Olig2 (oligodendrocyte transcription factor 2) - Rat Genome Database

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Gene: Olig2 (oligodendrocyte transcription factor 2) Rattus norvegicus
Analyze
Symbol: Olig2
Name: oligodendrocyte transcription factor 2
RGD ID: 1307098
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and identical protein binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Biomarker of status epilepticus. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304103; oligodendrocyte lineage transcription factor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21130,475,510 - 30,478,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,475,398 - 30,480,152 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1139,162,510 - 39,165,873 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01131,833,948 - 31,837,317 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01131,008,354 - 31,011,714 (+)NCBIRnor_WKY
Rnor_6.01131,389,514 - 31,392,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,389,514 - 31,392,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01134,998,542 - 35,001,918 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,205,416 - 31,208,792 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,244,022 - 31,245,269 (+)NCBI
Celera1130,143,763 - 30,147,131 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS. Fancy SP, etal., Mol Cell Neurosci 2004 Nov;27(3):247-54.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Neurotoxocarosis alters myelin protein gene transcription and expression. Heuer L, etal., Parasitol Res. 2015 Jun;114(6):2175-86. doi: 10.1007/s00436-015-4407-1. Epub 2015 Mar 17.
4. Effects of Olig2-overexpressing neural stem cells and myelin basic protein-activated T cells on recovery from spinal cord injury. Hu JG, etal., Neurotherapeutics. 2012 Apr;9(2):422-45. doi: 10.1007/s13311-011-0090-9.
5. Gene Expression Profiling of Breast Cancer Brain Metastasis. Lee JY, etal., Sci Rep. 2016 Jun 24;6:28623. doi: 10.1038/srep28623.
6. Demyelination contributes to depression comorbidity in a rat model of chronic epilepsy via dysregulation of Olig2/LINGO-1 and disturbance of calcium homeostasis. Ma T, etal., Exp Neurol. 2019 Nov;321:113034. doi: 10.1016/j.expneurol.2019.113034. Epub 2019 Aug 12.
7. Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis. Masliah E, etal., J Neuroimmunol. 2004 Dec;157(1-2):163-75. doi: 10.1016/j.jneuroim.2004.08.026.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. Qiu X, etal., J Immunol Res. 2018 Feb 27;2018:2952471. doi: 10.1155/2018/2952471. eCollection 2018.
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Local injection of Lenti-Olig2 at lesion site promotes functional recovery of spinal cord injury in rats. Tan BT, etal., CNS Neurosci Ther. 2017 Jun;23(6):475-487. doi: 10.1111/cns.12694. Epub 2017 Apr 27.
13. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Yu Y, etal., Cell. 2013 Jan 17;152(1-2):248-61. doi: 10.1016/j.cell.2012.12.006.
14. [Effect of Yishen Daluo Decoction on the expression of PLP, Olig1, and Olig2 in mice with experimental autoimmune encephalomyelitis]. Zhu WH, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 May;34(5):562-5.
Additional References at PubMed
PMID:11566099   PMID:11955448   PMID:14573534   PMID:15655114   PMID:16436615   PMID:16582099   PMID:17488716   PMID:17510983   PMID:17872503   PMID:18287202   PMID:18682850   PMID:19357274  
PMID:19473238   PMID:20181579   PMID:21338882   PMID:22162276   PMID:23973956   PMID:25200619   PMID:30143582   PMID:35301318  


Genomics

Comparative Map Data
Olig2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21130,475,510 - 30,478,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,475,398 - 30,480,152 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1139,162,510 - 39,165,873 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01131,833,948 - 31,837,317 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01131,008,354 - 31,011,714 (+)NCBIRnor_WKY
Rnor_6.01131,389,514 - 31,392,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,389,514 - 31,392,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01134,998,542 - 35,001,918 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,205,416 - 31,208,792 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,244,022 - 31,245,269 (+)NCBI
Celera1130,143,763 - 30,147,131 (+)NCBICelera
Cytogenetic Map11q11NCBI
OLIG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382133,025,935 - 33,029,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2133,025,935 - 33,029,196 (+)EnsemblGRCh38hg38GRCh38
GRCh372134,398,243 - 34,401,493 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,320,109 - 33,323,370 (+)NCBINCBI36Build 36hg18NCBI36
Build 342133,320,162 - 33,323,371NCBI
Celera2119,583,840 - 19,587,101 (+)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2119,809,438 - 19,812,730 (+)NCBIHuRef
CHM1_12133,960,322 - 33,963,610 (+)NCBICHM1_1
T2T-CHM13v2.02131,394,108 - 31,397,358 (+)NCBIT2T-CHM13v2.0
Olig2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,016,745 - 91,025,567 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,022,345 - 91,025,565 (+)EnsemblGRCm39 Ensembl
GRCm381691,225,550 - 91,228,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1691,225,457 - 91,228,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv371691,225,795 - 91,228,922 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361691,114,409 - 91,117,536 (+)NCBIMGSCv36mm8
Celera1692,308,914 - 92,312,041 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1652.6NCBI
Olig2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540732,433,849 - 32,434,923 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540732,432,888 - 32,436,209 (+)NCBIChiLan1.0ChiLan1.0
OLIG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12132,766,039 - 32,769,408 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02119,387,860 - 19,391,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OLIG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13127,674,112 - 27,677,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3127,674,107 - 27,676,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3127,667,931 - 27,670,007 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03127,878,129 - 27,880,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3127,878,117 - 27,880,829 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13127,745,936 - 27,748,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03127,755,719 - 27,757,790 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03128,259,002 - 28,261,083 (+)NCBIUU_Cfam_GSD_1.0
Olig2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497128,219,922 - 28,222,625 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365009,245,880 - 9,247,756 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365009,244,595 - 9,247,756 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OLIG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13196,599,822 - 196,600,793 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113196,596,838 - 196,602,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213206,661,824 - 206,663,897 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OLIG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,151,151 - 59,161,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl259,152,487 - 59,153,458 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660711,690,456 - 1,693,867 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Olig2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474521,270,965 - 21,272,932 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474521,270,804 - 21,274,225 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Olig2
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:184
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000000325
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
D11Got136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21130,476,293 - 30,476,492 (+)MAPPERmRatBN7.2
Rnor_6.01131,390,298 - 31,390,496NCBIRnor6.0
Rnor_5.01134,999,326 - 34,999,524UniSTSRnor5.0
RGSC_v3.41131,206,200 - 31,206,398UniSTSRGSC3.4
Celera1130,144,547 - 30,144,745UniSTS
Cytogenetic Map11q11UniSTS
Olig2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21130,476,806 - 30,477,057 (+)MAPPERmRatBN7.2
Rnor_6.01131,390,811 - 31,391,061NCBIRnor6.0
Rnor_5.01134,999,839 - 35,000,089UniSTSRnor5.0
RGSC_v3.41131,206,713 - 31,206,963UniSTSRGSC3.4
Celera1130,145,060 - 30,145,310UniSTS
Cytogenetic Map11q11UniSTS
D21S392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21130,477,249 - 30,477,329 (+)MAPPERmRatBN7.2
Rnor_6.01131,391,254 - 31,391,333NCBIRnor6.0
Rnor_5.01135,000,282 - 35,000,361UniSTSRnor5.0
RGSC_v3.41131,207,156 - 31,207,235UniSTSRGSC3.4
Celera1130,145,503 - 30,145,582UniSTS
Cytogenetic Map11q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 62 1
Low 13 14 12 8 7
Below cutoff 3 8 12 9 5 9 8 8 8 10 2 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000325   ⟹   ENSRNOP00000000325
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,475,398 - 30,480,152 (+)Ensembl
Rnor_6.0 Ensembl1131,389,514 - 31,392,890 (+)Ensembl
RefSeq Acc Id: NM_001100557   ⟹   NP_001094027
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,475,510 - 30,478,886 (+)NCBI
Rnor_6.01131,389,514 - 31,392,890 (+)NCBI
Rnor_5.01134,998,542 - 35,001,918 (+)NCBI
RGSC_v3.41131,205,416 - 31,208,792 (+)RGD
Celera1130,143,763 - 30,147,131 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094027 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE92724 (Get FASTA)   NCBI Sequence Viewer  
  EDM10712 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001094027   ⟸   NM_001100557
- UniProtKB: G3V612 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000325   ⟸   ENSRNOT00000000325
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V612-F1-model_v2 AlphaFold G3V612 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307098 AgrOrtholog
BioCyc Gene G2FUF-21909 BioCyc
Ensembl Genes ENSRNOG00000028658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000325 ENTREZGENE
  ENSRNOP00000000325.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000325 ENTREZGENE
  ENSRNOT00000000325.7 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro HLH_DNA-bd_sf UniProtKB/TrEMBL
  HLH_dom UniProtKB/TrEMBL
  Olig2 UniProtKB/TrEMBL
KEGG Report rno:304103 UniProtKB/TrEMBL
NCBI Gene 304103 ENTREZGENE
PANTHER PTHR19290:SF32 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PhenoGen Olig2 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
UniProt G3V612 ENTREZGENE, UniProtKB/TrEMBL
  Q1XIC8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Olig2  oligodendrocyte transcription factor 2  Olig2  oligodendrocyte lineage transcription factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Olig2  oligodendrocyte lineage transcription factor 2  Olig2  oligodendrocyte transcription factor 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Olig2  oligodendrocyte transcription factor 2   Olig2_predicted  oligodendrocyte transcription factor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Olig2_predicted  oligodendrocyte transcription factor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED