Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | autistic disorder | | ISO | PCP4 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Autism | ClinVar | PMID:21681106 and PMID:30208311 | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | autistic disorder | | ISO | PCP4 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Autism | ClinVar | PMID:21681106 and PMID:30208311 | |
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# | Reference Title | Reference Citation |
1. | Expression of PEP-19 inhibits apoptosis in PC12 cells. | Erhardt JA, etal., Neuroreport. 2000 Nov 27;11(17):3719-23. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Gene expression in the rat supraoptic nucleus induced by chronic hyperosmolality versus hyposmolality. | Glasgow E, etal., Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1239-50. |
4. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
5. | Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release. | Harashima S, etal., J Neurosci Res. 2011 Oct;89(10):1519-30. doi: 10.1002/jnr.22688. Epub 2011 Jun 10. |
6. | Peptide 19-immunoreactive primary sensory neurons in the rat trigeminal ganglion. | Ichikawa H and Sugimoto T, Brain Res. 1999 Nov 6;846(2):274-9. |
7. | Calmodulin-binding peptide PEP-19 modulates activation of calmodulin kinase II In situ. | Johanson RA, etal., J Neurosci. 2000 Apr 15;20(8):2860-6. |
8. | PEP-19 overexpression in human uterine leiomyoma. | Kanamori T, etal., Mol Hum Reprod. 2003 Nov;9(11):709-17. |
9. | Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload. | Kanazawa Y, etal., Neuroscience. 2008 Jun 23;154(2):473-81. doi: 10.1016/j.neuroscience.2008.03.044. Epub 2008 Mar 26. |
10. | Transcriptome analysis of the hippocampal CA1 pyramidal cell region after kainic acid-induced status epilepticus in juvenile rats. | Lauren HB, etal., PLoS One. 2010 May 20;5(5):e10733. doi: 10.1371/journal.pone.0010733. |
11. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
12. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
13. | GOA pipeline | RGD automated data pipeline |
14. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
15. | RNA-binding activity of the rat calmodulin-binding PEP-19 protein and of the long PEP-19 isoform. | Saladino P, etal., Int J Mol Med. 2012 Feb;29(2):141-5. doi: 10.3892/ijmm.2011.819. Epub 2011 Oct 20. |
16. | Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development. | Sangameswaran L, etal., Proc Natl Acad Sci U S A 1989 Jul;86(14):5651-5. |
17. | Gene expression profiling during rat mammary carcinogenesis induced by 7,12-dimethylbenzanthracene. | Souda M, etal., Int J Cancer. 2009 Sep 15;125(6):1285-97. doi: 10.1002/ijc.24396. |
18. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
19. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
20. | PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease. | Utal AK, etal., Neuroscience. 1998 Oct;86(4):1055-63. |
21. | Expression of Pcp4 gene during osteogenic differentiation of bone marrow mesenchymal stem cells in vitro. | Xiao J, etal., Mol Cell Biochem. 2008 Feb;309(1-2):143-50. Epub 2007 Nov 16. |
PMID:3464961 | PMID:12060780 | PMID:15489334 | PMID:16780588 | PMID:17273800 | PMID:19106096 | PMID:21491429 | PMID:22197496 | PMID:22458599 | PMID:23204517 | PMID:25048017 | PMID:31686426 |
Pcp4 (Rattus norvegicus - Norway rat) |
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PCP4 (Homo sapiens - human) |
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Pcp4 (Mus musculus - house mouse) |
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Pcp4 (Chinchilla lanigera - long-tailed chinchilla) |
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PCP4 (Pan paniscus - bonobo/pygmy chimpanzee) |
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PCP4 (Canis lupus familiaris - dog) |
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Pcp4 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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PCP4 (Sus scrofa - pig) |
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PCP4 (Chlorocebus sabaeus - green monkey) |
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Pcp4 (Heterocephalus glaber - naked mole-rat) |
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Variants in Pcp4
680 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH130970 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 1 | 1 | 68 | 7 | ||||||||
Low | 28 | 20 | 5 | 18 | 5 | 7 | 7 | 6 | 31 | 24 | 11 | 7 | |
Below cutoff | 10 | 29 | 29 | 29 | 1 | 2 | 4 | 9 | 1 |
RefSeq Transcripts | NM_001270538 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_013002 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039088042 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC142238 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AJ493658 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC059147 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BG665749 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BG666168 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB613293 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ097405 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ211827 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ212601 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000011 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M24852 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000002221 ⟹ ENSRNOP00000002221 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000061047 ⟹ ENSRNOP00000057764 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000105621 ⟹ ENSRNOP00000082469 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000119525 ⟹ ENSRNOP00000085635 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001270538 ⟹ NP_001257467 | ||||||||||||||||||||
RefSeq Status: | REVIEWED | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NM_013002 ⟹ NP_037134 | ||||||||||||||||||||||||||||
RefSeq Status: | REVIEWED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039088042 ⟹ XP_038943970 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_001257467 | (Get FASTA) | NCBI Sequence Viewer |
NP_037134 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038943970 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA41828 | (Get FASTA) | NCBI Sequence Viewer |
AAH59147 | (Get FASTA) | NCBI Sequence Viewer | |
CAD38515 | (Get FASTA) | NCBI Sequence Viewer | |
EDM10956 | (Get FASTA) | NCBI Sequence Viewer | |
EDM10957 | (Get FASTA) | NCBI Sequence Viewer | |
EDM10958 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000002221 | ||
ENSRNOP00000002221.5 | |||
ENSRNOP00000057764 | |||
ENSRNOP00000057764.2 | |||
ENSRNOP00000082469.1 | |||
ENSRNOP00000085635.1 | |||
ENSRNOP00055023130 | |||
ENSRNOP00060031000 | |||
ENSRNOP00065017791 | |||
GenBank Protein | P63055 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_037134 ⟸ NM_013002 |
- Peptide Label: | isoform PEP19 |
- UniProtKB: | P63055 (UniProtKB/Swiss-Prot), A0A8I5ZX37 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | NP_001257467 ⟸ NM_001270538 |
- Peptide Label: | isoform LPI |
- UniProtKB: | Q8CHN7 (UniProtKB/TrEMBL), F7F9D7 (UniProtKB/TrEMBL), A0A8I6A0K8 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000057764 ⟸ ENSRNOT00000061047 |
RefSeq Acc Id: | ENSRNOP00000002221 ⟸ ENSRNOT00000002221 |
RefSeq Acc Id: | XP_038943970 ⟸ XM_039088042 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8I5ZX37 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000082469 ⟸ ENSRNOT00000105621 |
RefSeq Acc Id: | ENSRNOP00000085635 ⟸ ENSRNOT00000119525 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P63055-F1-model_v2 | AlphaFold | P63055 | 1-62 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:3271 | AgrOrtholog |
BioCyc Gene | G2FUF-21702 | BioCyc |
Ensembl Genes | ENSRNOG00000001628 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ENSRNOG00055016900 | UniProtKB/Swiss-Prot | |
ENSRNOG00060021646 | UniProtKB/Swiss-Prot | |
ENSRNOG00065013889 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000002221 | ENTREZGENE |
ENSRNOT00000002221.7 | UniProtKB/TrEMBL | |
ENSRNOT00000061047 | ENTREZGENE | |
ENSRNOT00000061047.4 | UniProtKB/Swiss-Prot | |
ENSRNOT00000105621.1 | UniProtKB/TrEMBL | |
ENSRNOT00000119525.1 | UniProtKB/TrEMBL | |
ENSRNOT00055028716 | UniProtKB/Swiss-Prot | |
ENSRNOT00060037606 | UniProtKB/Swiss-Prot | |
ENSRNOT00065022899 | UniProtKB/Swiss-Prot | |
IMAGE_CLONE | IMAGE:6888437 | IMAGE-MGC_LOAD |
KEGG Report | rno:25510 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:72910 | IMAGE-MGC_LOAD |
NCBI Gene | 25510 | ENTREZGENE |
PANTHER | IG-LIKE DOMAIN-CONTAINING PROTEIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR15359:SF7 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Pcp4 | PhenoGen |
RatGTEx | ENSRNOG00000001628 | RatGTEx |
ENSRNOG00055016900 | RatGTEx | |
ENSRNOG00060021646 | RatGTEx | |
ENSRNOG00065013889 | RatGTEx | |
TIGR | TC216655 | |
UniProt | A0A8I5ZX37 | ENTREZGENE, UniProtKB/TrEMBL |
A0A8I6A0K8 | ENTREZGENE, UniProtKB/TrEMBL | |
A6IQF3_RAT | UniProtKB/TrEMBL | |
A6IQF4_RAT | UniProtKB/TrEMBL | |
F7F9D7 | ENTREZGENE, UniProtKB/TrEMBL | |
P63055 | ENTREZGENE, UniProtKB/Swiss-Prot | |
Q8CHN7 | ENTREZGENE, UniProtKB/TrEMBL | |
UniProt Secondary | P07734 | UniProtKB/Swiss-Prot |
Q63890 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2015-07-29 | Pcp4 | Purkinje cell protein 4 | LOC102551106 | uncharacterized LOC102551106 | Data merged from RGD:7703115 | 737654 | PROVISIONAL |
2013-12-18 | LOC102551106 | uncharacterized LOC102551106 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_expression | expressed in cerebellum, thalamus caudate putamen, and olfactory bulb | 633595 |