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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69647
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4e
Name: eukaryotic translation initiation factor 4E
Acc ID: CHEBI:68478
Term: everolimus
Definition: A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.
Chemical ID: MESH:C107135
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4eincreases phosphorylationISOEIF4E (Homo sapiens)6480464CTDEverolimus results in increased phosphorylation of EIF4E proteinPMID:16033851
Eif4emultiple interactionsISOEIF4E (Homo sapiens)6480464CTDEverolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]PMID:16033851
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