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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69647
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4e
Name: eukaryotic translation initiation factor 4E
Acc ID: CHEBI:65329
Term: LY294002
Definition: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Chemical ID: MESH:C085911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4edecreases phosphorylationISOEIF4E (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of EIF4E proteinPMID:26282490
Eif4emultiple interactionsISOEIF4E (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]PMID:12781867
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