Dscam (DS cell adhesion molecule) - Rat Genome Database

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Gene: Dscam (DS cell adhesion molecule) Rattus norvegicus
Analyze
Symbol: Dscam
Name: DS cell adhesion molecule
RGD ID: 619992
Description: Predicted to enable cell-cell adhesion mediator activity; netrin receptor binding activity; and protein tyrosine kinase binding activity. Involved in positive regulation of axon extension involved in axon guidance. Predicted to be located in dendrite; growth cone; and synapse. Predicted to be active in axon; neuronal cell body; and plasma membrane. Orthologous to human DSCAM (DS cell adhesion molecule); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell adhesion molecule DSCAM; Down syndrome cell adhesion molecule; Down syndrome cell adhesion molecule homolog; Down syndrome cell adhesion molecule-like; LOC100360483; LOC686040; similar to Down syndrome cell adhesion molecule
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81149,391,385 - 49,976,861 (-)NCBIGRCr8
mRatBN7.21135,921,924 - 36,507,100 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,926,896 - 36,507,415 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1144,576,796 - 45,149,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01137,248,172 - 37,821,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01136,401,719 - 36,980,976 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,004,776 - 37,599,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,004,902 - 37,253,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01140,530,620 - 41,112,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,954,750 - 37,230,296 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,012,825 - 37,275,047 (-)NCBI
Celera1135,824,419 - 36,395,688 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IBA,ISO,ISS)
dendrite  (IEA,ISO,ISS)
growth cone  (IEA,ISO,ISS)
membrane  (IEA)
neuronal cell body  (IBA,IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,ISS)
synapse  (IEA,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain. Barlow GM, etal., Cytogenet Cell Genet 2001;94(3-4):155-62.
2. Down syndrome congenital heart disease: a narrowed region and a candidate gene. Barlow GM, etal., Genet Med 2001 Mar-Apr;3(2):91-101.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Ly A, etal., Cell. 2008 Jun 27;133(7):1241-54. doi: 10.1016/j.cell.2008.05.030.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Yamakawa K, etal., Hum Mol Genet 1998 Feb;7(2):227-37.
Additional References at PubMed
PMID:18216855   PMID:19196994   PMID:19558816   PMID:19945391   PMID:21360594   PMID:22685302  


Genomics

Comparative Map Data
Dscam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81149,391,385 - 49,976,861 (-)NCBIGRCr8
mRatBN7.21135,921,924 - 36,507,100 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,926,896 - 36,507,415 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1144,576,796 - 45,149,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01137,248,172 - 37,821,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01136,401,719 - 36,980,976 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,004,776 - 37,599,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,004,902 - 37,253,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01140,530,620 - 41,112,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,954,750 - 37,230,296 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,012,825 - 37,275,047 (-)NCBI
Celera1135,824,419 - 36,395,688 (-)NCBICelera
Cytogenetic Map11q11NCBI
DSCAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382140,010,999 - 40,847,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2140,010,999 - 40,847,158 (-)EnsemblGRCh38hg38GRCh38
GRCh372141,382,926 - 42,219,084 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362140,306,213 - 41,140,909 (-)NCBINCBI36Build 36hg18NCBI36
Build 342140,306,212 - 41,140,909NCBI
Celera2126,582,079 - 27,417,510 (-)NCBICelera
Cytogenetic Map21q22.2NCBI
HuRef2126,884,190 - 27,191,292 (-)NCBIHuRef
HuRef2127,195,979 - 27,689,477 (-)NCBIHuRef
CHM1_12140,945,084 - 41,641,065 (-)NCBICHM1_1
T2T-CHM13v2.02138,398,213 - 39,235,595 (-)NCBIT2T-CHM13v2.0
Dscam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391696,388,652 - 96,971,935 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1696,392,040 - 96,971,952 (-)EnsemblGRCm39 Ensembl
GRCm381696,587,452 - 97,171,113 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1696,590,840 - 97,170,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv371696,813,686 - 97,392,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361696,697,642 - 97,275,645 (-)NCBIMGSCv36mm8
Celera1697,670,177 - 98,230,565 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.02NCBI
Dscam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,986,108 - 40,473,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540739,985,501 - 40,473,330 (-)NCBIChiLan1.0ChiLan1.0
DSCAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22236,111,075 - 36,938,885 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12130,966,996 - 31,793,715 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02126,366,295 - 27,192,617 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12139,699,077 - 40,054,961 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2139,699,077 - 40,524,164 (-)Ensemblpanpan1.1panPan2
DSCAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13134,666,300 - 35,277,651 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3134,669,424 - 35,400,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3133,951,978 - 34,617,540 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03134,180,996 - 34,914,940 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3134,181,499 - 34,914,869 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13134,050,877 - 34,780,483 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03134,056,656 - 34,784,846 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03134,548,894 - 35,278,352 (-)NCBIUU_Cfam_GSD_1.0
Dscam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497134,128,713 - 34,780,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365002,686,850 - 3,338,498 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365002,686,847 - 3,339,110 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSCAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13203,567,129 - 204,313,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113203,566,765 - 204,292,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213213,656,399 - 213,751,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DSCAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1283,969,555 - 84,738,661 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605411,797,452 - 12,609,644 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dscam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,969,498 - 29,559,968 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,969,464 - 29,560,557 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dscam
4036 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000002215
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
D11Rat35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21136,109,214 - 36,109,441 (+)MAPPERmRatBN7.2
Rnor_6.01137,185,962 - 37,186,188NCBIRnor6.0
Rnor_5.01140,712,093 - 40,712,319UniSTSRnor5.0
RGSC_v3.41137,136,543 - 37,136,770RGDRGSC3.4
RGSC_v3.41137,136,544 - 37,136,770UniSTSRGSC3.4
RGSC_v3.11137,194,132 - 37,194,359RGD
Celera1136,007,191 - 36,007,412UniSTS
RH 2.0 Map11638.8RGD
SHRSP x BN Map1112.7099RGD
FHH x ACI Map1114.4199RGD
Cytogenetic Map11q12UniSTS
D11Rat108  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01137,372,263 - 37,372,397NCBIRnor6.0
Rnor_5.01140,893,271 - 40,893,405UniSTSRnor5.0
Celera1136,182,273 - 36,182,408UniSTS
SHRSP x BN Map1113.8499RGD
SHRSP x BN Map1113.8499UniSTS
Cytogenetic Map11q12UniSTS
D11Got141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21136,457,339 - 36,457,497 (+)MAPPERmRatBN7.2
Rnor_6.01137,539,942 - 37,540,099NCBIRnor6.0
Rnor_5.01141,056,012 - 41,056,169UniSTSRnor5.0
Celera1136,345,942 - 36,346,099UniSTS
Cytogenetic Map11q12UniSTS
Dscam  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,927,626 - 35,927,868 (+)MAPPERmRatBN7.2
Rnor_6.01137,005,012 - 37,005,253NCBIRnor6.0
Rnor_5.01140,530,856 - 40,531,097UniSTSRnor5.0
RGSC_v3.41136,955,464 - 36,955,705UniSTSRGSC3.4
Celera1135,824,655 - 35,824,896UniSTS
Cytogenetic Map11q12UniSTS
BE114490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21136,107,638 - 36,107,854 (+)MAPPERmRatBN7.2
Rnor_6.01137,184,386 - 37,184,601NCBIRnor6.0
Rnor_5.01140,710,517 - 40,710,732UniSTSRnor5.0
RGSC_v3.41137,134,968 - 37,135,183UniSTSRGSC3.4
Celera1136,005,615 - 36,005,830UniSTS
RH 3.4 Map11271.0UniSTS
Cytogenetic Map11q12UniSTS
UniSTS:259605  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,927,456 - 35,927,858 (+)MAPPERmRatBN7.2
Rnor_6.01137,004,842 - 37,005,243NCBIRnor6.0
Rnor_5.01140,530,686 - 40,531,087UniSTSRnor5.0
RGSC_v3.41136,955,294 - 36,955,695UniSTSRGSC3.4
Celera1135,824,485 - 35,824,886UniSTS
Cytogenetic Map11q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 12 113 50 49 19 24 19 6 103 53 93 17 58 30

Sequence


Ensembl Acc Id: ENSRNOT00000002215   ⟹   ENSRNOP00000002215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,927,403 - 36,174,266 (-)Ensembl
Rnor_6.0 Ensembl1137,004,902 - 37,253,776 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094934   ⟹   ENSRNOP00000085284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,927,403 - 36,507,415 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109924   ⟹   ENSRNOP00000093940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,926,896 - 36,507,415 (-)Ensembl
RefSeq Acc Id: NM_133587   ⟹   NP_598271
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,396,844 - 49,976,515 (-)NCBI
mRatBN7.21135,927,391 - 36,507,100 (-)NCBI
Rnor_6.01137,004,776 - 37,599,866 (-)NCBI
Rnor_5.01140,530,620 - 41,112,090 (-)NCBI
Celera1135,824,419 - 36,395,688 (-)RGD
Sequence:
RefSeq Acc Id: XM_039087935   ⟹   XP_038943863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,869,355 (-)NCBI
mRatBN7.21135,921,924 - 36,399,923 (-)NCBI
RefSeq Acc Id: XM_039087936   ⟹   XP_038943864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,976,859 (-)NCBI
mRatBN7.21135,921,924 - 36,507,019 (-)NCBI
RefSeq Acc Id: XM_039087937   ⟹   XP_038943865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,631,868 (-)NCBI
mRatBN7.21135,921,924 - 36,162,541 (-)NCBI
RefSeq Acc Id: XM_039087938   ⟹   XP_038943866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,454,292 - 49,976,859 (-)NCBI
mRatBN7.21135,984,833 - 36,506,774 (-)NCBI
RefSeq Acc Id: XM_039087939   ⟹   XP_038943867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,530,370 (-)NCBI
mRatBN7.21135,921,924 - 36,060,920 (-)NCBI
RefSeq Acc Id: XM_039087940   ⟹   XP_038943868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,530,369 (-)NCBI
mRatBN7.21135,921,924 - 36,060,920 (-)NCBI
RefSeq Acc Id: XM_039087941   ⟹   XP_038943869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,530,369 (-)NCBI
mRatBN7.21135,921,924 - 36,060,920 (-)NCBI
RefSeq Acc Id: XM_039087942   ⟹   XP_038943870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,539,144 (-)NCBI
mRatBN7.21135,921,924 - 36,063,907 (-)NCBI
RefSeq Acc Id: XM_039087943   ⟹   XP_038943871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,521,649 (-)NCBI
mRatBN7.21135,921,924 - 36,052,197 (-)NCBI
RefSeq Acc Id: XM_063270257   ⟹   XP_063126327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,391,385 - 49,530,368 (-)NCBI
RefSeq Acc Id: XM_063270258   ⟹   XP_063126328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,492,182 - 49,976,861 (-)NCBI
RefSeq Acc Id: XM_063270259   ⟹   XP_063126329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,503,669 - 49,976,861 (-)NCBI
RefSeq Acc Id: NP_598271   ⟸   NM_133587
- Peptide Label: precursor
- UniProtKB: Q8VHZ8 (UniProtKB/Swiss-Prot),   F1M9F4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002215   ⟸   ENSRNOT00000002215
RefSeq Acc Id: XP_038943864   ⟸   XM_039087936
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AL19 (UniProtKB/TrEMBL),   F1M9F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943863   ⟸   XM_039087935
- Peptide Label: isoform X2
- UniProtKB: F1M9F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943865   ⟸   XM_039087937
- Peptide Label: isoform X3
- UniProtKB: F1M9F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943870   ⟸   XM_039087942
- Peptide Label: isoform X7
- UniProtKB: A6IQF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943868   ⟸   XM_039087940
- Peptide Label: isoform X6
- UniProtKB: A6IQF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943869   ⟸   XM_039087941
- Peptide Label: isoform X7
- UniProtKB: A6IQF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943867   ⟸   XM_039087939
- Peptide Label: isoform X5
- UniProtKB: A6IQF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943871   ⟸   XM_039087943
- Peptide Label: isoform X9
- UniProtKB: A6IQF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943866   ⟸   XM_039087938
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000093940   ⟸   ENSRNOT00000109924
Ensembl Acc Id: ENSRNOP00000085284   ⟸   ENSRNOT00000094934
RefSeq Acc Id: XP_063126327   ⟸   XM_063270257
- Peptide Label: isoform X8
- UniProtKB: A6IQF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126328   ⟸   XM_063270258
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063126329   ⟸   XM_063270259
- Peptide Label: isoform X11
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHZ8-F1-model_v2 AlphaFold Q8VHZ8 1-2013 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619992 AgrOrtholog
BioCyc Gene G2FUF-21701 BioCyc
Ensembl Genes ENSRNOG00000027992 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055016915 UniProtKB/Swiss-Prot
  ENSRNOG00060021103 UniProtKB/Swiss-Prot
  ENSRNOG00065013902 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002215.8 UniProtKB/TrEMBL
  ENSRNOT00000094934.1 UniProtKB/Swiss-Prot
  ENSRNOT00000109924.1 UniProtKB/TrEMBL
  ENSRNOT00055028744 UniProtKB/Swiss-Prot
  ENSRNOT00060036567 UniProtKB/Swiss-Prot
  ENSRNOT00065022968 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171119 UniProtKB/Swiss-Prot
NCBI Gene 171119 ENTREZGENE
PANTHER DOWN SYNDROME CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10075 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dscam PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027992 RatGTEx
  ENSRNOG00055016915 RatGTEx
  ENSRNOG00060021103 RatGTEx
  ENSRNOG00065013902 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AL19 ENTREZGENE, UniProtKB/TrEMBL
  A6IQF6 ENTREZGENE, UniProtKB/TrEMBL
  DSCAM_RAT UniProtKB/Swiss-Prot
  F1M9F4 ENTREZGENE, UniProtKB/TrEMBL
  Q8VHZ8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Dscam  DS cell adhesion molecule  Dscam  Down syndrome cell adhesion molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Dscam  Down syndrome cell adhesion molecule  LOC100360483  Down syndrome cell adhesion molecule-like  Data merged from RGD:2322073 737654 PROVISIONAL
2013-04-17 Dscam  Down syndrome cell adhesion molecule  LOC686040  similar to Down syndrome cell adhesion molecule  Data merged from RGD:1586656 737654 PROVISIONAL
2010-05-06 LOC100360483  Down syndrome cell adhesion molecule-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC686040  similar to Down syndrome cell adhesion molecule      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Dscam  Down syndrome cell adhesion molecule      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dscam  Down syndrome cell adhesion molecule      Symbol and Name status set to provisional 70820 PROVISIONAL