EIF4E (eukaryotic translation initiation factor 4E) - Rat Genome Database

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Gene: EIF4E (eukaryotic translation initiation factor 4E) Pan paniscus
Analyze
Symbol: EIF4E
Name: eukaryotic translation initiation factor 4E
RGD ID: 11927816
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); enzyme binding (ortholog); eukaryotic initiation factor 4G binding (ortholog); INVOLVED IN behavioral fear response (ortholog); cellular response to dexamethasone stimulus (ortholog); G1/S transition of mitotic cell cycle (ortholog); PARTICIPATES IN CRM1 export pathway; mTOR signaling pathway; translation initiation pathway; ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); mantle cell lymphoma (ortholog); FOUND IN chromatoid body (ortholog); cytoplasmic ribonucleoprotein granule (ortholog); cytoplasmic stress granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2396,934,680 - 96,996,884 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,210,548 - 97,272,855 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,268,463 - 91,329,800 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14101,941,142 - 101,994,809 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4101,941,142 - 101,994,809 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EIF4E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2396,934,680 - 96,996,884 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,210,548 - 97,272,855 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,268,463 - 91,329,800 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14101,941,142 - 101,994,809 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4101,941,142 - 101,994,809 (-)Ensemblpanpan1.1panPan2
EIF4E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38498,879,276 - 98,929,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl498,879,276 - 98,929,133 (-)EnsemblGRCh38hg38GRCh38
GRCh37499,800,427 - 99,850,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,020,235 - 100,070,139 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,158,390 - 100,208,294NCBI
Celera497,096,811 - 97,149,290 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,536,964 - 95,590,638 (-)NCBIHuRef
CHM1_1499,776,200 - 99,828,797 (-)NCBICHM1_1
T2T-CHM13v2.04102,194,230 - 102,244,088 (-)NCBIT2T-CHM13v2.0
Eif4e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,231,952 - 138,265,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3138,231,940 - 138,265,457 (+)EnsemblGRCm39 Ensembl
GRCm383138,526,191 - 138,559,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,526,179 - 138,559,696 (+)EnsemblGRCm38mm10GRCm38
MGSCv373138,189,155 - 138,220,563 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363139,028,114 - 139,059,540 (+)NCBIMGSCv36mm8
MGSCv363138,463,578 - 138,494,986 (+)NCBIMGSCv36mm8
Celera3144,941,218 - 144,979,363 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.3NCBI
Eif4e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,736,309 - 229,772,628 (+)NCBIGRCr8
mRatBN7.22227,066,519 - 227,099,261 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2227,066,673 - 227,098,683 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,815,680 - 234,847,577 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,715,418 - 232,747,307 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,580,081 - 227,611,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,819,616 - 243,853,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,820,661 - 243,852,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,354,375 - 262,387,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42236,072,748 - 236,104,714 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12236,059,487 - 236,091,453 (+)NCBI
Celera2219,223,372 - 219,255,078 (+)NCBICelera
Cytogenetic Map2q44NCBI
Eif4e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554059,122,228 - 9,159,711 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554059,122,960 - 9,159,095 (-)NCBIChiLan1.0ChiLan1.0
EIF4E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,064,202 - 21,108,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,065,270 - 21,124,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,756,689 - 20,865,742 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03221,250,297 - 21,359,208 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13221,216,653 - 21,325,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,042,830 - 21,151,969 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,743,751 - 18,852,925 (+)NCBIUU_Cfam_GSD_1.0
Eif4e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530120,577,678 - 20,621,269 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365203,922,339 - 3,960,359 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365203,922,457 - 3,964,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,409,731 - 121,464,471 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,409,633 - 121,464,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,593,991 - 130,647,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,002,522 - 47,053,060 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,001,008 - 47,051,571 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603725,432,821 - 25,482,200 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000065055   ⟹   ENSPPAP00000042126
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4101,941,142 - 101,994,809 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000065056   ⟹   ENSPPAP00000042127
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4101,941,142 - 101,971,537 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000065057   ⟹   ENSPPAP00000042128
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4101,942,888 - 101,968,420 (-)Ensembl
RefSeq Acc Id: XM_003829919   ⟹   XP_003829967
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,996,884 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,272,855 (-)NCBI
Mhudiblu_PPA_v0491,268,463 - 91,329,800 (-)NCBI
PanPan1.14101,941,142 - 101,994,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003829920   ⟹   XP_003829968
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,994,502 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,270,472 (-)NCBI
Mhudiblu_PPA_v0491,268,463 - 91,328,303 (-)NCBI
PanPan1.14101,941,142 - 101,993,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955319   ⟹   XP_008953567
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,994,479 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,270,449 (-)NCBI
Mhudiblu_PPA_v0491,268,463 - 91,306,674 (-)NCBI
PanPan1.14101,941,142 - 101,971,537 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055111651   ⟹   XP_054967626
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,994,479 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,270,449 (-)NCBI
RefSeq Acc Id: XM_055111652   ⟹   XP_054967627
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,944,104 - 96,994,479 (-)NCBI
NHGRI_mPanPan1497,219,971 - 97,270,449 (-)NCBI
RefSeq Acc Id: XM_055111653   ⟹   XP_054967628
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,969,780 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,245,666 (-)NCBI
RefSeq Acc Id: XM_055111654   ⟹   XP_054967629
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,994,425 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,270,390 (-)NCBI
RefSeq Acc Id: XM_055111655   ⟹   XP_054967630
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,969,846 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,245,727 (-)NCBI
RefSeq Acc Id: XM_055111656   ⟹   XP_054967631
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,946,920 - 96,994,479 (-)NCBI
NHGRI_mPanPan1497,222,785 - 97,270,449 (-)NCBI
RefSeq Acc Id: XM_055111657   ⟹   XP_054967632
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,996,884 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,272,855 (-)NCBI
RefSeq Acc Id: XM_057302114   ⟹   XP_057158097
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2396,934,680 - 96,994,479 (-)NCBI
NHGRI_mPanPan1497,210,548 - 97,270,449 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003829967   ⟸   XM_003829919
- Peptide Label: isoform X8
- UniProtKB: A0A2R9CM77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003829968   ⟸   XM_003829920
- Peptide Label: isoform X7
- UniProtKB: A0A2R9CM77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008953567   ⟸   XM_008955319
- Peptide Label: isoform X5
- UniProtKB: A0A2R9CSB0 (UniProtKB/TrEMBL),   A0A2R9CM77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000042128   ⟸   ENSPPAT00000065057
RefSeq Acc Id: ENSPPAP00000042127   ⟸   ENSPPAT00000065056
RefSeq Acc Id: ENSPPAP00000042126   ⟸   ENSPPAT00000065055
RefSeq Acc Id: XP_054967632   ⟸   XM_055111657
- Peptide Label: isoform X11
RefSeq Acc Id: XP_054967626   ⟸   XM_055111651
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054967629   ⟸   XM_055111654
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CM77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054967630   ⟸   XM_055111655
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054967628   ⟸   XM_055111653
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054967627   ⟸   XM_055111652
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054967631   ⟸   XM_055111656
- Peptide Label: isoform X9
RefSeq Acc Id: XP_057158097   ⟸   XM_057302114
- Peptide Label: isoform X10


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043652 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000065055.1 UniProtKB/TrEMBL
  ENSPPAT00000065056.1 UniProtKB/TrEMBL
  ENSPPAT00000065057.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.760.10 UniProtKB/TrEMBL
InterPro TIF_eIF4e-like UniProtKB/TrEMBL
  TIF_eIF_4E UniProtKB/TrEMBL
  TIF_eIF_4E_CS UniProtKB/TrEMBL
NCBI Gene EIF4E ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 4E UniProtKB/TrEMBL
  PTHR11960 UniProtKB/TrEMBL
Pfam IF4E UniProtKB/TrEMBL
PROSITE IF4E UniProtKB/TrEMBL
Superfamily-SCOP SSF55418 UniProtKB/TrEMBL
UniProt A0A2R9CJJ5_PANPA UniProtKB/TrEMBL
  A0A2R9CM77 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CSB0 ENTREZGENE, UniProtKB/TrEMBL