421305   PMID:20427534   PMID:20430826   PMID:20434207   PMID:20458337  
PMID:20499137   PMID:20537983   PMID:20616046   PMID:20652449   PMID:20655307   PMID:20686366   PMID:20880835   PMID:20927323   PMID:21047768   PMID:21088106   PMID:21145089   PMID:21159249  
PMID:21191102   PMID:21238947   PMID:21320304   PMID:21334199   PMID:21389327   PMID:21415224   PMID:21661078   PMID:21750861   PMID:21798997   PMID:21832049   PMID:21873635   PMID:21876152  
PMID:21883093   PMID:21913890   PMID:21941146   PMID:21964297   PMID:21988832   PMID:21995271   PMID:22216185   PMID:22397984   PMID:22456335   PMID:22457629   PMID:22509910   PMID:22556409  
PMID:22578813   PMID:22586265   PMID:22614784   PMID:22623428   PMID:22678294   PMID:22681889   PMID:22684010   PMID:22748716   PMID:22759308   PMID:22797067   PMID:22851180   PMID:22863883  
PMID:22872150   PMID:22902403   PMID:22939629   PMID:23079111   PMID:23100465   PMID:23277284   PMID:23359369   PMID:23410891   PMID:23467026   PMID:23471078   PMID:23472659   PMID:23547259  
PMID:23588929   PMID:23665580   PMID:23665581   PMID:23667251   PMID:23737503   PMID:23788676   PMID:23814182   PMID:23831578   PMID:23883783   PMID:23901100   PMID:23974830   PMID:23991149  
PMID:24052408   PMID:24207126   PMID:24211447   PMID:24239466   PMID:24335285   PMID:24345331   PMID:24363449   PMID:24431103   PMID:24491247   PMID:24551240   PMID:24714040   PMID:24722188  
PMID:24814906   PMID:24818597   PMID:24840750   PMID:24845562   PMID:24931163   PMID:24971752   PMID:24981860   PMID:25004955   PMID:25025927   PMID:25049413   PMID:25193863   PMID:25197055  
PMID:25234597   PMID:25263391   PMID:25342548   PMID:25343550   PMID:25403230   PMID:25416956   PMID:25422161   PMID:25425688   PMID:25439783   PMID:25450520   PMID:25456498   PMID:25466251  
PMID:25524901   PMID:25533957   PMID:25588502   PMID:25615552   PMID:25702871   PMID:25717031   PMID:25755728   PMID:25813250   PMID:25835715   PMID:25839159   PMID:25884680   PMID:25915158  
PMID:25921289   PMID:25923732   PMID:25940091   PMID:25982998   PMID:25986608   PMID:26078354   PMID:26143374   PMID:26147685   PMID:26186194   PMID:26209609   PMID:26344197   PMID:26397141  
PMID:26427906   PMID:26498997   PMID:26522719   PMID:26572974   PMID:26668315   PMID:26829052   PMID:26854219   PMID:26931209   PMID:26944016   PMID:26945967   PMID:26951381   PMID:26972000  
PMID:27065194   PMID:27094611   PMID:27114554   PMID:27162083   PMID:27280636   PMID:27283511   PMID:27381497   PMID:27413184   PMID:27418099   PMID:27440383   PMID:27501049   PMID:27527252  
PMID:27578149   PMID:27588477   PMID:27591049   PMID:27601163   PMID:27618366   PMID:27662474   PMID:27714564   PMID:27773676   PMID:27840955   PMID:27840964   PMID:27864334   PMID:27879264  
PMID:27900644   PMID:27907907   PMID:27916520   PMID:27932243   PMID:27986751   PMID:28073841   PMID:28077445   PMID:28242042   PMID:28325843   PMID:28350134   PMID:28379136   PMID:28395726  
PMID:28447756   PMID:28487484   PMID:28514442   PMID:28515276   PMID:28661037   PMID:28718761   PMID:28733330   PMID:28745319   PMID:28843814   PMID:28849086   PMID:28852129   PMID:28942592  
PMID:28987382   PMID:29111978   PMID:29158530   PMID:29229926   PMID:29244122   PMID:29254314   PMID:29342273   PMID:29358667   PMID:29374693   PMID:29395067   PMID:29396141   PMID:29471506  
PMID:29509190   PMID:29527921   PMID:29676528   PMID:29931370   PMID:29987188   PMID:30066885   PMID:30232453   PMID:30297141   PMID:30361391   PMID:30374200   PMID:30573685   PMID:30677218  
PMID:30744688   PMID:30929914   PMID:30948266   PMID:30998968   PMID:31042468   PMID:31059266   PMID:31074051   PMID:31091453   PMID:31118010   PMID:31361897   PMID:31512056   PMID:31515488  
PMID:31527615   PMID:31607311   PMID:31685992   PMID:31782083   PMID:31811670   PMID:31894279   PMID:32023262   PMID:32066877   PMID:32189455   PMID:32296183   PMID:32336547   PMID:32421011  
PMID:32807901   PMID:32978410   PMID:33022573   PMID:33262313   PMID:33340431   PMID:33489719   PMID:33852892   PMID:34146250  


Genomics

Comparative Map Data
EIF4E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl498,879,276 - 98,929,133 (-)EnsemblGRCh38hg38GRCh38
GRCh38498,879,276 - 98,929,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37499,800,427 - 99,850,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,020,235 - 100,070,139 (-)NCBINCBI36hg18NCBI36
Build 344100,158,390 - 100,208,294NCBI
Celera497,096,811 - 97,149,290 (-)NCBI
Cytogenetic Map4q23NCBI
HuRef495,536,964 - 95,590,638 (-)NCBIHuRef
CHM1_1499,776,200 - 99,828,797 (-)NCBICHM1_1
Eif4e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,231,952 - 138,265,457 (+)NCBIGRCm39mm39
GRCm39 Ensembl3138,231,940 - 138,265,457 (+)Ensembl
GRCm383138,526,191 - 138,559,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,526,179 - 138,559,696 (+)EnsemblGRCm38mm10GRCm38
MGSCv373138,189,155 - 138,220,563 (+)NCBIGRCm37mm9NCBIm37
MGSCv363139,028,114 - 139,059,540 (+)NCBImm8
MGSCv363138,463,578 - 138,494,986 (+)NCBImm8
Celera3144,941,218 - 144,979,363 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.3NCBI
Eif4e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22227,066,519 - 227,099,261 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2227,066,673 - 227,098,683 (+)Ensembl
Rnor_6.02243,819,616 - 243,853,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,354,375 - 262,387,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42236,072,748 - 236,104,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12236,059,487 - 236,091,453 (+)NCBI
Celera2219,223,372 - 219,255,078 (+)NCBICelera
Cytogenetic Map2q44NCBI
Eif4e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554059,122,228 - 9,159,711 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554059,122,960 - 9,159,095 (-)NCBIChiLan1.0ChiLan1.0
EIF4E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14101,941,142 - 101,994,809 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4101,941,142 - 101,994,809 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0491,268,463 - 91,329,800 (-)NCBIMhudiblu_PPA_v0panPan3
EIF4E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,064,202 - 21,108,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,065,270 - 21,124,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,756,689 - 20,865,742 (+)NCBI
ROS_Cfam_1.03221,250,297 - 21,359,208 (-)NCBI
UMICH_Zoey_3.13221,216,653 - 21,325,304 (-)NCBI
UNSW_CanFamBas_1.03221,042,830 - 21,151,969 (-)NCBI
UU_Cfam_GSD_1.03218,743,751 - 18,852,925 (+)NCBI
Eif4e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530120,577,678 - 20,621,269 (+)NCBI
SpeTri2.0NW_0049365203,922,457 - 3,964,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,409,731 - 121,466,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,409,633 - 121,464,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,593,991 - 130,647,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,002,522 - 47,053,060 (-)NCBI
ChlSab1.1 Ensembl747,001,008 - 47,051,571 (-)Ensembl
Vero_WHO_p1.0NW_02366603725,432,821 - 25,482,200 (-)NCBI

Position Markers
SHGC-31816  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37499,800,443 - 99,800,571UniSTSGRCh37
Build 364100,019,466 - 100,019,594RGDNCBI36
Celera497,097,647 - 97,097,775RGD
Cytogenetic Map4q21-q25UniSTS
HuRef495,537,801 - 95,537,929UniSTS
TNG Radiation Hybrid Map461077.0UniSTS
GeneMap99-GB4 RH Map4492.11UniSTS
Whitehead-RH Map4534.0UniSTS
NCBI RH Map41156.0UniSTS
GeneMap99-G3 RH Map45586.0UniSTS
RH92334  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37499,850,721 - 99,850,883UniSTSGRCh37
Build 364100,069,744 - 100,069,906RGDNCBI36
Celera497,148,225 - 97,148,387RGD
Cytogenetic Map4q21-q25UniSTS
HuRef495,589,573 - 95,589,735UniSTS
GeneMap99-GB4 RH Map4494.15UniSTS
RH99170  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37499,800,051 - 99,800,171UniSTSGRCh37
Build 364100,019,074 - 100,019,194RGDNCBI36
Celera497,097,255 - 97,097,375RGD
Cytogenetic Map4q21-q25UniSTS
HuRef495,537,409 - 95,537,529UniSTS
GeneMap99-GB4 RH Map4494.43UniSTS
PMC56953P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,501,625 - 47,502,298UniSTSGRCh37
Build 361744,856,624 - 44,857,297RGDNCBI36
Celera1743,956,644 - 43,957,317RGD
HuRef1742,866,615 - 42,867,288UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR141hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI21238947

Predicted Target Of
Summary Value
Count of predictions:4546
Count of miRNA genes:1354
Interacting mature miRNAs:1747
Transcripts:ENST00000280892, ENST00000418385, ENST00000450253, ENST00000504432, ENST00000504472, ENST00000505194, ENST00000505829, ENST00000505992, ENST00000507665, ENST00000511644, ENST00000515638
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 166 18 70 23 323 24 271 58 504 97 478 295 12 1 1 3 5 2
Low 2273 2788 1655 600 1508 440 4086 2075 3229 321 982 1318 163 1202 2785 1
Below cutoff 185 1 1 120 1 64 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001331017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC019131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ844638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV708571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM849222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY994926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA419184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS060531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC388666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC742040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI923841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI927571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  R61891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000280892   ⟹   ENSP00000280892
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,880,765 - 98,929,092 (-)Ensembl
RefSeq Acc Id: ENST00000418385
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,925,972 - 98,929,125 (-)Ensembl
RefSeq Acc Id: ENST00000450253   ⟹   ENSP00000389624
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,879,276 - 98,929,133 (-)Ensembl
RefSeq Acc Id: ENST00000504432   ⟹   ENSP00000423977
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,880,845 - 98,929,125 (-)Ensembl
RefSeq Acc Id: ENST00000504472
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,895,122 - 98,929,133 (-)Ensembl
RefSeq Acc Id: ENST00000505194
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,881,010 - 98,890,898 (-)Ensembl
RefSeq Acc Id: ENST00000505829
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,887,163 - 98,891,571 (-)Ensembl
RefSeq Acc Id: ENST00000505992   ⟹   ENSP00000425561
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,880,898 - 98,929,133 (-)Ensembl
RefSeq Acc Id: ENST00000507665
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,886,351 - 98,929,128 (-)Ensembl
RefSeq Acc Id: ENST00000511644   ⟹   ENSP00000421287
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,880,845 - 98,929,101 (-)Ensembl
RefSeq Acc Id: ENST00000515638   ⟹   ENSP00000426602
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl498,880,772 - 98,929,125 (-)Ensembl
RefSeq Acc Id: NM_001130678   ⟹   NP_001124150
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38498,879,276 - 98,929,133 (-)NCBI
GRCh37499,799,607 - 99,851,786 (-)ENTREZGENE
HuRef495,536,964 - 95,590,638 (-)ENTREZGENE
CHM1_1499,776,200 - 99,827,254 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001130679   ⟹   NP_001124151
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38498,879,276 - 98,929,133 (-)NCBI
GRCh37499,799,607 - 99,851,786 (-)ENTREZGENE
HuRef495,536,964 - 95,590,638 (-)ENTREZGENE
CHM1_1499,776,200 - 99,828,797 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001331017   ⟹   NP_001317946
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38498,879,276 - 98,929,133 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001968   ⟹   NP_001959
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38498,879,276 - 98,929,133 (-)NCBI
GRCh37499,799,607 - 99,851,786 (-)ENTREZGENE
Build 364100,020,235 - 100,070,139 (-)NCBI Archive
HuRef495,536,964 - 95,590,638 (-)ENTREZGENE
CHM1_1499,776,200 - 99,828,797 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001959   ⟸   NM_001968
- Peptide Label: isoform 1
- UniProtKB: P06730 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001124151   ⟸   NM_001130679
- Peptide Label: isoform 2
- UniProtKB: P06730 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001124150   ⟸   NM_001130678
- Peptide Label: isoform 3
- UniProtKB: P06730 (UniProtKB/Swiss-Prot),   Q32Q75 (UniProtKB/TrEMBL),   X5D7E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001317946   ⟸   NM_001331017
- Peptide Label: isoform 4
- UniProtKB: P06730 (UniProtKB/Swiss-Prot),   D6RBW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000389624   ⟸   ENST00000450253
RefSeq Acc Id: ENSP00000423977   ⟸   ENST00000504432
RefSeq Acc Id: ENSP00000425561   ⟸   ENST00000505992
RefSeq Acc Id: ENSP00000280892   ⟸   ENST00000280892
RefSeq Acc Id: ENSP00000421287   ⟸   ENST00000511644
RefSeq Acc Id: ENSP00000426602   ⟸   ENST00000515638

Promoters
RGD ID:6868080
Promoter ID:EPDNEW_H7205
Type:initiation region
Name:EIF4E_1
Description:eukaryotic translation initiation factor 4E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7206  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38498,929,125 - 98,929,185EPDNEW
RGD ID:6868082
Promoter ID:EPDNEW_H7206
Type:initiation region
Name:EIF4E_2
Description:eukaryotic translation initiation factor 4E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7205  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38498,929,983 - 98,930,043EPDNEW
RGD ID:6812506
Promoter ID:HG_ACW:60257
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:EIF4E.GAPR07,   EIF4E.QAPR07,   MERSNOBY.AAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 364100,032,026 - 100,032,526 (-)MPROMDB
RGD ID:6802181
Promoter ID:HG_KWN:48776
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001130678,   NM_001130679,   NM_001968
Position:
Human AssemblyChrPosition (strand)Source
Build 364100,069,281 - 100,070,167 (-)MPROMDB
RGD ID:6851614
Promoter ID:EP73609
Type:multiple initiation site
Name:HS_EIF4E
Description:Eukaryotic translation initiation factor 4E.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 364100,069,299 - 100,069,359EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
EIF4E, 1-BP INS, -25C insertion Autism, susceptibility to, 19 [RCV000033167] Chr4:4q21-q25 risk factor
GRCh38/hg38 4q23(chr4:97972342-100038125)x3 copy number gain See cases [RCV000051632] Chr4:97972342..100038125 [GRCh38]
Chr4:98893493..100959282 [GRCh37]
Chr4:99112516..101178305 [NCBI36]
Chr4:4q23
uncertain significance
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3
pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
GRCh38/hg38 4q22.3-23(chr4:94954967-98967243)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053320]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053320]|See cases [RCV000053320] Chr4:94954967..98967243 [GRCh38]
Chr4:95876118..99888394 [GRCh37]
Chr4:96095141..100107417 [NCBI36]
Chr4:4q22.3-23
pathogenic
GRCh38/hg38 4q21.21-24(chr4:80427023-100855441)x1 copy number loss See cases [RCV000137269] Chr4:80427023..100855441 [GRCh38]
Chr4:81348177..101776598 [GRCh37]
Chr4:81567201..101995621 [NCBI36]
Chr4:4q21.21-24
pathogenic
GRCh38/hg38 4q22.1-24(chr4:92610413-101521991)x1 copy number loss See cases [RCV000140412] Chr4:92610413..101521991 [GRCh38]
Chr4:93531564..102443148 [GRCh37]
Chr4:93750587..102662171 [NCBI36]
Chr4:4q22.1-24
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q21.23-24(chr4:85805268-103678797)x1 copy number loss See cases [RCV000445741] Chr4:85805268..103678797 [GRCh37]
Chr4:4q21.23-24
pathogenic
GRCh37/hg19 4q23(chr4:99288284-99846320)x3 copy number gain See cases [RCV000510279] Chr4:99288284..99846320 [GRCh37]
Chr4:4q23
likely benign
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q22.3-23(chr4:97419923-99923880)x3 copy number gain See cases [RCV000510710] Chr4:97419923..99923880 [GRCh37]
Chr4:4q22.3-23
uncertain significance
GRCh37/hg19 4q22.1-24(chr4:92201567-103043808)x1 copy number loss See cases [RCV000511194] Chr4:92201567..103043808 [GRCh37]
Chr4:4q22.1-24
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q23(chr4:99687168-100200509)x3 copy number gain not provided [RCV000743861] Chr4:99687168..100200509 [GRCh37]
Chr4:4q23
benign
GRCh37/hg19 4q23(chr4:99687168-100202078)x3 copy number gain not provided [RCV000743862] Chr4:99687168..100202078 [GRCh37]
Chr4:4q23
benign
GRCh37/hg19 4q23(chr4:99774183-99808872)x3 copy number gain not provided [RCV000743863] Chr4:99774183..99808872 [GRCh37]
Chr4:4q23
benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_001968.4(EIF4E):c.540-8del deletion not provided [RCV000948279] Chr4:98881150 [GRCh38]
Chr4:99802301 [GRCh37]
Chr4:4q23
benign
NM_001130679.2(EIF4E):c.415A>G (p.Met139Val) single nucleotide variant not provided [RCV000894324] Chr4:98886531 [GRCh38]
Chr4:99807682 [GRCh37]
Chr4:4q23
likely benign
GRCh37/hg19 4q23(chr4:99769895-99811279)x3 copy number gain not provided [RCV000848150] Chr4:99769895..99811279 [GRCh37]
Chr4:4q23
uncertain significance
GRCh37/hg19 4q23(chr4:99769895-99810740)x3 copy number gain not provided [RCV000849740] Chr4:99769895..99810740 [GRCh37]
Chr4:4q23
uncertain significance
NM_001968.4(EIF4E):c.540-18dup duplication not provided [RCV000962989] Chr4:98881149..98881150 [GRCh38]
Chr4:99802300..99802301 [GRCh37]
Chr4:4q23
benign
GRCh37/hg19 4q22.2-24(chr4:94692345-101308220)x1 copy number loss not provided [RCV001259285] Chr4:94692345..101308220 [GRCh37]
Chr4:4q22.2-24
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3287 AgrOrtholog
COSMIC EIF4E COSMIC
Ensembl Genes ENSG00000151247 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000280892 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000389624 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000421287 UniProtKB/TrEMBL
  ENSP00000423977 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000425561 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000426602 UniProtKB/TrEMBL
Ensembl Transcript ENST00000280892 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000450253 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000504432 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000505992 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000511644 UniProtKB/TrEMBL
  ENST00000515638 UniProtKB/TrEMBL
Gene3D-CATH 3.30.760.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000151247 GTEx
HGNC ID HGNC:3287 ENTREZGENE
Human Proteome Map EIF4E Human Proteome Map
InterPro TIF_eIF4e-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIF_eIF_4E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIF_eIF_4E_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1977 UniProtKB/Swiss-Prot
NCBI Gene 1977 ENTREZGENE
OMIM 133440 OMIM
  615091 OMIM
PANTHER PTHR11960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IF4E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27714 PharmGKB
PROSITE IF4E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RBW1 ENTREZGENE, UniProtKB/TrEMBL
  D6RFJ3_HUMAN UniProtKB/TrEMBL
  H0Y8J7_HUMAN UniProtKB/TrEMBL
  IF4E_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q32Q75 ENTREZGENE, UniProtKB/TrEMBL
  X5D7E3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B7Z6V1 UniProtKB/Swiss-Prot
  D6RCQ6 UniProtKB/Swiss-Prot
  Q96E95 UniProtKB/Swiss-Prot